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Definitions

• the complement system is a branch of an organism’s immune system that enhances the ability of antibodies and phagocytic cells to destroy and remove foreign particles (e.g., pathogens) from the organism.
• the complement system comprises a set of plasma proteins that act together to attack extracellular forms of pathogens and induce a series of
• Complement activation can occur through several pathways. For example, complement activation can occur spontaneously in response to certain pathogens or by antibody binding to a pathogen. When complement proteins are activated a cascade is triggered by which one complement protein induces the activation of the next protein in the sequence. The activation of a small number of complement proteins at the start of the pathway is hugely amplified by each successive enzymatic reaction, resulting in the rapid generation of a disproportionately large complement response. (Marrides, S. Pharmacological Reviews 1998, Vol. 50, pages 59-88). In healthy organisms there are regulatory mechanisms to prevent uncontrolled complement activation.
• complement proteins When activated, complement proteins can bind to a pathogen, opsonizing them for engulfment by phagocytes bearing receptors for complement. Then, small fragments of some complement proteins act as chemoattractants to recruit more phagocytes to the site of complement activation, and also to activate these phagocytes. Next, the complement proteins create holes or pores in the invading organisms, leading to their destruction. While complement plays an important role in protecting the body from foreign organisms, it can also destroy healthy cells and tissue. The inappropriate activation of complement is implicated in a long list of disease pathologies (Morgan, B. Eur J Clin Invest 1994, Vol. 24, pages 219-228) affecting the immune, renal, cardiovascular, and neurological systems.
• the invention provides compounds having the structure of formula (I), and pharmaceutically acceptable salts and prodrugs thereof:
• aryl, heteroaryl, cycloalkyl, or heterocycloalkyl wherein: aryl, heteroaryl, cycloalkyl, or heterocycloalkyl; aryl, heteroaryl, heterocycloalkyl, or cycloalkyl; aryl or heteroaryl;
• R a is halogen, cyano, hydroxy, -NH2, -NH(Ac), - NH(alkyl), -NH(cycloalkyl), -NH(heterocycloalkyl), -NH(aryl), - NH(heteroaryl), -N(alkyl) 2 , -NHC(0)(alkyl), -CH(alkyl)NH2, - CH(hydroxyalkyl)NH2, -CH(haloalkyl)NH2, -CH(cycloalkyl)NH2, - CH(heterocycloalkyl)NH2, -CH(aryl)NH2, -CH(heteroaryl)NH2, - CH 2 NHC(0)(alkyl), -C(0)NH 2 , -C(0)(alkyl), -SO2NH2, -S0 2 (cydoalkyl), - S02(heterocycloalkyl), -S02(al
• R b independently for each occurrence, is halogen, cyano, -CH2(OCH2CH2)qOCH 3 , - alkylene-(branched or unbranched polyethylene glycol), -alkylene-O- (branched or unbranched polyethylene glycol), or -NR J R k ; or is selected from the group consisting of substituted or unsubstituted alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, (hydroxy)haloalkyl, hydroxy(cycloalkyl)alkyl, (cycloalkyl)alkyl, (heterocycloalkyl)alkyl, arylalkyl, heteroarylalkyl, (heteroarylalkoxy)alkyl, (arylalkoxy)alkyl, (aryloxy)alkyl, ((cycloalkyl)alkoxy)alkyl, ((heterocycloalkyl)alkoxy)alkyl,
• R c independently for each occurrence, is selected from the group consisting of
• R 1 is selected from the group consisting of -NH2, -COOH, -CH2COOH,
• cycloalkyl))COOH -CH(NH(CO)(heteroaryl substituted cycloalkyl))COOH, - CH(S(alkyl))COOH, -CO(NH)CH2(substituted or unsubstituted aryl), - CO(NH)CH2(substituted or unsubstituted heteroaryl), -CO(NH)(substituted or unsubstituted aryl), -CO(NH)(substituted or unsubstituted heteroaryl), and - CH2(tetrazolyl);
• n 0, 1, 2, 3, or 4;
• n 0, 1, 2, 3, or 4;
• p 0, 1, 2, 3, or 4;
• q is an integer from 1-20;
• J is -C(O)-, -NH-, -CH2-, -0-, -S-, -S(O)-, -SO2-, -N(alkyl)-, -CH(alkyl)-, -
• K is -C(O)-, -NH-, -CH2-, -0-, -S-, -S(O)-, -SO2-, -N(alkyl)-, -CH(alkyl)-, - CH(cycloalkyl)-, -N((C(0)0)arylalkyl)-, -N((C(0)0)heteroarylalkyl)-, or - N(C(0)arylalkyl)-;
• J and K is -C(O)-, -CH2-, or -CH(alkyl)-;
• L is selected from the group consisting of a bond, -CH2-, -CH2CH2-, -CHR 2 -,
• R L is H or alkyl
• R 2 is alkyl, cycloalkyl, hydroxyalkyl, or haloalkyl;
• R' and R k are each independently H or are selected from the group consisting of substituted or unsubstituted alkyl, aminoalkyl, (heterocycloalkyl)alkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroaryl alkyl, -CO(aryl), - CO(arylalkyl), -CO(heteroarylalkyl), and -CO((heterocycloalkyl)alkyl);
• U is N or CR 3 ;
• R 3 is H, halogen, alkyl, cycloalkyl, aryl, heteroaryl, alkoxy, haloalkyl, -CN, -CONH2, -CO2H, -CH2CO2H, -Nth, hydroxyalkyl, aminoalkyl, -OH, -NH(alkyl), - N(alkyl)2, thioalkyl, or -S(alkyl);
• V is N, CH, C(halogen), or C(alkyl) ;
• the stereochemical configuration at any chiral center is R , S , or a mixture of R and S.
• the invention provides compounds having the structure of formula (Il-g), and pharmaceutically acceptable salts and prodrugs thereof:
• ring is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl; aryl or heteroaryl;
• R a is halogen, cyano, hydroxy, -Nth, -NH(Ac), - NH(alkyl), -NH(cycloalkyl), -NH(heterocycloalkyl), -NH(aryl), - NH(heteroaryl), -N(alkyl)2, -NHC(0)(alkyl), -CH(alkyl)NH2, - CH(hydroxyalkyl)NH2, -CH(haloalkyl)NH2, -CH(cycloalkyl)NH2, - CH(heterocycloalkyl)NH2, -CH(aryl)NH2, -CH(heteroaryl)NH2, - CH 2 NHC(0)(alkyl), -C(0)Mh, -C(0)(alkyl), -SO2NH2, -S0 2 (cycloalkyl), - S02(heterocycloalkyl), -S02(alkyl), -SO2NH2, -
• T 2 is NR T2 or CR T2 ;
• T 3 is N, CH, NR T3 , or CR T3 ;
• T 1 is CR T1 or NR T1 , wherein R T1 and R T2 , taken together with the intervening atoms, form an optionally substituted cycloalkyl, aryl, or heteroaryl ring;
• T 3 is N or CH;
• T 3 is CR T3 or NR T3 ; wherein R T3 and R T2 , taken together with the intervening atoms, form an optionally substituted heteroaryl ring; and
• T 1 is N or CH
• T 2 is NR T2
• T 3 is N
• T 1 is NR T1 ;
• R 1 is selected from the group consisting of -NH2, -COOH, -CH2COOH,
• cycloalkyl))COOH -CH(NH(CO)(heteroaryl substituted cycloalkyl))COOH, - CH(S(alkyl))COOH, -CO(NH)CH2(substituted or unsubstituted aryl), - CO(NH)CH2(substituted or unsubstituted heteroaryl), -CO(NH)(substituted or unsubstituted aryl), -CO(NH)(substituted or unsubstituted heteroaryl), and - CH2(tetrazolyl);
• n 0, 1, 2, 3, or 4;
• p 0, 1, 2, 3, or 4;
• J is -C(O)-, -NH-, -CH2-, -0-, -S-, -S(O)-, -SO2-, -N(alkyl)-, -CH(alkyl)-, -
• K is -C(O)-, -NH-, -CH2-, -0-, -S-, -S(O)-, -SO2-, -N(alkyl)-, -CH(alkyl)-, - CH(cycloalkyl)-, -N((C(0)0)arylalkyl)-, -N((C(0)0)heteroarylalkyl)-, or - N(C(0)arylalkyl)-;
• R c independently for each occurrence, is selected from the group consisting of
• L is selected from the group consisting of a bond, -CH2-, -CH2CH2-, -CHR 2 -
• R L is H or alkyl; or wherein R L and an occurrence of R c taken together with the intervening atoms form a substituted or unsubstituted heteroaryl ring;
• R 2 is alkyl, cycloalkyl, hydroxyalkyl, or haloalkyl
• V is N or CH; and the stereochemical configuration at any chiral center is R , S, or a mixture of R and S.
• the invention provides compounds having the structure of formula (II), and pharmaceutically acceptable salts and prodrugs thereof:
• R a independently for each occurrence, is selected from the group consisting of halogen, cyano, hydroxy, -NH2, -NH(Ac), -NH(alkyl), -N(alkyl) 2 ,
• T 1 is N, CH, NR T1 , or CR T1 ;
• T 2 is NR T2 or CR T2 ;
• T 3 is N, CH, NR T3 , or CR T3 ;
• T 1 is CR T1 or NR T1 , wherein R T1 and R T2 , taken together with the intervening atoms, form an optionally substituted cycloalkyl, aryl, or heteroaryl ring;
• T 3 is N or CH;
• T 3 is CR T3 or NR T3 ; wherein R T3 and R T2 , taken together with the intervening atoms, form an optionally substituted heteroaryl ring; and T 1 is N or CH; and
• T 2 is NR T2
• T 3 is N
• T 1 is NR T1
• R 1 is selected from the group consisting of -NH2, -CH2COOH,
• p 0, 1, or 2;
• J is -C(0)- -NH-, -CH2-, -0-, -S-, -S(O)-, -SO2-, -N(alkyl)-, or -CH(alkyl)-;
• K is -C(O)-, -NH-, -0-, -CH2-, -S-, -S(O)-, -SO2-, -N(alkyl)-, or -CH(alkyl)-; wherein at least one of J and K is -C(O)-, -CH2-, or -CH(alkyl)-;
• W is N, CH, or CR C ;
• X is N, CH, or CR C ;
• Y is N, CH, or CR C ;
• Z is N, CH, or CR C ;
• R c independently for each occurrence, is selected from the group consisting of
• L is selected from the group consisting of a bond, -CH2-, -CH2CH2-, -CHR 2 -
• R L is H or alkyl
• R 2 is alkyl, hydroxyalkyl, or haloalkyl
• V is N or CH
• the stereochemical configuration at any chiral center is R , S, or a mixture of R and S.
• the invention provides a pharmaceutical composition, comprising a compound of the invention, or a pharmaceutically acceptable salt or prodrug thereof; and a pharmaceutically acceptable carrier.
• the invention provides methods of treating a disease or condition characterized by aberrant complement system activity, comprising administering to a subject in need thereof a therapeutically effective amount of a compound the invention, or a pharmaceutically acceptable salt or prodrug thereof.
• the disease or condition characterized by aberrant complement system activity is an immunological disorder.
• the disease or condition characterized by aberrant complement system activity is a disease of the central nervous system.
• the disease or condition characterized by aberrant complement system activity is a neurodegenerative disease or neurological disease.
• the disease or condition characterized by aberrant complement system activity is a renal disease.
• the disease or condition characterized by aberrant complement system activity is a cardiovascular disease.
• the disease or condition characterized by aberrant complement system activity is selected from the group consisting of paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, organ transplant rejection, myasthenia gravis, neuromyelitis optica, membranoproliferative
• Inhibitors of the complement system are useful in therapeutic methods and
• compositions suitable for use in treating disorders of the immune, renal, cardiovascular, and neurological systems are provided herein.
• compounds of formulae (I) and (II) and pharmaceutically acceptable salts and prodrugs thereof that are useful in treating or preventing a disease or condition characterized by aberrant activity of the complement system.
• heteroatom is art-recognized and refers to an atom of any element other than carbon or hydrogen.
