CN113557240B - 具有提高的稳定性的诺如病毒样颗粒 - Google Patents

具有提高的稳定性的诺如病毒样颗粒 Download PDF

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CN113557240B
CN113557240B CN202080020212.XA CN202080020212A CN113557240B CN 113557240 B CN113557240 B CN 113557240B CN 202080020212 A CN202080020212 A CN 202080020212A CN 113557240 B CN113557240 B CN 113557240B
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CN113557240A (zh
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F·贾佐夫斯基
A·迪斯纳
F·蒂梅
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Icon Genetics AG
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Icon Genetics AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202080020212.XA 2019-03-12 2020-03-11 具有提高的稳定性的诺如病毒样颗粒 Active CN113557240B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19162266 2019-03-12
EP19162266.1 2019-03-12
PCT/EP2020/056461 WO2020182860A1 (en) 2019-03-12 2020-03-11 Norovirus-like particles with improved stability

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CN113557240A CN113557240A (zh) 2021-10-26
CN113557240B true CN113557240B (zh) 2025-02-25

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US (1) US20220152186A1 (https=)
EP (1) EP3938378B1 (https=)
JP (2) JP7536031B2 (https=)
KR (1) KR20220021451A (https=)
CN (1) CN113557240B (https=)
AU (1) AU2020235344B2 (https=)
ES (1) ES2953232T3 (https=)
IL (1) IL285914B2 (https=)
MX (1) MX2021011059A (https=)
WO (1) WO2020182860A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020235344B2 (en) * 2019-03-12 2024-10-24 Icon Genetics Gmbh Norovirus-like particles with improved stability
US20250002539A1 (en) * 2021-07-26 2025-01-02 The University Of North Carolina At Chapel Hill Methods and compositions for norovirus chimeric therapeutics
CN118252924A (zh) * 2022-12-27 2024-06-28 远大赛威信生命科学(南京)有限公司 用于诱发哺乳动物针对诺如病毒的免疫反应的药物组合物及其制备方法和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3153578A1 (en) * 2010-07-06 2017-04-12 Novartis Ag Norovirus derived immunogenic compositions and methods
WO2018170603A1 (en) * 2017-03-23 2018-09-27 Medicago Inc. Norovirus fusion proteins and vlps comprising norovirus fusion proteins

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Publication number Priority date Publication date Assignee Title
EP1025234A1 (en) 1997-10-24 2000-08-09 E.I. Du Pont De Nemours And Company Binary viral expression system in plants
EP1115870A2 (en) 1998-09-23 2001-07-18 E.I. Du Pont De Nemours And Company Binary viral expression system in plants
DE10109354A1 (de) 2001-02-27 2002-09-05 Icon Genetics Ag Rekombinante virale Schaltersysteme
DE10121283B4 (de) 2001-04-30 2011-08-11 Icon Genetics GmbH, 80333 Verfahren und Vektoren zur Amplifikation oder Expression von gewünschten Nucleinsäuresequenzen in Pflanzen
CN1533438A (zh) 2001-06-08 2004-09-29 �����Ŵ��Ƽ���˾ 在植物生产蛋白质的方法
AU2002314021B2 (en) 2002-04-30 2008-04-10 Icon Genetics Gmbh Amplification vectors based on trans-splicing
WO2006012906A1 (en) 2003-11-10 2006-02-09 Icon Genetics Ag Rna virus-derived plant expression system
ATE469231T1 (de) 2003-11-10 2010-06-15 Icon Genetics Gmbh Von rna-virus abgeleitetes pflanzenexpressionssystem
EP1564295A1 (en) 2004-01-23 2005-08-17 Icon Genetics AG RNA virus-derived plant expression system
EP1616959A1 (en) 2004-07-07 2006-01-18 Icon Genetics AG Biological safe transient protein expression in plants
CA2648886C (en) 2006-05-29 2015-10-20 Icon Genetics Gmbh Plant virus-based inducible expression system
EP1897953A1 (en) 2006-09-06 2008-03-12 Icon Genetics GmbH Potexvirus-derived replicon
SG10202012986SA (en) 2006-09-29 2021-01-28 Ligocyte Pharmaceuticals Inc Norovirus vaccine formulations
JP5846908B2 (ja) * 2009-05-28 2016-01-20 東洋紡株式会社 特性の改変されたグルコースデヒドロゲナーゼ
EP2418283A1 (en) 2010-08-07 2012-02-15 Nomad Bioscience GmbH Process of transfecting plants
EP2647715A1 (en) 2012-04-03 2013-10-09 Nomad Bioscience GmbH Agrobacterium for transient transfection of whole plants
JOP20130186B1 (ar) 2012-06-22 2021-08-17 Takeda Vaccines Montana Inc تنقية الجزيئات الشبيهة بالفيروسات
CA2913068C (en) 2013-05-23 2023-01-10 Nomad Bioscience Gmbh Process of providing plants with abiotic stress resistance
US11208441B2 (en) * 2015-10-22 2021-12-28 Protenova Co., Ltd. Immunoglobulin-binding polypeptide
AU2020235344B2 (en) * 2019-03-12 2024-10-24 Icon Genetics Gmbh Norovirus-like particles with improved stability

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3153578A1 (en) * 2010-07-06 2017-04-12 Novartis Ag Norovirus derived immunogenic compositions and methods
WO2018170603A1 (en) * 2017-03-23 2018-09-27 Medicago Inc. Norovirus fusion proteins and vlps comprising norovirus fusion proteins

Also Published As

Publication number Publication date
EP3938378A1 (en) 2022-01-19
EP3938378C0 (en) 2023-08-02
IL285914A (en) 2021-10-31
JP2022522891A (ja) 2022-04-20
MX2021011059A (es) 2021-10-13
CA3133030A1 (en) 2020-09-17
AU2020235344A1 (en) 2021-09-23
JP7672460B2 (ja) 2025-05-07
EP3938378B1 (en) 2023-08-02
JP7536031B2 (ja) 2024-08-19
WO2020182860A1 (en) 2020-09-17
IL285914B1 (en) 2024-07-01
JP2024009801A (ja) 2024-01-23
US20220152186A1 (en) 2022-05-19
CN113557240A (zh) 2021-10-26
KR20220021451A (ko) 2022-02-22
IL285914B2 (en) 2024-11-01
AU2020235344B2 (en) 2024-10-24
ES2953232T3 (es) 2023-11-08

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