JP7438148B2 - 心臓サルコメア阻害剤 - Google Patents

心臓サルコメア阻害剤 Download PDF

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JP7438148B2
JP7438148B2 JP2020572525A JP2020572525A JP7438148B2 JP 7438148 B2 JP7438148 B2 JP 7438148B2 JP 2020572525 A JP2020572525 A JP 2020572525A JP 2020572525 A JP2020572525 A JP 2020572525A JP 7438148 B2 JP7438148 B2 JP 7438148B2
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substituted
pharmaceutically acceptable
compound
unsubstituted
acceptable salt
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JP2021529185A (ja
JPWO2020005887A5 (enExample
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ブラッドリー ピー. モーガン,
チーユアン チュアン,
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サイトキネティックス, インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2020572525A 2018-06-26 2019-06-25 心臓サルコメア阻害剤 Active JP7438148B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862690248P 2018-06-26 2018-06-26
US62/690,248 2018-06-26
PCT/US2019/038907 WO2020005887A1 (en) 2018-06-26 2019-06-25 Cardiac sarcomere inhibitors

Publications (3)

Publication Number Publication Date
JP2021529185A JP2021529185A (ja) 2021-10-28
JPWO2020005887A5 JPWO2020005887A5 (enExample) 2022-07-04
JP7438148B2 true JP7438148B2 (ja) 2024-02-26

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JP2020572525A Active JP7438148B2 (ja) 2018-06-26 2019-06-25 心臓サルコメア阻害剤

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US (1) US11964967B2 (enExample)
EP (1) EP3814342B1 (enExample)
JP (1) JP7438148B2 (enExample)
WO (1) WO2020005887A1 (enExample)

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JP2024508526A (ja) 2021-03-04 2024-02-27 サイトキネティックス, インコーポレイテッド 心筋サルコメア阻害剤
JP7751124B2 (ja) * 2022-01-27 2025-10-07 シーエムエス・リサーチ・アンド・ディベロップメント・プライベイト・リミテッド 7-アザスピロ[4,5]デカン-6,10-ジオン化合物の結晶形及びその調製方法
IL316204A (en) 2022-04-26 2024-12-01 Myokardia Inc Methods for administering myosin inhibitors
CN115894361A (zh) * 2022-12-28 2023-04-04 上海合全药业股份有限公司 一种钯催化合成1-乙酰基-6-氰基-四氢喹啉的方法
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JP2006515884A (ja) 2003-01-14 2006-06-08 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
JP2008526761A (ja) 2004-12-31 2008-07-24 アラントス ファーマシューティカルズ インコーポレイテッド 多環式ビス−アミドmmp阻害剤
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JP2021529746A (ja) 2018-06-26 2021-11-04 サイトキネティックス, インコーポレイテッド 心臓サルコメア阻害剤

Also Published As

Publication number Publication date
EP3814342A1 (en) 2021-05-05
JP2021529185A (ja) 2021-10-28
EP3814342B1 (en) 2022-07-27
US20210253563A1 (en) 2021-08-19
US11964967B2 (en) 2024-04-23
WO2020005887A1 (en) 2020-01-02

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