JP7425782B2 - 水中油型乳化日焼け止め化粧料 - Google Patents
水中油型乳化日焼け止め化粧料 Download PDFInfo
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- JP7425782B2 JP7425782B2 JP2021212442A JP2021212442A JP7425782B2 JP 7425782 B2 JP7425782 B2 JP 7425782B2 JP 2021212442 A JP2021212442 A JP 2021212442A JP 2021212442 A JP2021212442 A JP 2021212442A JP 7425782 B2 JP7425782 B2 JP 7425782B2
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- Prior art keywords
- oil
- mass
- ultraviolet absorber
- emulsified cosmetic
- present
- Prior art date
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- 239000002537 cosmetic Substances 0.000 title claims description 59
- 230000000475 sunscreen effect Effects 0.000 title claims description 15
- 239000000516 sunscreening agent Substances 0.000 title claims description 13
- 239000007764 o/w emulsion Substances 0.000 title claims description 12
- 239000003921 oil Substances 0.000 claims description 45
- 239000006097 ultraviolet radiation absorber Substances 0.000 claims description 22
- XVAMCHGMPYWHNL-UHFFFAOYSA-N bemotrizinol Chemical compound OC1=CC(OCC(CC)CCCC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=NC(C=2C(=CC(OCC(CC)CCCC)=CC=2)O)=N1 XVAMCHGMPYWHNL-UHFFFAOYSA-N 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- OOHTWBUKWQKKEE-UHFFFAOYSA-N [6-(diethylamino)-6-hydroxy-7-oxo-7-phenylheptyl] benzoate Chemical compound C=1C=CC=CC=1C(=O)C(O)(N(CC)CC)CCCCCOC(=O)C1=CC=CC=C1 OOHTWBUKWQKKEE-UHFFFAOYSA-N 0.000 claims description 16
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 claims description 15
- 229960001630 diethylamino hydroxybenzoyl hexyl benzoate Drugs 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 13
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 12
- 239000002736 nonionic surfactant Substances 0.000 claims description 12
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 12
- 125000000542 sulfonic acid group Chemical group 0.000 claims description 8
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 7
- 229960000735 docosanol Drugs 0.000 claims description 6
- UVCJGUGAGLDPAA-UHFFFAOYSA-N ensulizole Chemical compound N1C2=CC(S(=O)(=O)O)=CC=C2N=C1C1=CC=CC=C1 UVCJGUGAGLDPAA-UHFFFAOYSA-N 0.000 claims description 6
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 claims description 6
- 229960000601 octocrylene Drugs 0.000 claims description 6
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims description 5
- 229960000655 ensulizole Drugs 0.000 claims description 5
- 239000010696 ester oil Substances 0.000 claims description 5
- 229960001679 octinoxate Drugs 0.000 claims description 5
- -1 arachyl alcohol Chemical compound 0.000 description 22
- 239000006096 absorbing agent Substances 0.000 description 20
- 239000000839 emulsion Substances 0.000 description 13
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 12
- 230000006750 UV protection Effects 0.000 description 11
- 239000007788 liquid Substances 0.000 description 11
- 239000000049 pigment Substances 0.000 description 11
- 239000000843 powder Substances 0.000 description 11
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 9
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- 239000000194 fatty acid Substances 0.000 description 8
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 235000014113 dietary fatty acids Nutrition 0.000 description 7
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- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 6
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- 150000001298 alcohols Chemical class 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Substances CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 4
- 239000011787 zinc oxide Substances 0.000 description 4
- OIQXFRANQVWXJF-QBFSEMIESA-N (2z)-2-benzylidene-4,7,7-trimethylbicyclo[2.2.1]heptan-3-one Chemical class CC1(C)C2CCC1(C)C(=O)\C2=C/C1=CC=CC=C1 OIQXFRANQVWXJF-QBFSEMIESA-N 0.000 description 3
- DWYHDSLIWMUSOO-UHFFFAOYSA-N 2-phenyl-1h-benzimidazole Chemical class C1=CC=CC=C1C1=NC2=CC=CC=C2N1 DWYHDSLIWMUSOO-UHFFFAOYSA-N 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 3
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- HEAHZSUCFKFERC-IWGRKNQJSA-N [(2e)-2-[[4-[(e)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid Chemical group CC1(C)C2CCC1(CS(O)(=O)=O)C(=O)\C2=C\C(C=C1)=CC=C1\C=C/1C(=O)C2(CS(O)(=O)=O)CCC\1C2(C)C HEAHZSUCFKFERC-IWGRKNQJSA-N 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
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- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
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- VJZWIFWPGRIJSN-XRHABHTOSA-N dilinoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O.CCCCC\C=C/C\C=C/CCCCCCCC(O)=O VJZWIFWPGRIJSN-XRHABHTOSA-N 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- XFKBBSZEQRFVSL-UHFFFAOYSA-N dipropan-2-yl decanedioate Chemical compound CC(C)OC(=O)CCCCCCCCC(=O)OC(C)C XFKBBSZEQRFVSL-UHFFFAOYSA-N 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 2
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- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 2
- IRHTZOCLLONTOC-UHFFFAOYSA-N hexacosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCO IRHTZOCLLONTOC-UHFFFAOYSA-N 0.000 description 2
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- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
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- BWOROQSFKKODDR-UHFFFAOYSA-N oxobismuth;hydrochloride Chemical compound Cl.[Bi]=O BWOROQSFKKODDR-UHFFFAOYSA-N 0.000 description 2
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- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- DRRMRHKHTQRWMB-UHFFFAOYSA-N [3-(2-ethylhexanoyloxy)-2,2-bis(2-ethylhexanoyloxymethyl)propyl] 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(COC(=O)C(CC)CCCC)(COC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DRRMRHKHTQRWMB-UHFFFAOYSA-N 0.000 description 1
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- CQPFMGBJSMSXLP-UHFFFAOYSA-M acid orange 7 Chemical compound [Na+].OC1=CC=C2C=CC=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 CQPFMGBJSMSXLP-UHFFFAOYSA-M 0.000 description 1
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- 229940091509 beheneth-20 Drugs 0.000 description 1
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- 208000002458 carcinoid tumor Diseases 0.000 description 1
