JP7620374B2 - T細胞リンパ腫およびt細胞白血病に対するcd2/5/7ノックアウト抗cd2/5/7キメラ抗原受容体t細胞の使用 - Google Patents

T細胞リンパ腫およびt細胞白血病に対するcd2/5/7ノックアウト抗cd2/5/7キメラ抗原受容体t細胞の使用 Download PDF

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JP7620374B2
JP7620374B2 JP2021536031A JP2021536031A JP7620374B2 JP 7620374 B2 JP7620374 B2 JP 7620374B2 JP 2021536031 A JP2021536031 A JP 2021536031A JP 2021536031 A JP2021536031 A JP 2021536031A JP 7620374 B2 JP7620374 B2 JP 7620374B2
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マルコ ルエラ
ザール ギル
カール エイチ. ジューン
エイヴリー ディー. ポージー
ダニエル ジェイ. パウエル
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ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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JP2021536031A 2018-12-19 2019-12-19 T細胞リンパ腫およびt細胞白血病に対するcd2/5/7ノックアウト抗cd2/5/7キメラ抗原受容体t細胞の使用 Active JP7620374B2 (ja)

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JP2024046429A JP7843056B2 (ja) 2018-12-19 2024-03-22 T細胞リンパ腫およびt細胞白血病に対するcd2/5/7ノックアウト抗cd2/5/7キメラ抗原受容体t細胞の使用

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US201862782131P 2018-12-19 2018-12-19
US62/782,131 2018-12-19
PCT/US2019/067613 WO2020132327A1 (en) 2018-12-19 2019-12-19 Use of cd2/5/7 knock-out anti-cd2/5/7 chimeric antigen receptor t cells against t cell lymphomas and leukemias

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JP2022515194A JP2022515194A (ja) 2022-02-17
JPWO2020132327A5 JPWO2020132327A5 (https=) 2022-12-26
JP2022515194A5 JP2022515194A5 (https=) 2022-12-26
JP7620374B2 true JP7620374B2 (ja) 2025-01-23

