JP7439077B2 - ウイルスカプシドタンパク質組成の分析方法 - Google Patents

ウイルスカプシドタンパク質組成の分析方法 Download PDF

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JP7439077B2
JP7439077B2 JP2021522332A JP2021522332A JP7439077B2 JP 7439077 B2 JP7439077 B2 JP 7439077B2 JP 2021522332 A JP2021522332 A JP 2021522332A JP 2021522332 A JP2021522332 A JP 2021522332A JP 7439077 B2 JP7439077 B2 JP 7439077B2
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capsid
virus
aav
itr
viral
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シュンハイ ワン
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Regeneron Pharmaceuticals Inc
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    • G—PHYSICS
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    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0102—Alpha-glucosidase (3.2.1.20)
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    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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    • G01N21/64—Fluorescence; Phosphorescence
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/14011—Parvoviridae
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JP2021522332A 2018-10-25 2019-10-24 ウイルスカプシドタンパク質組成の分析方法 Active JP7439077B2 (ja)

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PCT/US2019/057936 WO2020086893A1 (en) 2018-10-25 2019-10-24 Methods for analysis of viral capsid protein composition

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US12280403B2 (en) 2015-07-16 2025-04-22 Sortera Technologies, Inc. Sorting based on chemical composition
US12290842B2 (en) 2015-07-16 2025-05-06 Sortera Technologies, Inc. Sorting of dark colored and black plastics
EP4076537A4 (en) * 2019-12-20 2024-02-28 University of Maryland, Baltimore NON-INVASIVE QUANTIFICATION OF FULL CAPSIDS VS. VACUUMS USING PROTON NMR OF WATER
US20240052322A1 (en) * 2020-12-15 2024-02-15 Pfizer Inc. HILIC UPLC-MS Method For Separating and Analyzing Intact Adeno-Associated Virus Capsid Proteins
TWI829131B (zh) * 2021-09-28 2024-01-11 美商索特拉科技公司 用於淘選材料之方法和系統以及儲存在電腦可讀儲存媒體上的電腦程式產品
EP4514984A4 (en) * 2022-04-25 2026-04-22 Beijing Hanmoluojie Tech Co Ltd 3D MOLECULAR SURFACE FEATURES MAPPING OF AAV CAPSIDS
WO2024249438A1 (en) * 2023-05-26 2024-12-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Copiparvovirus genetic vector platform
WO2025035009A1 (en) * 2023-08-08 2025-02-13 Brammer Bio, Llc Detection of variability in viruses

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JP2017524128A (ja) 2014-07-18 2017-08-24 ヘキサル・アクチェンゲゼルシャフト 血清試料中の糖タンパク質のグリカンをマッピングするための改善された方法
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JP2017078721A (ja) 2010-10-29 2017-04-27 コヒーシブ・テクノロジーズ・インコーポレイテッド 広範囲の疎水性を有する被検成分の精製及び検出のためのｌｃ−ｍｓ構成
JP2017524128A (ja) 2014-07-18 2017-08-24 ヘキサル・アクチェンゲゼルシャフト 血清試料中の糖タンパク質のグリカンをマッピングするための改善された方法
WO2018003559A1 (ja) 2016-07-01 2018-01-04 日立オートモティブシステムズ株式会社 燃料噴射弁

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CN113272649A (zh) 2021-08-17
IL282411B1 (en) 2025-05-01
AU2019366983A1 (en) 2021-05-13
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JP2023021996A (ja) 2023-02-14
AU2019366983B2 (en) 2025-10-16
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US11981913B2 (en) 2024-05-14
EA202191137A1 (ru) 2021-10-06
CA3115832A1 (en) 2020-04-30
EP3870976B1 (en) 2023-11-29
BR112021007550A2 (pt) 2021-07-27
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US20240102046A9 (en) 2024-03-28
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US11345929B2 (en) 2022-05-31
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