JP7563872B2 - 癌を処置するための方法及び組成物 - Google Patents

癌を処置するための方法及び組成物 Download PDF

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JP7563872B2
JP7563872B2 JP2018561512A JP2018561512A JP7563872B2 JP 7563872 B2 JP7563872 B2 JP 7563872B2 JP 2018561512 A JP2018561512 A JP 2018561512A JP 2018561512 A JP2018561512 A JP 2018561512A JP 7563872 B2 JP7563872 B2 JP 7563872B2
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cells
cancer
pluripotent
cell
population
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JP2019516754A (ja
JP2019516754A5 (cg-RX-API-DMAC7.html
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グリセリ，フランク
トゥラン，アリ
ブナスール－グリセリ，アンネリーズ
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Assistance Publique Hopitaux de Paris APHP
Universite Paris Cite
Universite Paris Saclay
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Assistance Publique Hopitaux de Paris APHP
Universite Paris Cite
Universite Paris Saclay
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Priority to JP2024168499A priority patent/JP2025000812A/ja
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JP2018561512A 2016-05-25 2017-05-24 癌を処置するための方法及び組成物 Active JP7563872B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022110028A JP7622006B2 (ja) 2016-05-25 2022-07-07 癌を処置するための方法及び組成物
JP2024168499A JP2025000812A (ja) 2016-05-25 2024-09-27 癌を処置するための方法及び組成物

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Application Number Priority Date Filing Date Title
EP16305607 2016-05-25
EP16305607.0 2016-05-25
PCT/EP2017/062604 WO2017202949A1 (en) 2016-05-25 2017-05-24 Methods and compositions for treating cancers

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JP2019516754A JP2019516754A (ja) 2019-06-20
JP2019516754A5 JP2019516754A5 (cg-RX-API-DMAC7.html) 2020-07-09
JP7563872B2 true JP7563872B2 (ja) 2024-10-08

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JP2024168499A Pending JP2025000812A (ja) 2016-05-25 2024-09-27 癌を処置するための方法及び組成物

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JP2024168499A Pending JP2025000812A (ja) 2016-05-25 2024-09-27 癌を処置するための方法及び組成物

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US (2) US11458194B2 (cg-RX-API-DMAC7.html)
EP (1) EP3463433A1 (cg-RX-API-DMAC7.html)
JP (3) JP7563872B2 (cg-RX-API-DMAC7.html)
KR (3) KR20240103039A (cg-RX-API-DMAC7.html)
CN (2) CN116376812A (cg-RX-API-DMAC7.html)
AU (2) AU2017270234B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018074192A8 (cg-RX-API-DMAC7.html)
CA (1) CA3025057A1 (cg-RX-API-DMAC7.html)
IL (2) IL263224B2 (cg-RX-API-DMAC7.html)
RU (1) RU2741786C2 (cg-RX-API-DMAC7.html)
WO (1) WO2017202949A1 (cg-RX-API-DMAC7.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
EP3092049A1 (en) 2014-01-08 2016-11-16 Flodesign Sonics Inc. Acoustophoresis device with dual acoustophoretic chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
EP3484478B1 (en) 2016-07-15 2025-11-05 Viracta Subsidiary, Inc. Histone deacetylase inhibitors for use in immunotherapy
EP3713596A1 (en) 2017-11-24 2020-09-30 Institut National de la Santé Et de la Recherche Médicale Methods and compositions for treating cancers
JP2021507561A (ja) 2017-12-14 2021-02-22 フロデザイン ソニックス， インク．Ｆｌｏｄｅｓｉｇｎ Ｓｏｎｉｃｓ， Ｉｎｃ． 音響トランスデューサドライバ及びコントローラ
SG11202006160RA (en) * 2018-01-02 2020-07-29 Khloris Biosciences Inc Ipsc-based vaccine as a prophylactic and therapeutic treatment for cancer
JP2021511293A (ja) * 2018-01-12 2021-05-06 ビラクタ セラピューティクス，インク． 細胞免疫療法で使用されるエピジェネティック修飾因子
EP3833383A1 (en) 2018-08-06 2021-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating cancers
US20220154219A1 (en) * 2019-03-22 2022-05-19 The Johns Hopkins University Gene delivery particles to induce tumor-derived antigen presenting cells
WO2020232373A1 (en) * 2019-05-15 2020-11-19 Board Of Regents, The University Of Texas System Crispr methods for treating cancers
JP7352937B2 (ja) * 2019-07-19 2023-09-29 公立大学法人福島県立医科大学 乳癌のサブタイプを鑑別又は分類するための鑑別マーカー遺伝子セット、方法およびキット
CN111358777A (zh) * 2020-02-24 2020-07-03 军事科学院军事医学研究院环境医学与作业医学研究所 一种提高外周血单个核细胞线粒体功能的方法和应用
GB202006254D0 (en) * 2020-04-28 2020-06-10 Institute Of Cancer Res Anti-cancer vaccines and related therapy
KR20230036063A (ko) * 2020-05-12 2023-03-14 러쉬 유니버시티 메디컬 센터 암을 치료하기 위한 조성물들 및 방법들
CN112603995B (zh) * 2020-12-30 2022-03-18 四川省肿瘤医院 靶向CAFs的肿瘤细胞疫苗、其制备方法及其应用
KR20230163364A (ko) * 2021-03-31 2023-11-30 셀레론 테라퓨틱스 리미티드 백신 보조제
KR102795600B1 (ko) * 2021-04-05 2025-04-15 주식회사 피노바이오 4'-티오-5-아자-2'-디옥시사이티딘 및 베네토클락스의 병용 요법
WO2023159124A2 (en) * 2022-02-17 2023-08-24 Memorial Sloan-Kettering Cancer Center Methods for overcoming tazemetostat-resistance in cancer patients
CN115494237B (zh) * 2022-09-19 2025-06-24 浙江省人民医院 Rps6ka2在制备卵巢癌诊断试剂和治疗药物中的应用
CN120936380A (zh) * 2023-02-27 2025-11-11 武汉大学 Pd-1信号调控及疾病治疗

