CA3136529A1 - Process for the continuous production of an active ingredient granulate - Google Patents
Process for the continuous production of an active ingredient granulate Download PDFInfo
- Publication number
- CA3136529A1 CA3136529A1 CA3136529A CA3136529A CA3136529A1 CA 3136529 A1 CA3136529 A1 CA 3136529A1 CA 3136529 A CA3136529 A CA 3136529A CA 3136529 A CA3136529 A CA 3136529A CA 3136529 A1 CA3136529 A1 CA 3136529A1
- Authority
- CA
- Canada
- Prior art keywords
- active ingredient
- particles
- process space
- solid particles
- granulate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 144
- 230000008569 process Effects 0.000 title claims abstract description 114
- 239000004480 active ingredient Substances 0.000 title claims abstract description 63
- 239000008187 granular material Substances 0.000 title claims abstract description 57
- 238000010924 continuous production Methods 0.000 title claims abstract description 8
- 239000002245 particle Substances 0.000 claims abstract description 126
- 239000007787 solid Substances 0.000 claims abstract description 45
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000000203 mixture Substances 0.000 claims abstract description 40
- 239000007788 liquid Substances 0.000 claims abstract description 28
- 229960004329 metformin hydrochloride Drugs 0.000 claims abstract description 26
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229960003105 metformin Drugs 0.000 claims abstract description 15
- 238000005507 spraying Methods 0.000 claims abstract description 9
- 239000002253 acid Substances 0.000 claims abstract description 7
- 230000002776 aggregation Effects 0.000 claims abstract description 7
- 150000003839 salts Chemical class 0.000 claims abstract description 7
- 238000005054 agglomeration Methods 0.000 claims abstract description 6
- 238000002347 injection Methods 0.000 claims abstract description 4
- 239000007924 injection Substances 0.000 claims abstract description 4
- 239000007921 spray Substances 0.000 claims description 52
- 239000000725 suspension Substances 0.000 claims description 28
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 15
- 238000000576 coating method Methods 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 210000001072 colon Anatomy 0.000 claims description 9
- 210000003405 ileum Anatomy 0.000 claims description 9
- 239000011230 binding agent Substances 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 6
- 238000013270 controlled release Methods 0.000 claims description 6
- 238000001704 evaporation Methods 0.000 claims description 5
- 239000007789 gas Substances 0.000 description 40
- 239000000047 product Substances 0.000 description 25
- 238000004519 manufacturing process Methods 0.000 description 18
- 239000002552 dosage form Substances 0.000 description 13
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 13
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 13
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- 239000000463 material Substances 0.000 description 11
- 229920000642 polymer Polymers 0.000 description 9
- 238000012545 processing Methods 0.000 description 7
- 239000013543 active substance Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 239000008188 pellet Substances 0.000 description 5
- 238000003825 pressing Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000001035 drying Methods 0.000 description 4
- 230000008020 evaporation Effects 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 238000001694 spray drying Methods 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 229920003143 Eudragit® FS 30 D Polymers 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 239000000428 dust Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 238000001000 micrograph Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000001069 triethyl citrate Substances 0.000 description 3
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 3
- 235000013769 triethyl citrate Nutrition 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000009969 flowable effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000012669 liquid formulation Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000011265 semifinished product Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229920003141 Eudragit® S 100 Polymers 0.000 description 1
- 229920003137 Eudragit® S polymer Polymers 0.000 description 1
- 229920003134 Eudragit® polymer Polymers 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000007931 coated granule Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011437 continuous method Methods 0.000 description 1
