JP7438148B2 - 心臓サルコメア阻害剤 - Google Patents

心臓サルコメア阻害剤 Download PDF

Info

Publication number
JP7438148B2
JP7438148B2 JP2020572525A JP2020572525A JP7438148B2 JP 7438148 B2 JP7438148 B2 JP 7438148B2 JP 2020572525 A JP2020572525 A JP 2020572525A JP 2020572525 A JP2020572525 A JP 2020572525A JP 7438148 B2 JP7438148 B2 JP 7438148B2
Authority
JP
Japan
Prior art keywords
substituted
pharmaceutically acceptable
compound
unsubstituted
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020572525A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021529185A5 (enExample
JP2021529185A (ja
Inventor
ブラッドリー ピー. モーガン,
チーユアン チュアン,
Original Assignee
サイトキネティックス, インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by サイトキネティックス, インコーポレイテッド filed Critical サイトキネティックス, インコーポレイテッド
Publication of JP2021529185A publication Critical patent/JP2021529185A/ja
Publication of JP2021529185A5 publication Critical patent/JP2021529185A5/ja
Application granted granted Critical
Publication of JP7438148B2 publication Critical patent/JP7438148B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2020572525A 2018-06-26 2019-06-25 心臓サルコメア阻害剤 Active JP7438148B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862690248P 2018-06-26 2018-06-26
US62/690,248 2018-06-26
PCT/US2019/038907 WO2020005887A1 (en) 2018-06-26 2019-06-25 Cardiac sarcomere inhibitors

Publications (3)

Publication Number Publication Date
JP2021529185A JP2021529185A (ja) 2021-10-28
JP2021529185A5 JP2021529185A5 (enExample) 2022-07-04
JP7438148B2 true JP7438148B2 (ja) 2024-02-26

Family

ID=67211970

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020572525A Active JP7438148B2 (ja) 2018-06-26 2019-06-25 心臓サルコメア阻害剤

Country Status (4)

Country Link
US (1) US11964967B2 (enExample)
EP (1) EP3814342B1 (enExample)
JP (1) JP7438148B2 (enExample)
WO (1) WO2020005887A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019144041A1 (en) 2018-01-19 2019-07-25 Cytokinetics, Inc. Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors
JP7610985B2 (ja) * 2018-06-26 2025-01-09 サイトキネティックス, インコーポレイテッド 心臓サルコメア阻害剤
JP7438148B2 (ja) 2018-06-26 2024-02-26 サイトキネティックス, インコーポレイテッド 心臓サルコメア阻害剤
MA53491A (fr) 2018-08-31 2021-09-15 Cytokinetics Inc Inhibiteurs de sarcomes cardiaques
MX2023002024A (es) 2020-08-28 2023-05-10 Myokardia Inc Métodos de tratamiento con modulador de miosina.
CN117083275A (zh) 2021-03-04 2023-11-17 赛特凯恩蒂克公司 心脏肌节抑制剂
AU2023213659A1 (en) * 2022-01-27 2024-08-29 Soter Biopharma Pte. Ltd. Crystal form of 7-azaspiro[4,5]decane-6,10-dione compound and preparation method therefor
EP4514355A1 (en) 2022-04-26 2025-03-05 MyoKardia, Inc. Methods of administering myosin inhibitors
CN115894361A (zh) * 2022-12-28 2023-04-04 上海合全药业股份有限公司 一种钯催化合成1-乙酰基-6-氰基-四氢喹啉的方法
WO2025096779A2 (en) 2023-11-01 2025-05-08 Bristol Myers Squibb Company Methods of treatment with a myosin inhibitor using protein levels

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006515884A (ja) 2003-01-14 2006-06-08 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
JP2008526761A (ja) 2004-12-31 2008-07-24 アラントス ファーマシューティカルズ インコーポレイテッド 多環式ビス−アミドmmp阻害剤
US20160289211A1 (en) 2011-04-22 2016-10-06 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
JP2021511331A (ja) 2018-01-19 2021-05-06 サイトキネティックス, インコーポレイテッド 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ
JP2021529746A (ja) 2018-06-26 2021-11-04 サイトキネティックス, インコーポレイテッド 心臓サルコメア阻害剤

