MX2022011765A - Usos novedosos de xantenos halogenados en oncologia y virologia. - Google Patents
Usos novedosos de xantenos halogenados en oncologia y virologia.Info
- Publication number
- MX2022011765A MX2022011765A MX2022011765A MX2022011765A MX2022011765A MX 2022011765 A MX2022011765 A MX 2022011765A MX 2022011765 A MX2022011765 A MX 2022011765A MX 2022011765 A MX2022011765 A MX 2022011765A MX 2022011765 A MX2022011765 A MX 2022011765A
- Authority
- MX
- Mexico
- Prior art keywords
- mammalian
- response
- halogenated xanthene
- mammalian subject
- immunogen
- Prior art date
Links
- 150000003732 xanthenes Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 125000001834 xanthenyl group Chemical class C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 abstract 3
- 150000001408 amides Chemical class 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 210000004962 mammalian cell Anatomy 0.000 abstract 2
- 230000010472 type I IFN response Effects 0.000 abstract 2
- 206010066476 Haematological malignancy Diseases 0.000 abstract 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 125000005907 alkyl ester group Chemical class 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- HBGGXOJOCNVPFY-UHFFFAOYSA-N diisononyl phthalate Chemical class CC(C)CCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCC(C)C HBGGXOJOCNVPFY-UHFFFAOYSA-N 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 230000004044 response Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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- A61K31/33—Heterocyclic compounds
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- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Un método para tratar una infección viral de un sujeto mamífero que comprende administrar una cantidad inhibidora de virus de un xanteno halogenado, una sal farmacéuticamente aceptable, un éster de alquilo o amida o éster aromático o derivado de amida del mismo como se describe en la presente, al sujeto mamífero. Un método para inducir una respuesta de interferón tipo I en un sujeto mamífero que presenta una infección microbiana, tumor canceroso o malignidad hematológica que comprende administrar una cantidad de un xanteno halogenado como se mencionó anteriormente, eficaz para inducir la respuesta de interferón tipo I. Un método para mejorar una respuesta inmune específica de un inmunógeno de mamífero que comprende poner en contacto células de mamífero, in vivo o presentes en un medio de soporte de crecimiento de células de mamífero, con una cantidad eficaz de un xanteno halogenado como adyuvante como se mencionó anteriormente, y un inmunógeno al que esa respuesta se va a mejorar.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063000231P | 2020-03-26 | 2020-03-26 | |
PCT/US2021/024185 WO2021195400A1 (en) | 2020-03-26 | 2021-03-25 | Novel uses of halogenated xanthenes in oncology and virology |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022011765A true MX2022011765A (es) | 2022-11-09 |
Family
ID=77855092
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022011765A MX2022011765A (es) | 2020-03-26 | 2021-03-25 | Usos novedosos de xantenos halogenados en oncologia y virologia. |
MX2022011867A MX2022011867A (es) | 2020-03-26 | 2021-09-29 | Xantenos halogenados como adyuvantes en vacunas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022011867A MX2022011867A (es) | 2020-03-26 | 2021-09-29 | Xantenos halogenados como adyuvantes en vacunas. |
Country Status (9)
Country | Link |
---|---|
US (2) | US11975106B2 (es) |
EP (3) | EP4103283A4 (es) |
JP (3) | JP2023519382A (es) |
KR (3) | KR20230005181A (es) |
CN (3) | CN115916343A (es) |
AU (3) | AU2021242300A1 (es) |
CA (3) | CA3172124A1 (es) |
MX (2) | MX2022011765A (es) |
WO (3) | WO2021195400A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11938182B2 (en) | 2020-03-26 | 2024-03-26 | Provectus Pharmatech, Inc. | Halogenated xanthenes as vaccine adjuvants |
MX2022011765A (es) * | 2020-03-26 | 2022-11-09 | Provectus Pharmatech Inc | Usos novedosos de xantenos halogenados en oncologia y virologia. |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
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CA993795A (en) | 1970-12-10 | 1976-07-27 | Richardson-Merrell (Canada) Ltd. | Antiviral compositions containing bis-basic ethers and thioethers of xanthene and xanthen-9-ones and methods of treating viruses therewith |
US3859286A (en) * | 1970-12-11 | 1975-01-07 | Richardson Merrell Inc | Bis-basic ketones of xanthene and xanthen-9-one |
US4599231A (en) | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
US5180806A (en) | 1988-05-16 | 1993-01-19 | The Scripps Research Institute | Polypeptides and compositions of human papillomavirus latent proteins, diagnostic systems and methods |
DE471794T1 (de) * | 1989-05-11 | 1992-07-23 | Oklahoma Medical Research Foundation, Oklahoma, Okla., Us | Antivirale therapie unter verwendung von thiazin- und xanthenfarbstoffen. |
