JP7519906B2 - ホスホリパーゼa2受容体キメラ自己受容体t細胞の組成物および方法 - Google Patents

ホスホリパーゼa2受容体キメラ自己受容体t細胞の組成物および方法 Download PDF

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JP7519906B2
JP7519906B2 JP2020561076A JP2020561076A JP7519906B2 JP 7519906 B2 JP7519906 B2 JP 7519906B2 JP 2020561076 A JP2020561076 A JP 2020561076A JP 2020561076 A JP2020561076 A JP 2020561076A JP 7519906 B2 JP7519906 B2 JP 7519906B2
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サー ギル
ジョナサン ホーガン
エイミー エス. ペイン
バオメイ ワン
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ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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JP2020561076A 2018-05-02 2019-05-02 ホスホリパーゼa2受容体キメラ自己受容体t細胞の組成物および方法 Active JP7519906B2 (ja)

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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170151281A1 (en) 2015-02-19 2017-06-01 Batu Biologics, Inc. Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
US10980836B1 (en) 2019-12-11 2021-04-20 Myeloid Therapeutics, Inc. Therapeutic cell compositions and methods of manufacturing and use thereof
CN113527507A (zh) * 2020-04-16 2021-10-22 上海赛比曼生物科技有限公司 靶向cd22的嵌合抗原受体及其制法和应用
CA3197423A1 (en) 2020-11-04 2022-05-12 Daniel Getts Engineered chimeric fusion protein compositions and methods of use thereof
WO2022136503A1 (en) 2020-12-22 2022-06-30 Deutsches Zentrum Für Neurodegenerative Erkrankungen E. V. (Dzne) Chimeric autoantibody receptor (caar) comprising a nicotinic acetylcholine receptor autoantigen
EP4308133A4 (en) 2021-03-17 2025-01-22 Myeloid Therapeutics, Inc. MANIPULATED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF
EP4083061A1 (en) * 2021-04-30 2022-11-02 Kilometro Rosso SPA Fusion proteins and use thereof in the treatment of membranous nephropathy
AU2022272235A1 (en) 2021-05-11 2023-12-21 Create Medicines, Inc. Methods and compositions for genomic integration
EP4380963A4 (en) * 2021-08-05 2025-06-04 The Trustees of The University of Pennsylvania Compositions and methods of chimeric autoantibody receptor cells expressing extended phospholipase a2 receptor fragments
US20250049849A1 (en) * 2021-12-15 2025-02-13 Shanghai Synvida Biotechnology Co. Ltd. Product and method for treating thrombocytopenia
CN114588881B (zh) * 2022-03-07 2023-07-18 大连理工大学 免疫吸附剂及其制备方法
CN116082517B (zh) * 2022-05-26 2025-08-22 成都地奥制药集团有限公司 融合蛋白及其用途
IL317811A (en) 2022-07-25 2025-02-01 Interius Biotherapeutics Inc Mutated polypeptides, compositions containing them and uses thereof
CN115838751A (zh) * 2022-11-22 2023-03-24 迪亚莱博(张家港)生物科技有限公司 一种磷脂酶a2受体重组蛋白的制备方法
AU2024318666A1 (en) * 2023-08-01 2026-01-22 Merida Biosciences, Inc. Molecules for controlling autoimmune response

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013007640A1 (en) 2011-07-08 2013-01-17 Centre Leon Berard Pla2r1 as anti-tumoral compound and as biomarker for the detection of cancer
WO2017009245A1 (en) 2015-07-10 2017-01-19 Chu De Nice Prognosis and monitoring of membranous nephropathy based on the analysis of pla2r1 epitope profile and spreading
US20170051035A1 (en) 2014-05-02 2017-02-23 The Trustees Of The University Of Pennsylvania Compositions and methods of chimeric autoantibody receptor t cells
WO2018031947A1 (en) 2016-08-12 2018-02-15 Immunowork, Llc Diagnosis, prevention, and/or treatment of autoimmune diseases

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US5199942A (en) 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
GB9125768D0 (en) 1991-12-04 1992-02-05 Hale Geoffrey Therapeutic method
US5350674A (en) 1992-09-04 1994-09-27 Becton, Dickinson And Company Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
ZA973051B (en) 1996-04-24 1998-10-12 Genentech Inc Type c lectins
CA2386270A1 (en) 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
CA2406864A1 (en) 2000-02-24 2001-08-30 Life Technologies Corporation Simultaneous stimulation and concentration of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
AU2001275474A1 (en) 2000-06-12 2001-12-24 Akkadix Corporation Materials and methods for the control of nematodes
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
AU2005250408B2 (en) 2004-05-27 2010-09-23 The Trustees Of The University Of Pennsylvania Novel artificial antigen presenting cells and uses therefor
EP2318036B1 (en) * 2008-06-30 2015-06-03 The Regents of the University of Michigan Lysosomal phospholipase a2 (lpla2) activity as a diagnostic and therapeutic target for identifying and treating systemic lupus erythematosis
PH12013501201A1 (en) * 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
US9708384B2 (en) * 2011-09-22 2017-07-18 The Trustees Of The University Of Pennsylvania Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens
AU2013243948A1 (en) * 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins associated with human disease
WO2018127585A1 (en) 2017-01-06 2018-07-12 Txcell Monospecific regulatory t cell population with cytotoxicity for b cells
CN107663235B (zh) * 2017-08-11 2018-05-22 南京诺唯赞医疗科技有限公司 特发性膜性肾病相关的pla2r重组蛋白及其应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013007640A1 (en) 2011-07-08 2013-01-17 Centre Leon Berard Pla2r1 as anti-tumoral compound and as biomarker for the detection of cancer
US20170051035A1 (en) 2014-05-02 2017-02-23 The Trustees Of The University Of Pennsylvania Compositions and methods of chimeric autoantibody receptor t cells
WO2017009245A1 (en) 2015-07-10 2017-01-19 Chu De Nice Prognosis and monitoring of membranous nephropathy based on the analysis of pla2r1 epitope profile and spreading
WO2018031947A1 (en) 2016-08-12 2018-02-15 Immunowork, Llc Diagnosis, prevention, and/or treatment of autoimmune diseases

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