JP7620565B2 - 有効成分顆粒の連続製造のためのプロセス - Google Patents

有効成分顆粒の連続製造のためのプロセス Download PDF

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Publication number
JP7620565B2
JP7620565B2 JP2021560695A JP2021560695A JP7620565B2 JP 7620565 B2 JP7620565 B2 JP 7620565B2 JP 2021560695 A JP2021560695 A JP 2021560695A JP 2021560695 A JP2021560695 A JP 2021560695A JP 7620565 B2 JP7620565 B2 JP 7620565B2
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active ingredient
particles
process space
liquid
spray composition
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Japanese (ja)
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JPWO2020208201A5 (enExample
JP2022528570A (ja
Inventor
ノヴァク，ラインハルト
ペリンガー，ノルベルト
グラーヴェ，アネット
ヤコブ，ミハエル
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ADD Advanced Drug Delivery Technologies AG
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ADD Advanced Drug Delivery Technologies AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glanulating (AREA)
JP2021560695A 2019-04-11 2020-04-09 有効成分顆粒の連続製造のためのプロセス Active JP7620565B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19168673.2 2019-04-11
EP19168673.2A EP3721870A1 (de) 2019-04-11 2019-04-11 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
PCT/EP2020/060277 WO2020208201A1 (de) 2019-04-11 2020-04-09 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats

Publications (3)

Publication Number Publication Date
JP2022528570A JP2022528570A (ja) 2022-06-14
JPWO2020208201A5 JPWO2020208201A5 (enExample) 2023-04-14
JP7620565B2 true JP7620565B2 (ja) 2025-01-23

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ID=66105201

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JP2021560695A Active JP7620565B2 (ja) 2019-04-11 2020-04-09 有効成分顆粒の連続製造のためのプロセス

Country Status (9)

Country Link
US (1) US20220323361A1 (enExample)
EP (2) EP3721870A1 (enExample)
JP (1) JP7620565B2 (enExample)
CN (1) CN114126591A (enExample)
AU (1) AU2020272151B2 (enExample)
BR (1) BR112021020320A2 (enExample)
CA (1) CA3136529A1 (enExample)
IL (1) IL287126A (enExample)
WO (1) WO2020208201A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3721871A1 (de) * 2019-04-11 2020-10-14 ADD Advanced Drug Delivery Technologies, Ltd. Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
KR102857295B1 (ko) 2020-11-24 2025-09-08 나노폼 핀란드 오와이제이 입자 생성을 위한 시스템, 장치, 기기 및 방법
CN116422227B (zh) * 2022-12-09 2024-01-30 山东奥诺能源科技股份有限公司 一种流化床造粒机

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030039699A1 (en) 2001-03-07 2003-02-27 Yasushi Ochiai Method of manufacturing drug granules, the drug granules and pharmaceutical preparation containing the drug granules
JP2017529381A (ja) 2014-10-13 2017-10-05 シージェイ ヘルスケア コーポレイションＣｊ Ｈｅａｌｔｈｃａｒｅ Ｃｏｒｐｏｒａｔｉｏｎ メトホルミン徐放性製剤及びその製造方法
WO2018034627A1 (en) 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19514187C1 (de) * 1995-04-21 1996-05-15 Degussa Verfahren und Vorrichtung zur Herstellung von Granulaten durch Wirbelschicht-Sprühgranulation
US6117451A (en) 1998-08-25 2000-09-12 Pharmalogix, Inc. Direct compression metformin hydrochloride tablets
DE10004939C1 (de) 2000-02-05 2001-08-23 Lothar Moerl Steuerbare Gasanströmeinrichtung für Strahlschichtapparate
US6667054B2 (en) 2001-12-05 2003-12-23 Bernard Charles Sherman Metformin hydrochloride tablets
DE10322062A1 (de) 2003-05-15 2004-12-02 Glatt Ingenieurtechnik Gmbh Verfahren und Vorrichtung zum Aufbringen von Flüssigkeiten in eine Feststoffströmung eines Strahlschichtapparates
PT1638678E (pt) 2003-06-11 2012-01-05 Glatt Ingtech Gmbh Método para produção de granulados enzimáticos e granulados enzimáticos assim obtidos
EP1781253A1 (en) * 2004-07-01 2007-05-09 Warner-Lambert Company LLC Preparation of pharmaceutical compositions containing nanoparticles
DE102007012105A1 (de) 2007-03-13 2008-09-18 Add Advanced Drug Delivery Technologies Ltd. Pellets enthaltend pharmazeutische Substanz, Verfahren zu deren Herstellung und deren Verwendung
CN102970981A (zh) * 2010-07-06 2013-03-13 詹森药业有限公司 糖尿病协同治疗制剂
WO2013143688A1 (en) * 2012-03-26 2013-10-03 Glatt Ag Taste-masked ibuprofen granules
WO2015012365A1 (ja) * 2013-07-25 2015-01-29 株式会社 三和化学研究所 医薬製剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030039699A1 (en) 2001-03-07 2003-02-27 Yasushi Ochiai Method of manufacturing drug granules, the drug granules and pharmaceutical preparation containing the drug granules
JP2017529381A (ja) 2014-10-13 2017-10-05 シージェイ ヘルスケア コーポレイションＣｊ Ｈｅａｌｔｈｃａｒｅ Ｃｏｒｐｏｒａｔｉｏｎ メトホルミン徐放性製剤及びその製造方法
WO2018034627A1 (en) 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet

Also Published As

Publication number Publication date
IL287126A (en) 2022-01-01
EP3721870A1 (de) 2020-10-14
WO2020208201A1 (de) 2020-10-15
CA3136529A1 (en) 2020-10-15
EP3952843B1 (de) 2025-08-06
EP3952843A1 (de) 2022-02-16
CN114126591A (zh) 2022-03-01
AU2020272151A1 (en) 2021-12-09
AU2020272151B2 (en) 2025-07-03
BR112021020320A2 (pt) 2021-12-14
JP2022528570A (ja) 2022-06-14
US20220323361A1 (en) 2022-10-13

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