• Illustrative heteroatoms include boron, nitrogen, oxygen, phosphorus, sulfur and selenium, and alternatively oxygen, nitrogen or sulfur.
• alkyl as used herein is a term of art and refers to saturated aliphatic groups, including straight-chain alkyl groups, branched-chain alkyl groups, cycloalkyl (alicyclic) groups, alkyl substituted cycloalkyl groups, and cycloalkyl substituted alkyl groups.
• a straight-chain or branched-chain alkyl has about 30 or fewer carbon atoms in its backbone (e.g., C1-C3 0 for straight chain, C3-C3 0 for branched chain), and alternatively, about 20 or fewer, or 10 or fewer.
• alkyl refers to a C1-C1 0 alkyl group. In certain embodiments, the term“alkyl” refers to a C1-C 6 alkyl group, for example a C1-C 6 straight-chain alkyl group. In certain embodiments, the term“alkyl” refers to a C 3 -C12 branched-chain alkyl group. In certain embodiments, the term“alkyl” refers to a C3-C8 branched-chain alkyl group.
• alkyl include, but are not limited to, methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso- butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, and n-hexyl.
• cycloalkyl means mono- or bicyclic or bridged saturated carbocyclic rings, each having from 3 to 12 carbon atoms. Certain cycloalkyls have from 5-12 carbon atoms in their ring structure, and may have 6-10 carbons in the ring structure. Preferably, cycloalkyl is (C3-C7)cycloalkyl, which represents a monocyclic saturated carbocyclic ring, having from 3 to 7 carbon atoms.
• Examples of monocyclic cycloalkyls include cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, and cyclooctyl.
• Bicyclic cycloalkyl ring systems include bridged monocyclic rings and fused bicyclic rings.
• Bridged monocyclic rings contain a monocyclic cycloalkyl ring where two non-adjacent carbon atoms of the monocyclic ring are linked by an alkylene bridge of between one and three additional carbon atoms (i.e., a bridging group of the form -(CFF)»-, where w is 1, 2, or 3).
• bicyclic ring systems include, but are not limited to, bicyclo[3. l.l]heptane, bicyclo[2.2. l]heptane, bicyclo[2.2.2]octane,
• Fused bicyclic cycloalkyl ring systems contain a monocyclic cycloalkyl ring fused to either a phenyl, a monocyclic cycloalkyl, a monocyclic cycloalkenyl, a monocyclic heterocyclyl, or a monocyclic heteroaryl.
• the bridged or fused bicyclic cycloalkyl is attached to the parent molecular moiety through any carbon atom contained within the monocyclic cycloalkyl ring. Cycloalkyl groups are optionally substituted.
• the fused bicyclic cycloalkyl is a 5 or 6 membered monocyclic cycloalkyl ring fused to either a phenyl ring, a 5 or 6 membered monocyclic cycloalkyl, a 5 or 6 membered monocyclic cycloalkenyl, a 5 or 6 membered monocyclic heterocyclyl, or a 5 or 6 membered monocyclic heteroaryl, wherein the fused bicyclic cycloalkyl is optionally substituted.
• (cycloalkyl)alkyl refers to an alkyl group substituted with one or more cycloalkyl groups.
• An example of cycloalkylalkyl is cyclohexylmethyl group.
• heterocycloalkyl refers to a radical of a non-aromatic ring system, including, but not limited to, monocyclic, bicyclic, and tricyclic rings, which can be completely saturated or which can contain one or more units of unsaturation, for the avoidance of doubt, the degree of unsaturation does not result in an aromatic ring system, and having 3 to 12 atoms including at least one heteroatom, such as nitrogen, oxygen, or sulfur.
• heterocyclic rings aziridinyl, azirinyl, oxiranyl, thiiranyl, thiirenyl, dioxiranyl, diazirinyl, diazepanyl, l,3-dioxanyl, l,3-dioxolanyl, 1,3- dithiolanyl, l,3-dithianyl, imidazolidinyl, isothiazolinyl, isothiazolidinyl, isoxazolinyl, isoxazolidinyl, azetyl, oxetanyl, oxetyl, thietanyl, thietyl, diazetidinyl, dioxetanyl, dioxetenyl, dithietanyl, dithietyl, dioxalany
• heterocycloalkylalkyl refers to an alkyl group substituted with one or more heterocycloalkyl (i.e., heterocyclyl) groups.
• alkenyl as used herein means a straight or branched chain hydrocarbon radical containing from 2 to 10 carbons and containing at least one carbon-carbon double bond formed by the removal of two hydrogens.
• Representative examples of alkenyl include, but are not limited to, ethenyl, 2-propenyl, 2-methyl-2-propenyl, 3-butenyl, 4-pentenyl, 5- hexenyl, 2-heptenyl, 2-methyl- l-heptenyl, and 3-decenyl.
• the unsaturated bond(s) of the alkenyl group can be located anywhere in the moiety and can have either the (Z) or the (E) configuration about the double bond(s).
• alkynyl as used herein means a straight or branched chain hydrocarbon radical containing from 2 to 10 carbon atoms and containing at least one carbon-carbon triple bond.
• Representative examples of alkynyl include, but are not limited, to acetylenyl, 1- propynyl, 2-propynyl, 3-butynyl, 2-pentynyl, and l-butynyl.
• alkylene refers to a disubstituted alkane, i.e., an alkane substituted at two positions with substituents such as halogen, azide, alkyl, arylalkyl, alkenyl, alkynyl, cycloalkyl, hydroxyl, alkoxyl, amino, nitro, sulfhydryl, imino, amido, phosphonate, phosphinate, carbonyl, carboxyl, silyl, ether, alkylthio, sulfonyl, sulfonamido, ketone, aldehyde, ester, heterocyclyl, aromatic or heteroaromatic moieties, fluoroalkyl (such as trifluromethyl), cyano, or the
• amino is a term of art and as used herein refers to both unsubstituted and substituted amines, e.g., a moiety that may be represented by the general formulas:
• Ra, Rb, and R c each independently represent a hydrogen, an alkyl, an
• Rd represents an aryl, a cycloalkyl, a cycloalkenyl, a heterocyclyl or a polycyclyl
• x is zero or an integer in the range of 1 to 8.
• R a or Rb may be a carbonyl, e.g., Ra, Rb, and the nitrogen together do not form an imide.
• R a and Rb each independently represent a hydrogen, an alkyl, an alkenyl, or -(CH2)x-Rd.
• the term“amino” refers to -NFb.
• alkylamino refers to -NH(alkyl).
• dialkylamino refers to -N(alkyl)2.
• acyl is a term of art and as used herein refers to any group or radical of the form RCO- where R is any organic group, e.g., alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl.
• R is any organic group, e.g., alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl.
• Representative acyl groups include acetyl, benzoyl, and malonyl.
• aminoalkyl refers to an alkyl group substituted with one or more one amino groups.
• aminoalkyl refers to an alkyl group substituted with one or more one amino groups.
• aminoacyl is a term of art and as used herein refers to an acyl group substituted with one or more amino groups.
• aminothionyl refers to an analog of an aminoacyl in which the O of RC(O)- has been replaced by sulfur, hence is of the form RC(S)-.
• phosphoryl is a term of art and as used herein may in general be represented by the formula: wherein Q50 represents S or O, and R59 represents hydrogen, a lower alkyl or an aryl; for example, -P(0)(0Me)- or -R(0)(0H) 2.
• R59 represents hydrogen, a lower alkyl or an aryl; for example, -P(0)(0Me)- or -R(0)(0H) 2.
• the phosphoryl group of the phosphorylalkyl may be represented by the general formulas:
• Q50 and R59 each independently, are defined above, and Q51 represents O, S or N; for example, -0-P(0)(0H)0Me or -NH-P(0)(0H)2.
• Q50 is S
• the phosphoryl moiety is a“phosphorothioate.”
• aminophosphoryl refers to a phosphoryl group substituted with at least one amino group, as defined herein; for example, -P(0)(0H)NMe2.
• azide or“azido”, as used herein, means an -N3 group.
• alkylphosphoryl refers to a phosphoryl group substituted with at least one alkyl group, as defined herein; for example, -P(0)(0H)Me.
• alkylthio refers to alkyl-S-.
• (alkylthio)alkyl refers to an alkyl group substituted by an alkylthio group.
• aryl is a term of art and as used herein refers to includes monocyclic, bicyclic and polycyclic aromatic hydrocarbon groups, for example, benzene, naphthalene, anthracene, and pyrene. Typically, an aryl group contains from 6-10 carbon ring atoms (i.e., (C 6 -Cio)aryl).
• the aromatic ring may be substituted at one or more ring positions with one or more substituents, such as halogen, azide, alkyl, arylalkyl, alkenyl, alkynyl, cycloalkyl, hydroxyl, alkoxyl, amino, nitro, sulfhydryl, imino, amido, phosphonate, phosphinate, carbonyl, carboxyl, silyl, ether, alkylthio, sulfonyl, sulfonamido, ketone, aldehyde, ester, heterocyclyl, aromatic or heteroaromatic moieties, fluoroalkyl (such as trifluromethyl), cyano, or the like.
• substituents such as halogen, azide, alkyl, arylalkyl, alkenyl, alkynyl, cycloalkyl, hydroxyl, alkoxyl, amino, nitro, sulfhydryl
• aryl also includes polycyclic ring systems having two or more cyclic rings in which two or more carbons are common to two adjoining rings (the rings are “fused rings”) wherein at least one of the rings is an aromatic hydrocarbon, e.g., the other cyclic rings may be cycloalkyls, cycloalkenyls, cycloalkynyls, aryls, heteroaryls, and/or heterocyclyl s.
• the term“aryl” refers to a phenyl group.
• heteroaryl is a term of art and as used herein refers to a monocyclic, bicyclic, and polycyclic aromatic group having 3 to 12 total atoms including one or more heteroatoms such as nitrogen, oxygen, or sulfur in the ring structure.
• heteroaryl groups include azaindolyl, benzo(b)thienyl, benzimidazolyl, benzofuranyl, benzoxazolyl, benzothiazolyl, benzothiadiazolyl, benzotriazolyl, benzoxadiazolyl, furanyl, imidazolyl, imidazopyridinyl, indolyl, indolinyl, indazolyl, isoindolinyl, isoxazolyl, isothiazolyl, isoquinolinyl, oxadiazolyl, oxazolyl, purinyl, pyranyl, pyrazinyl, pyrazolyl, pyridinyl, pyrimidinyl, pyrrolyl, pyrrolo[2,3-d]pyrimidinyl, pyrazolo[3,4-d]pyrimidinyl, quinolinyl, quinazolinyl, triazolyl, thio
• The“heteroaryl” may be substituted at one or more ring positions with one or more substituents such as halogen, azide, alkyl, arylalkyl, alkenyl, alkynyl, cycloalkyl, hydroxyl, alkoxyl, amino, nitro, sulfhydryl, imino, amido, phosphonate, phosphinate, carbonyl, carboxyl, silyl, ether, alkylthio, sulfonyl, sulfonamido, ketone, aldehyde, ester, heterocyclyl, aromatic or heteroaromatic moieties, fluoroalkyl (such as trifluromethyl), cyano, or the like.
• substituents such as halogen, azide, alkyl, arylalkyl, alkenyl, alkynyl, cycloalkyl, hydroxyl, alkoxyl, amino, nitro, sulf
• heteroaryl also includes polycyclic ring systems having two or more cyclic rings in which two or more carbons are common to two adjoining rings (the rings are“fused rings”) wherein at least one of the rings is an aromatic group having one or more heteroatoms in the ring structure, e.g., the other cyclic rings may be cycloalkyls, cycloalkenyls, cycloalkynyls, aryls, heteroaryls, and/or heterocyclyls.
• aralkyl or“arylalkyl” is a term of art and as used herein refers to an alkyl group substituted with an aryl group, wherein the moiety is appended to the parent molecule through the alkyl group.
• heteroarylkyl or“heteroarylalkyl” is a term of art and as used herein refers to an alkyl group substituted with a heteroaryl group, appended to the parent molecular moiety through the alkyl group.
• alkoxy as used herein means an alkyl group, as defined herein, appended to the parent molecular moiety through an oxygen atom.