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002518042A (ja) 1998-06-24 2002-06-25 ケース ウエスタン リザーブ ユニバーシティ 細胞内の対立遺伝子系統のゲノム改変
JP2009544362A (ja) 2006-07-20 2009-12-17 バート リチャード 損傷を受けた組織の修復のための有糸分裂的に不活性化された幹細胞の使用方法
JP2010511597A (ja) 2006-12-06 2010-04-15 北海道公立大学法人 札幌医科大学 ヒストン脱アセチル化酵素阻害活性を有する物質を用いた細胞性免疫増強剤

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8200523A (nl) 1982-02-11 1983-09-01 Univ Leiden Werkwijze voor het in vitro transformeren van planteprotoplasten met plasmide-dna.
US4806476A (en) 1983-09-08 1989-02-21 Lovelace Medical Foundation Efficient cell fusion process
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
EP0380646B1 (en) 1988-08-04 1999-01-20 Amrad Corporation Limited Use of leukaemia inhibitory factor (lif) for the (in vitro) propagation of embryonic stem cells
US5240840A (en) 1991-04-05 1993-08-31 Regents Of The University Of Michigan Dna superfragment cloning
JP3314241B2 (ja) 1992-04-06 2002-08-12 ヤマハ発動機株式会社 自動二輪車用エンジンの排気浄化装置
US5453357A (en) 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5690926A (en) 1992-10-08 1997-11-25 Vanderbilt University Pluripotential embryonic cells and methods of making same
US5618829A (en) 1993-01-28 1997-04-08 Mitsubishi Chemical Corporation Tyrosine kinase inhibitors and benzoylacrylamide derivatives
HUT74451A (en) 1993-07-15 1996-12-30 Cancer Res Campaign Tech Prodrugs of protein tyrosine kinase inhibitors, systems contg. them and process for preparing them
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
US5914268A (en) 1994-11-21 1999-06-22 National Jewish Center For Immunology & Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5639757A (en) 1995-05-23 1997-06-17 Pfizer Inc. 4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors
US6051227A (en) 1995-07-25 2000-04-18 The Regents Of The University Of California, Office Of Technology Transfer Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US5855887A (en) 1995-07-25 1999-01-05 The Regents Of The University Of California Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
CN1145614C (zh) 1996-04-12 2004-04-14 沃尼尔·朗伯公司 酪氨酸激酶的不可逆抑制剂，其制药用途及药物组合物
US6207157B1 (en) 1996-04-23 2001-03-27 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for nontypeable Haemophilus influenzae
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
US6100254A (en) 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
AU729377B2 (en) 1997-10-23 2001-02-01 Asterias Biotherapeutics, Inc. Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
EE05627B1 (et) 1998-12-23 2013-02-15 Pfizer Inc. CTLA-4 vastased inimese monoklonaalsed antikehad
US6740665B1 (en) 1999-02-10 2004-05-25 Ramachandran Murali Tyrosine kinase inhibitors and methods of using the same
US6245759B1 (en) 1999-03-11 2001-06-12 Merck & Co., Inc. Tyrosine kinase inhibitors
CA2383546A1 (en) 1999-06-30 2001-01-04 William H. Parsons Src kinase inhibitor compounds
AU5889100A (en) 1999-06-30 2001-01-31 Merck & Co., Inc. Src kinase inhibitor compounds
AU6605200A (en) 1999-06-30 2001-01-31 Merck & Co., Inc. Src kinase inhibitor compounds
ES2282133T3 (es) 1999-08-24 2007-10-16 Medarex, Inc. Anticuerpos frente a la ctla-4 humano y sus usos.
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
ES2250186T3 (es) 1999-09-10 2006-04-16 MERCK & CO., INC. Inhibidores de tirosina quinasa.
GEP20053530B (en) 1999-10-19 2005-05-25 Merck & Co Inc Tyrosine Kinase Inhibitors, Pharmaceutical Compositions Containing Them and Use Thereof
US6794393B1 (en) 1999-10-19 2004-09-21 Merck & Co., Inc. Tyrosine kinase inhibitors
