JP7383635B2 - 置換されたベンゾフラン、ベンゾピロール、ベンゾチオフェン、及び構造的に関連する補体阻害剤 - Google Patents
置換されたベンゾフラン、ベンゾピロール、ベンゾチオフェン、及び構造的に関連する補体阻害剤 Download PDFInfo
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- JP7383635B2 JP7383635B2 JP2020554437A JP2020554437A JP7383635B2 JP 7383635 B2 JP7383635 B2 JP 7383635B2 JP 2020554437 A JP2020554437 A JP 2020554437A JP 2020554437 A JP2020554437 A JP 2020554437A JP 7383635 B2 JP7383635 B2 JP 7383635B2
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- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/4164—1,3-Diazoles
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- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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| JP2022552186A (ja) * | 2019-10-09 | 2022-12-15 | バイオクリスト ファーマスーティカルズ,インコーポレイテッド | 経口補体d因子阻害剤 |
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| KR102925481B1 (ko) * | 2023-09-05 | 2026-02-10 | 광주과학기술원 | 신규 화합물 및 이의 건선 치료 용도 |
| WO2025080823A1 (en) | 2023-10-11 | 2025-04-17 | Regeneron Pharmaceuticals, Inc. | Treatment of macular degeneration with complement factor d (cfd) inhibitors |
| CN119504834B (zh) * | 2024-11-21 | 2025-10-17 | 南开大学 | 一种以含硅基团为疏水标签的pd-l1蛋白降解剂及其制备方法、药物组合物和应用 |
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| JP7741798B2 (ja) | 2019-10-09 | 2025-09-18 | バイオクリスト ファーマスーティカルズ,インコーポレイテッド | 経口補体d因子阻害剤 |
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