US6331286B1 (en) | 1998-12-21 | 2001-12-18 | Photogen, Inc. | Methods for high energy phototherapeutics |
US6493570B1 (en) | 1998-11-02 | 2002-12-10 | Photogen, Inc. | Method for improved imaging and photodynamic therapy |
US7390668B2 (en) | 1996-10-30 | 2008-06-24 | Provectus Pharmatech, Inc. | Intracorporeal medicaments for photodynamic treatment of disease |
US5829448A (en) | 1996-10-30 | 1998-11-03 | Photogen, Inc. | Method for improved selectivity in photo-activation of molecular agents |
US8974363B2 (en) | 1997-12-11 | 2015-03-10 | Provectus Pharmatech, Inc. | Topical medicaments and methods for photodynamic treatment of disease |
US7648695B2 (en) | 1998-08-06 | 2010-01-19 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
US8557298B2 (en) | 1998-08-06 | 2013-10-15 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
US20090117199A1 (en) * | 1998-08-06 | 2009-05-07 | Scott Timothy C | Method of treatment of cancer |
US6254891B1 (en) * | 1998-09-03 | 2001-07-03 | Ascent Pediatrics, Inc. | Extended release acetaminophen |
US20020022032A1 (en) | 1999-04-23 | 2002-02-21 | Curry Patrick Mark | Immuno-adjuvant PDT treatment of metastatic tumors |
US6942866B2 (en) | 2000-08-16 | 2005-09-13 | Apovia, Inc. | Malaria immunogen and vaccine |
US20020150541A1 (en) * | 2000-09-12 | 2002-10-17 | Gene Trol Biotherapeutics, Inc. | Compositions comprising mixtures of therapeutic proteins and methods of producing the same |
WO2002062333A1 (en) * | 2001-02-05 | 2002-08-15 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of 9h-xanthenes in a method of inhibiting viral replication targeting the nucleocapsid protein |
US7361352B2 (en) | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
US7750123B2 (en) * | 2003-11-25 | 2010-07-06 | Dana Farber Cancer Institute, Inc. | Antibodies against SARS-CoV and methods of use thereof |
PT2529626T (pt) * | 2006-05-01 | 2018-02-27 | Napo Pharmaceuticals Inc | Composições e métodos para tratamento ou prevenção do cancro do cólon |
KR101494055B1 (ko) | 2009-09-18 | 2015-02-16 | 프로벡투스 파마슈티컬스 인코포레이티드 | 4,5,6,7-테트라클로로-3'',6''-다이하이드록시-2'',4'',5'',7''- 테트라요오도-3h-스피로[이소벤조푸란-1,9''-잔텐]-3-온(로즈 벤갈) 및 관련 잔텐의 합성 방법 |
US9273022B2 (en) | 2009-09-18 | 2016-03-01 | Provectus Pharmaceuticals, Inc. | Process for the synthesis of 4,5,6,7-tetrachloro-3′,6′-dihydroxy-2′, 4′, 5′7′-tetraiodo-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (Rose Bengal) and related xanthenes |
WO2011133728A2 (en) * | 2010-04-23 | 2011-10-27 | Kineta, Inc. | Anti-viral compounds |
US8785434B2 (en) * | 2010-04-30 | 2014-07-22 | Prosetta Antiviral Inc. | Antiviral compounds |
US9107887B2 (en) * | 2011-03-10 | 2015-08-18 | Provectus Pharmaceuticals, Inc. | Combination of local and systemic immunomodulative therapies for enhanced treatment of cancer |
CA2927009C (en) * | 2013-10-21 | 2019-04-23 | Drexel University | Use of sting agonists to treat chronic hepatitis b virus infection |
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ES2964399T3 (es) * | 2018-05-16 | 2024-04-05 | Provectus Pharmatech Inc | Actividad antitumoral in vitro y xenoinjerto de un xanteno halogenado contra tumores sólidos pediátricos refractarios |
WO2020028532A1 (en) | 2018-08-02 | 2020-02-06 | The Board Of Regents Of The University Of Texas System | Adjuvant effect of the tlr1/2 agonist diprovocim synergizes with checkpoint-inhibiting antibodies to eliminate disease |
MX2022011765A (es) * | 2020-03-26 | 2022-11-09 | Provectus Pharmatech Inc | Usos novedosos de xantenos halogenados en oncologia y virologia. |
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2021
- 2021-03-25 MX MX2022011765A patent/MX2022011765A/es unknown
- 2021-03-25 CN CN202180037128.3A patent/CN115916343A/zh active Pending
- 2021-03-25 CA CA3172124A patent/CA3172124A1/en active Pending
- 2021-03-25 WO PCT/US2021/024185 patent/WO2021195400A1/en unknown
- 2021-03-25 EP EP21774987.8A patent/EP4103283A4/en active Pending
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EP4103283A4 (en) | 2024-02-28 |
KR20230005185A (ko) | 2023-01-09 |
EP4106814A4 (en) | 2024-05-01 |
CN115666646A (zh) | 2023-01-31 |
US20210299055A1 (en) | 2021-09-30 |
JP2023519382A (ja) | 2023-05-10 |
WO2021195400A1 (en) | 2021-09-30 |
WO2021195573A1 (en) | 2021-09-30 |
US11975106B2 (en) | 2024-05-07 |
EP4106814A1 (en) | 2022-12-28 |
KR20230005181A (ko) | 2023-01-09 |
WO2022203718A1 (en) | 2022-09-29 |
CA3172420A1 (en) | 2023-03-29 |
KR20230165107A (ko) | 2023-12-05 |
AU2021242300A1 (en) | 2022-10-13 |
JP7475481B2 (ja) | 2024-04-26 |
AU2021433087A1 (en) | 2022-10-20 |
CA3172124A1 (en) | 2021-09-30 |
JP2023526159A (ja) | 2023-06-21 |
AU2021242347A1 (en) | 2022-10-20 |
CN115916190A (zh) | 2023-04-04 |
JP2023519383A (ja) | 2023-05-10 |
CA3172134A1 (en) | 2021-09-30 |
EP4103283A1 (en) | 2022-12-21 |
MX2022011867A (es) | 2022-11-09 |
US20210299083A1 (en) | 2021-09-30 |
CN115916343A (zh) | 2023-04-04 |
EP4106749A1 (en) | 2022-12-28 |
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