JP7475481B2 - ハロゲン化キサンテンの経口投与による固形癌性腫瘍の治療 - Google Patents
ハロゲン化キサンテンの経口投与による固形癌性腫瘍の治療 Download PDFInfo
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Description
Claims (17)
- 固形腫瘍治療有効量のローズベンガルジナトリウム化合物をその被覆が5以上の生物学的pH値で溶解又は崩壊する腸溶解性被覆された固体希釈剤マトリックス内に含有する経口送達用の医薬組成物。
- 前記腸溶性被覆された固体希釈剤マトリックスが、錠剤、トローチ剤、又は複数の概ね球状の糖顆粒の形態をとる、請求項1に記載の医薬組成物。
- 前記ローズベンガルジナトリウム化合物が、固体希釈剤マトリックス中に溶解若しくは分散されるか又は固体希釈剤マトリックス上に分散される、請求項1に記載の医薬組成物。
- 固体希釈剤マトリックスが、前記ローズベンガルジナトリウム化合物の1つ又は複数の層で被覆された糖球体から構成される、請求項3に記載の医薬組成物。
- 前記腸溶性コーティングが、5.5から7.0の公表pH値で溶解又は崩壊する、請求項1に記載の医薬組成物。
- 哺乳類の被験体内の固形癌性腫瘍の治療に使用するための医薬組成物であって、前記医薬組成物は、前記固形癌性腫瘍治療有効量のローズベンガルジナトリウム化合物を含み、胃のpH値を上回るpH値で溶解又は分散するポリマー膜で被覆され前記哺乳類の被験体に経口投与される、医薬組成物。
- 前記投与が、少なくとも前記固形癌性腫瘍の体積が少なくとも30パーセント減少するまで複数回繰り返される、請求項6に記載の医薬組成物。
- 前記ローズベンガルジナトリウム化合物が固体医薬組成物の一部として投与される、請求項6に記載の医薬組成物。
- 前記固体医薬組成物が錠剤又は複数の概ね球状の顆粒の形態をとる、請求項8に記載の医薬組成物。
- 哺乳類の被験体内の消化管の癌の治療、又は癌の形成の抑制に使用するための固形薬剤の医薬組成物であって、前記医薬組成物は、癌形成抑制又は癌治療有効量のローズベンガルジナトリウム化合物を含み、前記哺乳類の被験体に経口投与され、前記投与が、前記哺乳類の被験体の消化管の癌を治療し、前記固形薬剤が、前記消化管の前記癌が位置する部分のpH値で、前記ローズベンガルジナトリウム化合物を放出する、医薬組成物。
- 前記投与が繰り返される、請求項10に記載の医薬組成物。
- 前記癌が胃にある、請求項10に記載の医薬組成物。
- 前記癌が小腸にある、請求項10に記載の医薬組成物。
- 前記癌が結腸にある、請求項10に記載の医薬組成物。
- 前記固形薬剤が錠剤である、請求項10に記載の医薬組成物。
- 前記固形薬剤が、前記ローズベンガルジナトリウム化合物を含有する複数の被覆された粒子を含むカプセルである、請求項10に記載の医薬組成物。
- 前記被覆された粒子のコーティングが、前記HX化合物を放出するために、5.5から7.0の公表pH値で溶解又は崩壊する、請求項16に記載の医薬組成物。
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