IL287126B1 - Process for continuous production of an active ingredient nucleus - Google Patents

Process for continuous production of an active ingredient nucleus

Info

Publication number
IL287126B1
IL287126B1 IL287126A IL28712621A IL287126B1 IL 287126 B1 IL287126 B1 IL 287126B1 IL 287126 A IL287126 A IL 287126A IL 28712621 A IL28712621 A IL 28712621A IL 287126 B1 IL287126 B1 IL 287126B1
Authority
IL
Israel
Prior art keywords
active ingredient
particles
process space
granulate
spray composition
Prior art date
Application number
IL287126A
Other languages
English (en)
Hebrew (he)
Other versions
IL287126A (en
Original Assignee
Add Advanced Drug Delivery Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Add Advanced Drug Delivery Tech Ltd filed Critical Add Advanced Drug Delivery Tech Ltd
Publication of IL287126A publication Critical patent/IL287126A/en
Publication of IL287126B1 publication Critical patent/IL287126B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glanulating (AREA)
IL287126A 2019-04-11 2021-10-10 Process for continuous production of an active ingredient nucleus IL287126B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19168673.2A EP3721870A1 (de) 2019-04-11 2019-04-11 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
PCT/EP2020/060277 WO2020208201A1 (de) 2019-04-11 2020-04-09 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats

Publications (2)

Publication Number Publication Date
IL287126A IL287126A (en) 2022-01-01
IL287126B1 true IL287126B1 (en) 2026-01-01

Family

ID=66105201

Family Applications (1)

Application Number Title Priority Date Filing Date
IL287126A IL287126B1 (en) 2019-04-11 2021-10-10 Process for continuous production of an active ingredient nucleus

Country Status (10)

Country Link
US (1) US20220323361A1 (enExample)
EP (2) EP3721870A1 (enExample)
JP (1) JP7620565B2 (enExample)
CN (1) CN114126591A (enExample)
AU (1) AU2020272151B2 (enExample)
BR (1) BR112021020320A2 (enExample)
CA (1) CA3136529A1 (enExample)
ES (1) ES3050631T3 (enExample)
IL (1) IL287126B1 (enExample)
WO (1) WO2020208201A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3721871A1 (de) * 2019-04-11 2020-10-14 ADD Advanced Drug Delivery Technologies, Ltd. Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
EP4251294A1 (en) * 2020-11-24 2023-10-04 Nanoform Finland PLC System, apparatuses, devices, and methods for producing particles
CN116422227B (zh) * 2022-12-09 2024-01-30 山东奥诺能源科技股份有限公司 一种流化床造粒机

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100080849A1 (en) * 2007-03-13 2010-04-01 Add Advanced Drug Delivery Technologies Ltd. Pellets containing a pharmaceutical substance, method for the production thereof and use of the same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19514187C1 (de) * 1995-04-21 1996-05-15 Degussa Verfahren und Vorrichtung zur Herstellung von Granulaten durch Wirbelschicht-Sprühgranulation
US6117451A (en) 1998-08-25 2000-09-12 Pharmalogix, Inc. Direct compression metformin hydrochloride tablets
DE10004939C1 (de) 2000-02-05 2001-08-23 Lothar Moerl Steuerbare Gasanströmeinrichtung für Strahlschichtapparate
DE60211769T2 (de) * 2001-03-07 2007-05-24 Dainippon Sumitomo Pharma Co., Ltd. Verfahren zur Herstellung von Arzneistoffgranulatkörnern, die Arzneistoffgranulatkörner sowie diese enthaltende pharmazeutische Zubereitungen
US6667054B2 (en) 2001-12-05 2003-12-23 Bernard Charles Sherman Metformin hydrochloride tablets
DE10322062A1 (de) 2003-05-15 2004-12-02 Glatt Ingenieurtechnik Gmbh Verfahren und Vorrichtung zum Aufbringen von Flüssigkeiten in eine Feststoffströmung eines Strahlschichtapparates
CA2528637C (en) 2003-06-11 2012-10-23 Glatt Ingenieurtechnik Gmbh Method for production of enzyme granules and enzyme granules produced thus
BRPI0512829A (pt) * 2004-07-01 2008-04-08 Warner Lambert Co preparação de composições farmacêuticas contendo nanopartìculas
EP2590631B1 (en) * 2010-07-06 2016-10-26 Janssen Pharmaceutica NV Formulation for co-therapy treatment of diabetes
EP2704696A1 (en) * 2012-03-26 2014-03-12 Glatt AG Taste-masked ibuprofen granules
WO2015012365A1 (ja) * 2013-07-25 2015-01-29 株式会社 三和化学研究所 医薬製剤
KR101642193B1 (ko) * 2014-10-13 2016-07-25 씨제이헬스케어 주식회사 메트포르민 서방성 제제 및 그의 제조방법
WO2018034627A1 (en) * 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100080849A1 (en) * 2007-03-13 2010-04-01 Add Advanced Drug Delivery Technologies Ltd. Pellets containing a pharmaceutical substance, method for the production thereof and use of the same

Also Published As

Publication number Publication date
AU2020272151B2 (en) 2025-07-03
EP3952843A1 (de) 2022-02-16
BR112021020320A2 (pt) 2021-12-14
CN114126591A (zh) 2022-03-01
IL287126A (en) 2022-01-01
US20220323361A1 (en) 2022-10-13
JP2022528570A (ja) 2022-06-14
EP3952843B1 (de) 2025-08-06
EP3721870A1 (de) 2020-10-14
JP7620565B2 (ja) 2025-01-23
CA3136529A1 (en) 2020-10-15
AU2020272151A1 (en) 2021-12-09
ES3050631T3 (en) 2025-12-22
WO2020208201A1 (de) 2020-10-15

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