JP7488774B2 - 化合物 - Google Patents

化合物 Download PDF

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Publication number
JP7488774B2
JP7488774B2 JP2020571762A JP2020571762A JP7488774B2 JP 7488774 B2 JP7488774 B2 JP 7488774B2 JP 2020571762 A JP2020571762 A JP 2020571762A JP 2020571762 A JP2020571762 A JP 2020571762A JP 7488774 B2 JP7488774 B2 JP 7488774B2
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JP
Japan
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compound
compounds
formula
group
amino
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JP2020571762A
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English (en)
Japanese (ja)
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JPWO2020002325A5 (https=
JP2021528449A5 (https=
JP2021528449A (ja
Inventor
ブラウン，パメラ
ドーソン，マイケル
シモノビック，モナ
ボークス，スティーブン
デュパーチー，エスター
リバース，ディーン
レスター，ロイ
コールマン，スコット
Original Assignee
スペロ・セラピューティクス・インコーポレーテッド
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Publication of JP2021528449A publication Critical patent/JP2021528449A/ja
Publication of JPWO2020002325A5 publication Critical patent/JPWO2020002325A5/ja
Publication of JP2021528449A5 publication Critical patent/JP2021528449A5/ja
Priority to JP2024077064A priority Critical patent/JP2024109664A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020571762A 2018-06-25 2019-06-25 化合物 Active JP7488774B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024077064A JP2024109664A (ja) 2018-06-25 2024-05-10 化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862689602P 2018-06-25 2018-06-25
US62/689,602 2018-06-25
PCT/EP2019/066819 WO2020002325A1 (en) 2018-06-25 2019-06-25 Compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024077064A Division JP2024109664A (ja) 2018-06-25 2024-05-10 化合物

Publications (4)

Publication Number Publication Date
JP2021528449A JP2021528449A (ja) 2021-10-21
JPWO2020002325A5 JPWO2020002325A5 (https=) 2022-07-07
JP2021528449A5 JP2021528449A5 (https=) 2022-07-07
JP7488774B2 true JP7488774B2 (ja) 2024-05-22

Family

ID=67107423

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020571762A Active JP7488774B2 (ja) 2018-06-25 2019-06-25 化合物
JP2024077064A Pending JP2024109664A (ja) 2018-06-25 2024-05-10 化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024077064A Pending JP2024109664A (ja) 2018-06-25 2024-05-10 化合物

Country Status (31)

Country Link
US (3) US11459357B2 (https=)
EP (2) EP4316504A3 (https=)
JP (2) JP7488774B2 (https=)
KR (1) KR20210054500A (https=)
CN (2) CN112789287B (https=)
AR (1) AR116663A1 (https=)
AU (2) AU2019294261B2 (https=)
BR (1) BR112020026663A2 (https=)
CA (1) CA3103158A1 (https=)
CO (1) CO2020016080A2 (https=)
DK (1) DK3810633T3 (https=)
EA (1) EA202092819A1 (https=)
ES (1) ES2971732T3 (https=)
FI (1) FI3810633T3 (https=)
HR (1) HRP20240028T1 (https=)
HU (1) HUE065134T2 (https=)
IL (2) IL279620B2 (https=)
LT (1) LT3810633T (https=)
MA (1) MA52946B1 (https=)
MD (1) MD3810633T2 (https=)
MX (1) MX2020013811A (https=)
PH (1) PH12020552240A1 (https=)
PL (1) PL3810633T3 (https=)
PT (1) PT3810633T (https=)
RS (1) RS65128B1 (https=)
SG (1) SG11202012747VA (https=)
SI (1) SI3810633T1 (https=)
TW (2) TWI851584B (https=)
UA (1) UA128162C2 (https=)
WO (1) WO2020002325A1 (https=)
ZA (1) ZA202301937B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024109664A (ja) * 2018-06-25 2024-08-14 スペロ・セラピューティクス・インコーポレーテッド 化合物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12146004B2 (en) 2014-11-26 2024-11-19 Spero Therapeutics, Inc. Polymyxin compounds and uses thereof
WO2022098950A1 (en) 2020-11-06 2022-05-12 Spero Therapeutics, Inc. Compounds
WO2022262823A1 (zh) * 2021-06-18 2022-12-22 华南理工大学 活性氧自由基响应的多粘菌素前药化合物及其应用
CN121426894A (zh) * 2025-07-24 2026-01-30 中国药科大学 一种抗菌肽、药物组合物及应用
CN120699105B (zh) * 2025-08-19 2025-11-21 中国药科大学 一种氘代抗菌肽及其组合物和应用

Citations (4)

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WO2012168820A1 (en) 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
JP2014533678A (ja) 2011-11-18 2014-12-15 ノヴァクタ バイオシステムズ リミティッド ポリミキシン誘導体
JP2017510570A (ja) 2014-03-11 2017-04-13 ニュー・ファーマ・ライセンス・ホールディングス・リミテッド 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用
JP2017538692A (ja) 2014-11-26 2017-12-28 ニュー・ファーマ・ライセンス・ホールディングス・リミテッド 化合物

