JP7429987B2 - 架橋ピロロベンゾジアゼピン二量体(pbd)誘導体及びその共役体 - Google Patents
架橋ピロロベンゾジアゼピン二量体(pbd)誘導体及びその共役体 Download PDFInfo
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68035—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a pyrrolobenzodiazepine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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Description
を表す;式中、2つの原子の中央にある化学結合は、隣接する2つの原子のいずれかと連結できることを意味する。
、X、X’、Y、Y’、Z、Z’、l、l’、m、m’、n、q、q’、R1、R1’、R2、R2’、R3、R3’、R4、R4’、V、V’、U、U’、L1、L2、G、Q、E1、及びE2は、式(I)と同じ定義である。
を表す;式中、2つの原子の中央にある化学結合は、隣接する2つの原子のいずれかと連結できることを意味する。
-(CR5R6)m(Aa)r(CR7R8)n(OCH2CH2)t-、-(CR5R6)m(CR7R8)n(Aa)r(OCH2CH2)t-、-(Aa)r-(CR5R6)m(CR7R8)n(OCH2CH2)t-、-(CR5R6)m(CR7R8)n(OCH2CH2)r(Aa)t-、-(CR5R6)m-(CR7=R8)(CR9R10)n(Aa)t(OCH2CH2)r-、-(CR5R6)m(NR11CO)(Aa)t(CR9R10)n(OCH2CH2)r-、-(CR5R6)m(Aa)t(NR11CO)(CR9R10)n(OCH2CH2)r-、-(CR5R6)m(OCO)(Aa)t(CR9R10)n(OCH2CH2)r-、-(CR5R6)m(OCNR7)(Aa)t(CR9R10)n(OCH2CH2)r-、-(CR5R6)m(CO)(Aa)t-(CR9R10)n(OCH2CH2)r-、-(CR5R6)m(NR11CO)(Aa)t(CR9R10)n(OCH2CH2)r-、-(CR5R6)m(OCO)(Aa)t(CR9R10)n-(OCH2CH2)r-、-(CR5R6)m(OCNR7)(Aa)t(CR9R10)n(OCH2CH2)r-、-(CR5R6)m(CO)(Aa)t(CR9R10)n(OCH2CH2)r-、-(CR5R6)m-フェニル-(CO)(Aa)t(CR7R8)n-、-(CR5R6)m-フリル-(CO)(Aa)t(CR7R8)n-、-(CR5R6)m-オキサゾリル-(CO)(Aa)t(CR7R8)n-、-(CR5R6)m-チアゾリル-(CO)(Aa)t(CCR7R8)n-、-(CR5R6)t-チエニル-(CO)(CR7R8)n-、-(CR5R6)t-イミダゾリル-(CO)(CR7R8)n-、-(CR5R6)t-モルホリノ-(CO)(Aa)t(CR7R8)n-、-(CR5R6)t-ピペラジノ-(CO)(Aa)t(CR7R8)n-、-(CR5R6)t-N-メチルピペラジン-(CO)(Aa)t(CR7R8)n-、-(CR5R)m-(Aa)tフェニル-、-(CR5R6)m-(Aa)tフリル-、-(CR5R6)m-オキサゾリル(Aa)t-、-(CR5R6)m-チアゾリル(Aa)t-、-(CR5R6)m-チエニル(Aa)t-、-(CR5R6)m-イミダゾリル(Aa)t-、-(CR5R6)m-モルホリノ-(Aa)t-、-(CR5R6)m-ピペラジノ-(Aa)t-、-(CR5R6)m-N-メチルピペラジノ-(Aa)t-、-K(CR5R6)m(Aa)r(CR7R8)n(OCH2CH2)t-、-K(CR5R6)m(CR7R8)n(Aa)r(OCH2CH2)t-、-K(Aa)r(CR5R6)m(CR7R8)n(OCH2CH2)t-、-K(CR5R6)m(CR7R8)n(OCH2CH2)r(Aa)t-、-K(CR5R6)m(CR7=R8)(CR9R10)n(Aa)t(OCH2CH2)r-、-K(CR5R6)m(NR11CO)(Aa)t(CR9R10)n(OCH2CH2)r-、-K(CR5R6)m(Aa)t(NR11CO)(CR9R10)n(OCH2CH2)r-、-K(CR5R6)m(OCO)(Aa)t(CR9R10)n(OCH2CH2)r-、-K(CR5R6)m(OCNR7)(Aa)t(CR9R10)n(OCH2CH2)r-、-K(CR5R6)m(CO)(Aa)t(CR9R10)n(OCH2CH2)r-、-K(CR5R6)m(NR11CO)(Aa)t(CR9R10)n(OCH2CH2)r-、-K(CR5R6)m(OCO)(Aa)t(CR9R10)n(OCH2CH2)r-、-K(CR5R6)m(OCNR7)(Aa)t(CR9R10)n(OCH2CH2)r-、-K(CR5R6)m(CO)(Aa)t(CR9R10)n(OCH2CH2)r-、-K(CR5R6)m-フェニル-(CO)(Aa)t(CR7R8)n-、-K(CR5R6)m-フリル-(CO)(Aa)t(CR7R8)n-、-K(CR5R6)m-オキサゾリル-(CO)(Aa)t(CR7R8)n-、-K(CR5R6)m-チアゾリル-(CO)(Aa)t(CR7R8)n-、-K(CR5R6)t-チエニル-(CO)(CR7R8)n-、-K(CR5R6)t-イミダゾリル-(CO)(CR7R8)n-、-K(CR5R6)t-モルホリノ-(CO)(Aa)t(CR7R8)n-、-K(CR5R6)t-ピペラジノ-(CO)(Aa)t(CR7R8)n-、-K(CR5R6)t-N-メチルピペラジン-(CO)(Aa)t(CR7R8)n-、-K(CR5R)m-(Aa)tフェニル-、-K(CR5R6)m-(Aa)tフリル-、-K(CR5R6)m-オキサゾリル(Aa)t-、-K(CR5R6)m-チアゾリル(Aa)t-、-K(CR5R6)m-チエニル(Aa)t-、-K(CR5R6)m-イミダゾリル(Aa)t-、-K(CR5R6)m-モルホリノ-(Aa)t-、-K(CR5R6)m-ピペラジノ-(Aa)tG-、-K(CR5R6)m-N-メチルピペラジノ-(Aa)t;式中、m、Aa、m、及びnは上記の通りである;t及びrは独立して0~100である;R3、R4、R5、R6、R7、及びR8は独立して、H;ハロゲン化物;C1~C8アルキル;C2~C8アリール、アルケニル、アルキニル、エーテル、エステル、アミン、又はアミドから選択され、これらは任意に、1又は複数のハロゲン化物、CN、NR1R2、CF3、OR1、アリール、複素環、S(O)R1、SO2R1、-
