JP7536031B2 - 安定性が改善されたノロウイルス様粒子 - Google Patents

安定性が改善されたノロウイルス様粒子 Download PDF

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JP7536031B2
JP7536031B2 JP2021552611A JP2021552611A JP7536031B2 JP 7536031 B2 JP7536031 B2 JP 7536031B2 JP 2021552611 A JP2021552611 A JP 2021552611A JP 2021552611 A JP2021552611 A JP 2021552611A JP 7536031 B2 JP7536031 B2 JP 7536031B2
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capsid protein
genogroup
amino acid
vlp
leu
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JP2022522891A (ja
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フランツィスカ ヤルチョヴスキ，
アンドレ ディエスナー，
フランク ティーメ，
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Icon Genetics AG
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Icon Genetics AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
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  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2021552611A 2019-03-12 2020-03-11 安定性が改善されたノロウイルス様粒子 Active JP7536031B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023148763A JP7672460B2 (ja) 2019-03-12 2023-09-13 安定性が改善されたノロウイルス様粒子

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19162266 2019-03-12
EP19162266.1 2019-03-12
PCT/EP2020/056461 WO2020182860A1 (en) 2019-03-12 2020-03-11 Norovirus-like particles with improved stability

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JP2023148763A Division JP7672460B2 (ja) 2019-03-12 2023-09-13 安定性が改善されたノロウイルス様粒子

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JP2022522891A JP2022522891A (ja) 2022-04-20
JP7536031B2 true JP7536031B2 (ja) 2024-08-19

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JP2021552611A Active JP7536031B2 (ja) 2019-03-12 2020-03-11 安定性が改善されたノロウイルス様粒子
JP2023148763A Active JP7672460B2 (ja) 2019-03-12 2023-09-13 安定性が改善されたノロウイルス様粒子

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US (1) US20220152186A1 (https=)
EP (1) EP3938378B1 (https=)
JP (2) JP7536031B2 (https=)
KR (1) KR20220021451A (https=)
CN (1) CN113557240B (https=)
AU (1) AU2020235344B2 (https=)
ES (1) ES2953232T3 (https=)
IL (1) IL285914B2 (https=)
MX (1) MX2021011059A (https=)
WO (1) WO2020182860A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024009801A (ja) * 2019-03-12 2024-01-23 アイコン ジェネティクス ゲーエムベーハー 安定性が改善されたノロウイルス様粒子

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250002539A1 (en) * 2021-07-26 2025-01-02 The University Of North Carolina At Chapel Hill Methods and compositions for norovirus chimeric therapeutics
CN118252924A (zh) * 2022-12-27 2024-06-28 远大赛威信生命科学(南京)有限公司 用于诱发哺乳动物针对诺如病毒的免疫反应的药物组合物及其制备方法和用途

Citations (3)

* Cited by examiner, † Cited by third party
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WO2010137489A1 (ja) 2009-05-28 2010-12-02 東洋紡績株式会社 特性の改変されたグルコースデヒドロゲナーゼ
WO2017069158A1 (ja) 2015-10-22 2017-04-27 プロテノバ株式会社 イムノグロブリン結合ポリペプチド
WO2018170603A1 (en) 2017-03-23 2018-09-27 Medicago Inc. Norovirus fusion proteins and vlps comprising norovirus fusion proteins

Family Cites Families (19)

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EP1025234A1 (en) 1997-10-24 2000-08-09 E.I. Du Pont De Nemours And Company Binary viral expression system in plants
EP1115870A2 (en) 1998-09-23 2001-07-18 E.I. Du Pont De Nemours And Company Binary viral expression system in plants
DE10109354A1 (de) 2001-02-27 2002-09-05 Icon Genetics Ag Rekombinante virale Schaltersysteme
DE10121283B4 (de) 2001-04-30 2011-08-11 Icon Genetics GmbH, 80333 Verfahren und Vektoren zur Amplifikation oder Expression von gewünschten Nucleinsäuresequenzen in Pflanzen
CN1533438A (zh) 2001-06-08 2004-09-29 �����Ŵ��Ƽ���˾ 在植物生产蛋白质的方法
AU2002314021B2 (en) 2002-04-30 2008-04-10 Icon Genetics Gmbh Amplification vectors based on trans-splicing
WO2006012906A1 (en) 2003-11-10 2006-02-09 Icon Genetics Ag Rna virus-derived plant expression system
ATE469231T1 (de) 2003-11-10 2010-06-15 Icon Genetics Gmbh Von rna-virus abgeleitetes pflanzenexpressionssystem
EP1564295A1 (en) 2004-01-23 2005-08-17 Icon Genetics AG RNA virus-derived plant expression system
EP1616959A1 (en) 2004-07-07 2006-01-18 Icon Genetics AG Biological safe transient protein expression in plants
CA2648886C (en) 2006-05-29 2015-10-20 Icon Genetics Gmbh Plant virus-based inducible expression system
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EP2647715A1 (en) 2012-04-03 2013-10-09 Nomad Bioscience GmbH Agrobacterium for transient transfection of whole plants
JOP20130186B1 (ar) 2012-06-22 2021-08-17 Takeda Vaccines Montana Inc تنقية الجزيئات الشبيهة بالفيروسات
CA2913068C (en) 2013-05-23 2023-01-10 Nomad Bioscience Gmbh Process of providing plants with abiotic stress resistance
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WO2010137489A1 (ja) 2009-05-28 2010-12-02 東洋紡績株式会社 特性の改変されたグルコースデヒドロゲナーゼ
WO2017069158A1 (ja) 2015-10-22 2017-04-27 プロテノバ株式会社 イムノグロブリン結合ポリペプチド
WO2018170603A1 (en) 2017-03-23 2018-09-27 Medicago Inc. Norovirus fusion proteins and vlps comprising norovirus fusion proteins

Non-Patent Citations (1)

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Title
Journal of Virological Methods，2004年，116，p. 109-117

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024009801A (ja) * 2019-03-12 2024-01-23 アイコン ジェネティクス ゲーエムベーハー 安定性が改善されたノロウイルス様粒子

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Publication number Publication date
EP3938378A1 (en) 2022-01-19
EP3938378C0 (en) 2023-08-02
IL285914A (en) 2021-10-31
JP2022522891A (ja) 2022-04-20
CN113557240B (zh) 2025-02-25
MX2021011059A (es) 2021-10-13
CA3133030A1 (en) 2020-09-17
AU2020235344A1 (en) 2021-09-23
JP7672460B2 (ja) 2025-05-07
EP3938378B1 (en) 2023-08-02
WO2020182860A1 (en) 2020-09-17
IL285914B1 (en) 2024-07-01
JP2024009801A (ja) 2024-01-23
US20220152186A1 (en) 2022-05-19
CN113557240A (zh) 2021-10-26
KR20220021451A (ko) 2022-02-22
IL285914B2 (en) 2024-11-01
AU2020235344B2 (en) 2024-10-24
ES2953232T3 (es) 2023-11-08

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