JP2021515772A5 - - Google Patents
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- Publication number
- JP2021515772A5 JP2021515772A5 JP2020546481A JP2020546481A JP2021515772A5 JP 2021515772 A5 JP2021515772 A5 JP 2021515772A5 JP 2020546481 A JP2020546481 A JP 2020546481A JP 2020546481 A JP2020546481 A JP 2020546481A JP 2021515772 A5 JP2021515772 A5 JP 2021515772A5
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- Japan
- Prior art keywords
- pharmaceutical composition
- patient
- composition according
- antigen
- binding fragment
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023207363A JP2024028919A (ja) | 2018-03-06 | 2023-12-08 | 心血管リスクを低減するためのｐｃｓｋ９阻害剤の使用 |
Applications Claiming Priority (35)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862639407P | 2018-03-06 | 2018-03-06 | |
| US62/639,407 | 2018-03-06 | ||
| US201862640361P | 2018-03-08 | 2018-03-08 | |
| US62/640,361 | 2018-03-08 | ||
| US201862641082P | 2018-03-09 | 2018-03-09 | |
| US62/641,082 | 2018-03-09 | ||
| US201862641918P | 2018-03-12 | 2018-03-12 | |
| US62/641,918 | 2018-03-12 | ||
| US201862657495P | 2018-04-13 | 2018-04-13 | |
| US62/657,495 | 2018-04-13 | ||
| US201862683695P | 2018-06-12 | 2018-06-12 | |
| US62/683,695 | 2018-06-12 | ||
| US201862688622P | 2018-06-22 | 2018-06-22 | |
| US62/688,622 | 2018-06-22 | ||
| US201862717530P | 2018-08-10 | 2018-08-10 | |
| US62/717,530 | 2018-08-10 | ||
| US201862736284P | 2018-09-25 | 2018-09-25 | |
| US62/736,284 | 2018-09-25 | ||
| US201862744008P | 2018-10-10 | 2018-10-10 | |
| US62/744,008 | 2018-10-10 | ||
| US201862746319P | 2018-10-16 | 2018-10-16 | |
| US62/746,319 | 2018-10-16 | ||
| US201862770530P | 2018-11-21 | 2018-11-21 | |
| US62/770,530 | 2018-11-21 | ||
| US201862775219P | 2018-12-04 | 2018-12-04 | |
| US62/775,219 | 2018-12-04 | ||
| US201962797680P | 2019-01-28 | 2019-01-28 | |
| US62/797,680 | 2019-01-28 | ||
| US201962802545P | 2019-02-07 | 2019-02-07 | |
| US62/802,545 | 2019-02-07 | ||
| US201962806313P | 2019-02-15 | 2019-02-15 | |
| US62/806,313 | 2019-02-15 | ||
| EP19305247.9 | 2019-03-04 | ||
| EP19305247 | 2019-03-04 | ||
| PCT/US2019/021034 WO2019173530A1 (en) | 2018-03-06 | 2019-03-06 | Use of pcsk9 inhibitor for reducing cardiovascular risk |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023207363A Division JP2024028919A (ja) | 2018-03-06 | 2023-12-08 | 心血管リスクを低減するためのｐｃｓｋ９阻害剤の使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021515772A JP2021515772A (ja) | 2021-06-24 |
| JP2021515772A5 true JP2021515772A5 (https=) | 2022-03-10 |
| JPWO2019173530A5 JPWO2019173530A5 (https=) | 2022-03-10 |
| JP7426940B2 JP7426940B2 (ja) | 2024-02-02 |
Family
ID=66001316
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020546481A Active JP7426940B2 (ja) | 2018-03-06 | 2019-03-06 | 心血管リスクを低減するためのｐｃｓｋ９阻害剤の使用 |
| JP2023207363A Pending JP2024028919A (ja) | 2018-03-06 | 2023-12-08 | 心血管リスクを低減するためのｐｃｓｋ９阻害剤の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023207363A Pending JP2024028919A (ja) | 2018-03-06 | 2023-12-08 | 心血管リスクを低減するためのｐｃｓｋ９阻害剤の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20190292273A1 (https=) |
| EP (1) | EP3762026B1 (https=) |
| JP (2) | JP7426940B2 (https=) |
| KR (1) | KR20200129127A (https=) |
| CN (1) | CN113015543A (https=) |
| AU (1) | AU2019231703A1 (https=) |
| CA (1) | CA3092936A1 (https=) |
| IL (1) | IL277127B2 (https=) |