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- 229960000541 cetyl alcohol Drugs 0.000 description 1
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- HBHZKFOUIUMKHV-UHFFFAOYSA-N chembl1982121 Chemical compound OC1=CC=C2C=CC=CC2=C1N=NC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O HBHZKFOUIUMKHV-UHFFFAOYSA-N 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 229910000423 chromium oxide Inorganic materials 0.000 description 1
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- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
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- 229940080423 cochineal Drugs 0.000 description 1
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- 230000001804 emulsifying effect Effects 0.000 description 1
- 235000012732 erythrosine Nutrition 0.000 description 1
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 description 1
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- 235000011957 flavonols Nutrition 0.000 description 1
- NWKFECICNXDNOQ-UHFFFAOYSA-N flavylium Chemical compound C1=CC=CC=C1C1=CC=C(C=CC=C2)C2=[O+]1 NWKFECICNXDNOQ-UHFFFAOYSA-N 0.000 description 1
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- 239000011888 foil Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
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- 150000004676 glycans Chemical class 0.000 description 1
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- 239000001056 green pigment Substances 0.000 description 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- OGEMCJNRDGZFQF-UHFFFAOYSA-N hexyl 2-benzoyl-4-(diethylamino)-3-hydroxybenzoate Chemical compound CCCCCCOC(=O)C1=CC=C(N(CC)CC)C(O)=C1C(=O)C1=CC=CC=C1 OGEMCJNRDGZFQF-UHFFFAOYSA-N 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
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- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N icosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 150000002462 imidazolines Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 1
- JCDAAXRCMMPNBO-UHFFFAOYSA-N iron(3+);oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[Ti+4].[Ti+4].[Fe+3].[Fe+3] JCDAAXRCMMPNBO-UHFFFAOYSA-N 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
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- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
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- 239000000463 material Substances 0.000 description 1
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- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
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- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- 229940078812 myristyl myristate Drugs 0.000 description 1
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- 150000002791 naphthoquinones Chemical class 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- ALSTYHKOOCGGFT-MDZDMXLPSA-N oleyl alcohol Chemical compound CCCCCCCC\C=C\CCCCCCCCO ALSTYHKOOCGGFT-MDZDMXLPSA-N 0.000 description 1
- 229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229910052628 phlogopite Inorganic materials 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
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- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