CO2H、-SO3H、-OR1、-CO2R1、-CONR1、-PO2R1R2、-PO3H、又はP(O)R1R2R3で置換されてもよい;KはNR1、-SS-、-C(=O)-、-C(=O)NH-、-C(=O)O-、-C=NH-O-、-C=N-NH-、-C(=O)NH-NH-、O、S、Se、B、Het(C3-C8を有する複素環式又はヘテロ芳香族環)、又は1~20アミノ酸を含むペプチドである;
は連結部位である;X2、X3、X4、X5、又はX6は独立して、NH、NHNH;N(R3);N(R3)N(R3’);O;S;C1-C6アルキル;C2-C6ヘテロアルキル、アルキルシクロアルキル、又はヘテロシクロアルキル;C3-C8アリール、Ar-アルキル、複素環式、炭素環式、シクロアルキル、ヘテロアルキルシクロアルキル、アルキルカルボニル、又はヘテロアリール;1~8個の同一の又は異なるアミノ酸から選択される;ここで、R3及びR3’は独立して、H;C1-C8アルキル;C2-C8ヘテロアルキル、アルキルシクロアルキル、又はヘテロシクロアルキル;C3-C8アリール、Ar-アルキル、複素環式、炭素環式、シクロアルキル、ヘテロアルキルシクロアルキル、アルキルカルボニル、又はヘテロアリール;又はC2-C8エステル、エーテル、又はアミド;又は式(OCH2CH2)p若しくは(OCH2CH(CH3))pを有するポリエチレンオキシ単位であり、pは、0から約5000までの整数、あるいは上記の組み合わせである。
、X、X’、Y、Y’、Z、Z’、l、l’、m、m’、n、q、q’、R1、R1’、R2、R2’、R3、R3’、R4、R4’、V、V’、U、U’、L1、L2、E1、E2、及びQは式(I)と同じである。
、X、X’、Y、Y’、Z、Z’、l、l’、m、m’、n、q、q’、R1、R1’、R2、R2’、R3、R3’、R4、R4’、V、V’、U、U’、L1、L2、G、Q、E1、及びE2は、式(I)で定義された通りである。
、X、X’、Y、Y’、Z、Z’、l、l’、m、m’、n、q、q’、R1、R1’、R2、R2’、R3、R3’、R4、R4’、V、V’、U、U’、L1、L2、E1、及びE2は、式(I)で定義された通りである。
菌抗体)、ウステキヌマブ(Ustekinumab)(別名:Stelara、抗IL-12、IL-23抗体)、バパリキシマブ(Vapaliximab)(抗AOC3(VAP-1)抗体)、ベドリズマブ(Vedolizumab)、(抗インテグリンα4β7抗体)、ベルツズマブ(抗CD20抗体)、ベパリモマブ(Vepalimomab)(抗AOC3(VAP-1))抗体)、ビシリズマブ(別名:Nuvion、抗CD3抗体)、ビタキシン(抗血管新生インテグリンavb3抗体)、ボロシキシマブ(Volociximab)(抗インテグリンα5β1)、ボツムマブ(Votumumab)(別名:HumaSPECT、抗腫瘍抗原CTAA16.88抗体)、ザルツムマブ(別名:HuMax-EGFr、(抗EGFR抗体)、ザノリムマブ(別名:HuMax-CD4、抗CD4抗体)、ジラリムマブ(Ziralimumab)(抗CD147(基本免疫グロブリン)抗体)、ゾリモマブ(zolimomab)(抗CD5抗体)、エタネルセプト(登録商標「Enbrel」)、アレファセプト(Alefacept)(登録商標「Amevive」)、アバタセプト(登録商標「Orencia」)、リロナセプト(Rilonacept)(Arcalyst)、14F7[抗IRP-2(鉄調節タンパク質2)抗体]、14G2a(Nat.Cancer Inst.から黒色腫及び固形腫瘍のための抗ガングリオシドGD2抗体)、J591(Weill Cornell Medical Schoolから前立腺癌を治療するための抗PSMA抗体、)、225.28S[黒色腫のための抗HMW-MAA(高分子量黒色腫関連抗原)抗体、Sorin Radiofarmaci S.R.L.(ミラノ、イタリア)]、COL-1(Nat. Cancer Inst.から大腸癌及び胃癌のための抗CEACAM3抗体、CGM1)、CYT-356(登録商標「Oncoltad」、前立腺癌)、HNK20(Ora Vax Inc.からRSウイルスのための)、ImmuRAIT(IMMUNOMEDICSから非ホジキンリンパ腫のための)、Lym-1(抗HLA-DR10抗体、Peregrine Pharmから腫瘍のため)、MAK-195F[Abbott/Knollから敗血症、毒素ショックのための抗TNF(腫瘍壊死因子;TNFA、TNF-α;TNFSF2)抗体]、MEDI-500[別名:T10B9、MedImmune Incから移植片対宿主病のための抗CD3抗体、TRαβ(T細胞受容体α/β)、]、RING SCAN[Neoprobe Corp.から乳癌、結腸癌及び結腸直腸癌のための抗TAG72(腫瘍関連糖タンパク質72)抗体)]、Avicidin(抗EPCAM(上皮細胞接着分子)抗体)、抗TACSTD1(腫瘍関連カルシウムシグナルトランスデューサー1)抗体、抗GA733-2(胃腸腫瘍関連タンパク質2)抗体、抗EGP-2(上皮糖タンパク質2)抗体;抗KSA抗体;KS1/4抗原;M4S;腫瘍抗原17-1A;NeoRx Corp.から結腸癌、卵巣癌、前立腺癌、及び非ホジキンリンパ腫のためのCD326;LYMPHOCIDE、スマートID10、Oncolym、Allomune、抗VEGF抗体(ジェネンテック、CA);CEAcide、IMC-1C11、並びにセツキシマブ。
は、本特許の側鎖連結体を連結する部位である;X4及びY1は独立して、O、NH、NHNH、NR1、S、C(O)O、C(O)NH、OC(O)NH、OC(O)O、NHC(O)NH、NHC(O)S、OC(O)N(R1)、N(R1)C(O)N(R1)、CH2、C(O)NHNHC(O)、及びC(O)NR1である;X1はH、CH2、OH、O、C(O)、C(O)NH、C(O)N(R1)、R1、NHR1、NR1、C(O)R1、又はC(O)Oである;X5はH、CH3、F、又はClである;M1及びM2は独立して、H、Na、K、Ca、Mg、NH4、N(R1R2R3R4)である;R1、R2、R3、及びR4は式(I)に定義されている。