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
ES2293638T3 (es) 1994-03-25 2008-03-16 Isotechnika, Inc. Mejora de la eficacia de farmacos por deuteracion.
US5919785A (en) 1996-04-03 1999-07-06 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU2002365057A1 (en) 2001-12-21 2003-07-30 Cytokinetics, Inc. Compositions and methods for treating heart failure
AU2004206955A1 (en) 2003-01-21 2004-08-05 Archemix Corp. Aptamer therapeutics useful in ocular pharmacotherapy
EP1605752B1 (en) 2003-03-27 2011-09-14 Cytokinetics, Inc. Sulfonamides for the treatment of congestive heart failure, their compositions and uses.
JP2007516176A (ja) 2003-06-20 2007-06-21 アムジエン・インコーポレーテツド ピペラジン誘導体及び使用方法
ES2522579T3 (es) 2004-06-17 2014-11-17 Cytokinetics, Inc. Compuestos, composiciones y métodos
TW200718692A (en) 2005-04-22 2007-05-16 Wyeth Corp Dihydrobenzofuran derivatives and uses thereof
WO2007078815A2 (en) 2005-12-16 2007-07-12 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
RU2318818C1 (ru) 2006-04-12 2008-03-10 Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" Азагетероциклы, комбинаторная библиотека, фокусированная библиотека, фармацевтическая композиция и способ получения (варианты)
SA08290245B1 (ar) 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
US20090192168A1 (en) 2008-01-04 2009-07-30 Alex Muci Compounds, Compositions and Methods
WO2010033701A2 (en) 2008-09-19 2010-03-25 Genzyme Corporation Inhibitors of sphingosine kinase 1
NZ596302A (en) 2009-05-15 2014-01-31 Novartis Ag Aryl pyridine as aldosterone synthase inhibitors
US8592426B2 (en) 2011-01-24 2013-11-26 Hoffmann—La Roche Inc. Aryl-benzocycloalkyl amide derivatives
US9493412B2 (en) 2011-09-27 2016-11-15 Bristol-Myers Squibb Company Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
US9409917B2 (en) 2012-01-20 2016-08-09 Actelion Pharmaceuticals Ltd. Heterocyclic amide derivatives as P2X7 receptor antagonists
SMT202000071T1 (it) 2013-06-21 2020-03-13 Myokardia Inc Composti di pirimidinadione contro le condizioni cardiache
US9199945B2 (en) 2013-06-21 2015-12-01 MyoKardia, Inc. Cycloalkyl-substituted pyrimidinedione compounds
AU2014362231B2 (en) 2013-12-11 2019-04-04 Biogen Ma Inc. Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
US9663516B2 (en) 2014-12-18 2017-05-30 MyoKardia, Inc. Bicyclic-pyrimidinedione compounds
EP4234017B1 (en) 2015-01-22 2026-04-15 MyoKardia, Inc. Preparation of 4-methylsulfonyl-substituted piperidine urea compounds useful for the treatment of cardiac disorders such as dilated cardiomyopathy (dcm)
CN108137517B (zh) 2015-10-02 2022-04-12 先正达参股股份有限公司 杀微生物的噁二唑衍生物
JP2019507110A (ja) 2015-12-17 2019-03-14 シンジェンタ パーティシペーションズ アーゲー 殺微生物性オキサジアゾール誘導体
CN108368098B (zh) 2015-12-18 2022-01-28 先正达参股股份有限公司 杀微生物的噁二唑衍生物
CA3022432A1 (en) 2016-04-29 2017-11-02 Board Of Regents, The University Of Texas System Sigma receptor binders
WO2017222951A1 (en) 2016-06-23 2017-12-28 Merck Sharp & Dohme Corp. 3-aryl and heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors
JP6681517B2 (ja) 2016-09-27 2020-04-15 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. mGluR2陰性アロステリック調節剤としてのクロマン、イソクロマン及びジヒドロイソベンゾフラン誘導体、組成物、及びそれらの使用
WO2018089433A1 (en) 2016-11-08 2018-05-17 Navitor Pharmaceuticals, Inc. PHENYL mTORC INHIBITORS AND USES THEREOF
JP2020023442A (ja) 2016-12-19 2020-02-13 住友化学株式会社 オキサジアゾール化合物及び植物病害防除方法
