KR102928289B1 - 핵산 전달을 위한 이온화 가능한 지질 - Google Patents

핵산 전달을 위한 이온화 가능한 지질

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Publication number
KR102928289B1
KR102928289B1 KR1020227003336A KR20227003336A KR102928289B1 KR 102928289 B1 KR102928289 B1 KR 102928289B1 KR 1020227003336 A KR1020227003336 A KR 1020227003336A KR 20227003336 A KR20227003336 A KR 20227003336A KR 102928289 B1 KR102928289 B1 KR 102928289B1
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pni
lipid
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KR20220042361A (ko
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아니타 토마스
니키타 자인
앤드류 윌리엄 브라운
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글로벌 라이프 사이언시즈 솔루션즈 캐나다 유엘씨
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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    • C07D307/20—Oxygen atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C12N15/09—Recombinant DNA-technology
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    • A61K2039/515—Animal cells
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    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
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  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020227003336A 2019-06-29 2020-06-26 핵산 전달을 위한 이온화 가능한 지질 Active KR102928289B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020267004502A KR20260033101A (ko) 2019-06-29 2020-06-26 핵산 전달을 위한 이온화 가능한 지질

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962868900P 2019-06-29 2019-06-29
US62/868,900 2019-06-29
US202063009042P 2020-04-13 2020-04-13
US63/009,042 2020-04-13
PCT/CA2020/050897 WO2021000041A1 (en) 2019-06-29 2020-06-26 Ionizable lipids for nucleic acid delivery

Related Child Applications (1)

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KR1020267004502A Division KR20260033101A (ko) 2019-06-29 2020-06-26 핵산 전달을 위한 이온화 가능한 지질

Publications (2)

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KR20220042361A KR20220042361A (ko) 2022-04-05
KR102928289B1 true KR102928289B1 (ko) 2026-02-20

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KR1020267004502A Pending KR20260033101A (ko) 2019-06-29 2020-06-26 핵산 전달을 위한 이온화 가능한 지질

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US (1) US20220378917A1 (https=)
EP (1) EP3990441A4 (https=)
JP (3) JP7420841B2 (https=)
KR (2) KR102928289B1 (https=)
CN (1) CN115279743B (https=)
CA (1) CA3143578A1 (https=)
WO (1) WO2021000041A1 (https=)

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CA3112837A1 (en) * 2018-10-19 2020-04-23 Translate Bio, Inc. Pumpless encapsulation of messenger rna
CZ310613B6 (cs) * 2020-09-23 2026-01-28 Ústav organické chemie a biochemie AV ČR, v. v. i. Lipidoidy pro transfekci nukleových kyselin a jejich použití
IL303195A (en) 2020-11-25 2023-07-01 Akagera Medicines Inc Lipid nanoparticles for delivery of nucleic acids and related methods of use
CN113993839B (zh) * 2021-02-05 2024-02-09 嘉晨西海(杭州)生物技术有限公司 一种可离子化脂质分子、其制备方法及其在制备脂质纳米颗粒中的应用
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TW202328067A (zh) 2021-09-14 2023-07-16 美商雷納嘉德醫療管理公司 環狀脂質及其使用方法
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