ATE512982T1 - Verfahren und zusammensetzung zum gezielten einbringen in exosome - Google Patents

Verfahren und zusammensetzung zum gezielten einbringen in exosome

Info

Publication number
ATE512982T1
ATE512982T1 AT02767380T AT02767380T ATE512982T1 AT E512982 T1 ATE512982 T1 AT E512982T1 AT 02767380 T AT02767380 T AT 02767380T AT 02767380 T AT02767380 T AT 02767380T AT E512982 T1 ATE512982 T1 AT E512982T1
Authority
AT
Austria
Prior art keywords
methods
relates
membrane vesicles
well
exosomes
Prior art date
Application number
AT02767380T
Other languages
English (en)
Inventor
Alain Delcayre
Pecq Jean-Bernard Le
Original Assignee
Exothera L L C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exothera L L C filed Critical Exothera L L C
Application granted granted Critical
Publication of ATE512982T1 publication Critical patent/ATE512982T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT02767380T 2001-08-17 2002-08-14 Verfahren und zusammensetzung zum gezielten einbringen in exosome ATE512982T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31315901P 2001-08-17 2001-08-17
US34399101P 2001-12-26 2001-12-26
PCT/EP2002/009108 WO2003016522A2 (en) 2001-08-17 2002-08-14 Methods and compounds for the targeting of protein to exosomes

Publications (1)

Publication Number Publication Date
ATE512982T1 true ATE512982T1 (de) 2011-07-15

Family

ID=26978714

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02767380T ATE512982T1 (de) 2001-08-17 2002-08-14 Verfahren und zusammensetzung zum gezielten einbringen in exosome

Country Status (10)

