AU2020272151B2 - Process for continuous production of an active ingredient granulate - Google Patents

Process for continuous production of an active ingredient granulate Download PDF

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Publication number
AU2020272151B2
AU2020272151B2 AU2020272151A AU2020272151A AU2020272151B2 AU 2020272151 B2 AU2020272151 B2 AU 2020272151B2 AU 2020272151 A AU2020272151 A AU 2020272151A AU 2020272151 A AU2020272151 A AU 2020272151A AU 2020272151 B2 AU2020272151 B2 AU 2020272151B2
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AU
Australia
Prior art keywords
particles
spray
thethe
active ingredient
metformin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020272151A
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English (en)
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AU2020272151A1 (en
Inventor
Annette Grave
Michael Jacob
Reinhard Nowak
Norbert Pöllinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADD Advanced Drug Delivery Technologies AG
Original Assignee
ADD Advanced Drug Delivery Technologies AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by ADD Advanced Drug Delivery Technologies AG filed Critical ADD Advanced Drug Delivery Technologies AG
Publication of AU2020272151A1 publication Critical patent/AU2020272151A1/en
Application granted granted Critical
Publication of AU2020272151B2 publication Critical patent/AU2020272151B2/en
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glanulating (AREA)
AU2020272151A 2019-04-11 2020-04-09 Process for continuous production of an active ingredient granulate Active AU2020272151B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19168673.2A EP3721870A1 (de) 2019-04-11 2019-04-11 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
EP19168673.2 2019-04-11
PCT/EP2020/060277 WO2020208201A1 (de) 2019-04-11 2020-04-09 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats

Publications (2)

Publication Number Publication Date
AU2020272151A1 AU2020272151A1 (en) 2021-12-09
AU2020272151B2 true AU2020272151B2 (en) 2025-07-03

Family

ID=66105201

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020272151A Active AU2020272151B2 (en) 2019-04-11 2020-04-09 Process for continuous production of an active ingredient granulate

Country Status (10)

Country Link
US (1) US20220323361A1 (enExample)
EP (2) EP3721870A1 (enExample)
JP (1) JP7620565B2 (enExample)
CN (1) CN114126591A (enExample)
AU (1) AU2020272151B2 (enExample)
BR (1) BR112021020320A2 (enExample)
CA (1) CA3136529A1 (enExample)
ES (1) ES3050631T3 (enExample)
IL (1) IL287126A (enExample)
WO (1) WO2020208201A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3721871A1 (de) * 2019-04-11 2020-10-14 ADD Advanced Drug Delivery Technologies, Ltd. Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
CA3199647A1 (en) 2020-11-24 2022-06-02 Goran MACONI System, apparatuses, devices, and methods for producing particles
CN116422227B (zh) * 2022-12-09 2024-01-30 山东奥诺能源科技股份有限公司 一种流化床造粒机

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159252A (en) * 1995-04-21 2000-12-12 Degussa-Hus Aktiengesellschaft Process and device for producing granulates by fluidized bed spray granulation
US20070020197A1 (en) * 2004-07-01 2007-01-25 Warner-Lambert Company Llc Preparation of pharmaceutical compositions containing nanoparticles
US20120009259A1 (en) * 2010-07-06 2012-01-12 Urbain Alfons Clementina Delaet Formulation for co-therapy treatment of diabetes
WO2015012365A1 (ja) * 2013-07-25 2015-01-29 株式会社 三和化学研究所 医薬製剤
WO2018034627A1 (en) * 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117451A (en) 1998-08-25 2000-09-12 Pharmalogix, Inc. Direct compression metformin hydrochloride tablets
DE10004939C1 (de) 2000-02-05 2001-08-23 Lothar Moerl Steuerbare Gasanströmeinrichtung für Strahlschichtapparate
ATE327737T1 (de) 2001-03-07 2006-06-15 Dainippon Sumitomo Pharma Co Verfahren zur herstellung von arzneistoffgranulatkörnern, die arzneistoffgranulatkörner sowie diese enthaltende pharmazeutische zubereitungen
US6667054B2 (en) 2001-12-05 2003-12-23 Bernard Charles Sherman Metformin hydrochloride tablets
DE10322062A1 (de) 2003-05-15 2004-12-02 Glatt Ingenieurtechnik Gmbh Verfahren und Vorrichtung zum Aufbringen von Flüssigkeiten in eine Feststoffströmung eines Strahlschichtapparates
WO2004108911A2 (de) 2003-06-11 2004-12-16 Glatt Ingenieurtechnik Gmbh Enzym-granulat-herstellungsverfahren und erhältliche enzym-granulate
DE102007012105A1 (de) 2007-03-13 2008-09-18 Add Advanced Drug Delivery Technologies Ltd. Pellets enthaltend pharmazeutische Substanz, Verfahren zu deren Herstellung und deren Verwendung
EP2704696A1 (en) * 2012-03-26 2014-03-12 Glatt AG Taste-masked ibuprofen granules
KR101642193B1 (ko) 2014-10-13 2016-07-25 씨제이헬스케어 주식회사 메트포르민 서방성 제제 및 그의 제조방법

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159252A (en) * 1995-04-21 2000-12-12 Degussa-Hus Aktiengesellschaft Process and device for producing granulates by fluidized bed spray granulation
US20070020197A1 (en) * 2004-07-01 2007-01-25 Warner-Lambert Company Llc Preparation of pharmaceutical compositions containing nanoparticles
US20120009259A1 (en) * 2010-07-06 2012-01-12 Urbain Alfons Clementina Delaet Formulation for co-therapy treatment of diabetes
WO2015012365A1 (ja) * 2013-07-25 2015-01-29 株式会社 三和化学研究所 医薬製剤
WO2018034627A1 (en) * 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PALIS STEFAN ET AL: "Online parameter identification for continuous fluidized bed spray granulation with external sieve-mill cycle", 2017 22ND INTERNATIONAL CONFERENCE ON MMAR, IEEE, 28 August 2017, pages 594 - 598 *

Also Published As

Publication number Publication date
JP7620565B2 (ja) 2025-01-23
EP3721870A1 (de) 2020-10-14
JP2022528570A (ja) 2022-06-14
BR112021020320A2 (pt) 2021-12-14
CA3136529A1 (en) 2020-10-15
EP3952843A1 (de) 2022-02-16
AU2020272151A1 (en) 2021-12-09
WO2020208201A1 (de) 2020-10-15
US20220323361A1 (en) 2022-10-13
EP3952843B1 (de) 2025-08-06
ES3050631T3 (en) 2025-12-22
IL287126A (en) 2022-01-01
CN114126591A (zh) 2022-03-01

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