WO2018156883A1 (en) 2017-02-23 2018-08-30 Board Of Regents, The University Of Texas System Methods of treatment for cancer, sterol homeostasis, and neurological diseases
CN110325517B (zh) * 2017-02-28 2021-03-02 南京明德新药研发有限公司 螺环类化合物及其应用
CA3071948A1 (en) 2017-08-04 2019-02-07 MyoKardia, Inc. Mavacamten for use in the treatment of hypertrophic cardiomyopathy
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US10710994B2 (en) 2018-03-19 2020-07-14 Genentech, Inc. Oxadiazole transient receptor potential channel inhibitors
JP7438148B2 (ja) 2018-06-26 2024-02-26 サイトキネティックス, インコーポレイテッド 心臓サルコメア阻害剤
MA53491A (fr) 2018-08-31 2021-09-15 Cytokinetics Inc Inhibiteurs de sarcomes cardiaques
MX2021001380A (es) 2018-08-31 2021-05-27 Xenon Pharmaceuticals Inc Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapeuticos.
EP3999180B1 (en) 2019-07-17 2024-05-08 Cytokinetics, Inc. Polymorphs of (r)-n-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-1h-pyrazole-4-carboxamide
BR112022000523A2 (pt) 2019-07-17 2022-03-03 Cytokinetics Inc Polimorfo, métodos para preparar polimorfo, para tratar doença cardíaca, para tratar uma doença ou condição e para inibir o sarcômero cardíaco, e, composição farmacêutica
RS65302B1 (sr) 2019-07-17 2024-04-30 Cytokinetics Inc Oralne formulacije inhibitora srčanog sarkomera
MX2023002024A (es) 2020-08-28 2023-05-10 Myokardia Inc Métodos de tratamiento con modulador de miosina.
CN117083275A (zh) 2021-03-04 2023-11-17 赛特凯恩蒂克公司 心脏肌节抑制剂
PT4370116T (pt) 2021-07-16 2025-03-14 Cytokinetics Inc Regimes de administração de aficamten para o tratamento da cardiomiopatia hipertrófica obstrutiva
EP4514355A1 (en) 2022-04-26 2025-03-05 MyoKardia, Inc. Methods of administering myosin inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006515884A (ja) 2003-01-14 2006-06-08 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
JP2008526761A (ja) 2004-12-31 2008-07-24 アラントス ファーマシューティカルズ インコーポレイテッド 多環式ビス−アミドmmp阻害剤
US20160289211A1 (en) 2011-04-22 2016-10-06 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
JP2021511331A (ja) 2018-01-19 2021-05-06 サイトキネティックス, インコーポレイテッド 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ
JP2021529746A (ja) 2018-06-26 2021-11-04 サイトキネティックス, インコーポレイテッド 心臓サルコメア阻害剤

Also Published As

Publication number Publication date
WO2020005887A1 (en) 2020-01-02
US20210253563A1 (en) 2021-08-19
EP3814342A1 (en) 2021-05-05
JP2021529185A (ja) 2021-10-28
EP3814342B1 (en) 2022-07-27
US11964967B2 (en) 2024-04-23

Similar Documents

Publication Publication Date Title
JP7438148B2 (ja) 心臓サルコメア阻害剤
JP7610985B2 (ja) 心臓サルコメア阻害剤
KR102797441B1 (ko) 심장 근절 억제제
JP7825650B2 (ja) 心筋サルコメア阻害剤
JP2024508526A (ja) 心筋サルコメア阻害剤
JP7736712B2 (ja) Namptモジュレーター
HK40106567A (zh) 作为心肌节抑制剂的二氢苯并呋喃和茚类似物
HK40039882A (en) Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors
HK40039882B (zh) 作为心肌节抑制剂的二氢苯并呋喃和茚类似物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220624

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220624

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20230615

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230710

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20231005

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240110

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20240126

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240213

R150 Certificate of patent or registration of utility model

Ref document number: 7438148

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150