Country Link
US (1) US7704964B2 (de)
EP (1) EP1417229B1 (de)
JP (1) JP4662708B2 (de)
CN (1) CN100590131C (de)
AT (1) ATE512982T1 (de)
AU (1) AU2002331244B2 (de)
CA (1) CA2454756C (de)
HK (1) HK1062444A1 (de)
IL (1) IL160142A0 (de)
WO (1) WO2003016522A2 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE512982T1 (de) 2001-08-17 2011-07-15 Exothera L L C Verfahren und zusammensetzung zum gezielten einbringen in exosome
AU2003237870A1 (en) * 2002-06-07 2003-12-22 The Brigham & Women's Hospital, Inc. Method and composition for inhibing or slowing blood coagulation
JP4939926B2 (ja) * 2003-02-14 2012-05-30 アノシス・インコーポレーテッド 抗体を生成し抗体レパートリーをスクリーニングするための方法とコンパウンド
US7771956B2 (en) * 2003-06-30 2010-08-10 Brigham & Women's Hospital, Inc. Method for detecting the presence of a phospholipid
US7439221B2 (en) * 2003-10-17 2008-10-21 Emory University Methods and compositions for modulating gamete adhesion
CA2608271C (en) * 2005-05-13 2016-01-19 The Feinstein Institute For Medical Research Milk fat globule epidermal growth factor-factor viii and sepsis
CN1322115C (zh) * 2005-07-06 2007-06-20 清华大学 载有外源配体分子的胞外体及其制备方法与应用
WO2007103572A2 (en) * 2006-03-09 2007-09-13 Aethlon Medical, Inc. Extracorporeal removal of microvesicular particles
US9085778B2 (en) 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
BRPI0806436A2 (pt) * 2007-01-26 2011-09-06 Univ Lousville Res Foundation Inc modificação de componentes exossomais para uso como uma vacina
CA2697629A1 (en) 2007-09-24 2009-04-02 The University Of Queensland Molecular delivery vesicle
FR2928926B1 (fr) * 2008-03-18 2015-08-21 Centre Nat Rech Scient Polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leur utilisation pour la production de compositions immunogenes
BRPI0919882A8 (pt) * 2008-10-30 2017-09-19 Caris Life Sciences Luxembourg Holdings Métodos para avaliar padrões de rna
WO2010056337A2 (en) * 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
ES2749393T3 (es) * 2009-04-17 2020-03-20 Univ Oxford Innovation Ltd Composición para entrega de material genético
FR2950350B1 (fr) * 2009-09-24 2013-12-13 Centre Nat Rech Scient Nouveaux polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leurs utilisations
WO2011097480A1 (en) * 2010-02-05 2011-08-11 University Of Louisville Research Foundation, Inc. Exosomal compositions and methods for the treatment of disease
AU2011223789A1 (en) 2010-03-01 2012-09-20 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
CA2795776A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
CA2807942C (en) 2010-08-10 2021-07-27 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
WO2012135844A2 (en) 2011-04-01 2012-10-04 Cornell University Circulating exosomes as diagnostic/prognostic indicators and therapeutic targets of melanoma and other cancers
ITRM20110403A1 (it) 2011-07-28 2013-01-29 Ospedale Pediatrico Bambino Gesu Microvescicole isolate da cellule mesenchimali come agenti immunosoppressori.
KR20130032646A (ko) * 2011-09-23 2013-04-02 삼성전자주식회사 막단백질 및 광발생 단백질이 결합된 융합단백질을 포함하는 재조합 엑소좀을 이용한 엑소좀 수득율을 측정하는 방법
GB201121070D0 (en) * 2011-12-07 2012-01-18 Isis Innovation composition for delivery of biotherapeutics
WO2014168721A2 (en) * 2013-04-12 2014-10-16 Tufts Medical Center Methods and systems for designing and/or characterizing soluble lipidated ligand agents
US11274139B2 (en) 2013-04-12 2022-03-15 Evox Therapeutics Ltd Therapeutic delivery vesicles
US10877033B2 (en) 2013-06-18 2020-12-29 Oxford University Innovation Limited Method of detecting the presence or absence of autoantibodies
GB201313249D0 (en) * 2013-07-25 2013-09-11 Isis Innovation Method
EP2862874B1 (de) * 2013-10-15 2018-12-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung polyklonaler Antikörper mit einer Antigenzusammensetzung mit proteinhaltigen Membranvesikeln
EP3057662A4 (de) * 2013-10-17 2017-03-29 Children's Hospital Los Angeles Antikörperabhängige exosomtherapie
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
JP6744227B2 (ja) 2014-02-21 2020-08-19 エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ（ウペエフエル）Ｅｃｏｌｅ Ｐｏｌｙｔｅｃｈｎｉｑｕｅ Ｆｅｄｅｒａｌｅ ｄｅ Ｌａｕｓａｎｎｅ （ＥＰＦＬ） 糖標的化治療剤
TW201627318A (zh) * 2014-10-22 2016-08-01 臺北醫學大學 膽固醇酯轉運蛋白抗原肽及其融合蛋白以及其組合物及應用
KR20160130937A (ko) * 2015-05-04 2016-11-15 한국과학기술원 목적 단백질을 포함하는 엑소솜의 제조 방법 및 상기 제조 방법에 의해 제조된 엑소솜을 이용하여 목적 단백질을 세포질로 전달시키는 방법
US10702581B2 (en) 2015-05-04 2020-07-07 Ilias Biologics Inc. Compositions containing protein loaded exosome and methods for preparing and delivering the same
AU2016275046B2 (en) 2015-06-10 2022-07-28 Board Of Regents, The University Of Texas System Use of exosomes for the treatment of disease
US9840542B2 (en) 2015-09-11 2017-12-12 Nomadogen Biotechnologies Inc. Methods and compositions for the packaging of nucleic acids into microglial exosomes for the targeted expression of polypeptides in neural cells