| MX (1) | MX2020009246A (https=) |
| TW (2) | TW201945401A (https=) |
| WO (1) | WO2019173530A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9402707B2 (en) | 2008-07-22 | 2016-08-02 | Neuravi Limited | Clot capture systems and associated methods |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| WO2012052982A1 (en) | 2010-10-22 | 2012-04-26 | Neuravi Limited | Clot engagement and removal system |
| PL3395836T3 (pl) | 2011-01-28 | 2021-12-13 | Sanofi Biotechnology | Ludzkie przeciwciała przeciwko pcsk9 do zastosowania w sposobach leczenia konkretnych grup osobników |
| ES3029850T3 (en) | 2011-03-09 | 2025-06-25 | Neuravi Ltd | A clot retrieval device for removing occlusive clot from a blood vessel |
| US12076037B2 (en) | 2011-03-09 | 2024-09-03 | Neuravi Limited | Systems and methods to restore perfusion to a vessel |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| US9433429B2 (en) | 2013-03-14 | 2016-09-06 | Neuravi Limited | Clot retrieval devices |
| SI2967610T1 (sl) | 2013-03-14 | 2019-07-31 | Neuravi Limited | Naprava za odkrivanje strdka za odstranjevanje okluzivnega strdka in krvne žile |
| EP2967611B1 (en) | 2013-03-14 | 2019-01-16 | Neuravi Limited | Devices for removal of acute blockages from blood vessels |
| MX2016006226A (es) | 2013-11-12 | 2016-09-07 | Sanofi Biotechnology | Regimenes de dosificacion para uso con inhibidores de pcsk9. |
| US11253278B2 (en) | 2014-11-26 | 2022-02-22 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
| EP3223723B1 (en) | 2014-11-26 | 2020-01-08 | Neuravi Limited | A clot retrieval device for removing occlusive clot from a blood vessel |
| US10617435B2 (en) | 2014-11-26 | 2020-04-14 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
| JP2018523684A (ja) | 2015-08-18 | 2018-08-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | リポタンパク質アフェレーシスを受けている高脂血症の患者を治療するための抗ｐｃｓｋ９阻害抗体 |
| KR102494176B1 (ko) | 2016-09-06 | 2023-02-02 | 뉴라비 리미티드 | 혈관으로부터 폐색 혈전을 제거하기 위한 혈전 회수 장치 |
| US10842498B2 (en) * | 2018-09-13 | 2020-11-24 | Neuravi Limited | Systems and methods of restoring perfusion to a vessel |
| US11406416B2 (en) | 2018-10-02 | 2022-08-09 | Neuravi Limited | Joint assembly for vasculature obstruction capture device |
| TWI759867B (zh) * | 2019-09-19 | 2022-04-01 | 大陸商信達生物製藥（蘇州）有限公司 | 抗前蛋白轉化酶枯草桿菌蛋白酶／ｋｅｘｉｎ型９抗體用於製備治療膽固醇相關疾病之藥物的用途 |
| US11712231B2 (en) | 2019-10-29 | 2023-08-01 | Neuravi Limited | Proximal locking assembly design for dual stent mechanical thrombectomy device |
| US11517340B2 (en) | 2019-12-03 | 2022-12-06 | Neuravi Limited | Stentriever devices for removing an occlusive clot from a vessel and methods thereof |
| US11717308B2 (en) | 2020-04-17 | 2023-08-08 | Neuravi Limited | Clot retrieval device for removing heterogeneous clots from a blood vessel |
| US11871946B2 (en) | 2020-04-17 | 2024-01-16 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
| US11730501B2 (en) | 2020-04-17 | 2023-08-22 | Neuravi Limited | Floating clot retrieval device for removing clots from a blood vessel |
| US11737771B2 (en) | 2020-06-18 | 2023-08-29 | Neuravi Limited | Dual channel thrombectomy device |
| US11937836B2 (en) | 2020-06-22 | 2024-03-26 | Neuravi Limited | Clot retrieval system with expandable clot engaging framework |
| US11439418B2 (en) | 2020-06-23 | 2022-09-13 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
