IL284196A - Use of cd2/5/7 knock-out anti-cd2/5/7 chimeric antigen receptor t cells against t cell lymphomas and leukemias - Google Patents

Use of cd2/5/7 knock-out anti-cd2/5/7 chimeric antigen receptor t cells against t cell lymphomas and leukemias

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Publication number
IL284196A
IL284196A IL284196A IL28419621A IL284196A IL 284196 A IL284196 A IL 284196A IL 284196 A IL284196 A IL 284196A IL 28419621 A IL28419621 A IL 28419621A IL 284196 A IL284196 A IL 284196A
Authority
IL
Israel
Prior art keywords
leukemias
cells
antigen receptor
chimeric anti
cell lymphomas
Prior art date
Application number
IL284196A
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English (en)
Hebrew (he)
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of IL284196A publication Critical patent/IL284196A/en

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001129—Molecules with a "CD" designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
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    • C07K2319/00—Fusion polypeptide
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IL284196A 2018-12-19 2021-06-20 Use of cd2/5/7 knock-out anti-cd2/5/7 chimeric antigen receptor t cells against t cell lymphomas and leukemias IL284196A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862782131P 2018-12-19 2018-12-19
PCT/US2019/067613 WO2020132327A1 (en) 2018-12-19 2019-12-19 Use of cd2/5/7 knock-out anti-cd2/5/7 chimeric antigen receptor t cells against t cell lymphomas and leukemias

Publications (1)

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IL284196A true IL284196A (en) 2021-08-31

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IL284196A IL284196A (en) 2018-12-19 2021-06-20 Use of cd2/5/7 knock-out anti-cd2/5/7 chimeric antigen receptor t cells against t cell lymphomas and leukemias