- 229960001681 croscarmellose sodium Drugs 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- RDYMFSUJUZBWLH-UHFFFAOYSA-N endosulfan Chemical compound C12COS(=O)OCC2C2(Cl)C(Cl)=C(Cl)C1(Cl)C2(Cl)Cl RDYMFSUJUZBWLH-UHFFFAOYSA-N 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000005243 fluidization Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000009480 moisture-activated dry granulation Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910052756 noble gas Inorganic materials 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000009490 roller compaction Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000005549 size reduction Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Glanulating (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19168673.2 | 2019-04-11 | ||
| EP19168673.2A EP3721870A1 (de) | 2019-04-11 | 2019-04-11 | Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats |
| PCT/EP2020/060277 WO2020208201A1 (de) | 2019-04-11 | 2020-04-09 | Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3136529A1 true CA3136529A1 (en) | 2020-10-15 |
Family
ID=66105201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3136529A Pending CA3136529A1 (en) | 2019-04-11 | 2020-04-09 | Process for the continuous production of an active ingredient granulate |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20220323361A1 (enExample) |
| EP (2) | EP3721870A1 (enExample) |
| JP (1) | JP7620565B2 (enExample) |
| CN (1) | CN114126591A (enExample) |
| AU (1) | AU2020272151B2 (enExample) |
| BR (1) | BR112021020320A2 (enExample) |
| CA (1) | CA3136529A1 (enExample) |
| IL (1) | IL287126A (enExample) |
| WO (1) | WO2020208201A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3721871A1 (de) * | 2019-04-11 | 2020-10-14 | ADD Advanced Drug Delivery Technologies, Ltd. | Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats |
| KR102857295B1 (ko) | 2020-11-24 | 2025-09-08 | 나노폼 핀란드 오와이제이 | 입자 생성을 위한 시스템, 장치, 기기 및 방법 |
| CN116422227B (zh) * | 2022-12-09 | 2024-01-30 | 山东奥诺能源科技股份有限公司 | 一种流化床造粒机 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19514187C1 (de) * | 1995-04-21 | 1996-05-15 | Degussa | Verfahren und Vorrichtung zur Herstellung von Granulaten durch Wirbelschicht-Sprühgranulation |
| US6117451A (en) | 1998-08-25 | 2000-09-12 | Pharmalogix, Inc. | Direct compression metformin hydrochloride tablets |
| DE10004939C1 (de) | 2000-02-05 | 2001-08-23 | Lothar Moerl | Steuerbare Gasanströmeinrichtung für Strahlschichtapparate |
| EP1238662B1 (en) | 2001-03-07 | 2006-05-31 | Dainippon Sumitomo Pharma Co., Ltd. | Method for manufacturing drug granules, the drug granules and pharmaceutical preparation containing the drug granules |
| US6667054B2 (en) | 2001-12-05 | 2003-12-23 | Bernard Charles Sherman | Metformin hydrochloride tablets |
| DE10322062A1 (de) | 2003-05-15 | 2004-12-02 | Glatt Ingenieurtechnik Gmbh | Verfahren und Vorrichtung zum Aufbringen von Flüssigkeiten in eine Feststoffströmung eines Strahlschichtapparates |
| PT1638678E (pt) | 2003-06-11 | 2012-01-05 | Glatt Ingtech Gmbh | Método para produção de granulados enzimáticos e granulados enzimáticos assim obtidos |
| EP1781253A1 (en) * | 2004-07-01 | 2007-05-09 | Warner-Lambert Company LLC | Preparation of pharmaceutical compositions containing nanoparticles |
| DE102007012105A1 (de) | 2007-03-13 | 2008-09-18 | Add Advanced Drug Delivery Technologies Ltd. | Pellets enthaltend pharmazeutische Substanz, Verfahren zu deren Herstellung und deren Verwendung |
| CN102970981A (zh) * | 2010-07-06 | 2013-03-13 | 詹森药业有限公司 | 糖尿病协同治疗制剂 |
| WO2013143688A1 (en) * | 2012-03-26 | 2013-10-03 | Glatt Ag | Taste-masked ibuprofen granules |
| WO2015012365A1 (ja) * | 2013-07-25 | 2015-01-29 | 株式会社 三和化学研究所 | 医薬製剤 |
| KR101642193B1 (ko) | 2014-10-13 | 2016-07-25 | 씨제이헬스케어 주식회사 | 메트포르민 서방성 제제 및 그의 제조방법 |
| WO2018034627A1 (en) * | 2016-08-18 | 2018-02-22 | İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi | Pharmaceutical composition of antidiabetic tablet |
-
2019
- 2019-04-11 EP EP19168673.2A patent/EP3721870A1/de active Pending
-
2020
- 2020-04-09 CA CA3136529A patent/CA3136529A1/en active Pending
- 2020-04-09 WO PCT/EP2020/060277 patent/WO2020208201A1/de not_active Ceased
- 2020-04-09 AU AU2020272151A patent/AU2020272151B2/en active Active
- 2020-04-09 EP EP20722226.6A patent/EP3952843B1/de active Active
- 2020-04-09 US US17/602,356 patent/US20220323361A1/en active Pending
- 2020-04-09 CN CN202080042850.1A patent/CN114126591A/zh active Pending
- 2020-04-09 JP JP2021560695A patent/JP7620565B2/ja active Active
- 2020-04-09 BR BR112021020320A patent/BR112021020320A2/pt unknown
-
2021
- 2021-10-10 IL IL287126A patent/IL287126A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL287126A (en) | 2022-01-01 |
| EP3721870A1 (de) | 2020-10-14 |
| WO2020208201A1 (de) | 2020-10-15 |
| JP7620565B2 (ja) | 2025-01-23 |
| EP3952843B1 (de) | 2025-08-06 |
| EP3952843A1 (de) | 2022-02-16 |
| CN114126591A (zh) | 2022-03-01 |
| AU2020272151A1 (en) | 2021-12-09 |
| AU2020272151B2 (en) | 2025-07-03 |
| BR112021020320A2 (pt) | 2021-12-14 |
| JP2022528570A (ja) | 2022-06-14 |
| US20220323361A1 (en) | 2022-10-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20240402 |