WO2017118764A1 (en) * 2016-01-07 2017-07-13 Thomas Brocker Novel approaches for the in vivo and in vitro visualization of dying cells
EP3405208B1 (de) 2016-01-22 2020-04-29 Tufts Medical Center, Inc. Verbindungen und verfahren zur behandlung von entzündungen
CA3013685A1 (en) 2016-03-03 2017-09-08 Institut Gustave Roussy Ptps-based vaccines against cancer
WO2017173367A2 (en) 2016-03-31 2017-10-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Extracellular vesicles, methods of making them, and methods of reducing liver uptake of extracellular vesicles
US20190112351A1 (en) * 2016-04-04 2019-04-18 National Institutes Of Biomedical Innovation, Health And Nutrition Exosome-targeted dna vaccine
CN108473973A (zh) * 2016-09-30 2018-08-31 赛尔莱克斯生命科学公司 包含负载蛋白的外泌体的组合物以及制备和递送该组合物的方法
US10487143B2 (en) * 2016-10-05 2019-11-26 Duke University Vaccines against HER3 antigens and methods of using the same
CN108324735B (zh) * 2017-01-20 2024-02-09 李莉 用于疾病治疗的胞外体制剂及其应用
CN107185612B (zh) * 2017-03-17 2020-12-01 庶安永龄(厦门)健康产业有限公司 一种应用于外泌体捕获的微流体芯片及其制备方法
US11672849B2 (en) * 2017-05-10 2023-06-13 University Of Louisville Research Foundation, Inc. Method of inhibiting lung or breast cancer growth with engineered embryonic stem-cell derived exosomes compositions
WO2018232176A1 (en) 2017-06-16 2018-12-20 The University Of Chicago Compositions and methods for inducing immune tolerance
WO2019027847A1 (en) 2017-07-29 2019-02-07 University Of Southern California SYNTHETIC EXTRACELLULAR VESICLES FOR NEW THERAPIES
WO2019067464A1 (en) * 2017-09-27 2019-04-04 The Board Of Trustees Of The Leland Stanford Junior University THERAPEUTIC AGENTS SPECIALLY ADMINISTERED BY EXOSOMES FOR THE TREATMENT OF CANCER
EA202091134A1 (ru) * 2017-12-28 2020-11-20 Кодиак Байосайенсес, Инк. Экзосомы для иммуноонкологической и противовоспалительной терапии
WO2019199941A1 (en) * 2018-04-10 2019-10-17 Northwestern University Extracellular vesicles comprising targeting affinity domain-based membrane proteins
US20220409741A1 (en) * 2019-09-02 2022-12-29 Kyungpook National University Industry-Academic Cooperation Foundation Composition for preventing or treating cancer, containing il-2 surface expression-extracellular vesicles as active ingredient
CN112824530A (zh) * 2019-11-20 2021-05-21 中国科学院深圳先进技术研究院 一种hek293f悬浮细胞高效电转染方法
WO2021151029A1 (en) * 2020-01-22 2021-07-29 Agex Therapeutics, Inc. Therapeutic exosomes and method of producing them
JP2023512562A (ja) 2020-02-05 2023-03-27 ダイアデム バイオセラピューティクス インコーポレイテッド 人工シナプス
CA3240174A1 (en) 2021-12-06 2023-06-15 Zaine El Abiddine Robert Mamoun Chimeric adiponectin polypeptides, extracellular vesicle comprising the same, and uses thereof
CN116676265B (zh) * 2023-04-18 2024-05-24 河南中医药大学第一附属医院 一种酸敏融合肽靶向外泌体及其制备方法和应用
CN116769717B (zh) * 2023-04-18 2024-06-11 河南中医药大学第一附属医院 一种靶向外泌体及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455031A (en) 1990-11-01 1995-10-03 Cancer Research Fund Of Contra Costa Polypeptide with 46 Kdalton HMFG differentiation antigen binding specificity, composition, kit and diagnostic method
US5972337A (en) * 1990-11-01 1999-10-26 Cancer Research Fund Of Contra Costa 46 kilodalton human milk fat globule (HMFG) antigen, fragments and fusion protein
IT1264516B1 (it) 1993-05-31 1996-09-24 Biotop Sas Di Rita Cassarin Cellule dendritiche immortalizzate
DE69635895D1 (de) 1995-08-03 2006-05-04 Rijksuniversiteit Te Leiden Le Antigen presentierende bläschen, die von zellen ableiten
US5834015A (en) 1996-09-11 1998-11-10 Albany Medical College Protein-lipid vesicles and autogenous vaccine comprising the same
FR2766205B1 (fr) 1997-07-16 2002-08-30 Inst Nat Sante Rech Med Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede
FR2785543B1 (fr) 1998-11-05 2003-02-28 Inst Nat Sante Rech Med Exosomes modifies et utilisations
EP1004664A1 (de) 1998-11-24 2000-05-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) Zusammensetzungen und Verfahren unter Verwendung von Lactadherin oder Lactadherinderivaten
FR2788780B1 (fr) 1999-01-27 2001-03-30 Ap Cells Inc Procede de preparation de vesicules membranaires
US20040241176A1 (en) 2000-04-27 2004-12-02 Ap Cells. Inc. Method of producing membrane vesicles
US6410271B1 (en) 2000-06-23 2002-06-25 Genetastix Corporation Generation of highly diverse library of expression vectors via homologous recombination in yeast
WO2002056831A2 (en) 2000-12-27 2002-07-25 Dana-Farber Cancer Institute, Inc. Immunogenic proteoliposomes, and uses thereof
ATE512982T1 (de) 2001-08-17 2011-07-15 Exothera L L C Verfahren und zusammensetzung zum gezielten einbringen in exosome
CA2479021A1 (en) 2002-03-14 2003-09-18 Anosys, Inc. Functionalization of t cell derived vesicles and use thereof for the preparation of immunogenic pharmaceutical compositions