• Representative examples of alkoxy include, but are not limited to, methoxy, ethoxy, propoxy, 2-propoxy, butoxy, tert-butoxy, pentyloxy, and hexyloxy.
• alkoxyalkyl refers to an alkyl group substituted by an alkoxy group.
• Representative examples of alkoxycarbonyl include, but are not limited to, methoxycarbonyl, ethoxycarbonyl, and tert- butoxycarbonyl.
• alkylcarbonyl means an alkyl group, as defined herein, appended to the parent molecular moiety through a carbonyl group, as defined herein.
• alkylcarbonyl include, but are not limited to, acetyl, l-oxopropyl, 2, 2-dimethyl- l-oxopropyl, l-oxobutyl, and l-oxopentyl.
• aryl carbonyl means an aryl group, as defined herein, appended to the parent molecular moiety through a carbonyl group, as defined herein.
• arylcarbonyl include, but are not limited to, benzoyl and (2- pyridinyl)carbonyl.
• alkylcarbonyloxy and“arylcarbonyloxy”, as used herein, means an alkylcarbonyl or arylcarbonyl group, as defined herein, appended to the parent molecular moiety through an oxygen atom.
• alkylcarbonyloxy include, but are not limited to, acetyloxy, ethylcarbonyloxy, and tert- butyl carbonyloxy.
• arylcarbonyloxy include, but are not limited to phenyl carbonyloxy.
• alkenoxy or“alkenoxyl” means an alkenyl group, as defined herein, appended to the parent molecular moiety through an oxygen atom.
• aryloxy as used herein means an aryl group, as defined herein, appended to the parent molecular moiety through an oxygen atom.
• heteroaryloxy as used herein means a heteroaryl group, as defined herein, appended to the parent molecular moiety through an oxygen atom.
• carrier means a monocyclic or multicyclic (e.g., bicyclic, tricyclic, etc.) hydrocarbon radical containing from 3 to 12 carbon atoms that is completely saturated or has one or more unsaturated bonds, and for the avoidance of doubt, the degree of unsaturation does not result in an aromatic ring system (e.g., phenyl).
• carbocyclyl groups include 1 -cyclopropyl, 1 -cyclobutyl, 2-cyclopentyl, 1- cyclopentenyl, 3 -cyclohexyl, l-cyclohexenyl and 2-cyclopentenylmethyl.
• cyano is a term of art and as used herein refers to -CN.
• halo is a term of art and as used herein refers to -F, -Cl, -Br, or -I.
• haloalkyl refers to an alkyl group, as defined herein, wherein some or all of the hydrogens are replaced with halogen atoms.
• hydroxy is a term of art and as used herein refers to -OH.
• hydroxyalkyl as used herein, means at least one hydroxy group, as defined herein, is appended to the parent molecular moiety through an alkyl group, as defined herein. Representative examples of hydroxyalkyl include, but are not limited to,
• silyl includes hydrocarbyl derivatives of the silyl (EESi-) group (i.e., (hydrocarbyl)3Si-), wherein a hydrocarbyl groups are univalent groups formed by removing a hydrogen atom from a hydrocarbon, e.g., ethyl, phenyl.
• the hydrocarbyl groups can be combinations of differing groups which can be varied in order to provide a number of silyl groups, such as trimethyl silyl (TMS), tert-butyldiphenylsilyl (TBDPS), tert- butyldimethylsilyl (TBS/TBDMS), triisopropyl silyl (TIPS), and [2- (trimethylsilyl)ethoxy]methyl (SEM).
• TMS trimethyl silyl
• TDPS tert-butyldiphenylsilyl
• TIPS triisopropyl silyl
• SEM [2- (trimethylsilyl)ethoxy]methyl
• silyloxy means a silyl group, as defined herein, is appended to the parent molecule through an oxygen atom.
• compositions of the present invention may exist in particular geometric or stereoisomeric forms.
• compounds of the present invention may also be optically active.
• the present invention contemplates all such compounds, including cis- and /ra//.s-i somers, (R)- and fV)-enantiomers, diastereoi somers, (D)-isomers, (L)-isomers, the racemic mixtures thereof, and other mixtures thereof, as falling within the scope of the invention.
• Additional asymmetric carbon atoms may be present in a substituent such as an alkyl group. All such isomers, as well as mixtures thereof, are intended to be included in this invention.
• a particular enantiomer of compound of the present invention may be prepared by asymmetric synthesis, or by derivation with a chiral auxiliary, where the resulting diastereomeric mixture is separated and the auxiliary group cleaved to provide the pure desired enantiomers.
• the molecule contains a basic functional group, such as amino, or an acidic functional group, such as carboxyl,
• diastereomeric salts are formed with an appropriate optically-active acid or base, followed by resolution of the diastereomers thus formed by fractional crystallization or chromatographic means well known in the art, and subsequent recovery of the pure enantiomers.
• substitution or“substituted with” includes the implicit proviso that such substitution is in accordance with permitted valence of the substituted atom and the substituent, and that the substitution results in a stable compound, e.g., which does not spontaneously undergo transformation such as by rearrangement, fragmentation, decomposition, cyclization, elimination, or other reaction.
• the term“substituted” is also contemplated to include all permissible substituents of organic compounds.
• the permissible substituents include acyclic and cyclic, branched and unbranched, carbocyclic and heterocyclic, aromatic and nonaromatic substituents of organic compounds.
• Illustrative substituents include, for example, those described herein above.
• the permissible substituents may be one or more and the same or different for appropriate organic compounds.
• the heteroatoms such as nitrogen may have hydrogen substituents and/or any permissible substituents of organic compounds described herein which satisfy the valences of the heteroatoms. This invention is not intended to be limited in any manner by the permissible substituents of organic compounds.
• “substituted or unsubstituted” when it precedes a list of chemical moieties means that the list of chemical moieities that follow are each substituted or unsubstituted.
• “substituted or unsubstituted aryl, heteroaryl, and cycloalkyl” means substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and substituted or unsubstituted cycloalkyl.
• protecting group means temporary substituents which protect a potentially reactive functional group from undesired chemical transformations.
• protecting groups include esters of carboxylic acids, silyl ethers of alcohols, and acetals and ketals of aldehydes and ketones, respectively.
• the field of protecting group chemistry has been reviewed (Greene, T.W.; Wuts, P.G.M. Protective Groups in Organic Synthesis , 2 nd ed.; Wiley: New York, 1991). Protected forms of the inventive compounds are included within the scope of this invention.
• salts derived from inorganic or organic acids including, for example, hydrochloric, hydrobromic, sulfuric, nitric, perchloric, phosphoric, formic, acetic, lactic, maleic, fumaric, succinic, tartaric, glycolic, salicylic, citric, methanesulfonic, benzenesulfonic, benzoic, malonic, trifluoroacetic, trichloroacetic, naphthalene-2-sulfonic, and other acids.
• Pharmaceutically acceptable salt forms can include forms wherein the ratio of molecules comprising the salt is not 1 : 1.
• the salt may comprise more than one inorganic or organic acid molecule per molecule of base, such as two hydrochloric acid molecules per molecule of compound of Formula I.
• the salt may comprise less than one inorganic or organic acid molecule per molecule of base, such as two molecules of compound of Formula I per molecule of tartaric acid.
• prodaig refers to a compound that can be metabolized in vivo to provide a compound of formula I or II
• prodrugs include compounds that can be prepared by modifying one or more functional groups in a compound of formula 1 or II to provide a corresponding compound that can be metabolized in vivo to provide a compound of formula I or II.
• modifications are known in the art.
• Prodrug forms of a compound bearing various nitrogen-containing functional groups may include the following types of derivatives, where each Rp group individually may be hydrogen, substituted or unsubstituted alkyl, aryl, alkenyl, alkynyi, heterocycle, alkylatyl, aryl alkyl, aralkenyi, araikyny!, cycloalkyl or cycloalkenyl .
• Prodrug forms of carboxyl-bearing compounds include esters (— CChRm), where the Ra group corresponds to any alcohol whose release in the body through enzymatic or hydrolytic processes would be at pharmaceutically acceptable levels.
• esters — CChRm
• Another prodaig derived from a carboxylic acid form of the disclosure may be a cjuaternary salt type of structure described by Bodor et al, J. Med. Chem. 1980, 23, 469
• carrier and“pharmaceutically acceptable carrier” as used herein refer to a diluent, adjuvant, excipient, or vehicle with which a compound is administered or formulated for administration.
• pharmaceutically acceptable carriers include liquids, such as water, saline, and oils; and solids, such as gum acacia, gelatin, starch paste, talc, keratin, colloidal silica, urea, and the like.
• auxiliary, stabilizing, thickening, lubricating, flavoring, and coloring agents may be used.
• suitable pharmaceutical carriers are described in Remington’s Pharmaceutical Sciences by E.W. Martin, herein incorporated by reference in its entirety.
• “treat” as used herein means prevent, halt or slow the progression of, or eliminate a disease or condition in a subject. In one embodiment“treat” means halt or slow the progression of, or eliminate a disease or condition in a subject. In one embodiment,
• treat means reduce at least one objective manifestation of a disease or condition in a subject.
• an effective amount refers to an amount that is sufficient to bring about a desired biological effect.
• terapéuticaally effective amount refers to an amount that is sufficient to bring about a desired therapeutic effect.
• inhibitor means decrease by an objectively measurable amount or extent. In various embodiments“inhibit” means decrease by at least 5, 10, 20, 30, 40, 50, 60, 70, 80, 90, or 95 percent compared to relevant control. In one embodiment “inhibit” means decrease 100 percent, i.e., halt or eliminate.
• a subject refers to a mammal.
• a subject is a mouse, rat, rabbit, cat, dog, pig, sheep, horse, cow, or non-human primate.
• a subject is a human.
• the present invention provides compounds having the structure of Formula (I), and pharmaceutically acceptable salts or prodrugs thereof:
• ring is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl
• ring is aryl, heteroaryl, heterocycloalkyl, or cycloalkyl
• ring aryl or heteroaryl
• R a is halogen, cyano, hydroxy, -NH2, -NH(Ac), - NH(alkyl), -NH(cycloalkyl), -NH(heterocycloalkyl), -NH(aryl), - NH(heteroaryl), -N(alkyl) 2 , -NHC(0)(alkyl), -CH(alkyl)NH2, - CH(hydroxyalkyl)NH2, -CH(haloalkyl)NH2, -CH(cycloalkyl)NH2, - CH(heterocycloalkyl)NH2, -CH(aryl)NH2, -CH(heteroaryl)NH2, - CH 2 NHC(0)(alkyl), -C(0)NH 2 , -C(0)(alkyl), -SO2NH2, -S0 2 (cycloalkyl), - S02(heterocycloalkyl), -S02(alkyl), -S02(al
• R b independently for each occurrence, is halogen, cyano, -CFhtOCFhCFhXiOCFh, - alkylene-(branched or unbranched polyethylene glycol), -alkylene-O- (branched or unbranched polyethylene glycol), or -NR J R k ; or is selected from the group consisting of substituted or unsubstituted alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, (hydroxy)haloalkyl, hydroxy(cycloalkyl)alkyl, (cycloalkyl)alkyl, (heterocycloalkyl)alkyl, arylalkyl, heteroarylalkyl, (heteroarylalkoxy)alkyl, (arylalkoxy)alkyl, (aryloxy)alkyl,
• R c independently for each occurrence, is selected from the group consisting of
• R 1 is selected from the group consisting of -NH2, -COOH, -CH2COOH,
• cycloalkyl))COOH -CH(NH(CO)(heteroaryl substituted cycloalkyl))COOH, - CH(S(alkyl))COOH, -CO(NH)CH2(substituted or unsubstituted aryl), - CO(NH)CH2(substituted or unsubstituted heteroaryl), -CO(NH)(substituted or unsubstituted aryl), -CO(NH)(substituted or unsubstituted heteroaryl), and - CH2(tetrazolyl);
• n 0, 1, 2, 3, or 4;
• n 0, 1, 2, 3, or 4;
• p 0, 1, 2, 3, or 4;
• q is an integer from 1-20;
• J is -C(O)-, -NH-, -CH2-, -0-, -S-, -S(O)-, -SO2-, -N(alkyl)-, -CH(alkyl)-, -
• K is -C(O)-, -NH-, -CH2-, -0-, -S-, -S(O)-, -SO2-, -N(alkyl)-, -CH(alkyl)-, - CH(cycloalkyl)-, -N((C(0)0)arylalkyl)-, -N((C(0)0)heteroarylalkyl)-, or - N(C(0)arylalkyl)-;
• J and K is -C(O)-, -CH2-, or -CH(alkyl)-;
• L is selected from the group consisting of a bond, -CH2-, -CH2CH2-, -CHR 2 -,
• R L is H or alkyl
• R 2 is alkyl, cycloalkyl, hydroxyalkyl, or haloalkyl
• R J and R k are each independently H or are selected from the group consisting of
• alkyl substituted or unsubstituted alkyl, aminoalkyl, (heterocycloalkyl)alkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroaryl alkyl, -CO(aryl), - CO(arylalkyl), -CO(heteroarylalkyl), and -CO((heterocycloalkyl)alkyl);
• U is N or CR 3 ;
• R 3 is H, halogen, alkyl, cycloalkyl, aryl, heteroaryl, alkoxy, haloalkyl, -CN, -CONH2, -CO2H, -CH2CO2H, -NH2, hydroxyalkyl, aminoalkyl, -OH, -NH(alkyl), - N(alkyl)2, thioalkyl, or -S(alkyl);
• V is N, CH, C(halogen), or C(alkyl);
• the stereochemical configuration at any chiral center is R , S, or a mixture of R and S.