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- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000001057 purple pigment Substances 0.000 description 1
- 239000001054 red pigment Substances 0.000 description 1
- 229940058287 salicylic acid derivative anticestodals Drugs 0.000 description 1
- 150000003872 salicylic acid derivatives Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- VVNRQZDDMYBBJY-UHFFFAOYSA-M sodium 1-[(1-sulfonaphthalen-2-yl)diazenyl]naphthalen-2-olate Chemical compound [Na+].C1=CC=CC2=C(S([O-])(=O)=O)C(N=NC3=C4C=CC=CC4=CC=C3O)=CC=C21 VVNRQZDDMYBBJY-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- LLZRNZOLAXHGLL-UHFFFAOYSA-J titanic acid Chemical compound O[Ti](O)(O)O LLZRNZOLAXHGLL-UHFFFAOYSA-J 0.000 description 1
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical compound C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 description 1
- 150000003918 triazines Chemical class 0.000 description 1
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- 239000010913 used oil Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000001052 yellow pigment Substances 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/411—Aromatic amines, i.e. where the amino group is directly linked to the aromatic nucleus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/415—Aminophenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4966—Triazines or their condensed derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/12—Face or body powders for grooming, adorning or absorbing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Description
(A)(a1)スルホン酸基含有水溶性紫外線吸収剤、
(a2)ビスエチルヘキシルオキシフェノールメトキシフェニルトリアジン、
(a3)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル、及び、
(a4)エチルヘキシルトリアゾンを含む紫外線吸収剤、
(B)極性油、
(C)高級アルコール、及び、
(D)非イオン性界面活性剤を含み、
前記(a2)ビスエチルヘキシルオキシフェノールメトキシフェニルトリアジン、(a3)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル、(a4)エチルヘキシルトリアゾン、及び(B)極性油の合計配合量が45質量%以下であることを特徴とする水中油型乳化化粧料を提供する。
(a1)成分としては、限定されないが、スルホン酸基を有するフェニルベンズイミダゾール誘導体又はベンジリデンショウノウ誘導体等が好ましく用いられる。
ベンジリデンショウノウ誘導体としては、ベンジリデンショウノウスルホン酸、テレフタリリデンジショウノウスルホン酸等が挙げられ、いずれも、シメックス(Chimex)社からメギゾリル(Mexoryl)SD及びメギゾリル(Mexoryl)SXという商品名で市販されている。
本発明の乳化化粧料におけるビスエチルヘキシルオキシフェノールメトキシフェニルトリアジン(a2成分)の配合量は、0.1~10質量%が好ましく、より好ましくは0.5~5質量%である。
本発明の乳化化粧料におけるジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル(a3成分)の配合量は、0.1~10質量%が好ましく、より好ましくは0.5~5質量%である。
本発明の乳化化粧料におけるエチルヘキシルトリアゾン(a4成分)の配合量は、0.1~10質量%が好ましく、より好ましくは0.5~5質量%である。
なお、(a2)、(a3)及び(a4)を含む油溶性紫外線吸収剤の合計配合量は、0.5~19.5質量%とするのが好ましく、より好ましくは1~15質量%である。
本発明の日焼け止め化粧料で使用する高級アルコール(C成分)としては、化粧品、医薬品、医薬部外品等の分野において使用できる炭素数6以上の高級アルコールであれば特に限定されず、飽和直鎖一価アルコール及び不飽和一価アルコール等を包含する。飽和直鎖一価アルコールとしては、ドデカノール(ラウリルアルコール)、トリドデカノール、テトラドデカノール(ミリスチルアルコール)、ペンタデカノール、ヘキサデカノール(セチルアルコール)、ヘプタデカノール、オクタデカノール(ステアリルアルコール)、ノナデカノール、イコサノール(アラキルアルコール)、ヘンイコサノール、ドコサノール(ベヘニルアルコール)、トリコサノール、テトラコサノール(カルナービルアルコール)、ペンタコサノール、ヘキサコサノール(セリルアルコール)等が挙げられる。不飽和一価アルコールとしては、エライジルアルコール等が挙げられる。本発明では経時安定性の点から飽和直鎖一価アルコールが好ましい。