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Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2014010185A (es) * 2012-02-22 2014-11-14 Univ Pennsylvania Uso de dominio de señalizacion cd2 en receptores de antigeno quimericos de segunda generacion.
US20170151281A1 (en) 2015-02-19 2017-06-01 Batu Biologics, Inc. Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
WO2020168122A1 (en) 2019-02-13 2020-08-20 Beam Therapeutics Inc. Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence
EP4034138A4 (en) 2019-09-27 2024-07-31 Beam Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS
US10980836B1 (en) 2019-12-11 2021-04-20 Myeloid Therapeutics, Inc. Therapeutic cell compositions and methods of manufacturing and use thereof
WO2022061115A1 (en) * 2020-09-18 2022-03-24 Vor Biopharma Inc. Compositions and methods for cd7 modification
AU2021347359A1 (en) * 2020-09-25 2023-05-18 Beam Therapeutics Inc. Fratricide resistant modified immune cells and methods of using the same
CN116568709A (zh) * 2020-11-01 2023-08-08 南京驯鹿生物技术股份有限公司 靶向cd5的全人源抗体、全人源嵌合抗原受体(car)及其应用
CA3197423A1 (en) 2020-11-04 2022-05-12 Daniel Getts Engineered chimeric fusion protein compositions and methods of use thereof
EP4279515A4 (en) * 2021-01-12 2025-02-19 Nanjing Iaso Biotechnology Co., Ltd. Fully human single-domain tandem chimeric antigen receptor (car) targeting cd5, and use thereof
CA3207861A1 (en) * 2021-02-11 2022-08-18 Carl H. June Ccr4-targeting chimeric antigen receptor cell therapy
CN115044617B (zh) * 2021-03-08 2024-08-13 河北森朗生物科技有限公司 Car t细胞的制备方法、car t细胞及其应用
EP4308133A4 (en) 2021-03-17 2025-01-22 Myeloid Therapeutics, Inc. MANIPULATED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF
AU2022272235A1 (en) 2021-05-11 2023-12-21 Create Medicines, Inc. Methods and compositions for genomic integration
CN115989244A (zh) * 2021-08-06 2023-04-18 上海驯鹿生物技术有限公司 Cd5和cd7双靶点的全人源嵌合抗原受体(car)及其应用
CA3240846A1 (en) * 2021-12-14 2023-06-22 The Trustees Of The University Of Pennsylvania Cd5 modified cells comprising chimeric antigen receptors (cars) for treatment of solid tumors
CN114645022B (zh) * 2022-05-13 2022-09-02 首都医科大学宣武医院 靶向CD5的CAR-γ δ T细胞及其制备方法与应用
CN117431217A (zh) * 2022-07-12 2024-01-23 上海驯鹿生物技术有限公司 表达靶向cd5的嵌合抗原受体(car)的细胞及其应用
KR102869461B1 (ko) * 2022-10-05 2025-10-17 주식회사 지씨셀 Cd5를 표적하는 키메라 항원 수용체 및 이를 발현하는 면역세포
KR20260051108A (ko) * 2023-05-23 2026-04-15 비토리아 바이오테라퓨틱스, 인코포레이티드. Cd5 유전자좌 영역에 삽입된 이종성 핵산 분자를 포함하는 유전자 변형 세포
EP4719467A2 (en) * 2023-05-31 2026-04-08 Vittoria Biotherapeutics, Inc. Methods of manufacturing t cells
CN119529071B (zh) * 2023-08-28 2025-11-18 东莞市朋志生物科技有限公司 一种抗登革病毒或其ns1蛋白的抗体及其应用
WO2025122896A1 (en) * 2023-12-08 2025-06-12 The Trustees Of The University Of Pennsylvania Cd5 modified cells comprising heterologous tcrs and methods of using the same
CN118891290A (zh) * 2024-04-12 2024-11-01 科济生物医药(上海)有限公司 细胞免疫疗法的组合物和方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5951983A (en) 1993-03-05 1999-09-14 Universite Catholique De Louvain Methods of inhibiting T cell mediated immune responses with humanized LO-CD2A-specific antibodies
MX2011000970A (es) 2008-08-29 2011-03-15 Symphogen As Anticuerpos anti-cd5.
US11047010B2 (en) * 2014-02-06 2021-06-29 Immunexpress Pty Ltd Biomarker signature method, and apparatus and kits thereof
JP7237449B2 (ja) 2015-02-27 2023-03-13 アイセル・ジーン・セラピューティクス・エルエルシー 血液系腫瘍を標的としたキメラ抗体受容体(CARs)の構成およびその使用方法
WO2017112877A1 (en) 2015-12-22 2017-06-29 Icell Gene Therapeutics, Llc Chimeric antigen receptors and enhancement of anti-tumor activity
WO2017172981A2 (en) * 2016-03-29 2017-10-05 University Of Southern California Chimeric antigen receptors targeting cancer
EP3448874A4 (en) * 2016-04-29 2020-04-22 Voyager Therapeutics, Inc. COMPOSITIONS FOR TREATING A DISEASE
CN110352068A (zh) 2016-12-02 2019-10-18 南加利福尼亚大学 合成的免疫受体及其使用方法
WO2018156180A1 (en) * 2017-02-24 2018-08-30 Kindred Biosciences, Inc. Anti-il31 antibodies for veterinary use
EP4414380A3 (en) * 2017-03-31 2024-12-04 Cellectis SA Universal anti-cd22 chimeric antigen receptor engineered immune cells
CA3065126A1 (en) * 2017-06-01 2018-12-06 Innovative Cellular Therapeutics CO., LTD. Chimeric antigen receptor cell preparation and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Oncoimmunology,2017年,Vol. 7, No. 3,e1407898,doi: 10.1080/2162402X.2017.1407898.

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