| US11395669B2 (en) | 2020-06-23 | 2022-07-26 | Neuravi Limited | Clot retrieval device with flexible collapsible frame |
| US11864781B2 (en) | 2020-09-23 | 2024-01-09 | Neuravi Limited | Rotating frame thrombectomy device |
| US11937837B2 (en) | 2020-12-29 | 2024-03-26 | Neuravi Limited | Fibrin rich / soft clot mechanical thrombectomy device |
| US12029442B2 (en) | 2021-01-14 | 2024-07-09 | Neuravi Limited | Systems and methods for a dual elongated member clot retrieval apparatus |
| US12064130B2 (en) | 2021-03-18 | 2024-08-20 | Neuravi Limited | Vascular obstruction retrieval device having sliding cages pinch mechanism |
| US11974764B2 (en) | 2021-06-04 | 2024-05-07 | Neuravi Limited | Self-orienting rotating stentriever pinching cells |
| CN115413625A (zh) * | 2022-08-22 | 2022-12-02 | 郑咏秋 | 一种类风湿性冠心病动物模型及其构建方法和应用 |
| CN118116596B (zh) * | 2024-04-25 | 2024-07-02 | 青岛宝迈得生物科技有限公司 | 基于大数据分析的肝胆与心血管疾病共发风险评估方法 |
| CN121015868B (zh) * | 2025-10-29 | 2026-03-20 | 核工业四一六医院 | Pcsk9抑制剂在制备用于治疗甲减伴高脂血症的药物中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| PL3395836T3 (pl) | 2011-01-28 | 2021-12-13 | Sanofi Biotechnology | Ludzkie przeciwciała przeciwko pcsk9 do zastosowania w sposobach leczenia konkretnych grup osobników |
| WO2012168491A1 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Pharmaceutical formulations of pcsk9 antagonists |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| ES2992345T3 (es) | 2011-09-16 | 2024-12-11 | Regeneron Pharma | Métodos para reducir los niveles de lipoproteína(a) mediante la administración de un inhibidor de la proproteína convertasa subtilisina kexina-9 (PCSK9) |
| EA039663B1 (ru) | 2012-05-03 | 2022-02-24 | Амген Инк. | Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств |
| NZ727849A (en) * | 2012-06-29 | 2018-06-29 | Amarin Pharmaceuticals Ie Ltd | Methods of reducing the risk of a cardiovascular event in a subject on statin therapy |
| KR20220048051A (ko) * | 2013-10-11 | 2022-04-19 | 사노피 바이오테크놀로지 | 고지혈증을 치료하기 위한 ｐｃｓｋ9 억제제의 용도 |
| AU2015231713B2 (en) * | 2014-03-17 | 2020-11-19 | Regeneron Pharmaceuticals, Inc. | Methods for reducing cardiovascular risk |
| RU2723018C2 (ru) | 2014-07-16 | 2020-06-08 | Санофи Байотекнолоджи | Способы лечения пациентов с высоким риском возникновения сердечно-сосудистых заболеваний, имеющих гиперхолестеринемию |
| JP2018523684A (ja) * | 2015-08-18 | 2018-08-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | リポタンパク質アフェレーシスを受けている高脂血症の患者を治療するための抗ｐｃｓｋ９阻害抗体 |
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2019
- 2019-03-06 CA CA3092936A patent/CA3092936A1/en active Pending
- 2019-03-06 JP JP2020546481A patent/JP7426940B2/ja active Active
- 2019-03-06 TW TW108107481A patent/TW201945401A/zh unknown
- 2019-03-06 WO PCT/US2019/021034 patent/WO2019173530A1/en not_active Ceased
- 2019-03-06 CN CN201980029013.2A patent/CN113015543A/zh active Pending
- 2019-03-06 EP EP19715280.4A patent/EP3762026B1/en active Active
- 2019-03-06 AU AU2019231703A patent/AU2019231703A1/en not_active Abandoned
- 2019-03-06 US US16/294,635 patent/US20190292273A1/en not_active Abandoned
- 2019-03-06 IL IL277127A patent/IL277127B2/en unknown
- 2019-03-06 TW TW113130634A patent/TW202521589A/zh unknown
- 2019-03-06 MX MX2020009246A patent/MX2020009246A/es unknown
- 2019-03-06 KR KR1020207028410A patent/KR20200129127A/ko not_active Ceased
-
2023
- 2023-12-08 JP JP2023207363A patent/JP2024028919A/ja active Pending