1614666467490_0
、アルデヒド(例えば、グルタルアルデヒド)、ビスアジド化合物(例えば、ビス(p-アジドベンゾイル)ヘキサンジアミン)、ビス-ジアゾニウム誘導体(例えば、ビス-(p-ジアゾニウムベンゾイル)-エチレンジアミン)、ジイソシアネート(例えば、トルエン-2,6-ジイソシアネート)、 ビス-活性化フッ素系化合物(例えば、1,5-ジフルオロ-2,4-ジニトロベンゼン) 、γ-マレイミド酪酸N-スクシンイミドエステル(GMBS)、E-マレイミドカプロン酸N-ヒドロキシスクシンイミドエステル(EMCS)、5-マレイミド吉草酸NHS、HBVS、N-スクシンイミジル-4-(N-マレイミドメチル)-シクロヘキサン-1-カルボキシ-(6-アミノカプロン酸エステル)(SMCCの長鎖類縁物質(LC-SMCC))、m-マレイミドベンゾイル-N-ヒドロキシスクシンイミドエステル(MBS)、4-(4-N-マレイミドフェニル)-酪酸ヒドラジド又は塩酸塩(MPBH)、N-スクシンイミジル-3-(ブロモアセトアミド)プロピオン酸エステル(SBAP)、N-スクシンイミジル-ヨード酢酸エステル(SIA)、κ-マレイミドウンデカン酸スクシンイミドエステル(KMUA)、N-スクシンイミジル-4-(p-マレイミドフェニル)酪酸エステル(SMPB)、スクシンイミジル-6-(β-マレイミドプロピオニルアミド)-ヘキサン酸エステル(SMPH)、スクシンイミジル-(4-ビニルスルホニル)安息香酸エステル(SVSB)、ジチオビス-マレイミドエタン(DTME)、1,4-ビス-マレイミドブタン(BMB)、1,4-ビスマレイミジル-2,3-ジヒドロキシブタン(BMDB)、ビス-マレイミドヘキサン(BMH)、ビス-マレイミドエタン(BMOE)、スルホスクシンイミジル-4-(N-マレイミドメチル)シクロヘキサン-1-カルボン酸エステル(sulfo-SMCC)、スルホスクシンイミジル(4-ヨードアセチル)アミノ安息香酸エステル(sulfo-SIAB)、m-マレイミドベンゾイル-N-ヒドロキシスルホスクシンイミドエステル(sulfo-MBS)、N-(γ-マレイミドブチルオキシ)スルホスクシンイミドエステル(sulfo-GMBS)、N-(ε-マレイミドカプロイルオキシ)スルホスクシンイミドエステル(sulfo-EMCS)、N-(κ-マレイミドウンデカノイルオキシ)スルホスクシンイミドエステル(sulfo-KMUS)、及びスルホスクシンイミジル-4-(p-マレイミドフェニル)酪酸エステル(sulfo-SMPB);又は商業的に入手可能な連結体 (例えば、Thermo Scientific’s Pierceから購入できるイミドエステル結合物:DMA(アジプイミド酸ジメチル二塩酸塩)、DMP(ピメルイミド酸ジメチル二塩酸塩)、DMS(スベルイミド酸ジメチル二塩酸塩)、DTBP(3,3-ジチオビスプロピオンイミド酸ジメチル二塩酸塩);NHS-エステル架橋アミン:BS(PEG)5(ビス(スクシンイミジル)ペンタ(エチレングリコール)、BS(PEG)9(ビス(スクシンイミジル)ノナ(エチレングリコール)、BS3(ビス[スルホスクシンイミジル]スベリン酸塩)、BSOCOES(ビス[2-(スクシンイミドオキシカルボニルオキシ)エチル]スルホン酸塩)、DSG(グルタル酸ジスクシンイミジル)、DSP(ジチオビス[スクシンイミジル]プロピオン酸エステル)、DSS(スベリン酸ジスクシンイミジル)、DST(酒石酸ジスクシンイミジル)、DTSSP(3,3’-ジチオビス[スルホスクシンイミジルプロピオン酸エステル])、EGS(エチレングリコールビス[コハク酸スクシンイミジル])、Sulfo-EGS(エチレングリコールビス(コハク酸スルホスクシンイミジル))、TSAT(トリス-スクシンイミジルアミノトリ酢酸エステル)、DFDNB(1,5-ジフルオロ-2,4-ジニトロベンゼン);アミン-スルフヒドリル架橋剤:Sulfo-SIAB(スルホスクシンイミジル(4-ヨードアセチル)アミノ安息香酸エステル)、SIAB(スクシンイミジル(4-ヨウ化アセチル)アミノ安息香酸エステル)、SBAP(スクシンイミジル-3-(ブロモアセトアミド)プロピオン酸エステル)、SIA(スクシンイミジルN-ヨウ化酢酸エステル)、Sulfo-SMCC(スルホスクシンイミジル-4-(N-マレイミドメチル)-シクロヘキサン-1-カルボン酸エステル)、SM(PEG)n(NHS-PEG-マレイミド架橋剤:スクシンイミジル-([N-マレイミドプロピオンアミド)-#エチレングリコール)エステル、#=1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、18、20、22、24)、LC-SMCC(スクシンイミジル-4-(N-マレイミドメチル)シクロヘキサン-1-カルボキシ-(6-アミドカプロン酸エステル))、Sulfo-EMCS(N-ε-マレイミドカプロイルオキシスルホスクシンイミドエステル)、EMCS(N-ε-マレイミドカプロイルオキシスクシンイミドエステル)、Sulfo-GMBS(N-γ-マレイミドブチルオキシスルホスクシンイミドエステル)、GMBS(N-γ-マレイミドブチルオキシスクシンイミドエステル)、Sulfo-KMUS(N-κ-マレイミドウンデカノイルオキシスルホスクシンイミドエステル)、Sulfo-MBS(m-マレイミドベンゾイル-N-ヒドロキシスルホスクシンイミドエステル)、MBS(m-マレイミドベンゾイル-N-ヒドロキシスクシンイミドエステル)、Sulfo-SMPB((スルホスクシンイミジル-4-(p-マレイミドフェニル)酪酸エステル)、SMPB((スクシンイミジル-4-(p-マレイミジルフェニル)酪酸エステル)、AMAS(N-(α-マレイミドアセトキシ)スクシンイミドエステル)、BMPS(N-β-マレイミジルプロピルオキシスクシンイミドエステル)、SMPH(スクシンイミジル-6-[(β-マレイミドプロピオンアミド)ヘキサン酸エステル)、PEG12-SPDP(2-ピリジルジチオール-テトラオキサオクタトリアコンタン-N-ヒドロキシスクシンイミドエステル)、PEG4-SPDP(2-ピリジルジチオール-テトラオキサテトラデカン-N-ヒドロキシスクシンイミドエステル)、Sulfo-LC-SPDP(スルホスクシンイミジル-6-[3’-(2-ピリジルジチオ)プロピオンアミド]ヘキサン酸エステル)、LC-SPDP(スクシンイミジル-6-[3-(2-ピリジルジチオ)プロピオンアミド]ヘキサン酸エステル)、SMPT(4-スクシンイミジルオキシカルボニル-α-メチル-α(2-ピリジルジチオ)トルエン);カルボニル-アミン架橋剤:DCC(ジシクロヘキシルカルボジイミド)、EDC(1-エチル-3-(3-ジメチルアミノプロピル)カルボジイミド);光活性化架橋剤:ANB-NOS(N-5-アジド-2-ニトロベンゾイルオキシスクシンイミドエステル);NHS-ジアジリン(SDA)架橋剤:SDA(NHS-ジアジリン)(スクシンイミジル-4,4’-アジペンタノエート)、LC-SDA(NHS-LC-ジアジリン)(スクシンイミジル-6-(4,4’-アジペンタンアミド)ヘキサン酸エステル)、SDAD(NHS-SS-ジアジリン)(スクシンイミジル-2-([4,4’-アジペンタンアミド]エチル)-1,3’-ジチオプロピオン酸エステル)、Sulfo-SDA(Sulfo-NHS-ジアジリン)(スルホスクシンイミジル-4,4’-アジペンタノエート)、Sulfo-LC-SDA(Sulfo-NHS-LC-ジアジリン)(スルホスクシンイミジル-6-(4,4’-アジペンタンアミド)へキサン酸エステル)、Sulfo-SDAD(Sulfo-NHS-SS-ジアジリン)(スルホスクシンイミジル-2-([4,4’-アジペンタンアミド]エチル)-1,3’-ジチオプロピオン酸エステル)、Sulfo-SANPAH(スルホスクシンイミジル-6-(4’-アジド-2’-ニトロフェニルアミノ)-ヘキサン酸エステル)、SPB(スクシンイミジル-[4-(ソラレン-8-イルオキシ)]-酪酸エステル);スルフィドリル-炭化水素架橋剤:BMPH(N-β-マレイミジルプロピオン酸ヒドラジド-TFA)、EMCH(N-ε-マレイミジドカプロン酸ヒドラジド-TFA)、KMUH(N-κ-マレイミドウンデカン酸ヒドラジド-TFA)、MPBH(4-(4-N-マレイミドフェニル)酪酸ヒドラジド塩酸塩)、PDPH(3-(2-ピリジルジチオ)プロピオニルヒドラジド);スルフィドリル-ヒドロキシ架橋剤:PMPI(p-マレイミドフェニルイソシアネート);スルフヒドリル-スルフヒドリル架橋剤:BM(PEG)2(1,8-ビスマレイミド-ジエチレングリコール)、BM(PEG)3(1,11-ビスマレイミド-トリエチレングリコール)、BMB(1,4-ビスマレイミドブタン)、BMDB(1,4-ビスマレイミド-2,3-ジヒドロキシブタン)、BMH(ビスマレイミドヘキサン)、BMOE(ビスマレイミドエタン)、DTME(ジチオビスマレイミドエタン)、TMEA(トリス(2-マレイミドエチル)アミン)、及びSVSB(スクシンイミジル-(4-ビニルスルフォン)安息香酸エステル)が含まれる。
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Claims (9)
- 以下の式(I-01)~(I-07)、(I-11)、(I-13)~(I-20)のいずれかである、架橋PBD二量体誘導体と細胞結合分子との共役体又はそれらの薬学的に許容される塩、水和物、若しくは水和塩、又はこれらの化合物の多形結晶若しくはそれらの光学異性体、ラセミ体、ジアステレオマー、若しくはエナンチオマー:
式中:
V及びV’は同一の又は異なる、H、OH;OR5(エーテル);NR5NR5’NR5’’(アミン);SO3、HSO3、HSO2、又はHSO3-、SO3 2-、若しくは-HSO2 -の塩(亜硫酸塩);OSO3(重亜硫酸塩);からなる群から独立して選択される;式中、R5、R5’、及びR5’’は独立して、H、C 1 ~C 8 のアルキル、アルケニル、アルキル、ヘテロアルキル、アリール、アリールアルキル、又はカルボニルから選択される;
m、q、及びm’は独立して、0、1、2、3、4、又は5である;
nは1~30である;
r及びr’は独立して0~200である;
mAbは、抗体、一本鎖抗体、標的細胞に結合する抗体フラグメント、モノクローナル抗体、一本鎖モノクローナル抗体に結合するモノクローナル抗体フラグメント、標的細胞、キメラ抗体、標的細胞に結合するキメラ抗体フラグメント、ドメイン抗体、標的細胞に結合するドメイン抗体フラグメントから選択される細胞結合分子(CBA)である; - 以下の式(II-01)~(II-03)、(II-06)、(II-07)、又は (IV-01)、(IV-03)、(IV-07)~(IV-11)である、架橋PBD二量体誘導体と細胞結合分子との共役体:
式中、
m、m’、n、q、V、及びV’は、請求項1の定義と同じである;r、r1、r2、及びr’は独立して0~200、m3は0~30である。mAbは細胞結合分子である。 - 以下の式31、45、57、61、90、96、148、162、176、184、188、209、214、CC-3、CC-4、CC-5、CC-7、CC-8、CC-10、CC-11、CC-12、CC-14、CC-15、CC-17、CC-18、CC-20、CC-21、CC-27、CC-29である、請求項1又は2に記載の架橋PBD二量体誘導体と細胞結合分子との共役体:
式中、r、r1、及びr 2 は独立して0~200である;mAbは細胞結合分子である;nは1~30である。 - 前記細胞結合分子は、腫瘍細胞、ウイルス感染細胞、微生物感染細胞、寄生虫感染細胞、自己免疫疾患細胞、活性化腫瘍細胞、骨髄細胞、活性化T細胞、影響されているB細胞、メラニン細胞、又は以下の抗原若しくは受容体のいずれか1つを発現する任意の細胞を標的とする、請求項1~3のいずれか1項に記載の共役体:CD1、CD1a、CD1b、CD1c、CD1d、CD1e、CD2、CD3、CD3d、CD3e、CD3g、CD4、CD5、CD6、CD7、CD8、CD8a、CD8b、CD9、CD10、CD11a、CD11b、CD11c、CD11d、CD12w、CD14、CD15、CD16、CD16a、CD16b、CDw17、CD18、CD19、CD20、CD21、CD22、CD23、CD24、CD25、CD26、CD27、CD28、CD29、CD30、CD31、CD32、CD32a、CD32b、CD33、CD34、CD35、CD36、CD37、CD38、CD39、CD40、CD41、CD42、CD42a、CD42b、CD42c、CD42d、CD43、CD44、CD45、CD46、CD47、CD48、CD49b、CD49c、CD49c、CD49d、CD49f、CD50、CD51、CD52、CD53、CD54、CD55、CD56、CD57、CD58、CD59、CD60、CD60a、CD60b、CD60c、CD61、CD62E、CD62L、CD62P、CD63、CD64、CD65、CD65s、CD66、CD66a、CD66b、CD66c、CD66d、CD66e、CD66f、CD67、CD68、CD69、CD70、CD71、CD72、CD73、CD74、CD75、CD75s、CD76、CD77、CD78、CD79、CD79a、CD79b、CD80、CD81、CD82、CD83、CD84、CD85、CD85a、CD85b、CD85c、CD85d、CD85e、CD85f、CD85g、CD85g、CD85i、CD85j、CD85k、CD85m、CD86、CD87、CD88、CD89、CD90、CD91、CD92、CD93、CD94、CD95、CD96、CD97、CD98、CD99、CD100、CD101、CD102、CD103、CD104、CD105、CD106、CD107、CD107a、CD107b、CD108、CD109、CD110、CD111、CD112、CD113、CD114、CD115、CD116、CD117、CD118、CD119、CD120、CD120a、CD120b、CD121、CD121a、CD121b、CD122、CD123、CD123a、CD124、CD125、CD126、CD127、CD128、CD129、CD130、CD131、CD132、CD133、CD134、CD135、CD136、CD137、CD138、CD139、CD140、CD140a、CD140b、CD141、CD142、CD143、CD144、CD145、CDw145、CD146、CD147、CD148、CD149、CD150、CD151、CD152、CD153、CD154、CD155、CD156、CD156a、CD156b、CD156c、CD156d、CD157、CD158、CD158a、CD158b1、CD158b2、CD158c、CD158d、CD158e1、CD158e2、CD158f2、CD158g、CD158h、CD158i、CD158j、CD158k、CD159、CD159a、CD159b、CD159c、CD160、CD161、CD162、CD163、CD164、CD165、CD166、CD167、CD167a、CD167b、CD168、CD169、CD170、CD171、CD172、CD172a、CD172b、CD172g、CD173、CD174、CD175、CD175s、CD176、CD177、CD178、CD179、CD179a、CD179b、CD180、CD181、CD182、CD183、CD184、CD185、CD186、CDw186、CD187、CD188、CD189、CD190、CD191、CD192、CD193、CD194、CD195、CD196、CD197、CD198、CD199、CDw198、CDw199、CD200、CD201、CD202、CD202(a,b)、CD203、CD203c、CD204、CD205、CD206、CD207、CD208、CD209、CD210、CDw210a、CDw210b、CD211、CD212、CD213、CD213a1、CD213a2、CD214、CD215、CD216、CD217、CD218、CD218a、CD218、CD21b9、CD220、CD221、CD222、CD223、CD224、CD225、CD226、CD227、CD228、CD229、CD230、CD231、CD232、CD233、CD234、CD235、CD235a、CD235b、CD236、CD237、CD238、CD239、CD240、CD240ce、CD240d、CD241、CD242、CD243、CD244、CD245、CD246、CD247、CD248、CD249、CD250、CD251、CD252、CD253、CD254、CD255、CD256、CD257、CD258、CD259、CD260、CD261、CD262、CD263、CD264、CD265、CD266、CD267、CD268、CD269、CD270、CD271、CD272、CD273、CD274、CD275、CD276、CD277、CD278、CD279、CD281、CD282、CD283、CD284、CD285、CD286、CD287、CD288、CD289、CD290、CD291、CD292、CD293、CD294、CD295、CD296、CD297、CD298、CD299、CD300、CD300a、CD300b、CD300c、CD301、CD302、CD303、CD304、CD305、CD306、CD307、CD307a、CD307b、CD307c、CD307d、CD307e、CD307f、CD308、CD309、CD310、CD311、CD312、CD313、CD314、CD315、CD316、CD317、CD318、CD319、CD320、CD321、CD322、CD323、CD324、CD325、CD326、CD327、CD328、CD329、CD330、CD331、CD332、CD333、CD334、CD335、CD336、CD337、CD338、CD339、CD340、CD341、CD342、CD343、CD344、CD345、CD346、CD347、CD348、CD349、CD350、CD351、CD352、CD353、CD354、CD355、CD356、CD357、CD358、CD359、CD360、CD361、CD362、CD363、CD364、CD365、CD366、CD367、CD368、CD369、CD370、CD371、CD372、CD373、CD374、CD375、CD376、CD377、CD378、CD379、CD381、CD382、CD383、CD384、CD385、CD386、CD387、CD388、CD389、CRIPTO、CRIPTO、CR、CR1、CRGF、CRIPTO、CXCR5、LY64、TDGF1、4-1BB、APO2、ASLG659、BMPR1B、4-1BB、5AC、5T4(絨毛性糖タンパク質、TPBG、5T4、Wnt活性化阻害因子1又はWAIF1)、腺癌抗原、AGS-5、AGS-22M6、アクチビン受容体様キナーゼ1、AFP、AKAP-4、ALK、αインテグリン、αvβ6、アミノペプチダーゼN、アミロイドβ、アンドロゲン受容体、アンジオポイエチン2、アンジオポイエチン3、アネキシンA1、炭疽菌トキシン防御抗原