JP7489079B2 - 新規コラーゲン再利用促進作用剤 - Google Patents
新規コラーゲン再利用促進作用剤 Download PDFInfo
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- JP7489079B2 JP7489079B2 JP2017174324A JP2017174324A JP7489079B2 JP 7489079 B2 JP7489079 B2 JP 7489079B2 JP 2017174324 A JP2017174324 A JP 2017174324A JP 2017174324 A JP2017174324 A JP 2017174324A JP 7489079 B2 JP7489079 B2 JP 7489079B2
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Description
〔1〕Endo180活性化成分を有効成分とすることを特徴とする断片化コラーゲン代謝促進剤。
〔2〕前記Endo180活性化成分が植物由来成分であることを特徴とする〔1〕に記載の断片化コラーゲン代謝促進剤。
〔3〕前記植物由来成分が、ステビア抽出物、ルブソサイド、ステビオサイド、レバウディオサイドAおよびレバウディオサイドCからなる群より選ばれる1種または2種以上であることを特徴とする〔1〕〔2〕に記載の断片化コラーゲン代謝促進剤。
〔4〕〔1〕~〔3〕に記載の断片化コラーゲン代謝促進剤を含有することを特徴とするシワ改善用組成物。
〔5〕コラーゲン産生促進剤、血流促進剤、コラーゲン、タンパク質、ペプチドおよびアミノ酸からなる群より選ばれる1種または2種以上の成分を含有することを特徴とする〔4〕に記載のシワ改善用組成物。
〔6〕〔4〕〔5〕に記載のシワ改善用組成物を含有することを特徴とするシワ改善用飲食品。
〔7〕〔1〕~〔3〕に記載の断片化コラーゲン代謝促進剤を含有することを特徴とする関節炎予防・改善用組成物。
〔8〕コラーゲン産生促進剤、抗炎症剤、血流促進剤、コラーゲン、タンパク質、ペプチド、アミノ酸、ブラックジンジャー、グルコサミン、N-アセチルグルコサミン、コンドロイチンから選ばれる1種または2種以上の成分を含有することを特徴とする〔7〕に記載の関節炎予防・改善用組成物。
〔9〕〔7〕〔8〕に記載の関節炎予防・改善用組成物を含有することを特徴とする関節炎予防・改善用飲食品。
本実施形態の断片化コラーゲン代謝促進剤は、Endo180活性化成分を有効成分とするものである。また、本実施形態のシワ改善用組成物および関節炎予防・改善用組成物は、上記断片化コラーゲン代謝促進剤を含有するものである。
本実施形態において、「ステビア抽出物」には、ステビアを抽出原料として得られる抽出液、当該抽出液の希釈液若しくは濃縮液、当該抽出液を乾燥して得られる乾燥物、又はこれらの粗精製物若しくは精製物のいずれもが含まれる。
ルブソサイド(13β-(β-D-グルコピラノシルオキシ)カウラ-16-エン-18-酸β-D-グルコピラノシル)、ステビオサイド(13-[(2-O-β-D-グルコピラノシル-β-D-グルコピラノシル)オキシ]カウラ-16-エン-18-酸β-D-グルコピラノシル)、レバウディオサイドA(13-[(2-O-β-D-グルコピラノシル-3-O-β-D-グルコピラノシル-β-D-グルコピラノシル)オキシ]カウラ-16-エン-18-酸β-D-グルコピラノシル)、およびレバウディオサイドC(13-[[2-O-(6-デオキシ-α-L-マンノピラノシル)-3-O-(β-D-グルコピラノシル)-β-D-グルコピラノシル]オキシ]カウラ-16-エン-18-酸β-D-グルコピラノシル)は、いずれも植物抽出物から得ることのできるステビオール配糖体である。
以上のようにして得られるステビア抽出物、ルブソサイド、ステビオサイド、レバウディオサイドAおよびレバウディオサイドCは、優れたEndo180活性化作用を有しているため、断片化コラーゲン代謝促進剤の有効成分として好適である。本実施形態の断片化コラーゲン代謝促進剤は、医薬品、医薬部外品、化粧品、飲食品等の幅広い用途に使用することができる。
上記Endo180活性化成分は、優れた断片化コラーゲン代謝促進作用を有しているため、シワ改善用組成物または関節炎予防・改善用組成物に配合するのに好適である。この場合、上記Endo180活性化成分、特にステビア抽出物、ルブソサイド、ステビオサイド、レバウディオサイドAまたはレバウディオサイドCは、そのまま配合してもよいし、上記Endo180活性化成分から製剤化した断片化コラーゲン代謝促進剤を配合してもよい。
また、本実施形態に係るシワ改善用組成物および関節炎予防・改善用組成物の剤型としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、錠剤、粉剤、カプセル剤、顆粒剤、エキス剤、シロップ剤等の経口投与剤;注射剤、点滴剤、坐剤等の非経口投与剤;軟膏等の外用剤などが挙げられる。
上記シワ改善用組成物は、上記Endo180活性化成分、特にステビア抽出物、ルブソサイド、ステビオサイド、レバウディオサイドAおよびレバウディオサイドCが有する優れた断片化コラーゲン代謝促進作用を付与すべく、シワ改善用飲食品に配合するのに好適である。同様に、上記関節炎予防・改善用組成物は、関節炎予防・改善用飲食品に配合するのに好適である。この場合、上記Endo180活性化成分、特にステビア抽出物、ルブソサイド、ステビオサイド、レバウディオサイドAまたはレバウディオサイドCをそのまま配合してもよいし、これらの成分を製剤化した断片化コラーゲン代謝促進剤を配合してもよい。
