JP7462718B2 - 皮膚、毛髪及び頭皮の健康を改善する酵母ベースのマスク - Google Patents
皮膚、毛髪及び頭皮の健康を改善する酵母ベースのマスク Download PDFInfo
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- JP7462718B2 JP7462718B2 JP2022163795A JP2022163795A JP7462718B2 JP 7462718 B2 JP7462718 B2 JP 7462718B2 JP 2022163795 A JP2022163795 A JP 2022163795A JP 2022163795 A JP2022163795 A JP 2022163795A JP 7462718 B2 JP7462718 B2 JP 7462718B2
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Description
本出願は、2017年7月28日出願の米国仮出願第62/538,152号の優先権を主張するものであり、内容を参照することにより組み込まれる。
本明細書で用いる、「微生物ベースの組成物」とは、微生物やその他細胞培養物の結果生成された成分を含む組成物を意味する。このように、微生物ベースの組成物は、微生物自体及び/又は微生物成長副生成物(例えば、生物界面活性剤、溶剤及び/又は酵素)を含む。細胞は、植物状態、胞子の形態、又は両方の混合であってよい。細胞は、プランクトン、又はバイオフィルム形態、又は両方の混合であってよい。細胞は、無傷又は溶解していてもよい。細胞は、例えば、組成物1ミリリトル当たり、1×104、1×105、1×106、1×107、1×108、1×109、1×1010又は1×1011以上の濃度で、成長したブロスに存在する。一実施形態において、微生物ベースの組成物は、細胞が成長し、細胞が除去されたブロスのみを含む。成長副生成物は、ブロスに存在し、例えば、代謝物、細胞膜成分、発現タンパク質及び/又は他の細胞状成分を含む。
本発明は、治療有効量の培養微生物及び/又はその成長副生成物を含む、皮膚、頭皮及び/又は毛髪の健康を改善する局所化粧組成物を提供する。好ましくは、化粧組成物は、フェイシャルマスク又はヘアマスクの形態にある。一実施形態において、組成物は、10%~50%w/w酵母細胞、より好ましくは、20%~40%、さらにより好ましくは、30%w/w含む。
本発明は、微生物を培養し、微生物代謝物及び/又は微生物成長のその他副生成物を生成する方法を提供する。微生物培養システムは、典型的に、浸水培養発酵を用いるが、表面培養及びハイブリッドシステムも用いることができる。本明細書で用いる「発酵」は、制御された条件下での細胞の成長を指す。成長は、好気性又は嫌気性とすることができる。
本発明の1つの微生物ベースの生成物は、単に、微生物を含む発酵ブロス及び/又は微生物により生成された微生物代謝物及び/又は残余の栄養素である。発酵生成物は、抽出や精製なしで直接使用される。
本発明は、微生物ベースの組成物を利用して、対象者の顔面皮膚、頭皮及び/又は毛髪の健康を改善する方法を提供する。より具体的に、本方法は、本発明の局所化粧組成物を利用して、対象者の顔面皮膚、頭皮及び/又は毛髪の健康及び/又は外観を改善するものである。
a)非薬用クレンザーを用いて対象者の顔面皮膚をクリーニングして、メイクアップ、汚れ、油を皮膚から除去し、
b)酵母細胞及び/又はその成長副生成物を含むフェイシャルマスク組成物を生成し、
c)フェイシャルマスク組成物の薄層を、顔面皮膚に適用し、
d)フェイシャルマスク組成物を、数分間、皮膚で乾燥させ、
e)フェイシャルマスク組成物を、温水を使って洗い流す、
ことを含む、方法が提供される。
a)非薬用クレンザーを用いて対象者の顔面皮膚をクリーニングして、メイクアップ、汚れ、油を皮膚から除去し、
b)酵母細胞及び/又はその成長副生成物を含むピールオフフェイシャルマスク組成物を生成し、
c)フェイシャルマスク組成物の薄層を、顔面皮膚に適用し、
d)フェイシャルマスク組成物を、数分間、皮膚で乾燥させ、コンパクトフィルムを形成し、
e)フィルムを皮膚から剥がし、
f)フェイシャルマスク組成物を、温水を使って洗い流す、
ことを含み、
ステップb)は、酵母細胞を、アルギン酸ナトリウム、キサンタンガム、硫酸カルシウム二水和物、ソルビトール、酸化マグネシウム、グアーガム、珪藻土及びピロリン酸四ナトリウムを含む粉末混合物に添加して、酵母粉末混合物を形成し、酵母粉末混合物を、例えば、約1:25の比率で水と混合して、液体又は半液体フェイシャルマスク組成物を形成することを含む。
a)約30~50gの酵母細胞を天然油、例えば、ヤシ油又はオリーブ油と混合して、酵母油混合物を形成し、
b)水を酵母油混合物に添加して、固練ペーストを形成し、
c)ペーストを、対象者の乾燥毛髪及び頭皮に適用し、
d)対象者の毛髪をプラスチックラップでカバーし、
e)ペーストを毛髪と頭皮に少なくとも1時間放置し、
f)ペーストを毛髪と頭皮から濯ぎ流すことを含む。任意で、方法は、乾燥及び/又は毛髪をファッションでスタイリングすることをさらに含むことができる。
本明細書に記載した実施例及び実施形態は例示のためのみであり、それを考慮して様々な修正や変更が当業者には示唆され、本出願の原理及び範囲に含まれるものとする。
ある実施形態において、本発明は、本局所化粧微生物ベースの組成物の調製と使用のための便利な家庭用キットを提供する。
Pichia酵母を用いて、様々なパーソナルケア組成物を生成することができ、その細胞誘導体は、皮膚を汚染する菌類を除去し、皮膚や粘膜表面で成長する病原性酵母を減じ、皮膚や粘膜のバクテリア汚染を減じ、コラーゲンやエラスチンの皮膚細胞での生成を刺激する(いくつか例を挙げたに過ぎない)。
Wickerhamomyces anomalus酵母を、殺菌されていない状態で、バイオマス及びソホロリピド生成のための800Lの作業用溶液を備えたリアクターで成長させる。空容器衛生法を用いて、内面を2~3%の過酸化水素で処理して、漂白剤及び高圧温水で濯ぐ。必要な成分を全て含む培養培地成分は、85~90℃で浄化するか、3%過酸化水素に溶解する。発酵温度は、25~30℃に保つ。pHは、5.0~5.5で始め、3.0~3.5まで下げて安定化させる。バイオマスの生成は、発酵約48時間でなされる。
SLP生成のために、Starmerella bombicolaの発酵を、流加発酵で、0.5%酵母エキス、10%グルコース、10%キャノーラ油、1%尿素を含有する栄養培地にて、14リットルのリアクターで行った。初期pHは、5.5であった。培養温度は、25℃であった。
Claims (13)
- 対象者の顔面皮膚の健康を改善する方法であって、
a)非薬用クレンザーを用いて対象者の顔面皮膚をクリーニングして、メイクアップ、汚れ、油を前記皮膚から除去し、
b)30~50gの酵母細胞及び50~300mlのヤシ油又はオリーブ油を含むフェイシャルマスク組成物を提供し、前記酵母細胞は、Pichia anomala(Wickerhamomyces anomalus)であり、
c)前記フェイシャルマスク組成物の薄層を、前記顔面皮膚に適用し、
d)前記フェイシャルマスク組成物を、数分間、前記皮膚で乾燥させ、
e)前記皮膚に残った前記マスク組成物のあらゆる部分を、水を使って洗い流す、
ことを含む、
方法。 - ステップb)は、1つ以上の微生物成長副生成物及び/又は1つ以上のコスメティック添加剤及び/又はアジュバントを、前記組成物に添加することをさらに含む、請求項1に記載の方法。
- 前記1つ以上の微生物成長副生成物は、微生物界面活性剤である、請求項2に記載の方法。
- ステップb)は、ステップc)の直前に行われ、直前とは、ステップc)の5分以下を意味する、請求項1に記載の方法。
- ステップb)は、
前記酵母細胞を、アルギン酸ナトリウム、キサンタンガム、硫酸カルシウム二水和物、ソルビトール、酸化マグネシウム、グアーガム、珪藻土及びピロリン酸四ナトリウムを含む粉末混合物に添加して、酵母粉末混合物を形成し、
前記酵母粉末混合物を、1:25の比率で水と混合して、液体又は半液体フェイシャルマスク組成物を形成することを含む、請求項1に記載の方法。 - ステップd)は、前記フェイシャルマスク組成物を、数分間、前記皮膚で乾燥させて、コンパクトフィルムを形成することを含み、前記方法は、さらに、e)前記皮膚から前記フィルムを剥がすことを含む、請求項5に記載の方法。
- 前記マスクは、対象者の瞼、前記対象者の目の周りの前記対象者の皮膚、又は前記対象者の唇には適用しない、請求項1に記載の方法。
- 前記フェイシャルマスク組成物を前記対象者の顔面皮膚に適用する前、前記方法は、さらに、前記対象者の顔を蒸して、前記皮膚の毛穴を開くことを含む、請求項1に記載の方法。
- 1日に1回又は2回行う、請求項1に記載の方法。
- 対象者の頭皮及び毛髪の健康を改善する方法であって、
a)30~50gの酵母細胞を50~300mlのヤシ油又はオリーブ油と混合し、
b)水を前記酵母オリーブ油混合物に添加して、固練ペーストを形成し、
c)前記ペーストを、対象者の乾燥毛髪及び頭皮に適用し、
d)前記対象者の毛髪をプラスチックラップでカバーし、
e)前記ペーストを前記毛髪と頭皮に少なくとも1時間放置し、
f)前記ペーストを前記毛髪と頭皮から濯ぎ流す、ことを含み、
前記酵母細胞は、Pichia anomala(Wickerhamomyces anomalus)から選択される、方法。 - ステップb)は、1つ以上の微生物成長副生成物及び/又は1つ以上のコスメティック添加剤及び/又はアジュバントを組成物に添加することをさらに含む、請求項10に記載の方法。
- 前記組成物を毎日適用する、請求項10に記載の方法。
- 前記毎日の適用を、1週間以上繰り返す、請求項10に記載の方法。
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CA3107300A1 (en) * | 2018-05-25 | 2019-11-28 | Locus Ip Company, Llc | Therapeutic compositions for enhanced healing of wounds and scars |
CN114727956A (zh) * | 2019-08-10 | 2022-07-08 | 轨迹Ip有限责任公司 | 提高非处方药(otc)和制药药品生物利用度的方法 |
RU2760315C2 (ru) * | 2020-04-21 | 2021-11-23 | Михаил Самуилович Борц | Косметическое средство и способ его получения |
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KR102633132B1 (ko) * | 2021-05-21 | 2024-02-05 | (주)메디톡스 | 효모 유래 세포외 소낭을 유효성분으로 포함하는 조성물 및 방법 |