、抗トランスフェリン受容体、AOC3(VAP-1)、B7-H3、炭疽菌、BAFF(B-細胞活性化因子)、BCMA、B-リンパ腫細胞、bcr-abl、ボンベシン、BORIS、C5、C242抗原、CA125(炭水化物抗原125、MUC16)、CA-IX(又はCAIX、炭酸脱水酵素9)、CALLA、CanAg、イヌIL31、炭酸脱水酵素IX、心筋ミオシン、CCL11(C-Cモチーフケモカイン11)、CCR4(CCケモカイン受容体4型)、CCR5、CD3E(イプシロン)、CEA(癌胎児性抗原)、CEACAM3、CEACAM5(癌胎児性抗原)、CFD(因子D)、Ch4D5、コレシストキニン2(CCK2R)、CLDN18(クラウディン-18)、クランピング因子A、cMet、CRIPTO、FCSF1R(コロニー刺激因子1受容体)、CSF2(コロニー刺激因子2、顆粒球マクロファージコロニー刺激因子(GM-CSF))、CSP4、CTLA4(細胞傷害性Tリンパ球関連タンパク質4)、CTAA16.88腫瘍抗原、CXCR4、CXCケモカイン受容体4型、cADPリボースヒドロラーゼ、サイクリンB1、CYP1B1、サイトメガロウイルス、サイトメガロウイルス糖タンパク質B、ダビガトラン、DLL4(デルタ様リガンド4)、DPP4(ジペプチジルペプチダーゼ4)、DR5(デスレセプター5)、大腸菌志賀毒素1型、大腸菌志賀毒素2型、ED-B、EGFL7(EGF様ドメイン含有タンパク質7)、EGFR、EGFRII、EGFRvIII、エンドグリン、エンドセリンB受容体、エンドトキシン、EpCAM(上皮細胞接着分子)、EphA2、エピシアリン、ERBB2(上皮成長因子受容体2)、ERBB3、ERG(TMPRSS2ETS融合遺伝子)、大腸菌、ETV6-AML、FAP(線維芽細胞活性化タンパク質α)、FCGR1、α-フェトプロテイン、フィブリンII、β鎖、フィブロネクチン外部ドメインB、FOLR(葉酸受容体)、葉酸受容体α、葉酸ヒドロラーゼ、Fos関連抗原1F、RSウイルスのFタンパク質、Frizzled受容体、フコシルGM1、GD2ガングリオシド、G-28(細胞表面糖脂質抗原)、GD3イディオタイプ、GloboH、グリピカン3、N-グリコリルノイラミン酸、GM3、GMCSF受容体α鎖、成長分化因子8、GP100、GPNMB(膜貫通タンパク質NMB)、GUCY2C(グアニル酸シクラーゼ2C、グアニル酸シクラーゼC(GC-C)、腸グアニル酸シクラーゼ、グアニル酸シクラーゼ-C受容体、熱安定性エンテロトキシン受容体(hSTAR))、熱ショックタンパク質、血球凝集素、B型肝炎表面抗原、B型肝炎ウイルス、HER1(ヒト上皮成長因子受容体1)、HER2、HER2/neu、HER3(ERBB-3)、IgG4、HGF/SF(幹細胞増殖因子/細胞分散因子)、HHGFR、HIV-1、ヒストン複合体、HLA-DA(ヒト白血球抗原)、HLA-DR10、HLA-DRB、HMWMAA、ヒト絨毛性ゴナドトロピン、HNGF、ヒト細胞散乱因子受容体キナーゼ、HPV E6/E7、Hsp90、hTERT、ICAM-1(細胞間接着分子1)、イディオタイプ、IGF1R(IGF-1、インスリン様増殖因子1受容体)、IGHE、IFN-γ、インフルエンザ赤血球凝集素、IgE、IgE Fc領域、IGHE、インターロイキン(IL-1、IL-2、IL-3、IL-4、IL-5、IL-6、IL-6R、IL-7、IL-8、IL-9、IL-10、IL-11、IL-12、IL-13、IL-15、IL-17、IL-17A、IL-18、IL-19、IL-20、IL-21、IL-22、IL-23、IL-27、又はIL-28)、IL-31RA、ILGF2(インスリン様増殖因子2)、インテグリン(α4、αIIIbβ3、αvβ3、α4β7、α5β1、α6β4、α7β7、αIIβ3、α5β5、αvβ5)、インターフェロンγ誘導タンパク質、ITAGA2、ITGB2、KIR2D、LCK、Le、レグマイン
、ルイス-Y抗原、LFA-1(リンパ球機能関連抗原1、CD11a)、LHRH、LINGO-1、リポタイコ酸、LIV1A、LMP2、LTA、MAD-CT-1、MAD-CT-2、MAGE-1、MAGE-2、MAGE-3、MAGEA1、MAGEA3、MAGE4、MART1、MCP-1、MIF(マクロファージ遊走阻止因子又はグリコシル化阻害因子(GIF))、MS4A1(膜貫通4ドメインサブファミリーAメンバー1)、MSLN(メソテリン)、MUC1(ムチン1、細胞表面関連(MUC1)又は多型性上皮ムチン(PEM))、MUC1-KLH、MUC16(CA125)、MCP1(単球走化性タンパク質1)、MelanA/MART1、ML-IAP、MPG、MS4A1(膜貫通型4ドメインサブファミリーA)、MYCN、ミエリン関連糖タンパク質、ミオスタチン、NA17、NARP-1、NCA-90(顆粒球抗原)、ネクチン-4(ASG-22ME)、NGF、神経アポトーシス制御プロテイナーゼ1、NOGO-A、Notch受容体、ヌクレオリン、Neu癌遺伝子産物、NY-BR-1、NY-ESO-1、OX-40、OxLDL(酸化低密度リポタンパク質)、OY-TES1、P21、p53非変異体、P97、Page4、PAP、抗(N-グリコリルノイラミン酸)のパラトープ、PAX3、PAX5、PCSK9、PDCD1(PD-1、プログラムされた細胞死タンパク質1)、PDGF-Rα、(血小板由来成長因子受容体α)、PDGFR-β、PDL-1、PLAC1、PLAP様精巣アルカリホスファターゼ、血小板由来成長因子受容体β、リン酸ナトリウム共輸送体、PMEL17、ポリシアル酸、プロテイナーゼ3(PR1)、前立腺癌、PS(ホスファチジルセリン)、前立腺癌細胞、緑膿菌、PSMA、PSA、PSCA、狂犬病ウイルス糖タンパク質、RHD(Rhポリペプチド1(RhPI))、アカゲザル因子(Rhesus