上記天然物由来成分(試料1~5)について、以下のようにしてEndo180 mRNA発現促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加での補正値
B:被験試料無添加での補正値
結果を表1に示す。
上記天然物由来成分(試料1~5)について、以下のようにしてEndo180産生促進作用を試験した。
式中の各項はそれぞれ以下を表す。
A:被験試料添加でのEndo180産生量
B:試料無添加でのEndo180産生量
式中の各項はそれぞれ以下を表す。
C :被験試料添加における細胞あたりのEndo180産生量
D :被験試料無添加における細胞あたりのEndo180産生量
結果を表2および表3に示す。
下記組成に従い、乳液を常法により製造した。
ステビア抽出物 0.01g
ホホバオイル 4.00g
1,3-ブチレングリコール 3.00g
アルブチン 3.00g
ポリオキシエチレンセチルエーテル(20E.O.) 2.50g
オリーブオイル 2.00g
スクワラン 2.00g
セタノール 2.00g
モノステアリン酸グリセリル 2.00g
オレイン酸ポリオキシエチレンソルビタン(20E.O.) 2.00g
パラオキシ安息香酸メチル 0.15g
グリチルリチン酸ステアリル 0.10g
黄杞エキス 0.10g
グリチルリチン酸ジカリウム 0.10g
イチョウ葉エキス 0.10g
コンキオリン 0.10g
オウバクエキス 0.10g
カミツレエキス 0.10g
香料 0.05g
精製水 残部(全量を100gとする)
下記組成のクリームを常法により製造した。
ルブソサイド 0.05g
クジンエキス 0.1g
オウゴンエキス 0.1g
流動パラフィン 5.0g
サラシミツロウ 4.0g
スクワラン 10.0g
セタノール 3.0g
ラノリン 2.0g
ステアリン酸 1.0g
オレイン酸ポリオキシエチレンソルビタン(20E.O.) 1.5g
モノステアリン酸グリセリル 3.0g
油溶性甘草エキス 0.1g
1,3-ブチレングリコール 6.0g
パラオキシ安息香酸メチル 1.5g
香料 0.1g
精製水 残部(全量を100gとする)
下記組成の美容液を常法により製造した。
ステビオサイド 0.01g
カミツレエキス 0.1g
ニンジンエキス 0.1g
キサンタンガム 0.3g
ヒドロキシエチルセルロース 0.1g
カルボキシビニルポリマー 0.1g
1,3-ブチレングリコール 4.0g
グリチルリチン酸ジカリウム 0.1g
グリセリン 2.0g
水酸化カリウム 0.25g
香料 0.01g
防腐剤(パラオキシ安息香酸メチル) 0.15g
エタノール 2.0g
精製水 残部(全量を100gとする)
下記組成のヘアトニックを常法により製造した。
レバウディオサイドA 0.4g
酢酸トコフェロール 適量
セファラチン 0.002g
イソプロピルメチルフェノール 0.1g
ヒアルロン酸ナトリウム 0.15g
グリセリン 15.0g
エタノール 15.0g
香料 適量
キレート剤(エデト酸ナトリウム) 適量
防腐剤(ヒノキチオール) 適量
可溶化剤(ポリオキシエチレンセチルエーテル) 適量
精製水 残部(全量を100gとする)
下記組成のシャンプーを常法により製造した。
レバウディオサイドC 0.5g
マジョラム抽出物 1.0g
ウメ果実部抽出物 0.2g
ヤシ油脂肪酸メチルタウリンナトリウム 10.0g
ヤシ油脂肪酸アミドプロピルベタイン 10.0g
ポリオキシエチレンアルキルエーテル硫酸ナトリウム 20.0g
ヤシ油脂肪酸ジエタノールアミド 4.0g
プロピレングリコール 2.0g
香料 適量
精製水 残部(全量を100gとする)
常法により、以下の組成を有する錠剤を製造した。
ステビア抽出物 5.0mg
ドロマイト(カルシウム20%、マグネシウム10%含有) 83.4mg
カゼインホスホペプチド 16.7mg
ビタミンC 33.4mg
マルチトール 136.8mg
コラーゲン 12.7mg
ショ糖脂肪酸エステル 12.0mg
常法により、以下の組成を有する経口液状製剤を製造した。
<1アンプル(1本100mL)中の組成>
レバウディオサイドA 0.3質量%
ヒハツエキス 0.15質量%
ソルビット 12.0質量%
安息香酸ナトリウム 0.1質量%
香料 1.0質量%
硫酸カルシウム 0.5質量%
精製水 残部(100質量%)
Claims (4)
- ステビア抽出物、ルブソサイド、ステビオサイド、レバウディオサイドAおよびレバウディオサイドCからなる群より選ばれる1種または2種以上を有効成分とすることを特徴とするEndo180活性化剤。
- 請求項1に記載のEndo180活性化剤を含有することを特徴とする、関節炎予防・改善用組成物。
- コラーゲン産生促進剤、抗炎症剤、血流促進剤、コラーゲン、タンパク質、ペプチド、アミノ酸、ブラックジンジャー、グルコサミン、N-アセチルグルコサミン、コンドロイチンから選ばれる1種または2種以上の成分を含有することを特徴とする請求項2に記載の関節炎予防・改善用組成物。
- 請求項2または3に記載の関節炎予防・改善用組成物を含有することを特徴とする、関節炎予防・改善用飲食品。
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