• the compound of formula (I) has the structure of formula (la):
• W is N, CH, or CR C ;
• X is N, CH, or CR C ;
• Y is N, CH, or CR C ;
• Z is N, CH, or CR C .
• ring is napthyl, indenyl, cyclopentyl, pyrrolidinyl, phenyl, benzofuranyl, thiophenyl, or pyridinyl.
• ring is phenyl, thiophenyl, or pyridinyl, preferably phenyl.
• the compound of formula (I) has the structure of formula
• R a is halogen, cyano, hydroxy, -NH2, -NH(Ac), - NH(alkyl), -N(alkyl) 2 , -NHC(0)(alkyl), -CH 2 NHC(0)(alkyl), -C(0)NH 2 , or -C(0)(alkyl); or is selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl, alkoxy, alkyl, (cycloalkyl)alkyl, hydroxyalkyl, aminoalkyl, and haloalkyl.
• R a is halogen, cyano, -NH 2 , -NH(Ac), -C(0)CH 3 , - C(0)NH 2 , hydroxymethyl, or substituted or unsubstituted aryl, heteroaryl, cycloalkyl, alkoxy, alkyl, or aminoalkyl.
• R a is halogen, -NH(Ac), -C(0)CH 3 , or substituted or unsubstituted aryl, heteroaryl, cycloalkyl, alkoxy, alkyl, or aminoalkyl. In further such embodiments, R a is alkyl, cycloalkyl, or halogen.
• p is 0.
• R 1 is -CH 2 COOH.
• R 1 is -CO(NH)CH 2 (substituted or unsubstituted aryl).
• J is -C(O)-, -NH-, -CH 2- , -0-, -S-, -S(O)-, -S0 2- , -N(alkyl)-, -CH(alkyl)-, or - N(C(0)arylalkyl)-;
• K is -C(O)-, -NH-, -0-, -CH 2- , -S-, -S(O)-, -S0 2- , -N(alkyl)-, -CH(alkyl)-, or - N(C(0)arylalkyl)-.
• -J-K- is selected from the group consisting of-C(0)-NH- - NH-C(O)-, and -CH 2 0-, preferably -CH 2 0-
• U is N or CR 3
• R 3 is H, halogen, alkyl, cycloalkyl, aryl, heteroaryl, alkoxy, or haloalkyl.
• U is CH.
• V is CH.
• U is CR 3 and R 3 is H, halogen, alkyl, alkoxy, or haloalkyl.
• the compound of formula (I) has the structure of formula (Ic):
• the compound of formula (I) has the structure of formula (Id):
• the compound of formula (I) has the structure of formula
• the compound of formula (I) has the structure of formula
• ring may be heteroaryl.
• ring is furyl, oxazolyl, isoxazolyl, thiophenyl, pyrrolyl, pyrazolyl, or imidazolyl.
• ring is furyl, thiophenyl, or pyrrolyl, preferably furyl.
• m is 0.
• R b independently for each occurrence, is halogen, cyano, -CFbCOCFbCFbXiOCFh, or -NR J R k ; or is selected from the group consisting of substituted or unsubstituted alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, (hydroxy)haloalkyl, hydroxy(cycloalkyl)alkyl, (cycloalkyl)alkyl,
• heterocycloalkyl alkyl
• arylalkyl heteroarylalkyl
• heteroarylalkoxy alkyl
• arylalkoxy alkyl
• aryloxy alkyl
• cycloalkyl heterocycloalkyl, aryl, heteroaryl, -alkylene-NR J R k , tosyl, - S02(alkyl), -S02(cycloalkyl), -CO(alkyl), -CO(cycloalkyl), -CONH(alkyl), - CONH(arylalkyl), -CON(alkyl)2, and -CONH(cycloalkyl).
• q is an integer from 1-5.
• R b is selected from the group consisting of substituted or unsubstituted alkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, haloalkyl, and (cycloalkyl)alkyl.
• R b is substituted or unsubstituted -alkylene-NR i R k .
• m is 2. In certain such embodiments, each R b is alkyl.
• each of W, X, Y, and Z is CH.
• At least one of W, X, Y, and Z is CR C .
• Z may be CR C and/or Y may be CR C .
• R c is selected from the group consisting of halogen, -OH, -NR J R k , alkoxy, and alkyl.
• R c is halogen, e.g., fluoride.
• At least one of W, X, Y, and Z is N.
• Z may be N.
• Y may be N.
• L is selected from the group consisting of a bond, -CH2-, -
• L is -CH2-.
• ring is aryl, heteroaryl, heterocycloalkyl, or cycloalkyl; ring aryl or heteroaryl;
• R a independently for each occurrence, is selected from the group consisting of
• R b independently for each occurrence, is selected from the group consisting of
• halogen cyano, -NR J R k , alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl,
• heterocycloalkyl alkyl
• arylalkyl arylalkyl
• heteroarylalkyl cycloalkyl
• heterocycloalkyl optionally substituted aryl, optionally substituted heteroaryl, -alkylene-NR-R ⁇ tosyl, -S0 2 (alkyl), -S0 2 (cycloalkyl),
• R c independently for each occurrence, is selected from the group consisting of
• R 1 is selected from the group consisting of -NH 2 , -CH 2 COOH,
• n 0, 1, or 2;
• n 0, 1, or 2;
• p 0, 1, or 2;
• J is -C(O)-, -NH-, -CH 2- , -0-, -S-, -S(O)-, -S0 2- , -N(alkyl)-, or -CH(alkyl)-;
• K is -C(O)-, -NH-, -0-, -CH 2- , -S-, -S(O)-, -S0 2- , -N(alkyl)-, or -CH(alkyl)-; wherein at least one of J and K is -C(O)-, -CH 2- , or -CH(alkyl)-;
• L is selected from the group consisting of a bond, -CH 2- , -CH 2 CH 2- , -CHR 2 -,
• R L is H or alkyl; or wherein R L and an occurrence of R c taken together with the intervening atoms form a substituted or unsubstituted heteroaryl ring;
• R 2 is alkyl, hydroxyalkyl, or haloalkyl
• R 1 and R k are each independently selected from the group consisting of H, alkyl, aminoalkyl, (heterocycloalkyl)alkyl, and heterocycloalkyl;
• U is N or CR 3 ;
• R 3 is H, halogen, alkyl, alkoxy, or haloalkyl
• V is N or CH.
• the compound of formula (I) is selected from the following table of compounds, and pharmaceutically acceptable salts and prodrugs thereof:
• the invention provides compounds having the structure of Formula (Il-g), or a pharmaceutically acceptable salt or prodrug thereof:
• R a is halogen, cyano, hydroxy, -NH2, -NH(Ac), NH(alkyl), -NH(cycloalkyl), -NH(heterocycloalkyl), -NH(aryl), - NH(heteroaryl), -N(alkyl) 2 , -NHC(0)(alkyl), -CH(alkyl)NH2, - CH(hydroxyalkyl)NH2, -CH(haloalkyl)NH2, -CH(cycloalkyl)NH2, - CH(heterocycloalkyl)NH2, -CH(aryl)NH2, -CH(heteroaryl)NH2, - CH 2 NHC(0)(alkyl), -C(0)NH 2 , -C(0)(alkyl), -SO2NH2, -S0 2 (cycloalkyl), - S02(heterocycloalkyl), -S02(alkyl), -SO2NH2, -
• T 1 is N, CH, NR T1 , or CR T1 ;
• T 2 is NR T2 or CR T2 ;
• T 3 is N, CH, NR T3 , or CR T3 ;
• T 1 is CR T1 or NR T1 , wherein R T1 and R T2 , taken together with the intervening atoms, form an optionally substituted cycloalkyl, aryl, or heteroaryl ring;
• T 3 is N or CH;
• T 3 is CR T3 or NR T3 ; wherein R T3 and R T2 , taken together with the intervening atoms, form an optionally substituted heteroaryl ring; and
• T 1 is N or CH
• T 2 is NR T2
• T 3 is N
• T 1 is NR T1 ;
• R 1 is selected from the group consisting of -NH2, -COOH, -CH2COOH,
• cycloalkyl))COOH -CH(NH(CO)(heteroaryl substituted cycloalkyl))COOH, - CH(S(alkyl))COOH, -CO(NH)CH2(substituted or unsubstituted aryl), - CO(NH)CH2(substituted or unsubstituted heteroaryl), -CO(NH)(substituted or unsubstituted aryl), -CO(NH)(substituted or unsubstituted heteroaryl), and - CH2(tetrazolyl);
• n 0, 1, 2, 3, or 4;
• p 0, 1, 2, 3, or 4;
• J is -C(O)-, -NH-, -CH2-, -0-, -S-, -S(O)-, -SO2-, -N(alkyl)-, -CH(alkyl)-, -
• K is -C(O)-, -NH-, -CH2-, -0-, -S-, -S(O)-, -SO2-, -N(alkyl)-, -CH(alkyl)-, - CH(cycloalkyl)-, -N((C(0)0)arylalkyl)-, -N((C(0)0)heteroarylalkyl)-, or - N(C(0)arylalkyl)-;
• R c independently for each occurrence, is selected from the group consisting of halogen, -OH, -NR J R k , alkoxy, alkyl, cycloalkyl, and heterocycloalkyl;
• L is selected from the group consisting of a bond, -CH2-, -CH2CH2-, -CHR 2 -,
• R L is H or alkyl
• R 2 is alkyl, cycloalkyl, hydroxyalkyl, or haloalkyl
• V is N or CH
• the stereochemical configuration at any chiral center is R , S, or a mixture of R and S.
• the invention provides compounds having the structure of Formula (II), or a pharmaceutically acceptable salt or prodrug thereof:
• R a independently for each occurrence, is selected from the group consisting of halogen, cyano, hydroxy, -NH2, -NH(Ac), -NH(alkyl), -N(alkyl)2,
• T 1 is N, CH, NR T1 , or CR T1 ;
• T 2 is NR T2 or CR T2 ;
• T 3 is N, CH, NR T3 , or CR T3 ;
• T 1 is CR T 1 or NR T1 , wherein R T1 and R T2 , taken together with the intervening atoms, form an optionally substituted cycloalkyl, aryl, or heteroaryl ring; and
• T 3 is N or CH;
• T 3 is CR T3 or NR T3 ; wherein R T3 and R T2 , taken together with the intervening atoms, form an optionally substituted heteroaryl ring; and
• T 1 is N or CH
• T 2 is NR T2
• T 3 is N
• T 1 is NR T1 ;
• R 1 is selected from the group consisting of -NH2, -CH2COOH,
• p 0, 1, or 2;
• J is -C(O)-, -NH-, -CH2-, -0-, -S-, -S(O)-, -SO2-, -N(alkyl)-, or -CH(alkyl)-;
• K is -C(O)-, -NH-, -0-, -CH2-, -S-, -S(O)-, -SO2-, -N(alkyl)-, or -CH(alkyl)-; wherein at least one of J and K is -C(O)-, -CH2-, or -CH(alkyl)-;
• W is N, CH, or CR C ;
• X is N, CH, or CR C ;
• Y is N, CH, or CR C ;
• Z is N, CH, or CR C ;
• R c independently for each occurrence, is selected from the group consisting of
• L is selected from the group consisting of a bond, -CH2-, -CH2CH2-, -CHR 2 -
• R L is H or alkyl
• R 2 is alkyl, hydroxyalkyl, or haloalkyl
• V is N or CH
• the stereochemical configuration at any chiral center is R , S , or a mixture of R and S.