Also Published As

Publication number Publication date
WO2003016522A2 (en) 2003-02-27
AU2002331244B2 (en) 2007-02-15
JP4662708B2 (ja) 2011-03-30
CA2454756C (en) 2014-02-18
CA2454756A1 (en) 2003-02-27
IL160142A0 (en) 2004-06-20
US20040197314A1 (en) 2004-10-07
JP2005503791A (ja) 2005-02-10
EP1417229B1 (de) 2011-06-15
EP1417229A2 (de) 2004-05-12
US7704964B2 (en) 2010-04-27
CN100590131C (zh) 2010-02-17
HK1062444A1 (en) 2004-11-05
WO2003016522A3 (en) 2003-08-28
CN1543476A (zh) 2004-11-03

Similar Documents

Publication Publication Date Title
ATE512982T1 (de) Verfahren und zusammensetzung zum gezielten einbringen in exosome
EP2141243A3 (de) Proteingerüste für Antikörpermimetika und andere Bindungsproteine
MXPA02010670A (es) Nuevas moleculas co-estimuladoras de celula dendritica.
MY162624A (en) Antibodies directed to her-3 and uses thereof
BG104149A (en) Interleukin-18-binding proteins, methods for their preparation and administration
NZ591415A (en) Haemophilus influenzae type B
ATE184647T1 (de) Embryonische stammzelle zur herstellung von chimäre und transgen-ongulaten
ATE200679T1 (de) Neues verfahren zur herstellung von anti-humanen antigenrezeptoren und deren verwendungen
BG100771A (en) Hematopoeic protein and ways and methods for its preparation
MX348154B (es) Anticuerpos de enlace a il-1-beta y fragmentos de los mismos.
DE69826465D1 (de) Verfahren zur in vitro evolution von proteinfunktionen
MXPA02008724A (es) Receptores del gusto t1r y genes que codifican los mismos.
ATE315652T1 (de) Polypeptidzusammensetzungen von bacillus thuringiensis cryet70 die für diabrotica insekten toxisch sind, und methoden zur dessen verwendung
MX2009013824A (es) Proteinas de enlace de antigeno que enlazan par-2.
TR200001861T2 (tr) Yeni G protein birleştirilmiş alıcı
ES2061038T3 (es) Secuencia de cdna de lactoferrina humana.
DE60310385D1 (de) Sekretion von proteinen mit mehreren disulfidbindungen in bakterien und verwendungen davon
DE50112802D1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
IL172729A0 (en) Reagents and methods for the formation of disulfide bonds and the glycosylation of proteins
WO1995019435A3 (en) T cell antigen receptor v region proteins and methods of preparation thereof
ATE135371T1 (de) Mit akuter pankreatitis assoziiertes protein, mittel zur diagnose von akuter pankreatitis
ATE337336T1 (de) Nukleinsäuren, die für stichodactylidae chromoproteine kodieren
DE69737651D1 (de) Cortistatin: neuropeptide, zusammensetzungen und methoden
WO1999019470A3 (en) Gfp-annexin fusion proteins
MX9703676A (es) Inmunogenos para estimular la inmunidad de las mucosas.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties