RU2741786C2 - Способы и композиции для лечения опухолей - Google Patents

Способы и композиции для лечения опухолей Download PDF

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RU2741786C2
RU2741786C2 RU2018141200A RU2018141200A RU2741786C2 RU 2741786 C2 RU2741786 C2 RU 2741786C2 RU 2018141200 A RU2018141200 A RU 2018141200A RU 2018141200 A RU2018141200 A RU 2018141200A RU 2741786 C2 RU2741786 C2 RU 2741786C2
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cells
cancer
pluripotent
population
carcinoma
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RU2018141200A
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RU2018141200A3 (cg-RX-API-DMAC7.html
RU2018141200A (ru
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Франк ГРИССЕЛЛИ
Али ТЮРАН
Аннелиз БЕННАСЕР-ГРИССЕЛЛИ
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Энсэрм (Энститю Насьональ Де Ла Санте Э Де Ла Решерш Медикаль)
Юниверсите Пари-Сюд
Юниверсите Пари Декарт
АССИСТАНС ПЮБЛИК-ОПИТО ДЕ ПАРИ (АПеАшПе)
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RU2018141200A 2016-05-25 2017-05-24 Способы и композиции для лечения опухолей RU2741786C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16305607 2016-05-25
EP16305607.0 2016-05-25
PCT/EP2017/062604 WO2017202949A1 (en) 2016-05-25 2017-05-24 Methods and compositions for treating cancers

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RU2018141200A RU2018141200A (ru) 2020-06-25
RU2018141200A3 RU2018141200A3 (cg-RX-API-DMAC7.html) 2020-07-29
RU2741786C2 true RU2741786C2 (ru) 2021-01-28

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US (2) US11458194B2 (cg-RX-API-DMAC7.html)
EP (1) EP3463433A1 (cg-RX-API-DMAC7.html)
JP (3) JP7563872B2 (cg-RX-API-DMAC7.html)
KR (3) KR20240103039A (cg-RX-API-DMAC7.html)
CN (2) CN116376812A (cg-RX-API-DMAC7.html)
AU (2) AU2017270234B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018074192A8 (cg-RX-API-DMAC7.html)
CA (1) CA3025057A1 (cg-RX-API-DMAC7.html)
IL (2) IL263224B2 (cg-RX-API-DMAC7.html)
RU (1) RU2741786C2 (cg-RX-API-DMAC7.html)
WO (1) WO2017202949A1 (cg-RX-API-DMAC7.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
EP3092049A1 (en) 2014-01-08 2016-11-16 Flodesign Sonics Inc. Acoustophoresis device with dual acoustophoretic chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
EP3484478B1 (en) 2016-07-15 2025-11-05 Viracta Subsidiary, Inc. Histone deacetylase inhibitors for use in immunotherapy
EP3713596A1 (en) 2017-11-24 2020-09-30 Institut National de la Santé Et de la Recherche Médicale Methods and compositions for treating cancers
JP2021507561A (ja) 2017-12-14 2021-02-22 フロデザイン ソニックス， インク．Ｆｌｏｄｅｓｉｇｎ Ｓｏｎｉｃｓ， Ｉｎｃ． 音響トランスデューサドライバ及びコントローラ
SG11202006160RA (en) * 2018-01-02 2020-07-29 Khloris Biosciences Inc Ipsc-based vaccine as a prophylactic and therapeutic treatment for cancer
JP2021511293A (ja) * 2018-01-12 2021-05-06 ビラクタ セラピューティクス，インク． 細胞免疫療法で使用されるエピジェネティック修飾因子
EP3833383A1 (en) 2018-08-06 2021-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating cancers
US20220154219A1 (en) * 2019-03-22 2022-05-19 The Johns Hopkins University Gene delivery particles to induce tumor-derived antigen presenting cells
WO2020232373A1 (en) * 2019-05-15 2020-11-19 Board Of Regents, The University Of Texas System Crispr methods for treating cancers
JP7352937B2 (ja) * 2019-07-19 2023-09-29 公立大学法人福島県立医科大学 乳癌のサブタイプを鑑別又は分類するための鑑別マーカー遺伝子セット、方法およびキット
CN111358777A (zh) * 2020-02-24 2020-07-03 军事科学院军事医学研究院环境医学与作业医学研究所 一种提高外周血单个核细胞线粒体功能的方法和应用
GB202006254D0 (en) * 2020-04-28 2020-06-10 Institute Of Cancer Res Anti-cancer vaccines and related therapy
KR20230036063A (ko) * 2020-05-12 2023-03-14 러쉬 유니버시티 메디컬 센터 암을 치료하기 위한 조성물들 및 방법들
CN112603995B (zh) * 2020-12-30 2022-03-18 四川省肿瘤医院 靶向CAFs的肿瘤细胞疫苗、其制备方法及其应用
KR20230163364A (ko) * 2021-03-31 2023-11-30 셀레론 테라퓨틱스 리미티드 백신 보조제
KR102795600B1 (ko) * 2021-04-05 2025-04-15 주식회사 피노바이오 4'-티오-5-아자-2'-디옥시사이티딘 및 베네토클락스의 병용 요법
WO2023159124A2 (en) * 2022-02-17 2023-08-24 Memorial Sloan-Kettering Cancer Center Methods for overcoming tazemetostat-resistance in cancer patients
CN115494237B (zh) * 2022-09-19 2025-06-24 浙江省人民医院 Rps6ka2在制备卵巢癌诊断试剂和治疗药物中的应用
CN120936380A (zh) * 2023-02-27 2025-11-11 武汉大学 Pd-1信号调控及疾病治疗

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130136722A1 (en) * 2011-11-11 2013-05-30 The Board Of Trustees Of The University Of Illinois Methods of Ex Vivo Expansion of Blood Progenitor Cells, and Generation of Composite Grafts

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8200523A (nl) 1982-02-11 1983-09-01 Univ Leiden Werkwijze voor het in vitro transformeren van planteprotoplasten met plasmide-dna.
US4806476A (en) 1983-09-08 1989-02-21 Lovelace Medical Foundation Efficient cell fusion process
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
EP0380646B1 (en) 1988-08-04 1999-01-20 Amrad Corporation Limited Use of leukaemia inhibitory factor (lif) for the (in vitro) propagation of embryonic stem cells
US5240840A (en) 1991-04-05 1993-08-31 Regents Of The University Of Michigan Dna superfragment cloning
JP3314241B2 (ja) 1992-04-06 2002-08-12 ヤマハ発動機株式会社 自動二輪車用エンジンの排気浄化装置
US5453357A (en) 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5690926A (en) 1992-10-08 1997-11-25 Vanderbilt University Pluripotential embryonic cells and methods of making same
US5618829A (en) 1993-01-28 1997-04-08 Mitsubishi Chemical Corporation Tyrosine kinase inhibitors and benzoylacrylamide derivatives
HUT74451A (en) 1993-07-15 1996-12-30 Cancer Res Campaign Tech Prodrugs of protein tyrosine kinase inhibitors, systems contg. them and process for preparing them
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
US5914268A (en) 1994-11-21 1999-06-22 National Jewish Center For Immunology & Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5639757A (en) 1995-05-23 1997-06-17 Pfizer Inc. 4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors
US6051227A (en) 1995-07-25 2000-04-18 The Regents Of The University Of California, Office Of Technology Transfer Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US5855887A (en) 1995-07-25 1999-01-05 The Regents Of The University Of California Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
CN1145614C (zh) 1996-04-12 2004-04-14 沃尼尔·朗伯公司 酪氨酸激酶的不可逆抑制剂，其制药用途及药物组合物
US6207157B1 (en) 1996-04-23 2001-03-27 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for nontypeable Haemophilus influenzae
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
US6100254A (en) 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
AU729377B2 (en) 1997-10-23 2001-02-01 Asterias Biotherapeutics, Inc. Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture
US6835867B1 (en) 1998-06-24 2004-12-28 Richard P. Woychik Allelic series of genomic modifications in cells
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
EE05627B1 (et) 1998-12-23 2013-02-15 Pfizer Inc. CTLA-4 vastased inimese monoklonaalsed antikehad
US6740665B1 (en) 1999-02-10 2004-05-25 Ramachandran Murali Tyrosine kinase inhibitors and methods of using the same
US6245759B1 (en) 1999-03-11 2001-06-12 Merck & Co., Inc. Tyrosine kinase inhibitors
CA2383546A1 (en) 1999-06-30 2001-01-04 William H. Parsons Src kinase inhibitor compounds
AU5889100A (en) 1999-06-30 2001-01-31 Merck & Co., Inc. Src kinase inhibitor compounds
AU6605200A (en) 1999-06-30 2001-01-31 Merck & Co., Inc. Src kinase inhibitor compounds
ES2282133T3 (es) 1999-08-24 2007-10-16 Medarex, Inc. Anticuerpos frente a la ctla-4 humano y sus usos.
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
ES2250186T3 (es) 1999-09-10 2006-04-16 MERCK & CO., INC. Inhibidores de tirosina quinasa.
GEP20053530B (en) 1999-10-19 2005-05-25 Merck & Co Inc Tyrosine Kinase Inhibitors, Pharmaceutical Compositions Containing Them and Use Thereof
US6794393B1 (en) 1999-10-19 2004-09-21 Merck & Co., Inc. Tyrosine kinase inhibitors
EP1226119B1 (en) 1999-10-19 2005-03-16 MERCK & CO. INC. Tyrosine kinase inhibitors
US6420382B2 (en) 2000-02-25 2002-07-16 Merck & Co., Inc. Tyrosine kinase inhibitors
US6313138B1 (en) 2000-02-25 2001-11-06 Merck & Co., Inc. Tyrosine kinase inhibitors
NL1017973C2 (nl) 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
WO2002018549A1 (en) 2000-08-30 2002-03-07 Maria Biotech Co., Ltd. Human embryonic stem cells derived from frozen-thawed embryo
US7250255B2 (en) 2001-05-31 2007-07-31 Shinya Yamanaka Genes with ES cell-specific expression
EP1404672B1 (en) 2001-06-22 2006-01-18 Merck & Co., Inc. Tyrosine kinase inhibitors
US6958340B2 (en) 2001-08-01 2005-10-25 Merck & Co., Inc. Tyrosine kinase inhibitors
US6927293B2 (en) 2001-08-30 2005-08-09 Merck & Co., Inc. Tyrosine kinase inhibitors
CA2466279A1 (en) 2001-11-13 2003-05-22 Dana-Farber Cancer Institute, Inc. Agents that modulate immune cell activation and methods of use thereof
JP4511943B2 (ja) 2002-12-23 2010-07-28 ワイス エルエルシー Ｐｄ−１に対する抗体およびその使用
US7592177B2 (en) 2003-11-10 2009-09-22 The Scripps Research Institute Compositions and methods for inducing cell dedifferentiation
EP3530736A3 (en) 2005-05-09 2019-11-06 ONO Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
KR101888321B1 (ko) 2005-07-01 2018-08-13 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US8129187B2 (en) 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
WO2007109571A2 (en) 2006-03-17 2007-09-27 Prometheus Laboratories, Inc. Methods of predicting and monitoring tyrosine kinase inhibitor therapy
CA2659021A1 (en) 2006-07-20 2008-01-24 Richard Burt Method of using mitotically inactivated stem cells for damaged tissue repair
CN101626763A (zh) 2006-12-06 2010-01-13 北海道公立大学法人札幌医科大学 使用组蛋白脱乙酰酶（hdac）抑制物的细胞免疫增强
NZ600758A (en) 2007-06-18 2013-09-27 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
EP2262837A4 (en) 2008-03-12 2011-04-06 Merck Sharp & Dohme PD-1 BINDING PROTEINS
SG10201400329YA (en) 2008-05-02 2014-05-29 Univ Kyoto Method of nuclear reprogramming
HUE030807T2 (en) 2008-09-26 2017-05-29 Dana Farber Cancer Inst Inc Human anti-PD-1, anti-PD-L1 and anti-PD-L2 antibodies and their applications
TWI605828B (zh) 2008-12-09 2017-11-21 建南德克公司 抗ｐｄ-ｌ１抗體及其於增進ｔ細胞功能之用途
EP2393835B1 (en) 2009-02-09 2017-04-05 Université d'Aix-Marseille Pd-1 antibodies and pd-l1 antibodies and uses thereof
EP2504028A4 (en) 2009-11-24 2014-04-09 Amplimmune Inc SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
WO2011082400A2 (en) 2010-01-04 2011-07-07 President And Fellows Of Harvard College Modulators of immunoinhibitory receptor pd-1, and methods of use thereof
CA2802344C (en) 2010-06-18 2023-06-13 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
US8907053B2 (en) 2010-06-25 2014-12-09 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
JP5888753B2 (ja) 2010-11-04 2016-03-22 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
US9534206B2 (en) * 2010-12-16 2017-01-03 General Electric Company Cell carrier, associated methods for making cell carrier and culturing cells using the same
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130136722A1 (en) * 2011-11-11 2013-05-30 The Board Of Trustees Of The University Of Illinois Methods of Ex Vivo Expansion of Blood Progenitor Cells, and Generation of Composite Grafts

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Jay L Vivian et al. An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells // Proc Natl Acad Sci U S A, 2002 Nov 26;99(24):15542-7. *
Richard K Burt et al. Mitotically Inactivated Embryonic Stem Cells Can Be Used as an In Vivo Feeder Layer to Nurse Damaged Myocardium after Acute Myocardial Infarction // Circulation Research. 2012;111:1286-1296. *
Richard K Burt et al. Mitotically Inactivated Embryonic Stem Cells Can Be Used as an In Vivo Feeder Layer to Nurse Damaged Myocardium after Acute Myocardial Infarction // Circulation Research. 2012;111:1286-1296. Jay L Vivian et al. An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells // Proc Natl Acad Sci U S A, 2002 Nov 26;99(24):15542-7. *
Seth A Brodie et al. Could valproic acid be an effective anticancer agent? The evidence so far // Expert Rev Anticancer Ther. 2014 Oct; 14(10): 1097-1100. *
Seth A Brodie et al. Could valproic acid be an effective anticancer agent? The evidence so far // Expert Rev Anticancer Ther. 2014 Oct; 14(10): 1097-1100. Upendar Rao Golla et al. Investigation of molecular mechanisms of action of Valproic acid, an anticancer drug using budding yeast as a model organism // Conference: XXVII International Conference on Yeast Genetics and Molecular Biology //At: Levico Terme (Trento), Italy, Volume: Poster Sessions. Yeast 32, S93 (2015), abstract, S179-S180, ;[он-лайн], [найдено 27.07.2020]. Найдено из Интернет: < URL: https://www.researchgate.net/publication/281816194_Investigation_of_molecular_mechanisms_of_action_of_Valproic_acid_an_anticancer_drug_using_budding_yeast_as_a_model_organism. Wei Dong et al. Antitumor Effect of Embryonic Stem Cells in a Non-Small Cell Lung Cancer Model: Antitumor Factors and Immune Responses // Int J Med Sci. 2013; 10(10): 1314-1320). *
Upendar Rao Golla et al. Investigation of molecular mechanisms of action of Valproic acid, an anticancer drug using budding yeast as a model organism // Conference: XXVII International Conference on Yeast Genetics and Molecular Biology // At: Levico Terme (Trento), Italy, Volume: Poster Sessions. Yeast 32, S93 (2015), abstract, S179-S180,; [online], [found 27.07.2020]. Found from the Internet: <URL: https: //www.researchgate. net / publication / 281816194_Investigation_of_molecular_mechanisms_of_action_of_Valproic_acid_an_anticancer_drug_using_budding_yeast_as_a_model_organism. *
Wei Dong et al. Antitumor Effect of Embryonic Stem Cells in a Non-Small Cell Lung Cancer Model: Antitumor Factors and Immune Responses // Int J Med Sci. 2013; 10 (10): 1314-1320). *

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