• ring (T) is phenyl, thiophenyl, furyl, pyrazole, or pyridinyl, preferably phenyl.
• the compound of formula (II) has the structure of formula
• p is 1.
• R a is alkyl or alkoxy.
• p is 0.
• R 1 is -CH2COOH.
• -J-K- is selected from the group consisting of -C(0)-NH- - NH-C(O)-, and -CH2O-, preferably -CH2O-.
• U is CH.
• V is CH.
• each of W, X, Y, and Z is CH.
• At least one of W, X, Y, and Z is CR C .
• Z may be CR C and/or Y may be CR C .
• R c is halogen, e.g., fluoride.
• At least one of W, X, Y, and Z is N.
• Z may be N.
• Y may be N.
• L is -CH2-.
• T 1 is CR T1 ; and R T1 and R T2 , taken together with the intervening atoms, form an optionally substituted heteroaryl ring, such as pyrrole, imidazole, or 1,2, 4-triazole.
• T 3 is CR T3 ; and R T3 and R T2 , taken together with the intervening atoms, form an optionally substituted heteroaryl ring, such as pyrrole, imidazole, 1,2, 4-triazole, or pyridine.
• the compound of formula (II) is selected from the following table of compounds, and pharmaceutically acceptable salts and prodrugs thereof:
• compositions each comprising one or more compounds of the invention, or pharmaceutically acceptable salts or prodrugs thereof, and a pharmaceutically acceptable carrier.
• the pharmaceutical compositions each comprising one or more compounds of the invention, or pharmaceutically acceptable salts or prodrugs thereof, and a pharmaceutically acceptable carrier.
• the pharmaceutical compositions each comprising one or more compounds of the invention, or pharmaceutically acceptable salts or prodrugs thereof, and a pharmaceutically acceptable carrier.
• the pharmaceutical compositions each comprising one or more compounds of the invention, or pharmaceutically acceptable salts or prodrugs thereof, and a pharmaceutically acceptable carrier.
• composition comprises a compound of the invention, or a pharmaceutically acceptable salt or prodrug thereof, and a pharmaceutically acceptable carrier.
• pharmaceutical composition comprises a plurality of compounds of the invention, which may include pharmaceutically acceptable salts and/or prodrugs thereof, and a pharmaceutically acceptable carrier.
• a pharmaceutical composition of the invention further comprises at least one additional pharmaceutically active agent other than a compound of the invention.
• the at least one additional pharmaceutically active agent can be an agent useful in the treatment of a disease or condition characterized by aberrant complement system activity.
• compositions of the invention can be prepared by combining one or more compounds of the invention with a pharmaceutically acceptable carrier and, optionally, one or more additional pharmaceutically active agents.
• the present invention provides compounds, and pharmaceutically acceptable salts and prodrugs thereof, that are useful for treating or preventing a disease or condition
• the invention provides a compound of the invention, or a pharmaceutically acceptable salt or prodrug thereof, for use as a medicament.
• the invention provides methods of treating or preventing a disease or condition characterized by aberrant complement system activity.
• the method includes the step of administering to a subject in need thereof a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt or prodrug thereof, thereby treating or preventing the disease or condition characterized by aberrant complement system activity.
• a compound of the invention or a pharmaceutically acceptable salt or prodrug thereof.
• the invention provides a compound of the invention, or a pharmaceutically acceptable salt or prodrug thereof, for treatment of a disease or condition characterized by aberrant complement system activity.
• the invention provides the use of a compound of the invention, or a pharmaceutically acceptable salt or prodrug thereof, for the manufacture of a medicament for use in treatment of a disease or condition characterized by aberrant complement system activity.
• a“disease or condition characterized by aberrant complement system activity” refers to any disease or condition in which it is desirable to reduce complement system activity. For example, it may be desirable to reduce complement system activity in the setting of inappropriate activation or hyperactivation of the complement system.
• the disease or condition characterized by aberrant complement system activity is an immunological disorder.
• the disease or condition characterized by aberrant complement system activity is a disease of the central nervous system.
• the disease or condition characterized by aberrant complement system activity is a renal disease.
• the disease or condition characterized by aberrant complement system activity is a cardiovascular disease.
• the disease or condition characterized by aberrant complement system activity is a neurodegenerative disease or neurological disease
• the disease or condition characterized by aberrant complement system activity is selected from the group consisting of paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, organ transplant rejection, myasthenia gravis, neuromyelitis optica, membranoproliferative glomerulonephritis, dense-deposit disease, cold agglutinin disease, and catastrophic antiphospholipid syndrome.
• the disease or condition is paroxysmal nocturnal
• the disease or condition is atypical hemolytic uremic syndrome.
• the disease or condition is organ transplant rejection. In certain embodiments, the disease or condition is myasthenia gravis.
• the disease or condition is neuromyelitis optica.
• the disease or condition is membranoproliferative gl omerul onephriti s .
• the disease or condition is dense-deposit disease.
• the disease or condition is cold agglutinin disease.
• the disease or condition is catastrophic antiphospholipid syndrome.
• the disease or condition characterized by aberrant complement system activity is adult respiratory distress syndrome, myocardial infarct, lung inflammation, hyperacute rejection (transplantation rejection), sepsis, cardiopulmonary bypass, burns, asthma, restenosis, multiple organ dysfunction syndrome, Guillain-Barre syndrome, hemorrhagic shock, paroxysmal nocturnal hemoglobinuria, glomerulonephritis, systemic lupus erythematosus, rheumatoid arthritis, infertility, Alzheimer’s disease, organ rejection (transplantation), myasthenia gravis, multiple sclerosis, platelet storage, or hemodialysis.
• the disease or condition characterized by aberrant complement system activity is selected from the group consisting of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), warm autoimmune hemolytic anemia, IgA
• the disease or condition characterized by aberrant complement system activity is a hematological disorder.
• the disease or condition characterized by aberrant complement system activity is an ocular disorder or an eye disorder.
• the disease or condition characterized by aberrant complement system activity is macular degeneration, age-related macular degeneration (AMD), macular edema, diabetic macular edema, choroidal neovascularization (CNV), uveitis, Behcet’s uveitis, proliferative diabetic retinopathy, non-proliferative diabetic retinopathy, glaucoma, hypertensive retinopathy, a corneal neovascularization disease, post- corneal transplant rejection, a corneal dystrophic disease, an autoimmune dry eye disease, Stevens- Johnson syndrome, Sjogren’s syndrome, an environmental dry eye disease, Fuchs’ endothelial dystrophy, retinal vein occlusion, or post-operative inflammation.
• AMD age-related macular degeneration
• CNV choroidal neovascularization
• Behcet’s uveitis proliferative diabetic retinopathy, non-proliferative diabetic retinopathy,
• the compounds of the invention, and pharmaceutically acceptable salts or prodrugs thereof, can be formulated as pharmaceutical compositions and administered to a mammalian host, such as a human patient, in a variety of forms adapted to the chosen route of
• administration e.g., orally or parenterally, by intravenous, intraperitoneal, intramuscular, topical, or subcutaneous routes. Additional routes of administration are also contemplated by the invention.
• the present compounds may be systemically administered, e.g., orally, in combination with a pharmaceutically acceptable vehicle such as an inert diluent or an assimilable edible carrier. They may be enclosed in hard or soft shell gelatin capsules, may be compressed into tablets, or may be incorporated directly with the food of the patient's diet.
• a pharmaceutically acceptable vehicle such as an inert diluent or an assimilable edible carrier.
• the active compound may be combined with one or more excipients and used in the form of ingestible tablets, buccal tablets, troches, capsules, elixirs, suspensions, syrups, wafers, and the like.
• Such compositions and preparations should contain at least 0.1% of active compound.
• the percentage of the compositions and preparations may, of course, be varied and may conveniently be between about 2% to about 60% of the weight of a given unit dosage form.
• the amount of active compound in such therapeutically useful compositions is such that an effective dosage level will be obtained
• the tablets, troches, pills, capsules, and the like may also contain the following diluents and carriers: binders such as gum tragacanth, acacia, corn starch or gelatin;
• excipients such as dicalcium phosphate; a disintegrating agent such as corn starch, potato starch, alginic acid and the like; a lubricant such as magnesium stearate; and a sweetening agent such as sucrose, fructose, lactose or aspartame or a flavoring agent such as peppermint, oil of wintergreen, or cherry flavoring may be added.
• a liquid carrier such as a vegetable oil or a polyethylene glycol.
• Various other materials may be present as coatings or to otherwise modify the physical form of the solid unit dosage form.
• tablets, pills, or capsules may be coated with gelatin, wax, shellac or sugar and the like.
• a syrup or elixir may contain the active compound, sucrose or fructose as a sweetening agent, methyl and propylparabens as preservatives, a dye and flavoring such as cherry or orange flavor.
• any material used in preparing any unit dosage form should be pharmaceutically acceptable and substantially non-toxic in the amounts employed.
• the active compound may be incorporated into sustained-release preparations and devices.
• the active compound may also be administered intravenously or intraperitoneally by infusion or injection.
• Solutions of the active compound or its salts can be prepared in water or physiologically acceptable aqueous solution, optionally mixed with a nontoxic surfactant.
• Dispersions can also be prepared in glycerol, liquid polyethylene glycols, triacetin, and mixtures thereof and in oils. Under ordinary conditions of storage and use, these preparations contain a preservative to prevent the growth of microorganisms
• the pharmaceutical dosage forms suitable for injection or infusion can include sterile aqueous solutions or dispersions or sterile powders comprising the active ingredient which are adapted for the extemporaneous preparation of sterile injectable or infusible solutions or dispersions, optionally encapsulated in liposomes.
• the ultimate dosage form should be sterile, fluid and stable under the conditions of manufacture and storage.
• the liquid carrier or vehicle can be a solvent or liquid dispersion medium comprising, for example, water, ethanol, a polyol (for example, glycerol, propylene glycol, liquid
• the proper fluidity can be maintained, for example, by the formation of liposomes, by the maintenance of the required particle size in the case of dispersions or by the use of surfactants.
• the prevention of the action of microorganisms can be brought about by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, sorbic acid, thimerosal, and the like. In many cases, it will be preferable to include isotonic agents, for example, sugars, buffers or sodium chloride. Prolonged absorption of the injectable compositions can be brought about by the use in the compositions of agents delaying absorption, for example, aluminum monostearate and gelatin.
• Sterile injectable solutions are prepared by incorporating the active compound in the required amount in the appropriate solvent with various of the other ingredients enumerated above, as required, followed by filter sterilization.
• methods of preparation can include vacuum drying and the freeze drying techniques, which yield a powder of the active ingredient plus any additional desired ingredient present in the previously sterile-filtered solutions.
• the present compounds may be applied in pure form, i.e., when they are liquids. However, it will generally be desirable to administer them to the skin as compositions or formulations, in combination with a dermatologically acceptable carrier, which may be a solid or a liquid.
• Useful solid carriers include finely divided solids such as talc, clay, microcrystalline cellulose, silica, alumina and the like.
• Useful liquid carriers include water, alcohols or glycols or water-alcohol/glycol blends, in which the present compounds can be dissolved or dispersed at effective levels, optionally with the aid of non-toxic surfactants.
• Adjuvants such as fragrances and additional antimicrobial agents can be added to optimize the properties for a given use.
• the resultant liquid compositions can be applied from absorbent pads, used to impregnate bandages and other dressings, or sprayed onto the affected area using pump-type or aerosol sprayers.
• Thickeners such as synthetic polymers, fatty acids, fatty acid salts and esters, fatty alcohols, modified celluloses or modified mineral materials can also be employed with liquid carriers to form spreadable pastes, gels, ointments, soaps, and the like, for application directly to the skin of the user.
• Examples of useful dermatological compositions which can be used to deliver the compounds of the invention to the skin are known in the art; for example, see Jacquet et al. (U.S. Pat. No. 4,608,392; incorporated herein by reference), Geria (U.S. Pat. No. 4,992,478; incorporated herein by reference), Smith et al. (U.S. Pat. No. 4,559,157; incorporated herein by reference), and Wortzman (U.S. Pat. No. 4,820,508; incorporated herein by reference).
• Useful dosages of the compounds of the invention can be determined, at least initially, by comparing their in vitro activity and in vivo activity in animal models. Methods for the extrapolation of effective dosages in mice, and other animals, to humans are known in the art; for example, see U.S. Pat. No. 4,938,949 (incorporated herein by reference).
• the amount of the compound, or pharmaceutically acceptable salt or prodrug thereof, required for use in treatment will vary not only with the particular compound, salt, or prodrug selected but also with the route of administration, the nature of the condition being treated, and the age and condition of the patient and will be ultimately at the discretion of the attendant physician or clinician.
• a suitable dose will be in the range of from about 0.5 to about 100 mg/kg body weight of the recipient per day, e.g., from about 3 to about 90 mg/kg of body weight per day, from about 6 to about 75 mg per kilogram of body weight per day, from about of 10 to about 60 mg/kg of body weight per day, or from about 15 to about 50 mg/kg of body weight per day.
• Compounds of the invention, or pharmaceutically acceptable salts or prodrugs thereof, can be conveniently formulated in unit dosage form; for example, containing 5 to 1000 mg,
• the invention provides a composition comprising a compound of the invention, or
• the desired dose may conveniently be presented in a single dose or as divided doses to be administered at appropriate intervals, for example, as two, three, four or more sub-doses per day.
• the sub-dose itself may be further divided, e.g., into a number of discrete loosely spaced administrations.
• Compounds of the invention, or pharmaceutically acceptable salts or prodrugs thereof can also be administered in combination with other therapeutic agents, for example, other agents that are useful for treating or preventing ischemia, blood loss, or reperfusion injury.
• compounds of the invention, and pharmaceutically acceptable salts or prodrugs thereof can also be administered in combination with one or more other therapeutic agents that are useful for treating or preventing an ocular disorder or eye disorder.
• Other delivery systems can include time-release, delayed release, or sustained release delivery systems such as are well-known in the art. Such systems can avoid repeated administrations of the active compound, increasing convenience to the subject and the physician. Many types of release delivery systems are available and known to those of ordinary skill in the art. Use of a long-term sustained release implant may be desirable.
• Long-term release means that the delivery system or is implant constructed and arranged to deliver therapeutic levels of the active ingredient for at least 30 days, and preferably 60 days.
• a compound of the invention is formulated for intraocular administration, for example direct injection or insertion within or in association with an intraocular medical device.
• a compound of the invention is formulated as an ophthalmic solution.
• a compound of the invention can be administered via ocular delivery, for example, by local ocular administration, including topical, intravitreal, periocular, transscleral, retrobulbar, juxtascleral,
• a compound of the invention can be any compound of the invention.
• the compounds of the invention may be formulated for depositing into a medical device, which may include any of a variety of conventional grafts, stents, including stent grafts, catheters, balloons, baskets, or other device that can be deployed or permanently implanted within a body lumen.
• a medical device such as a stent, and delivered to the treatment site for treatment of a portion of the body.
• Stents have been used as delivery vehicles for therapeutic agents (i.e., drugs).
• Intravascular stents are generally permanently implanted in coronary or peripheral vessels.
• Stent designs include those of U.S. Pat. No. 4,733,655 (Palmaz), U.S. Pat. No. 4,800,882 (Gianturco), or U.S. Pat. No. 4,886,062 (Wiktor).
• Such designs include both metal and polymeric stents, as well as self-expanding and balloon-expandable stents.
• Stents may also be used to deliver a drug at the site of contact with the vasculature, as disclosed in U.S. Pat. No. 5,102,417 (Palmaz), U.S. Pat. No. 5,419,760 (Narciso, Jr.), U.S. Pat. No. 5,429,634 (Narciso, Jr.), and in International Patent Application Nos. WO 91/12779 (Medtronic, Inc.) and WO 90/13332 (Cedars-Sanai
• deposited means that the compound is coated, adsorbed, placed, or otherwise incorporated into the device by methods known in the art.
• the compound may be embedded and released from within (“matrix type”) or surrounded by and released through (“reservoir type”) polymer materials that coat or span the medical device.
• the compound may be entrapped within the polymer materials or coupled to the polymer materials using one or more the techniques for generating such materials known in the art.
• the compound may be linked to the surface of the medical device without the need for a coating, for example by means of detachable bonds, and release with time or can be removed by active mechanical or chemical processes.
• the compound may be in a permanently immobilized form that presents the compound at the implantation site.
• the compound may be incorporated with polymer
• compositions during the formation of biocompatible coatings for medical devices, such as stents are typically homogeneous and are useful for coating a number of devices designed for implantation.
• the polymer may be either a biostable or a bioabsorbable polymer depending on the desired rate of release or the desired degree of polymer stability, but frequently a
• bioabsorbable polymer is preferred for this embodiment since, unlike a biostable polymer, it will not be present long after implantation to cause any adverse, chronic local response.
• Bioabsorbable polymers that could be used include, but are not limited to, poly(L-lactic acid), polycaprolactone, polyglycolide (PGA), poly(lactide-co-glycolide) (PLLA/PGA),
• polyphosphoester polyphosphoester urethane, poly(amino acids), cyanoacrylates, poly(trimethylene carbonate), poly(iminocarbonate), copoly(ether-esters) (e.g., PEO/PLA), polyalkylene oxalates, polyphosphazenes and biomolecules such as fibrin, fibrinogen, cellulose, starch, collagen and hyaluronic acid, polyepsilon caprolactone, polyhydroxy butyric acid, polyorthoesters, polyacetals, polydihydropyrans, polycyanoacrylates, cross linked or amphipathic block copolymers of hydrogels, and other suitable bioabsorbable poplymers known in the art.
• PEO/PLA polyalkylene oxalates
• biomolecules such as fibrin, fibrinogen, cellulose, starch, collagen and hyaluronic acid, polyepsilon caprolactone, polyhydroxy butyric acid, polyortho
• biostable polymers with a relatively low chronic tissue response such as polyurethanes, silicones, and polyesters could be used, and other polymers could also be used if they can be dissolved and cured or polymerized on the medical device such as polyolefins, polyisobutylene and ethylene-alphaolefm copolymers; acrylic polymers and copolymers, vinyl halide polymers and copolymers, such as polyvinyl chloride;
• polyvinylpyrrolidone polyvinyl ethers, such as polyvinyl methyl ether; polyvinylidene halides, such as polyvinylidene fluoride and polyvinylidene chloride; polyacrylonitrile, polyvinyl ketones; polyvinyl aromatics, such as polystyrene, polyvinyl esters, such as polyvinyl acetate; copolymers of vinyl monomers with each other and olefins, such as ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, ABS resins, and ethylene-vinyl acetate copolymers; pyran copolymer; polyhydroxy -propyl-methacrylamide- phenol; polyhydroxyethyl-aspartamide-phenol; polyethyleneoxide-polylysine substituted with palmitoyl residues; polyamides, such as Nylon 66 and polycaprolactam; alkyd resin
• Polymers and semipermeable polymer matrices may be formed into shaped articles, such as valves, stents, tubing, prostheses and the like.
• the compound of the invention is coupled to a polymer or semipermeable polymer matrix that is formed as a stent or stent-graft device.
• polymers are applied to the surface of an implantable device by spin coating, dipping, or spraying. Additional methods known in the art can also be utilized for this purpose. Methods of spraying include traditional methods as well as microdeposition techniques with an inkjet type of dispenser. Additionally, a polymer can be deposited on an implantable device using photo-patterning to place the polymer on only specific portions of the device. This coating of the device provides a uniform layer around the device which allows for improved diffusion of various analytes through the device coating.
• the compound is formulated for release from the polymer coating into the environment in which the medical device is placed.
• the compound is released in a controlled manner over an extended time frame (e.g., months) using at least one of several well-known techniques involving polymer carriers or layers to control elution. Some of these techniques are described in U.S. Patent Application
• the reagents and reaction conditions of the polymer compositions can be manipulated so that the release of the compound from the polymer coating can be controlled.
• the diffusion coefficient of the one or more polymer coatings can be modulated to control the release of the compound from the polymer coating.
• the diffusion coefficient of the one or more polymer coatings can be controlled to modulate the ability of an analyte that is present in the environment in which the medical device is placed (e.g., an analyte that facilitates the breakdown or hydrolysis of some portion of the polymer) to access one or more components within the polymer composition (and for example, thereby modulate the release of the compound from the polymer coating).
• an analyte that is present in the environment in which the medical device is placed e.g., an analyte that facilitates the breakdown or hydrolysis of some portion of the polymer
• the release of the compound from the polymer coating can be modulated by the plurality of polymer coatings.
• the release of the compound from the polymer coating is controlled by modulating one or more of the properties of the polymer composition, such as the presence of one or more endogenous or exogenous compounds, or alternatively, the pH of the polymer composition.
• the properties of the polymer composition such as the presence of one or more endogenous or exogenous compounds, or alternatively, the pH of the polymer composition.
• compositions can be designed to release a compound in response to a decrease in the pH of the polymer composition.
• the invention also provides a kit, comprising a compound of the invention, or a pharmaceutically acceptable salt or prodrug thereof, at least one other therapeutic agent, packaging material, and instructions for administering the compound of the invention or the pharmaceutically acceptable salt or prodrug thereof and the other therapeutic agent or agents to a mammal to treat or prevent a disease or condition characterized by aberrant complement activity.
• the mammal is a human.
