JP7426940B2 - 心血管リスクを低減するためのｐｃｓｋ９阻害剤の使用 - Google Patents

心血管リスクを低減するためのｐｃｓｋ９阻害剤の使用 Download PDF

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JP7426940B2
JP7426940B2 JP2020546481A JP2020546481A JP7426940B2 JP 7426940 B2 JP7426940 B2 JP 7426940B2 JP 2020546481 A JP2020546481 A JP 2020546481A JP 2020546481 A JP2020546481 A JP 2020546481A JP 7426940 B2 JP7426940 B2 JP 7426940B2
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alirocumab
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JP2021515772A5 (https=
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JPWO2019173530A5 (https=
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ローレンス・ベサック
コリンヌ・アノタン
ロバート・ポーディー
ウィリアム・サシーラ
グレゴリー・シュウォルツ
フィリップ・シュテグ
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Regeneron Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction

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  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2020546481A 2018-03-06 2019-03-06 心血管リスクを低減するためのｐｃｓｋ９阻害剤の使用 Active JP7426940B2 (ja)

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JP2023207363A JP2024028919A (ja) 2018-03-06 2023-12-08 心血管リスクを低減するためのｐｃｓｋ９阻害剤の使用

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US201862639407P 2018-03-06 2018-03-06
US62/639,407 2018-03-06
US201862640361P 2018-03-08 2018-03-08
US62/640,361 2018-03-08
US201862641082P 2018-03-09 2018-03-09
US62/641,082 2018-03-09
US201862641918P 2018-03-12 2018-03-12
US62/641,918 2018-03-12
US201862657495P 2018-04-13 2018-04-13
US62/657,495 2018-04-13
US201862683695P 2018-06-12 2018-06-12
US62/683,695 2018-06-12
US201862688622P 2018-06-22 2018-06-22
US62/688,622 2018-06-22
US201862717530P 2018-08-10 2018-08-10
US62/717,530 2018-08-10
US201862736284P 2018-09-25 2018-09-25
US62/736,284 2018-09-25
US201862744008P 2018-10-10 2018-10-10
US62/744,008 2018-10-10
US201862746319P 2018-10-16 2018-10-16
US62/746,319 2018-10-16
US201862770530P 2018-11-21 2018-11-21
US62/770,530 2018-11-21
US201862775219P 2018-12-04 2018-12-04
US62/775,219 2018-12-04
US201962797680P 2019-01-28 2019-01-28
US62/797,680 2019-01-28
US201962802545P 2019-02-07 2019-02-07
US62/802,545 2019-02-07
US201962806313P 2019-02-15 2019-02-15
US62/806,313 2019-02-15
EP19305247.9 2019-03-04
EP19305247 2019-03-04
PCT/US2019/021034 WO2019173530A1 (en) 2018-03-06 2019-03-06 Use of pcsk9 inhibitor for reducing cardiovascular risk

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JP2021515772A JP2021515772A (ja) 2021-06-24
JP2021515772A5 JP2021515772A5 (https=) 2022-03-10
JPWO2019173530A5 JPWO2019173530A5 (https=) 2022-03-10
JP7426940B2 true JP7426940B2 (ja) 2024-02-02

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JP2023207363A Pending JP2024028919A (ja) 2018-03-06 2023-12-08 心血管リスクを低減するためのｐｃｓｋ９阻害剤の使用

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US (1) US20190292273A1 (https=)
EP (1) EP3762026B1 (https=)
JP (2) JP7426940B2 (https=)
KR (1) KR20200129127A (https=)
CN (1) CN113015543A (https=)
AU (1) AU2019231703A1 (https=)
CA (1) CA3092936A1 (https=)
IL (1) IL277127B2 (https=)
MX (1) MX2020009246A (https=)
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US10842498B2 (en) * 2018-09-13 2020-11-24 Neuravi Limited Systems and methods of restoring perfusion to a vessel
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TWI759867B (zh) * 2019-09-19 2022-04-01 大陸商信達生物製藥（蘇州）有限公司 抗前蛋白轉化酶枯草桿菌蛋白酶／ｋｅｘｉｎ型９抗體用於製備治療膽固醇相關疾病之藥物的用途
US11712231B2 (en) 2019-10-29 2023-08-01 Neuravi Limited Proximal locking assembly design for dual stent mechanical thrombectomy device
US11517340B2 (en) 2019-12-03 2022-12-06 Neuravi Limited Stentriever devices for removing an occlusive clot from a vessel and methods thereof
US11717308B2 (en) 2020-04-17 2023-08-08 Neuravi Limited Clot retrieval device for removing heterogeneous clots from a blood vessel
US11871946B2 (en) 2020-04-17 2024-01-16 Neuravi Limited Clot retrieval device for removing clot from a blood vessel
US11730501B2 (en) 2020-04-17 2023-08-22 Neuravi Limited Floating clot retrieval device for removing clots from a blood vessel
US11737771B2 (en) 2020-06-18 2023-08-29 Neuravi Limited Dual channel thrombectomy device
US11937836B2 (en) 2020-06-22 2024-03-26 Neuravi Limited Clot retrieval system with expandable clot engaging framework
US11439418B2 (en) 2020-06-23 2022-09-13 Neuravi Limited Clot retrieval device for removing clot from a blood vessel
US11395669B2 (en) 2020-06-23 2022-07-26 Neuravi Limited Clot retrieval device with flexible collapsible frame
US11864781B2 (en) 2020-09-23 2024-01-09 Neuravi Limited Rotating frame thrombectomy device
US11937837B2 (en) 2020-12-29 2024-03-26 Neuravi Limited Fibrin rich / soft clot mechanical thrombectomy device
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JP2017509624A (ja) 2014-03-17 2017-04-06 サノフィ・バイオテクノロジー 心血管リスクを低減させる方法
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JP2024028919A (ja) 2024-03-05
KR20200129127A (ko) 2020-11-17
EP3762026A1 (en) 2021-01-13
WO2019173530A1 (en) 2019-09-12
IL277127B1 (en) 2025-07-01
CA3092936A1 (en) 2019-09-12
TW202521589A (zh) 2025-06-01
US20190292273A1 (en) 2019-09-26
RU2020132463A (ru) 2022-04-06
IL277127B2 (en) 2025-11-01
TW201945401A (zh) 2019-12-01
IL277127A (en) 2020-10-29
MX2020009246A (es) 2021-01-15
AU2019231703A1 (en) 2020-10-22
JP2021515772A (ja) 2021-06-24
EP3762026B1 (en) 2026-04-08
CN113015543A (zh) 2021-06-22

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