JP7438148B2 - 心臓サルコメア阻害剤 - Google Patents

心臓サルコメア阻害剤 Download PDF

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JP7438148B2
JP7438148B2 JP2020572525A JP2020572525A JP7438148B2 JP 7438148 B2 JP7438148 B2 JP 7438148B2 JP 2020572525 A JP2020572525 A JP 2020572525A JP 2020572525 A JP2020572525 A JP 2020572525A JP 7438148 B2 JP7438148 B2 JP 7438148B2
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substituted
pharmaceutically acceptable
compound
unsubstituted
acceptable salt
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JP2021529185A5 (enExample
JP2021529185A (ja
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ブラッドリー ピー. モーガン,
チーユアン チュアン,
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サイトキネティックス, インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2020572525A 2018-06-26 2019-06-25 心臓サルコメア阻害剤 Active JP7438148B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862690248P 2018-06-26 2018-06-26
US62/690,248 2018-06-26
PCT/US2019/038907 WO2020005887A1 (en) 2018-06-26 2019-06-25 Cardiac sarcomere inhibitors

Publications (3)

Publication Number Publication Date
JP2021529185A JP2021529185A (ja) 2021-10-28
JP2021529185A5 JP2021529185A5 (enExample) 2022-07-04
JP7438148B2 true JP7438148B2 (ja) 2024-02-26

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JP2020572525A Active JP7438148B2 (ja) 2018-06-26 2019-06-25 心臓サルコメア阻害剤

Country Status (4)

Country Link
US (1) US11964967B2 (enExample)
EP (1) EP3814342B1 (enExample)
JP (1) JP7438148B2 (enExample)
WO (1) WO2020005887A1 (enExample)

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JP7438148B2 (ja) 2018-06-26 2024-02-26 サイトキネティックス, インコーポレイテッド 心臓サルコメア阻害剤
EP3814343B1 (en) 2018-06-26 2023-01-11 Cytokinetics, Inc. Cardiac sarcomere inhibitors
MA53491A (fr) 2018-08-31 2021-09-15 Cytokinetics Inc Inhibiteurs de sarcomes cardiaques
MX2022000498A (es) 2019-07-17 2022-02-03 Cytokinetics Inc Polimorfos de (r)-n-(5-(5-isopropil-1,2,4-oxadiazol-3-il)-2,3-dihi dro-1h-inden-1-il) -2-metil-2h- tetrazol-5-carboxamida.
KR20230079053A (ko) 2020-08-28 2023-06-05 미요카디아, 인크. 미오신 조절제를 이용한 치료 방법
KR20240015622A (ko) 2021-03-04 2024-02-05 싸이토키네틱스, 인코포레이티드 심장 근절 억제제
CN118591527A (zh) * 2022-01-27 2024-09-03 深圳市康哲生物科技有限公司 7-氮杂螺[4,5]癸烷-6,10-二酮类化合物的晶型及其制备方法
CN119789856A (zh) 2022-04-26 2025-04-08 迈奥卡迪亚公司 施用肌球蛋白抑制剂的方法
CN115894361A (zh) * 2022-12-28 2023-04-04 上海合全药业股份有限公司 一种钯催化合成1-乙酰基-6-氰基-四氢喹啉的方法
CN122070481A (zh) 2023-11-01 2026-05-19 百时美施贵宝公司 基于蛋白质水平用肌球蛋白抑制剂进行治疗的方法
WO2026143034A1 (en) * 2024-12-23 2026-07-02 Cytokinetics, Incorporated Fast skeletal muscle myosin inhibitors

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Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
JP2006515884A (ja) 2003-01-14 2006-06-08 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
JP2008526761A (ja) 2004-12-31 2008-07-24 アラントス ファーマシューティカルズ インコーポレイテッド 多環式ビス−アミドmmp阻害剤
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JP2021511331A (ja) 2018-01-19 2021-05-06 サイトキネティックス, インコーポレイテッド 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ
JP2021529746A (ja) 2018-06-26 2021-11-04 サイトキネティックス, インコーポレイテッド 心臓サルコメア阻害剤

Also Published As

Publication number Publication date
US20210253563A1 (en) 2021-08-19
EP3814342A1 (en) 2021-05-05
EP3814342B1 (en) 2022-07-27
JP2021529185A (ja) 2021-10-28
US11964967B2 (en) 2024-04-23
WO2020005887A1 (en) 2020-01-02

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