WO2023196763A1 (en) * | 2022-04-04 | 2023-10-12 | Locus Solutions Ipco, Llc | Therapeutic compositions for enhanced healing of wounds and scars |
CN115252485A (zh) * | 2022-08-08 | 2022-11-01 | 澳宝化妆品(惠州)有限公司 | 毕赤酵母提取物的制备方法及含有其的头皮护理组合物 |
CN115607457A (zh) * | 2022-08-15 | 2023-01-17 | 星智豫美(上海)生物科技有限公司 | 一种适用于敏感肌的软膜粉面膜及其制备方法 |
CN115813816B (zh) * | 2022-09-16 | 2024-05-28 | 江苏集萃功能材料研究所有限公司 | 一种温和的凝胶面膜及其应用 |
CN115770210A (zh) * | 2022-12-02 | 2023-03-10 | 江南大学 | 一种用于化妆品的大米紫甘薯复合发酵滤液及其制备方法与应用 |
CN116463227B (zh) * | 2023-05-25 | 2024-01-12 | 云南英格生物技术有限公司 | 一种具有修复功效的异常威克汉姆酵母菌及其培养方法和应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008044855A (ja) | 2006-08-11 | 2008-02-28 | Toyobo Co Ltd | バイオサーファクタントを有効成分とする賦活化剤 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0710735A (ja) * | 1993-06-21 | 1995-01-13 | Dowa Mining Co Ltd | 化粧料 |
FR2720941B1 (fr) * | 1994-06-13 | 1996-08-23 | Inst Francais Du Petrole | Utilisation des sophorolipides et compositions cosmétiques et dermatologiques. |
FR2735979B1 (fr) * | 1995-06-28 | 1997-08-14 | Inst Francais Du Petrole | Utilisation comme substances therapeutiquement actives ou produits cosmetiques des sophorolipides, en particulier pour le traitement de la peau |
FR2757766B1 (fr) * | 1996-12-27 | 1999-02-19 | Inst Francais Du Petrole | Utilisation des sophorolipides en tant qu'agent stimulateur du metabolisme des fibroblastes dermiques |
RU2185147C2 (ru) * | 1999-09-17 | 2002-07-20 | Михайлова Наталья Семеновна | Косметическая регенерирующая маска |
US6403108B1 (en) | 2000-03-31 | 2002-06-11 | Sheikh Ahmed Abdullah | Cosmetic composition and method of use |
ITMI20010207A1 (it) * | 2001-02-02 | 2002-08-02 | Istituto Profilattico Italiano | Composizioni cosmetiche contenenti cellule di lievito naturale |
US20090071493A1 (en) * | 2007-09-14 | 2009-03-19 | L'oreal | Compositions and methods for conditioning hair |
FR2927254B1 (fr) * | 2008-02-12 | 2010-03-26 | Lesaffre & Cie | Utilisation de substances actives naturelles dans des compositions cosmetiques ou therapeutiques |
KR101608687B1 (ko) | 2009-07-31 | 2016-04-05 | (주)아모레퍼시픽 | 사이클릭 리포펩티드를 함유하는 항산화 및 항노화용 화장료 조성물 |
FR2953412B1 (fr) * | 2009-12-08 | 2012-04-20 | Biocodex | Medicament pour le traitement des ulceres gastro-intestinaux |
CN102465150B (zh) * | 2010-11-09 | 2014-06-18 | 花王株式会社 | 神经酰胺产生促进剂的制造方法 |
CN102533866B (zh) * | 2010-12-30 | 2015-04-01 | 花王株式会社 | 抗氧化剂的制造方法 |
CN102078282B (zh) * | 2011-01-12 | 2011-12-07 | 扬州大学 | 一种酒泥酵母营养面膜及其制备方法 |
EP2540170A1 (de) * | 2011-06-29 | 2013-01-02 | Evonik Degussa GmbH | Dermatologisch wirksamer Hefeextrakt |
CA2863681A1 (en) * | 2012-02-14 | 2013-08-22 | The Procter & Gamble Company | Topical use of a skin-commensal prebiotic agent and compositions containing the same |
CN103800224A (zh) | 2012-11-12 | 2014-05-21 | 陈英滨 | 护理皮肤用的美容组合物及美容方法 |
CN102965290B (zh) * | 2012-11-21 | 2014-01-29 | 浙江工业大学 | 库德里阿兹威毕赤酵母zjph0802及其在制备姜黄素衍生物中的应用 |
JP2014058500A (ja) * | 2013-04-08 | 2014-04-03 | Isehan:Kk | ベニバナ発酵液 |
KR101365711B1 (ko) | 2013-04-30 | 2014-02-21 | 재단법인 경북해양바이오산업연구원 | 효모로부터 분리된 신규한 생물학적 계면활성제 |
PT106959B (pt) | 2013-05-17 | 2020-04-20 | Inst Superior Tecnico | Processos para a produção de glicolípidos microbianos do tipo manosileritritolípidos, a partir de materiais lenhocelulósicos e suas aplicações |
WO2015061798A2 (en) * | 2013-10-25 | 2015-04-30 | R.F. Technology Consultants, Inc. | Compositions and methods comprising yeast organisms and lipid extracts thereof |
JP2014114291A (ja) * | 2013-12-13 | 2014-06-26 | Showa Denko Kk | 化粧料または皮膚外用剤 |
KR102479151B1 (ko) * | 2015-01-19 | 2022-12-19 | 가부시키가이샤 야쿠르트 혼샤 | 위커하모마이세스속 미생물 배양물 |
WO2016205613A1 (en) * | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Crispr enzyme mutations reducing off-target effects |
US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
DE102015217507A1 (de) * | 2015-09-14 | 2017-03-16 | Henkel Ag & Co. Kgaa | Biotenside enthaltende kosmetische Reinigungsmittel mit prebiotischer Aktivität |
US20170172913A1 (en) * | 2015-12-17 | 2017-06-22 | Johnson & Johnson Consumer Inc. | Topical Compositions Comprising Pichia Anomala and Chicory Root Extracts |
CN105420132B (zh) * | 2016-01-25 | 2019-06-18 | 伽蓝(集团)股份有限公司 | 一种酿酒酵母及其在制备皮肤外用剂中的应用 |
US20170087199A1 (en) * | 2016-02-10 | 2017-03-30 | Senomyx, Inc. | Compositions for delivering a cooling sensation |
CN105640870B (zh) * | 2016-03-02 | 2018-12-07 | 名臣健康用品股份有限公司 | 一种含酵母提取物的皮肤护理组合物及皮肤护理产品 |
CN106721797B (zh) * | 2016-12-06 | 2020-10-09 | 上海应用技术大学 | 一种苹果酵素及其制备方法与应用 |
MX2019013262A (es) | 2017-05-07 | 2020-01-13 | Locus Ip Co Llc | Composiciones cosmeticas para la salud de la piel y metodos de uso de los mismos. |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US11759414B2 (en) | 2023-09-19 |
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