JP7594913B2 - 抗体コンジュゲート - Google Patents

抗体コンジュゲート Download PDF

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Publication number
JP7594913B2
JP7594913B2 JP2020557617A JP2020557617A JP7594913B2 JP 7594913 B2 JP7594913 B2 JP 7594913B2 JP 2020557617 A JP2020557617 A JP 2020557617A JP 2020557617 A JP2020557617 A JP 2020557617A JP 7594913 B2 JP7594913 B2 JP 7594913B2
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Japan
Prior art keywords
antibody
tau protein
conjugate
epitope
seq
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Japanese (ja)
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JPWO2020105700A1 (ja
Inventor
ヘールト ヤネス
マルチネ ダウエ
雄一 石井
涼 岡田
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Fujirebio Inc
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Fujirebio Inc
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Priority to JP2024161331A priority Critical patent/JP2024178283A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/14—Post-translational modifications [PTMs] in chemical analysis of biological material phosphorylation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
JP2020557617A 2018-11-22 2019-11-21 抗体コンジュゲート Active JP7594913B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024161331A JP2024178283A (ja) 2018-11-22 2024-09-18 抗体コンジュゲート

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018219558 2018-11-22
JP2018219558 2018-11-22
PCT/JP2019/045589 WO2020105700A1 (ja) 2018-11-22 2019-11-21 抗体コンジュゲート

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024161331A Division JP2024178283A (ja) 2018-11-22 2024-09-18 抗体コンジュゲート

Publications (2)

Publication Number Publication Date
JPWO2020105700A1 JPWO2020105700A1 (ja) 2021-10-07
JP7594913B2 true JP7594913B2 (ja) 2024-12-05

Family

ID=70773827

Family Applications (2)

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JP2020557617A Active JP7594913B2 (ja) 2018-11-22 2019-11-21 抗体コンジュゲート
JP2024161331A Pending JP2024178283A (ja) 2018-11-22 2024-09-18 抗体コンジュゲート

Family Applications After (1)

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JP2024161331A Pending JP2024178283A (ja) 2018-11-22 2024-09-18 抗体コンジュゲート

Country Status (5)

Country Link
US (1) US20220018856A1 (enExample)
EP (1) EP3885362A4 (enExample)
JP (2) JP7594913B2 (enExample)
CN (1) CN113166235A (enExample)
WO (1) WO2020105700A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021065306A1 (ja) * 2019-09-30 2021-04-08 ニプロ株式会社 血液試料を検体とするタウタンパク質検出方法
CN113533746B (zh) * 2021-07-22 2022-05-10 深圳市天大生物医疗器械有限公司 一种P-Tau蛋白化学发光检测试剂盒及其制备方法
EP4399524A4 (en) 2021-09-09 2025-10-08 Alzpath Inc PHOSPHO-TAU ANTIBODIES AND METHODS OF USE
CN115015228A (zh) * 2022-02-22 2022-09-06 上海科华生物工程股份有限公司 一种检测血液中p-tau181蛋白的化学发光试剂盒及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010189413A (ja) 2002-12-31 2010-09-02 Immunomedics Inc 非コンジュゲートおよびコンジュゲート抗体、抗体の組合せおよび融合タンパク質を用いるｂ細胞悪性腫瘍および自己免疫疾患の免疫療法
US20130095492A1 (en) 2010-03-05 2013-04-18 Albert Einstein College Of Medicine Of Yeshiva University Method of detecting tau protein and tau fragments in serum
JP2014523742A (ja) 2011-07-14 2014-09-18 カソリック ウニヴェルシテイト ルーヴェン リン酸化タウ凝集体に対する抗体
JP2018512863A (ja) 2015-04-17 2018-05-24 アイジーエム バイオサイエンシズ エー／エス 多価ヒト免疫不全ウイルス抗原結合分子およびその使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69318420T2 (de) 1992-12-14 1999-01-28 Naamloze Vennootschap Innogenetics S.A., Gent Monoklonale antikörper gegen das mikrotubulusassoziierte tauprotein,hybridomen, die diese antikörper sezernieren, antigenerkennung durch diese monoklonalen antikörper und deren verwendung
JPH06239899A (ja) * 1993-02-12 1994-08-30 Teijin Ltd ヒトタウ蛋白に対する抗体、並びに該抗体を利用する体液中のヒトタウ蛋白の測定方法
PT737208E (pt) 1993-12-21 2006-12-29 Innogenetics Nv Anticorpos monoclonais específicos para phf-tau, hibridomas que os segregam, reconhecimento de antigénios por estes anticorpos e suas aplicações
JP5247963B2 (ja) * 2000-01-24 2013-07-24 インノジェネティクス・エヌ・ブイ タウオパチーの診断
WO2014011972A1 (en) * 2012-07-13 2014-01-16 Bristol-Myers Squibb Company Tau immunoassay
JP2017512056A (ja) * 2014-02-10 2017-05-18 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ヒト・タウに結合する抗体および該抗体を使用してヒト・タウを定量するためのアッセイ

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010189413A (ja) 2002-12-31 2010-09-02 Immunomedics Inc 非コンジュゲートおよびコンジュゲート抗体、抗体の組合せおよび融合タンパク質を用いるｂ細胞悪性腫瘍および自己免疫疾患の免疫療法
US20130095492A1 (en) 2010-03-05 2013-04-18 Albert Einstein College Of Medicine Of Yeshiva University Method of detecting tau protein and tau fragments in serum
JP2014523742A (ja) 2011-07-14 2014-09-18 カソリック ウニヴェルシテイト ルーヴェン リン酸化タウ凝集体に対する抗体
JP2018512863A (ja) 2015-04-17 2018-05-24 アイジーエム バイオサイエンシズ エー／エス 多価ヒト免疫不全ウイルス抗原結合分子およびその使用方法

Also Published As

Publication number Publication date
WO2020105700A1 (ja) 2020-05-28
CN113166235A (zh) 2021-07-23
JP2024178283A (ja) 2024-12-24
JPWO2020105700A1 (ja) 2021-10-07
EP3885362A1 (en) 2021-09-29
EP3885362A4 (en) 2022-08-17
US20220018856A1 (en) 2022-01-20

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