EP1226119B1 (en) 1999-10-19 2005-03-16 MERCK & CO. INC. Tyrosine kinase inhibitors
US6420382B2 (en) 2000-02-25 2002-07-16 Merck & Co., Inc. Tyrosine kinase inhibitors
US6313138B1 (en) 2000-02-25 2001-11-06 Merck & Co., Inc. Tyrosine kinase inhibitors
NL1017973C2 (nl) 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
WO2002018549A1 (en) 2000-08-30 2002-03-07 Maria Biotech Co., Ltd. Human embryonic stem cells derived from frozen-thawed embryo
US7250255B2 (en) 2001-05-31 2007-07-31 Shinya Yamanaka Genes with ES cell-specific expression
EP1404672B1 (en) 2001-06-22 2006-01-18 Merck & Co., Inc. Tyrosine kinase inhibitors
US6958340B2 (en) 2001-08-01 2005-10-25 Merck & Co., Inc. Tyrosine kinase inhibitors
US6927293B2 (en) 2001-08-30 2005-08-09 Merck & Co., Inc. Tyrosine kinase inhibitors
CA2466279A1 (en) 2001-11-13 2003-05-22 Dana-Farber Cancer Institute, Inc. Agents that modulate immune cell activation and methods of use thereof
JP4511943B2 (ja) 2002-12-23 2010-07-28 ワイス エルエルシー Ｐｄ−１に対する抗体およびその使用
US7592177B2 (en) 2003-11-10 2009-09-22 The Scripps Research Institute Compositions and methods for inducing cell dedifferentiation
EP3530736A3 (en) 2005-05-09 2019-11-06 ONO Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
KR101888321B1 (ko) 2005-07-01 2018-08-13 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US8129187B2 (en) 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
WO2007109571A2 (en) 2006-03-17 2007-09-27 Prometheus Laboratories, Inc. Methods of predicting and monitoring tyrosine kinase inhibitor therapy
NZ600758A (en) 2007-06-18 2013-09-27 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
EP2262837A4 (en) 2008-03-12 2011-04-06 Merck Sharp & Dohme PD-1 BINDING PROTEINS
SG10201400329YA (en) 2008-05-02 2014-05-29 Univ Kyoto Method of nuclear reprogramming
HUE030807T2 (en) 2008-09-26 2017-05-29 Dana Farber Cancer Inst Inc Human anti-PD-1, anti-PD-L1 and anti-PD-L2 antibodies and their applications
TWI605828B (zh) 2008-12-09 2017-11-21 建南德克公司 抗ｐｄ-ｌ１抗體及其於增進ｔ細胞功能之用途
EP2393835B1 (en) 2009-02-09 2017-04-05 Université d'Aix-Marseille Pd-1 antibodies and pd-l1 antibodies and uses thereof
EP2504028A4 (en) 2009-11-24 2014-04-09 Amplimmune Inc SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
WO2011082400A2 (en) 2010-01-04 2011-07-07 President And Fellows Of Harvard College Modulators of immunoinhibitory receptor pd-1, and methods of use thereof
CA2802344C (en) 2010-06-18 2023-06-13 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
US8907053B2 (en) 2010-06-25 2014-12-09 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
JP5888753B2 (ja) 2010-11-04 2016-03-22 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
US9534206B2 (en) * 2010-12-16 2017-01-03 General Electric Company Cell carrier, associated methods for making cell carrier and culturing cells using the same
US20130136722A1 (en) * 2011-11-11 2013-05-30 The Board Of Trustees Of The University Of Illinois Methods of Ex Vivo Expansion of Blood Progenitor Cells, and Generation of Composite Grafts
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002518042A (ja) 1998-06-24 2002-06-25 ケース ウエスタン リザーブ ユニバーシティ 細胞内の対立遺伝子系統のゲノム改変
JP2009544362A (ja) 2006-07-20 2009-12-17 バート リチャード 損傷を受けた組織の修復のための有糸分裂的に不活性化された幹細胞の使用方法
JP2010511597A (ja) 2006-12-06 2010-04-15 北海道公立大学法人 札幌医科大学 ヒストン脱アセチル化酵素阻害活性を有する物質を用いた細胞性免疫増強剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ｃａｎｃｅｒ Ｉｍｍｕｎｏｌ Ｉｍｍｕｎｔｈｅｒ （２０１０） ５９：１６９７－１７０５

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