factor)、RANKL、PhoC、Ras変異体、RG55、ROBO4、RSウイルス、RON、肉腫転移ブレイクポイント、SART3、スクレロスチン、SLAMF7(SLAMファミリーメンバー7)、セレクチンP、SDC1(シンデカン1)、sLe(a)、ソマトメジンC、SIP(スフィンゴシン-1-ホスフェート)、ソマトスタチン、精子タンパク質17、SSX2、STEAP1(前立腺1の6回膜貫通上皮抗原)、STEAP2、STn、TAG-22(腫瘍関連糖タンパク質72)、サバイビン、T細胞受容体、T細胞膜貫通タンパク質、TEM1(腫瘍上皮マーカー1)、TENB2、テナスシンC(TN-C)、TGF-α、TGF-β(トランスフォーミング増殖因子β)、TGF-β1、TGF-β2(トランスフォーミング増殖因子β2)、Tie(CD202b)、Tie2、TIM-1(CDX-014)、TN、TNF、TNF-α、TNFRSF8、TNFRSF10B(腫瘍壊死因子受容体スーパーファミリーメンバー10B)、TNFRSF13B(腫瘍壊死因子受容体スーパーファミリーメンバー13B)、TPBG(栄養膜糖タンパク質)、TRAIL-R1(腫瘍壊死アポトーシス誘導リガンド受容体1)、TRAILR2(細胞死受容体5(DR5))、主要関連カルシウムシグナルトランスデューサー2、MUC1の腫瘍特異的グリコシル化、TWEAK受容体、TYRP1(糖タンパク質75)、TRP-2、チロシナーゼ、VCAM-1、VEGF、VEGF-A、VEGF-2、VEGFR-1、VEGFR2、又はビメンチン、WT1、XAGE1、又は任意のインスリン成長因子受容体を発現する細胞、又は任意の上皮増殖因子受容体。 - 前記腫瘍細胞は、リンパ腫細胞、骨髄腫細胞、腎細胞、乳癌細胞、前立腺癌細胞、卵巣癌細胞、結腸直腸癌細胞、胃癌細胞、扁平上皮癌細胞、小細胞から選択される。肺がん細胞、小細胞肺がん細胞、精巣がん細胞、又は悪性細胞からなる群から選択される、請求項4に記載の共役体。
- 治療有効量の請求項1~3のいずれか1項に記載の共役体及び薬学的に許容される塩、担体、希釈剤若しくは賦形剤、又は前記共役体の組み合わせを含む、がん、自己免疫疾患、又は感染症の治療又は予防のための医薬組成物。
- 請求項1~3のいずれか1項に記載の1以上の共役体を0.01%~99重量%;
1又は複数のポリオールを0.0%~20.0%;
1又は複数の界面活性剤を0.0%~2.0%;
1又は複数の保存剤を0.0%~5.0%;
1又は複数のアミノ酸を0.0%~30%;
1又は複数の抗酸化剤を0.0%~5.0%;
1又は複数の金属キレート剤を0.0%~0.3%;
製剤のpHをpH4.5~8.5に調整するための1又は複数の緩衝塩を0.0%~30.0%;及び
患者への投与のために再構成された場合に、浸透圧を250~350mOsmに調整するための1又は複数の等張化剤を0.0%~30.0%;
を含み、
前記ポリオールは、フルクトース、マンノース、マルトース、ラクトース、アラビノース、キシロース、リボース、ラムノース、ガラクトース、グルコース、スクロース、トレハロース、ソルボース、メレジトース、ラフィノース、マンニトール、キシリトール、エリスリトール、マルチトール、ラクチトール、エリスリトール、スレイトール、ソルビトール、グリセロール、又はL-グルコン酸塩及びその金属塩から選択される;
前記界面活性剤は、ポリソルベート20、ポリソルベート40、ポリソルベート65、ポリソルベート80、ポリソルベート81、又はポリソルベート85、ポロキサマー、ポリ(エチレンオキシド)-ポリ(プロピレンオキシド)、ポリエチレン-ポリプロピレン、トリトン、ドデシル硫酸ナトリウム(SDS)、ラウレル硫酸ナトリウム;オクチルグリコシドナトリウム;ラウリル-、ミリスチル-、リノレイル-、又はステアリル-スルホベタイン;ラウリル-、ミリスチル-、リノレイル-、又はステアリル-サルコシン;リノレイル-、ミリスチル-、又はセチル-ベタイン;ラウロアミドプロピル-、コカミドプロピル-、リノールアミドプロピル-、ミリスタミドプロピル-、パルミドプロピル-、又はイソステアラミドプロピル-ベタイン(ラウロアミドプロピル);ミリスタミドプロピル-、パルミドプロピル-、又はイソステアラミドプロピル-ジメチルアミン;ナトリウムメチルココイル-又は二ナトリウムメチルオレイル-タウレート;ドデシルベタイン、ドデシルジメチルアミンオキシド、コカミドプロピルベタイン、及びココアンフォグリシネート;又はイソステアリルエチルイミドニウムエトサルフェート;ポリエチルグリコール、ポリプロピレングリコール、及びエチレンとプロピレングリコールとの共重合体から選択される;
前記保存剤は、ベンジルアルコール、オクタデシルジメチルベンジルアンモニウムクロリド、ヘキサメトニウムクロリド、ベンザルコニウムクロリド、ベンゼトニウムクロリド、フェノール、ブチルおよびベンジルアルコール、アルキルパラベン、メチルまたはプロピルパラベン、カテコール、レゾルシノール、シクロヘキサノール、3-ペンタノール、又はm-クレゾールから選択される;
前記アミノ酸は、アルギニン、シスチン、グリシン、リジン、ヒスチジン、オルニチン、イソロイシン、ロイシン、アラニン、グルタミン酸、又はアスパラギン酸から選択される;
前記抗酸化剤は、アスコルビン酸、グルタチオン、シスチン、又はメチオニンから選択される;
前記キレート剤は、EDTA又はEGTAから選択される;
前記緩衝塩は、クエン酸、アスコルビン酸、グルコン酸、炭酸、酒石酸、コハク酸、酢酸、又はフタル酸のナトリウム、カリウム、アンモニウム、又はトリヒドロキシエチルアミノ塩;トリス又はトロメタミンの塩酸塩、リン酸塩又は硫酸塩;アルギニン、グリシン、グリシルグリシン、又はヒスチジンとアニオン性の酢酸塩、塩化物、リン酸塩、硫酸塩、又はコハク酸塩から選択される;
前記等張化剤は、マンニトール、ソルビトール、酢酸ナトリウム、塩化カリウム、リン酸ナトリウム、リン酸カリウム、クエン酸三ナトリウム、または塩化ナトリウムから選択される、液体処方物又は処方された凍結乾燥固体のいずれかである請求項6に記載の医薬組成物。 - 液体または凍結乾燥粉末/固体の形態で、バイアル、ボトル、プレフィルドシリンジ、またはプレフィルドオートインジェクターシリンジに充填される、請求項6または7に記載の医薬組成物。
- インビトロ、インビボまたはエクスビボで細胞殺傷活性を有する,請求項1~3のいずれか1項に記載の共役体、または請求項6若しくは7に記載の医薬組成物。
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---|---|---|---|---|
WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
CA3070765A1 (en) | 2017-08-18 | 2019-02-21 | Medimmune Limited | Pyrrolobenzodiazepine conjugates for the treatment of a proliferative disease |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