本発明の水中油型乳化化粧料に使用される非イオン性界面活性剤(D成分)は、特に限定されるものではない。具体例としては、ポリエチレングリコール脂肪酸エステル、ポリオキシエチレン脂肪酸グリセリル、ポリオキシエチレン・メチルポリシロキサン共重合体、脂肪酸ポリオキシエチレンソルビタン、ポリオキシエチレンアルキルエーテル、マルチトールヒドロキシ脂肪族アルキルエーテル、アルキル化多糖、アルキルグルコシド、ショ糖脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油グリセリル、ポリオキシエチレンソルビット脂肪酸エステル、ポリオキシエチレン・ポリオキシプロピレンブロック共重合体、テトラポリオキシエチレン・テトラポリオキシプロピレン-エチレンジアミン縮合物、ポリオキシエチレン-ミツロウ・ラノリン誘導体、アルカノールアミド、ポリオキシエチレン-プロピレングリコール脂肪酸エステル、ポリオキシエチレン-アルキルアミン、ポリオキシエチレン-脂肪酸アミド、アルキルエトキシジメチルアミンオキシド、トリオレイルリン酸などが挙げられる。本発明の化粧料では、HLBが8以上の親水性の非イオン性界面活性剤、例えば、ベヘネス-20、ポリソルベート60、ステアリン酸PEG-40等が特に好ましい例として挙げられる。非イオン性界面活性剤は、1種又は2種以上を用いることができる。
本発明の日焼け止め化粧料は水中油型乳化物であるので、水(E成分)を含んでいる。本発明では、前記(C)高級アルコールは、前記(D)非イオン性界面活性剤及び(E)水とともにラメラ液晶構造を有する会合体(「αゲル」ともいう)を形成する。(C)高級アルコールと(D)界面活性剤との配合比は、(C):(D)=2:1~25:1(モル比)の範囲内とするのが好ましい。
他の任意成分としては、限定されないが、例えば、粉末成分、色材、保湿剤、油分((A)油性の紫外線吸収剤及び(B)極性油を除く)、増粘剤、分散剤、防腐剤、香料、各種薬剤等が挙げられる。
評価基準:
A:析出や分離がみられず、極めて安定であった
B:乳化は可能だが、低温(0℃)で経時的に析出がみられた
C:乳化は可能だが、高温(37℃)で経時的に乳化粒子の増大がみられた
D:乳化は可能だが、室温で経時的に分離がみられた
各例の試料を1.75mg/cm2でPMMA製基板に塗布し、波長310nmにおける吸光度を、(吸光度計:HITACHI U-4100 Spectrophotometer)を用いて測定した。
専門パネルによる実使用試験を実施し、みずみずしさ及びべたつきの無さの観点から使用感を以下の基準で評価した。
+:優れている
-:劣っている
専門パネルによる実使用試験を実施し、塗布後の肌のつやを以下の基準で評価した。
A:優れている
B:普通
C:劣っている
処方例1:
配合成分 配合量(質量%)
フェニルベンズイミダゾールスルホン酸(a1) 3
ビスエチルヘキシルオキシフェノールメトキシ
フェニルトリアジン(a2) 0.3
ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル(a3) 0.3
エチルヘキシルトリアジン(a4) 0.3
セバシン酸ジイソプロピル(B) 5
ステアリルアルコール 2
ベヘニルアルコール 3
ベヘネス-20 1
イオン交換水 残余
EDTA-3Na,2H2O 0.1
グリセリン 5
トリエタノールアミン 2
エタノール 5
二酸化チタン 0.5
酸化鉄(ベンガラ) 0.002
黄酸化鉄 0.003
[第1項]
(A)(a1)スルホン酸基含有水溶性紫外線吸収剤、
(a2)ビスエチルヘキシルオキシフェノールメトキシフェニルトリアジン、
(a3)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル、及び、
(a4)エチルヘキシルトリアゾンを含む紫外線吸収剤、
(B)極性油、
(C)高級アルコール、及び、
(D)非イオン性界面活性剤を含み、
前記(a2)ビスエチルヘキシルオキシフェノールメトキシフェニルトリアジン、(a3)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル、(a4)エチルヘキシルトリアゾン、及び(B)極性油の合計配合量が45質量%以下であることを特徴とする水中油型乳化化粧料。
[第2項]
前記(B)極性油の配合量の、(a2)ビスエチルヘキシルオキシフェノールメトキシフェニルトリアジン、(a3)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル、及び(a4)エチルヘキシルトリアゾンの合計配合量に対する比率[(B)/(a2+a3+a4)]が0.6以上である、第1項に記載の乳化化粧料。
[第3項]
(A)紫外線吸収剤が、(a1)フェニルベンズイミダゾールスルホン酸、(a2)ビスエチルヘキシルオキシフェノールメトキシフェニルトリアジン、(a3)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル、及び(a4)エチルヘキシルトリアゾンのみからなる、第1項に記載の乳化化粧料。
[第4項]
(B)極性油が、IOB=0.1~0.5のエステル油からなる、第1項から第3項のいずれか一項に記載の乳化化粧料。
[第5項]
(C)高級アルコールが、ステアリルアルコールとベヘニルアルコールとの組み合わせからなる、第1項から第4項のいずれか一項に記載の乳化化粧料。
[第6項]
日焼け止め化粧料である、第1項から第5項のいずれか一項に記載の乳化化粧料。
Claims (6)
- (A)(a1)スルホン酸基含有水溶性紫外線吸収剤、並びに、
(a2)ビスエチルヘキシルオキシフェノールメトキシフェニルトリアジン、
(a3)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル、及び、
(a4)エチルヘキシルトリアゾンを含有する油性の紫外線吸収剤を含む紫外線吸収剤、
(B)極性油、
(C)高級アルコール、及び、
(D)HLBが8以上の非イオン性界面活性剤を含み、
メトキシケイ皮酸エチルヘキシル及びオクトクリレンを含まず、
前記油性の紫外線吸収剤が油相に配合され、
前記(a2)ビスエチルヘキシルオキシフェノールメトキシフェニルトリアジン、(a3)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル、(a4)エチルヘキシルトリアゾン、及び(B)極性油の合計配合量が45質量%以下であることを特徴とする水中油型乳化化粧料。 - 前記(B)極性油の配合量の、(a2)ビスエチルヘキシルオキシフェノールメトキシフェニルトリアジン、(a3)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル、及び(a4)エチルヘキシルトリアゾンの合計配合量に対する比率[(B)/(a2+a3+a4)]が0.6以上である、請求項1に記載の乳化化粧料。
- (A)紫外線吸収剤が、(a1)フェニルベンズイミダゾールスルホン酸、(a2)ビスエチルヘキシルオキシフェノールメトキシフェニルトリアジン、(a3)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル、及び(a4)エチルヘキシルトリアゾンのみからなる、請求項1に記載の乳化化粧料。
- (B)極性油が、IOB=0.1~0.5のエステル油からなる、請求項1から3のいずれか一項に記載の乳化化粧料。
- (C)高級アルコールが、ステアリルアルコールとベヘニルアルコールとの組み合わせからなる、請求項1から4のいずれか一項に記載の乳化化粧料。
- 日焼け止め化粧料である、請求項1から5のいずれか一項に記載の乳化化粧料。
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