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US (3) US11673964B2 (https=)
EP (1) EP3898692A4 (https=)
JP (2) JP7620374B2 (https=)
KR (1) KR20220002859A (https=)
CN (2) CN113454117B (https=)
AU (1) AU2019404302A1 (https=)
CA (1) CA3124467A1 (https=)
IL (1) IL284196A (https=)
MX (1) MX2021007547A (https=)
SG (1) SG11202106699VA (https=)
WO (1) WO2020132327A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2014010185A (es) * 2012-02-22 2014-11-14 Univ Pennsylvania Uso de dominio de señalizacion cd2 en receptores de antigeno quimericos de segunda generacion.
US20170151281A1 (en) 2015-02-19 2017-06-01 Batu Biologics, Inc. Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
WO2020168122A1 (en) 2019-02-13 2020-08-20 Beam Therapeutics Inc. Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence
EP4034138A4 (en) 2019-09-27 2024-07-31 Beam Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS
US10980836B1 (en) 2019-12-11 2021-04-20 Myeloid Therapeutics, Inc. Therapeutic cell compositions and methods of manufacturing and use thereof
WO2022061115A1 (en) * 2020-09-18 2022-03-24 Vor Biopharma Inc. Compositions and methods for cd7 modification
AU2021347359A1 (en) * 2020-09-25 2023-05-18 Beam Therapeutics Inc. Fratricide resistant modified immune cells and methods of using the same
CN116568709A (zh) * 2020-11-01 2023-08-08 南京驯鹿生物技术股份有限公司 靶向cd5的全人源抗体、全人源嵌合抗原受体（car）及其应用
CA3197423A1 (en) 2020-11-04 2022-05-12 Daniel Getts Engineered chimeric fusion protein compositions and methods of use thereof
EP4279515A4 (en) * 2021-01-12 2025-02-19 Nanjing Iaso Biotechnology Co., Ltd. Fully human single-domain tandem chimeric antigen receptor (car) targeting cd5, and use thereof
CA3207861A1 (en) * 2021-02-11 2022-08-18 Carl H. June Ccr4-targeting chimeric antigen receptor cell therapy
CN115044617B (zh) * 2021-03-08 2024-08-13 河北森朗生物科技有限公司 Car t细胞的制备方法、car t细胞及其应用
EP4308133A4 (en) 2021-03-17 2025-01-22 Myeloid Therapeutics, Inc. MANIPULATED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF
AU2022272235A1 (en) 2021-05-11 2023-12-21 Create Medicines, Inc. Methods and compositions for genomic integration
CN115989244A (zh) * 2021-08-06 2023-04-18 上海驯鹿生物技术有限公司 Cd5和cd7双靶点的全人源嵌合抗原受体(car)及其应用
CA3240846A1 (en) * 2021-12-14 2023-06-22 The Trustees Of The University Of Pennsylvania Cd5 modified cells comprising chimeric antigen receptors (cars) for treatment of solid tumors
CN114645022B (zh) * 2022-05-13 2022-09-02 首都医科大学宣武医院 靶向CD5的CAR-γ δ T细胞及其制备方法与应用
CN117431217A (zh) * 2022-07-12 2024-01-23 上海驯鹿生物技术有限公司 表达靶向cd5的嵌合抗原受体(car)的细胞及其应用
KR102869461B1 (ko) * 2022-10-05 2025-10-17 주식회사 지씨셀 Cd5를 표적하는 키메라 항원 수용체 및 이를 발현하는 면역세포
KR20260051108A (ko) * 2023-05-23 2026-04-15 비토리아 바이오테라퓨틱스, 인코포레이티드. Cd5 유전자좌 영역에 삽입된 이종성 핵산 분자를 포함하는 유전자 변형 세포
EP4719467A2 (en) * 2023-05-31 2026-04-08 Vittoria Biotherapeutics, Inc. Methods of manufacturing t cells
CN119529071B (zh) * 2023-08-28 2025-11-18 东莞市朋志生物科技有限公司 一种抗登革病毒或其ns1蛋白的抗体及其应用
WO2025122896A1 (en) * 2023-12-08 2025-06-12 The Trustees Of The University Of Pennsylvania Cd5 modified cells comprising heterologous tcrs and methods of using the same
CN118891290A (zh) * 2024-04-12 2024-11-01 科济生物医药（上海）有限公司 细胞免疫疗法的组合物和方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5951983A (en) 1993-03-05 1999-09-14 Universite Catholique De Louvain Methods of inhibiting T cell mediated immune responses with humanized LO-CD2A-specific antibodies
MX2011000970A (es) 2008-08-29 2011-03-15 Symphogen As Anticuerpos anti-cd5.
US11047010B2 (en) * 2014-02-06 2021-06-29 Immunexpress Pty Ltd Biomarker signature method, and apparatus and kits thereof
JP7237449B2 (ja) 2015-02-27 2023-03-13 アイセル・ジーン・セラピューティクス・エルエルシー 血液系腫瘍を標的としたキメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法
WO2017112877A1 (en) 2015-12-22 2017-06-29 Icell Gene Therapeutics, Llc Chimeric antigen receptors and enhancement of anti-tumor activity
WO2017172981A2 (en) * 2016-03-29 2017-10-05 University Of Southern California Chimeric antigen receptors targeting cancer
EP3448874A4 (en) * 2016-04-29 2020-04-22 Voyager Therapeutics, Inc. COMPOSITIONS FOR TREATING A DISEASE
CN110352068A (zh) 2016-12-02 2019-10-18 南加利福尼亚大学 合成的免疫受体及其使用方法
WO2018156180A1 (en) * 2017-02-24 2018-08-30 Kindred Biosciences, Inc. Anti-il31 antibodies for veterinary use
EP4414380A3 (en) * 2017-03-31 2024-12-04 Cellectis SA Universal anti-cd22 chimeric antigen receptor engineered immune cells
CA3065126A1 (en) * 2017-06-01 2018-12-06 Innovative Cellular Therapeutics CO., LTD. Chimeric antigen receptor cell preparation and uses thereof

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