JP7420841B2 - 核酸送達のためのイオン化可能な脂質 - Google Patents

核酸送達のためのイオン化可能な脂質 Download PDF

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JP7420841B2
JP7420841B2 JP2021577003A JP2021577003A JP7420841B2 JP 7420841 B2 JP7420841 B2 JP 7420841B2 JP 2021577003 A JP2021577003 A JP 2021577003A JP 2021577003 A JP2021577003 A JP 2021577003A JP 7420841 B2 JP7420841 B2 JP 7420841B2
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lipid
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JP2022539089A5 (https=
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アニタ トーマス，
ニキータ ジェイン，
アンドリュー ウィリアム ブラウン，
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Precision Nanosystems ULC
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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JP2021577003A 2019-06-29 2020-06-26 核酸送達のためのイオン化可能な脂質 Active JP7420841B2 (ja)

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JP2024002304A JP7667327B2 (ja) 2019-06-29 2024-01-11 核酸送達のためのイオン化可能な脂質
JP2025065109A JP2025105627A (ja) 2019-06-29 2025-04-10 核酸送達のためのイオン化可能な脂質

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962868900P 2019-06-29 2019-06-29
US62/868,900 2019-06-29
US202063009042P 2020-04-13 2020-04-13
US63/009,042 2020-04-13
PCT/CA2020/050897 WO2021000041A1 (en) 2019-06-29 2020-06-26 Ionizable lipids for nucleic acid delivery

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JP2022539089A JP2022539089A (ja) 2022-09-07
JP2022539089A5 JP2022539089A5 (https=) 2023-07-04
JPWO2021000041A5 JPWO2021000041A5 (https=) 2023-07-04
JP7420841B2 true JP7420841B2 (ja) 2024-01-23

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JP2024002304A Active JP7667327B2 (ja) 2019-06-29 2024-01-11 核酸送達のためのイオン化可能な脂質
JP2025065109A Pending JP2025105627A (ja) 2019-06-29 2025-04-10 核酸送達のためのイオン化可能な脂質

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US (1) US20220378917A1 (https=)
EP (1) EP3990441A4 (https=)
JP (3) JP7420841B2 (https=)
KR (2) KR102928289B1 (https=)
CN (1) CN115279743B (https=)
CA (1) CA3143578A1 (https=)
WO (1) WO2021000041A1 (https=)

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CA3112837A1 (en) * 2018-10-19 2020-04-23 Translate Bio, Inc. Pumpless encapsulation of messenger rna
CZ310613B6 (cs) * 2020-09-23 2026-01-28 Ústav organické chemie a biochemie AV ČR, v. v. i. Lipidoidy pro transfekci nukleových kyselin a jejich použití
IL303195A (en) 2020-11-25 2023-07-01 Akagera Medicines Inc Lipid nanoparticles for delivery of nucleic acids and related methods of use
CN113993839B (zh) * 2021-02-05 2024-02-09 嘉晨西海(杭州)生物技术有限公司 一种可离子化脂质分子、其制备方法及其在制备脂质纳米颗粒中的应用
CN112961065B (zh) * 2021-02-05 2023-03-14 嘉晨西海(杭州)生物技术有限公司 一种可电离脂质分子及其制备方法及其在制备脂质纳米颗粒的应用
CN114149337B (zh) * 2021-07-07 2022-04-29 天津键凯科技有限公司 一种用于核酸递送的新型可电离脂质及其lnp组合物
KR20230017730A (ko) 2021-07-27 2023-02-06 에스케이바이오사이언스(주) 단백질 발현을 위한 mRNA와 이를 위한 주형
TW202328067A (zh) 2021-09-14 2023-07-16 美商雷納嘉德醫療管理公司 環狀脂質及其使用方法
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