SG11202103424UA (en) * | 2018-10-12 | 2021-05-28 | Hangzhou Dac Biotech Co Ltd | Conjugation linkers containing 2,3-diaminosuccinyl group |
WO2020172002A1 (en) | 2019-02-18 | 2020-08-27 | Eli Lilly And Company | Therapeutic antibody formulation |
CN111205251B (zh) * | 2020-02-28 | 2022-04-15 | 苏州楚凯药业有限公司 | 手性配体(3s,4s)-2,5-二氧四氢呋喃-3,4-双氨基甲酸苄基酯的制备方法 |
EP4125920A4 (en) * | 2020-03-28 | 2024-04-10 | Esrail Medical Corp. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF COVID-19 |
US11045546B1 (en) | 2020-03-30 | 2021-06-29 | Cytodyn Inc. | Methods of treating coronavirus infection |
CN111635524B (zh) * | 2020-06-10 | 2023-07-07 | 陕西安得科技实业有限公司 | 一种环保型荧光示踪阻垢剂及其制备方法 |
GB202011993D0 (en) | 2020-07-31 | 2020-09-16 | Adc Therapeutics Sa | ANTI-IL 13Ra2 antibodies |
GB202105186D0 (en) * | 2021-04-12 | 2021-05-26 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
CN115677666A (zh) * | 2021-07-30 | 2023-02-03 | 上海艾力斯医药科技股份有限公司 | 一种吲哚联嘧啶类化合物、其中间体、制备方法及其应用 |
CN115737650B (zh) * | 2021-09-03 | 2024-06-28 | 复旦大学 | 一种嘧啶类衍生物或其药学上可接受的盐在制备治疗结核病药物中的应用 |
KR20240112819A (ko) | 2021-09-30 | 2024-07-19 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 피롤로벤조디아제핀 유도체 및 이의 접합체, 이의 제조 방법 및 이의 응용 |
CN115887793A (zh) * | 2022-10-08 | 2023-04-04 | 东华大学 | 一种多酚氧化酶催化的聚多酚涂层材料的制备及氨基化的方法 |
CN117524562B (zh) * | 2023-12-25 | 2024-05-28 | 安徽华海特种电缆集团有限公司 | 防钢水溅射抗拉移动圆电缆 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016059622A2 (en) | 2016-02-04 | 2016-04-21 | Suzhou M-Conj Biotech Co., Ltd. | Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof |
JP2020516595A (ja) | 2017-04-06 | 2020-06-11 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. | ビス連結による細胞毒性剤の共役 |
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WO2015028850A1 (en) * | 2013-09-02 | 2015-03-05 | Hangzhou Dac Biotech Co., Ltd | Novel cytotoxic agents for conjugation of drugs to cell binding molecule |
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AU2018430758B2 (en) | 2022-01-27 |
NZ772400A (en) | 2024-02-23 |
BR112020025212A2 (pt) | 2021-03-09 |
IL279645A (en) | 2021-03-01 |
EP3818062A1 (en) | 2021-05-12 |
JP2021529799A (ja) | 2021-11-04 |
KR20210030394A (ko) | 2021-03-17 |
CN112272669A (zh) | 2021-01-26 |
WO2020006722A1 (en) | 2020-01-09 |
MX2020014083A (es) | 2021-04-12 |
AU2018430758A1 (en) | 2021-02-18 |
KR20240005234A (ko) | 2024-01-11 |
MY196189A (en) | 2023-03-21 |
SG11202012514PA (en) | 2021-01-28 |
CA3105541A1 (en) | 2020-01-09 |
EA202190189A1 (ru) | 2021-04-16 |
US20210169896A1 (en) | 2021-06-10 |
EP3818062A4 (en) | 2022-03-16 |
CL2023000510A1 (es) | 2023-09-29 |
PH12020500675A1 (en) | 2021-05-17 |
JP2024023191A (ja) | 2024-02-21 |
CL2020003461A1 (es) | 2021-07-30 |
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