• Step-l Preparation of 2-chloro-4-(l-ethoxyvinyl)pyrrolo[2,l-f [l,2,4]triazine (lb)
• Step-2 Preparation of ethyl 2-chloropyrrolo[2,l-f][l,2,4]triazine-4-carboxylate (lc)
• Step-3 Preparation of 2-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)pyrrolo[2, l- f][l,2,4]triazine-4-carboxylic acid (le)
• Step-4 Preparation of methyl 2-(2-(2-(3 -(((tert- butoxycarbonyl)amino)methyl)phenyl)pyrrolo[2, 1 -f] [ 1 ,2,4]triazine-4- carboxamido)phenyl)acetate (If)
• Step-5 Preparation of methyl 2-(2-(2-(3-(aminomethyl)phenyl)pyrrolo[2,l-f][l,2,4]triazine- 4-carboxamido)phenyl)acetate (lg)
• Step-6 Preparation of 2-(2-(2-(3-(aminomethyl)phenyl)pyrrolo[2, l-f][l,2,4]triazine-4- carboxamido)phenyl)acetic acid (lh)
• Step-l Preparation of ethyl 2-(3-(((ter/-butoxycarbonyl)amino)methyl)phenyl)-6,7-dihydro- 5H-cyclopenta[d]pyrimidine-4-carboxylate (2b)
• Step-2 Preparation of 2-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)-6,7-dihydro-5H- cyclopenta[d]pyrimidine-4-carboxylic acid (2c)
• Step-3 Preparation of methyl 2-(2-(2-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)-6,7- dihydro-5H-cyclopenta[d]pyrimidine-4-carboxamido)phenyl)acetate (2d)
• Step-4 Preparation of methyl 2-(2-(2-(3-(aminomethyl)phenyl)-6,7-dihydro-5H- cyclopenta[d]pyrimidine-4-carboxamido)phenyl)acetate (2e)
• Step-5 Preparation of 2-(2-(2-(3-(aminomethyl)phenyl)-6,7-dihydro-5H- cyclopenta[d]pyrimidine-4-carboxamido)phenyl)acetic acid (2f)
• Step-l Preparation of /er/-butyl 3-(2-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)benzylcarbamate (3c)
• tripotassium phosphate (4.55 g, 21.43 mmol) in water (1 mL)
• Step-2 Preparation of /er/-butyl 3-(2-(l-ethoxyvinyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)benzylcarbamate (3d)
• Step-3 Preparation of ethyl 4-(3-((tert-butoxycarbonylamino)methyl)phenyl)-7-tosyl-7H- pyrrolo[2,3-d]pyrimidine-2-carboxylate (3e)
• Step-4 Preparation of 4-(3-((/er/-butoxycarbonylamino)methyl)phenyl)-7H-pyrrolo[2,3- d]pyrimidine-2-carboxylic acid (3f)
• Step-5 Preparation of methyl 2-(2-(4-(3-((/er/-butoxycarbonylamino)methyl)phenyl)-7H- pyrrolo[2,3-d]pyrimidine-2-carboxamido)phenyl)acetate (3g)
• Step-6 Preparation of methyl 2-(2-(4-(3-(aminomethyl)phenyl)-7H-pyrrolo[2,3- d]pyrimidine-2-carboxamido)phenyl)acetate (3h)
• Step-7 Preparation of 2-(2-(4-(3-(aminomethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidine-2- carboxamido)phenyl)acetic acid (3i)
• Step-l Preparation of (R)-2-(3-( 1 -(/c/7-b utoxy carbonyl a i no)ethyl)phenyl)pyrrolo[2, l - f [l,2,4]triazine-4-carboxylic acid (4b)
• tripotassium phosphate 564 mg, 2.66 mmol
• tricyclohexylphosphine 112 mg, 0.4 mmol
• Pd2(dba)3 122 mg, 0.13 mmol
• Step-2 Preparation of (R)-m ethyl 2-(2-(2-(3-(l -(tert- butoxycarbonylamino)ethyl)phenyl)pyrrolo[2, 1 -f] [ 1 ,2,4]triazine-4- carboxamido)phenyl)acetate (4c)
• Compound 4c was prepared according to the procedure reported in step-4 of Scheme- 1 from (R)-2-(3-(l-(/er/-butoxycarbonylamino)ethyl)phenyl)pyrrolo[2,l-f [l,2,4]triazine-4- carboxylic acid (4b) (150 mg, 0.39 mmol) in DMF (8 mL) using methyl 2-(2- aminophenyl)acetate (78 mg, 0.47 mmol), DIPEA (0.21 mL, 1.18 mmol) and HATU (179 mg, 0.47 mmol).
• Step-3 Preparation of (R)-methyl 2-(2-(2-(3-(l-aminoethyl)phenyl)pyrrolo[2,l- f][l,2,4]triazine-4-carboxamido)phenyl)acetate (4d)
• Step-4 Preparation of (R)-2-(2-(2-(3-(l-aminoethyl)phenyl)pyrrolo[2, l-f][l,2,4]triazine-4- carboxamido)phenyl)acetic acid (4e)
• Step-l Preparation of /er/-butyl 3-(2-chloropyrrolo[2,l-f [l,2,4]triazin-4-yl)benzylcarbamate (5a)
• Step-2 Preparation of /er/-butyl 3 -(2-(l -ethoxy vinyl)pyrrolo[2,l-f][ 1,2, 4]triazin-4- yl)benzylcarbamate (5b)
• Compound 5b was prepared according to the procedure reported in step-l of Scheme- 1 from /er/-butyl 3-(2-chloropyrrolo[2,l-f][l,2,4]triazin-4-yl)benzylcarbamate (5a) (3.2 g, 8.92 mmol) in DMF (60 mL) using 1 -ethoxy vinyltri-n-butyltin (3.65 mL, 10.70 mmol) and Pd(PPh 3 )4 (0.515 g, 0.45 mmol) in argon atmosphere and heating at 110 °C for lOh.
• Step-3 Preparation of ethyl 4-(3-(((ter/-butoxycarbonyl)amino)methyl)phenyl)pyrrolo[2,l- f] [ 1 ,2,4]triazine-2-carboxylate (5c)
• Step-4 Preparation of 4-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)pyrrolo[2,l- f][l,2,4]triazine-2-carboxylic acid (5d)
• Step-5 Preparation of ethyl 2-(2-(4-(3-(((/er/- butoxycarbonyl)amino)methyl)phenyl)pyrrolo[2, 1 -f] [ 1 ,2,4]triazine-2- carboxamido)phenyl)acetate (5f)
• Step-6 Preparation of ethyl 2-(2-(4-(3-(aminomethyl)phenyl)pyrrolo[2,l-f][l,2,4]triazine-2- carboxamido)phenyl)acetate (5g)
• Step-7 Preparation of 2-(2-(4-(3-(aminomethyl)phenyl)pyrrolo[2, l-f][l,2,4]triazine-2- carboxamido)phenyl)acetic acid (5h)
• Compound 5h was prepared according to the procedure reported in step-4 of Scheme-4 from ethyl 2-(2-(4-(3-(aminomethyl)phenyl)pyrrolo[2,l-f][l,2,4]triazine-2- carboxamido)phenyl)acetate (5g) (70 mg, 0.16 mmol) in MeOH (10 mL) using sodium hydroxide (33 mg, 0.82 mmol) in water (2 mL).
• Step-l Preparation of ethyl 2-(2-(6-chloroimidazo[l,2-a]pyridine-8- carboxamido)phenyl)acetate (6b)
• 6-chloroimidazo[l,2-a]pyridine-8-carboxylic acid (6a) (650 mg, 3.31 mmol; CAS# 155735-02-7) in MeOH (10 mL) was added ethyl 2-(2-aminophenyl)acetate (5e) (593 mg, 3.31 mmol; CAS # 87-25-2) and Nl-((ethylimino)methylene)-N3,N3-dimethylpropane- 1, 3-diamine hydrochloride (EDCI, 697 mg, 3.64 mmol), the resulting mixture was stirred at RT overnight and diluted with EtOAc (60 mL).
• Step-2 Preparation of ethyl 2-(2-(6-(3-(aminomethyl)phenyl)imidazo[l,2-a]pyridine-8- carboxamido)phenyl)acetate (6d)
• Step-3 Preparation of 2-(2-(6-(3-(aminomethyl)phenyl)imidazo[l,2-a]pyridine-8- carboxamido)phenyl)acetic acid (6e)
• Step-l Preparation of ethyl 2-(2-(4-bromo-lH-indazole-6-carboxamido)phenyl)acetate (7b)
• 4-bromo-lH-indazole-6-carboxylic acid (7a) 500 mg, 2.07 mmol; CAS# 885523-43-3
• MeOH MeOH
• ethyl 2-(2-aminophenyl)acetate 5e
• EDCI Nl-((ethylimino)methylene)-N3,N3-dimethylpropane- 1,3 -diamine hydrochloride
• Step-2 Preparation of ethyl 2-(2-(4-(3-(aminomethyl)phenyl)-lH-indazole-6- carboxamido)phenyl)acetate (7c)
• Compound 7 c was prepared according to the procedure reported in step-3 of Scheme- 1 from ethyl 2-(2-(4-bromo-lH-indazole-6-carboxamido)phenyl)acetate (7b) (300 mg, 0.75 mmol) in dioxane (3 mL) using 3-(aminomethyl)phenylboronic acid hydrochloride (6c) (210 mg, 1.12 mmol), tripotassium phosphate (1.3 M solution) (1.72 mL, 2.24 mmol),
• Step-3 Preparation of 2-(2-(4-(3-(aminomethyl)phenyl)-lH-indazole-6- carboxamido)phenyl)acetic acid (7d)
• Step-l Preparation of /er/-butyl 3-(2-(hydroxymethyl)pyrrolo[2,l-f [l,2,4]triazin-4- yl)benzylcarbamate (8a)
• Step-2 Preparation of ethyl 2-(2-((4-(3-(((/er/- butoxycarbonyl)amino)methyl)phenyl)pyrrolo[2, 1 -f] [ 1 ,2,4]triazin-2- yl)methoxy)phenyl)acetate (8c)
• Step-3 Preparation of ethyl 2-(2-((4-(3-(aminomethyl)phenyl)pyrrolo[2, l-f][l,2,4]triazin-2- yl)methoxy)phenyl)acetate (8d)
• Step-4 Preparation of 2-(2-((4-(3-(aminomethyl)phenyl)pyrrolo[2,l-f][l,2,4]triazin-2- yl)methoxy)phenyl)acetic acid (8e)
• Step-l Preparation of ethyl 2-(2-(4-bromo-lH-indole-6-carboxamido)phenyl)acetate (9b)
• Compound 9b was prepared according to the procedure reported in step-l of Scheme-7 from 4-bromo-lH-indole-6-carboxylic acid (9a) (500 mg, 2.08 mmol; CAS# 374633-27-9) in MeOH (10 mL) using ethyl 2-(2-aminophenyl)acetate (5e) (411 mg, 2.29 mmol) and EDCI (479 mg, 2.5 mmol).
• Step-2 Preparation of ethyl 2-(2-(4-(3-(aminomethyl)phenyl)-lH-indole-6- carboxamido)phenyl)acetate (9c)
• Step-l Preparation of ethyl 2-(2-(4-bromo-l-(cyclopropylmethyl)-lH-indazole-6- carboxamido)phenyl)acetate (10a) and ethyl 2-(2-(4-bromo-2-(cyclopropylmethyl)-2H- indazole-6-carboxamido)phenyl)acetate (10b)
• Step-2 Preparation of 2-(2-(4-(3-(aminomethyl)phenyl)-l-(cyclopropylmethyl)-lH-indazole- 6-carboxamido)phenyl)acetic acid (lOd)
• Step-l Preparation of (S)-ethyl 2-(2-((4-(2-((l,l-dimethylethylsulfmamido)methyl)-3- fluoropyridin-4-yl)-l-(methylsulfonyl)-lH-indol-6-yl)methoxy)phenyl)acetate (12a)
• Step-2 Preparation of ethyl 2-(2-((4-(2-(aminomethyl)-3-fluoropyridin-4-yl)-l- (methylsulfonyl)-lH-indol-6-yl)methoxy)phenyl)acetate (12b)
• Step-3 Preparation of 2-(2-((4-(2-(aminomethyl)-3-fluoropyridin-4-yl)-lH-indol-6- yl)methoxy)phenyl)acetic acid (12c)
• Compound 12c was prepared according to the procedure reported in step-6 of Scheme- 1 from ethyl 2-(2-((4-(2-(aminomethyl)-3-fluoropyridin-4-yl)-l-(methylsulfonyl)-lH-indol-6- yl)methoxy)phenyl)acetate (12b) (0.15 g, 0.29 mmol) in MeOH/THF (4 mL, each) using lithium hydroxide hydrate (123 mg, 2.93 mmol) in water (1 mL).
• Step-l Preparation of ethyl 2-(2-(8-bromoquinoline-6-carboxamido)phenyl)acetate (13b)
• Compound 13b was prepared according to the procedure reported in step-4 of Scheme- 1, from 8-bromoquinoline-6-carboxylic acid (13a) (250 mg, 0.992 mmol, CAS # 791632-21-8) using ethyl 2-(2-aminophenyl)acetate (5e) (213 mg, 1.19 mmol), DIPEA (0.52 mL, 2.98 mmol) and HATU (453 mg, 1.19 mmol).