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US20010021697A1 (en) 1987-09-14 2001-09-13 Henning Lowenstein Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom, proteinageous or polypeptide components thereof, or analogues of such proteinaceous or polypeptide components
TW274552B (https=) 1992-05-26 1996-04-21 Hoechst Ag
US5767068A (en) 1997-02-13 1998-06-16 Pathogenesis Corporation Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections
CA2540742A1 (en) 2003-09-30 2005-04-14 Terry Hicks Compositions and methods for treating burns
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
BRPI0715095B8 (pt) 2006-08-11 2021-05-25 Northern Antibiotics Oy derivado de polimixina da fórmula geral (i); produto de combinação; composição farmacêutica; método para se sensibilizar bactérias gram-negativas a um agente antibacteriano; método para o desenvolvimento de antibióticos; método para a redução da toxicidade de polimixinas, octapeptinas naturais e seus derivados durante a aplicação das mesmas no tratamento de infecções em um indivíduo; método para melhorar as propriedades farmacocinéticas, de polimixinas, octapeptinas naturais e seus derivados; método para a sensibilização de bactérias gram-negativas clinicamente importantes a um complemento de mecanismo de defesa presente no soro; uso de um derivado; e processo para a preparação de um derivado de polimixina da fórmula (i).
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US8193148B2 (en) 2008-02-08 2012-06-05 Northern Antibiotics Ltd. Short fatty acid tail polymyxin derivatives and uses thereof
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ES2334547B1 (es) 2008-09-10 2010-12-03 Universidad De Barcelona Compuestos peptidicos antibacterianos.
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KR102354902B1 (ko) 2013-05-22 2022-01-24 에버레스트 메디신즈 (싱가포르) 피티이. 리미티드 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도
JP2017512818A (ja) 2014-04-01 2017-05-25 モナシュ、ユニバーシティＭｏｎａｓｈ Ｕｎｉｖｅｒｓｉｔｙ 抗菌性化合物としてのポリミキシン誘導体
SG11201704627XA (en) * 2014-12-17 2017-07-28 Hoffmann La Roche Enzymatic one-pot reaction for double polypeptide conjugation in a single step using sortase
WO2016166103A1 (en) * 2015-04-13 2016-10-20 Xellia Pharmaceuticals Aps Polymyxin derivatives
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RS65128B1 (sr) * 2018-06-25 2024-02-29 Spero Therapeutics Inc Jedinjenja
WO2020014501A1 (en) 2018-07-11 2020-01-16 Cidara Therapeutics, Inc. Compositions and methods for the treatment of bacterial infections

Patent Citations (4)

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WO2012168820A1 (en) 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
JP2014533678A (ja) 2011-11-18 2014-12-15 ノヴァクタ バイオシステムズ リミティッド ポリミキシン誘導体
JP2017510570A (ja) 2014-03-11 2017-04-13 ニュー・ファーマ・ライセンス・ホールディングス・リミテッド 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用
JP2017538692A (ja) 2014-11-26 2017-12-28 ニュー・ファーマ・ライセンス・ホールディングス・リミテッド 化合物

Non-Patent Citations (1)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024109664A (ja) * 2018-06-25 2024-08-14 スペロ・セラピューティクス・インコーポレーテッド 化合物

Also Published As

Publication number Publication date
EP4316504A2 (en) 2024-02-07
JP2024109664A (ja) 2024-08-14
FI3810633T3 (fi) 2024-02-09
SG11202012747VA (en) 2021-01-28
IL279620B1 (en) 2025-11-01
US20260103491A1 (en) 2026-04-16
PT3810633T (pt) 2024-02-19
TW202019949A (zh) 2020-06-01
ZA202301937B (en) 2023-09-27
ES2971732T3 (es) 2024-06-06
MD3810633T2 (ro) 2024-05-31
CN112789287A (zh) 2021-05-11
US20230012121A1 (en) 2023-01-12
EP4316504A3 (en) 2024-04-17
IL279620B2 (en) 2026-03-01
KR20210054500A (ko) 2021-05-13
DK3810633T3 (da) 2024-01-15
EA202092819A1 (ru) 2021-05-21
SI3810633T1 (sl) 2024-04-30
EP3810633A1 (en) 2021-04-28
IL323560A (en) 2025-11-01
CN112789287B (zh) 2024-06-21
US12528837B2 (en) 2026-01-20
PL3810633T3 (pl) 2024-04-08
CO2020016080A2 (es) 2021-01-18
MX2020013811A (es) 2021-03-09
RS65128B1 (sr) 2024-02-29
US20210246169A1 (en) 2021-08-12
AR116663A1 (es) 2021-06-02
JP2021528449A (ja) 2021-10-21
MA52946A (fr) 2021-04-28
HRP20240028T1 (hr) 2024-03-29
MA52946B1 (fr) 2024-03-29
CA3103158A1 (en) 2020-01-02
AU2019294261B2 (en) 2024-02-29
US11459357B2 (en) 2022-10-04
TWI851584B (zh) 2024-08-11
HUE065134T2 (hu) 2024-05-28
AU2024203362A1 (en) 2024-06-06
LT3810633T (lt) 2024-01-10
UA128162C2 (uk) 2024-04-24
CN118878638A (zh) 2024-11-01
TW202446783A (zh) 2024-12-01
PH12020552240A1 (en) 2021-08-16
WO2020002325A1 (en) 2020-01-02
AU2019294261A1 (en) 2021-02-04
BR112020026663A2 (pt) 2021-03-23
IL279620A (en) 2021-03-01
EP3810633B1 (en) 2023-12-13
NZ771833A (en) 2024-09-27

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