• Step-2 Preparation of 2-(2-(8-(3-(aminomethyl)phenyl)quinoline-6- carboxamido)phenyl)acetic acid (13c)
• Compound 13c was prepared according to the procedure reported in step-3 of Scheme- 1 from ethyl 2-(2-(8-bromoquinoline-6-carboxamido)phenyl)acetate (13b) (150 mg, 0.36 mmol) in dioxane (2 mL) using 3-(aminomethyl)phenylboronic acid hydrochloride (6c) (68 mg, 0.363 mmol), tripotassium phosphate (1.3 M solution) (0.84 mL, 1.09 mmol),
• Step-l Preparation of ethyl 2-(2-(4-bromo-lH-pyrrolo[2,3-b]pyridine-6- carboxamido)phenyl)acetate (14b)
• Compound 14b was prepared according to the procedure reported in step-l of Scheme-7 from 4-bromo-lH-pyrrolo[2,3-b]pyridine-6-carboxylic acid (14a) (300 mg, 1.25 mmol; CAS # 1190321-81-3) in MeOH (10 mL) using ethyl 2-(2-aminophenyl)acetate (5e) (268 mg, 1.49 mmol) and EDCI (286 mg, 1.49 mmol).
• Step-2 Preparation of ethyl 2-(2-(4-(3-(aminomethyl)phenyl)-lH-pyrrolo[2,3-b]pyridine-6- carboxamido)phenyl)acetate (14c)
• Step-3 Preparation of 2-(2-(4-(3-(aminomethyl)phenyl)-lH-pyrrolo[2,3-b]pyridine-6- carboxamido)phenyl)acetic acid (14d)
• Step-l Preparation of ethyl 2-(2-(7-bromobenzofuran-5-carboxamido)phenyl)acetate
• Compound 15b was prepared according to the procedure reported in step-l of Scheme-7 from 7-bromobenzofuran-5-carboxylic acid (15a) (100 mg, 0.42 mmol; CAS# 286836-25-7) in MeOH (10 mL) using ethyl 2-(2-aminophenyl)acetate (5e) (89 mg, 0.5 mmol) and EDCI (95 mg, 0.5 mmol).
• Step-2 Preparation of 2-(2-(7-(3-(aminomethyl)phenyl)benzofuran-5- carboxamido)phenyl)acetic acid (15d)
• Step-2 Preparation of /er/-butyl 3-(2-chloro-7-(cyclopropylmethyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl)benzylcarbamate (16c)
• Step-3 Preparation of /er/-butyl 3-(7-(cyclopropylmethyl)-2-(l-ethoxyvinyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl)benzylcarbamate (16d)
• Compound 16d was prepared according to the procedure reported in step-l of Scheme-l from tert- butyl 3-(2-chloro-7-(cyclopropylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl)benzylcarbamate (16c) (3.2 g, 7.75 mmol) in DMF (35 mL) using 1 -ethoxy vinyltri-n- butyltin (3.17 mL, 9.30 mmol) and Pd(PPh 3 )4 (0.448 g, 0.39 mmol) in argon atmosphere and heating at 110 °C for 12 h.
• Step-4 Preparation of ethyl 4-(3-(((fer/-butoxycarbonyl)amino)methyl)phenyl)-7- (cyclopropylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carboxylate (16e)
• Step-5 Preparation of 4-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)-7- (cyclopropylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carboxylic acid (16f)
• Step-6 Preparation of ethyl 2-(2-(4-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)-7- (cyclopropylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carboxamido)phenyl)acetate (16g)
• Compound 16g was prepared according to the procedure reported in step-4 of Scheme- 1 from 4-(3 -(((/c/V-butoxycarbonyl )amino)m ethyl )phenyl)-7-(cy cl opropyl methyl )-7H-pyrrolo[2, 3- d]pyrimidine-2-carboxylic acid (16f) (150 mg, 0.536 mmol) in DMF (5 mL) using ethyl 2-(2- aminophenyl)acetate (5e) (95 mg, 0.533 mmol), DIPEA (0.12 mL, 0.71 mmol) and HATE! (
• Step-7 Preparation of ethyl 2-(2-(4-(3-(aminomethyl)phenyl)-7-(cyclopropylmethyl)-7H- pyrrolo[2,3-d]pyrimidine-2-carboxamido)phenyl)acetate (16h)
• Step-8 Preparation of 2-(2-(4-(3-(aminomethyl)phenyl)-7-(cyclopropylmethyl)-7H- pyrrolo[2,3-d]pyrimidine-2-carboxamido)phenyl)acetic acid (16i)
• Step-l Preparation of ethyl 2-(2-(8-bromo-[l,2,4]triazolo[4,3-a]pyridine-6- carboxamido)phenyl)acetate (17b)
• Compound 17b was prepared according to the procedure reported in step-4 of Scheme- 1, from 8-bromo-[l,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid (17a) (500 mg, 2.07 mmol, CAS # 1216475-30-7) using ethyl 2-(2-aminophenyl)acetate (5e) (648 mg, 3.62 mmol), DIPEA (1.08 mL, 6.2 mmol) and HATU (1375 mg, 3.62 mmol).
• Step-2 Preparation of 2-(2-(8-(3-(aminomethyl)phenyl)-[l,2,4]triazolo[4,3-a]pyridine-6- carboxamido)phenyl)acetic acid (17c)
• Step-2 Preparation of 4-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)-2-naphthoic acid (18c)
• Step-3 Preparation of ethyl 2-(2-(4-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)-2- naphthamido)phenyl)acetate (18d)
• Step-5 Preparation of 2-(2-(4-(3-(aminomethyl)phenyl)-2-naphthamido)phenyl)acetic acid
• Step-l Preparation of 2-(2-(4-(3-(((fer/-butoxycarbonyl)amino)methyl)-5-fluorophenyl)-lH- indole-6-carboxamido)phenyl)acetic acid (19b)
• Compound 19b was prepared according to the procedure reported in step-3 of Scheme- 1 from ethyl 2-(2-(4-bromo-lH-indole-6-carboxamido)phenyl)acetate (9b) (320 mg, 0.80 mmol) in dioxane (3 mL) using tert- butyl 3-fluoro-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)benzylcarbamate (19a) (420 mg, 1.2 mmol; CAS# 1421773-36-5), tripotassium phosphate (1.3 M solution) (1.23 mL, 1.60 mmol), tricyclohexy
• Step-2 Preparation of 2-(2-(4-(3-(aminomethyl)-5-fluorophenyl)-lH-indole-6- carboxamido)phenyl)acetic acid (19c)
• Step-l Preparation of 6-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)-[l,2,4]triazolo[l,5- a]pyridine-8-carboxylic acid (20b)
• Step-2 Preparation of ethyl 2-(2-(6-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)- [ 1 ,2,4]triazolo[ 1 ,5-a]pyridine-8-carboxamido)phenyl)acetate (20c)
• Compound 20c was prepared according to the procedure reported in step-4 of Scheme- 1, from 6-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)-[l,2,4]triazolo[l,5-a]pyridine-8- carboxylic acid (20b) (200 mg, 0.54 mmol) in DMF (8 mL) using ethyl 2-(2- aminophenyl)acetate (5e) (170 mg, 0.95 mmol), DIPEA (0.28 mL, 1.63 mmol) and HATU (361 mg, 0.95 mmol).
• Step-3 Preparation of ethyl 2-(2-(6-(3-(aminomethyl)phenyl)-[l,2,4]triazolo[l,5-a]pyridine- 8-carboxamido)phenyl)acetate (20d)
• Step-4 Preparation of 2-(2-(6-(3-(aminomethyl)phenyl)-[l,2,4]triazolo[l,5-a]pyridine-8- carboxamido)phenyl)acetic acid (20e)
• Step-l Preparation of 2-(3-(((/c77-butoxycarbonyl)amino)methyl)-5- fluorophenyl)pyrrolo[2,l-f][l,2,4]triazine-4-carboxylic acid (21a)
• Step-2 Preparation of ethyl 2-(2-(2-(3-(((/er/-butoxycarbonyl)amino)methyl)-5- fluorophenyl)pyrrolo[2, 1 -f] [ 1 ,2,4]triazine-4-carboxamido)phenyl)acetate (21b)
• Compound 21b was prepared according to the procedure reported in step-4 of Scheme- 1 from 2-(3-(((/er/-butoxycarbonyl)amino)methyl)-5-fluorophenyl)pyrrolo[2,l-f [l,2,4]triazine-4- carboxylic acid (21a) (110 mg, 0.29 mmol) in DMF (5 mL) using ethyl 2-(2- aminophenyl)acetate (5e) (77 mg, 0.43 mmol), DIPEA (0.1 mL, 0.57 mmol) and HATU (162 mg, 0.43 mmol).
• Step-3 Preparation of ethyl 2-(2-(2-(3-(aminomethyl)-5-fluorophenyl)pyrrolo[2,l- f][l,2,4]triazine-4-carboxamido)phenyl)acetate (21c)
• Step-4 Preparation of 2-(2-(2-(3-(aminomethyl)-5-fluorophenyl)pyrrolo[2,l-f][l,2,4]triazine- 4-carboxamido)phenyl)acetic acid (21d)
• Step-2 Preparation of ethyl 2-(2-((7-bromobenzofuran-5-yl) methoxy) phenyl) acetate (23c) To a solution of (7-bromobenzofuran-5-yl) methanol (23a) (9 g, 39.6 mmol),
• triphenylphosphine 11.44 g, 43.6 mmol
• ethyl 2-(2-hydroxyphenyl) acetate 23b
• DCM ethyl 2-(2-hydroxyphenyl) acetate
• DCAD bis(4-chlorobenzyl)azodicarboxylate
• Step-4 Preparation of 2-(2-((7-(3-(aminomethyl) phenyl) benzofuran-5-yl) methoxy) phenyl) acetic acid (23e)
• Step-l Preparation of ethyl 2-(2-((4-(3-(aminomethyl)-2-fluorophenyl)-2-chlorobenzofuran- 6-yl)methoxy)phenyl)acetate (24a)
• Step-2 Preparation of 2-(2-((4-(3-(aminomethyl)-2-fluorophenyl)-2-chlorobenzofuran-6- yl)methoxy)phenyl)acetic acid (24b)
• Compound 24b was prepared according to the procedure reported in step-6 of Scheme- 1, from ethyl 2-(2-((4-(3-(aminomethyl)-2-fluorophenyl)-2-chlorobenzofuran-6- yl)methoxy)phenyl)acetate (24a) (205 mg, 0.438 mmol) in MeOH/THF (6 mL) using a solution of lithium hydroxide (132 mg, 3.15 mmol) in water (2 mL).
• Step-l Preparation of /er/-butyl 3-(4-(hydroxymethyl)pyrrolo[2,l-f [l,2,4]triazin-2- yl)benzylcarbamate (25a)
• Step-3 Preparation of ethyl 2-(2-((2-(3-(aminomethyl)phenyl)pyrrolo[2,l-f][l,2,4]triazin-4- yl)methoxy)phenyl)acetate (25c)
• Step-4 Preparation of 2-(2-((2-(3-(aminomethyl)phenyl)pyrrolo[2,l-f][l,2,4]triazin-4- yl)methoxy)phenyl)acetic acid (25d)
• Step-l Preparation of /er/-butyl 3-(7-(cyclopropylmethyl)-2-(hydroxymethyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl)benzylcarbamate (26a)
• Step-2 Preparation of ethyl 2-(2-((4-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)-7- (cyclopropylmethyl)-7H-pynOlo[2,3-d]pyrimidin-2-yl)methoxy)phenyl)acetate (26b)
• Step-3 Preparation of ethyl 2-(2-((4-(3-(aminomethyl)phenyl)-7-(cyclopropylmethyl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)methoxy)phenyl)acetate (26c)
• Step-4 Preparation of 2-(2-((4-(3-(aminomethyl)phenyl)-7-(cyclopropylmethyl)-7H- pyrrolo[2,3-d]pyrimidin-2-yl)methoxy)phenyl)acetic acid (26d)
• Step-l Preparation of 6-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)imidazo[l,2- b]pyridazine-8-carboxylic acid (27c)
• Step-2 Preparation of ethyl 2-(2-(6-(3-(((/c/V- butoxycarbonyl)amino)methyl)phenyl)imidazo[l,2-b]pyridazine-8- carboxamido)phenyl)acetate (27d)
• Step-3 Preparation of ethyl 2-(2-(6-(3-(aminomethyl)phenyl)imidazo[l,2-b]pyridazine-8- carboxamido)phenyl)acetate (27e)
• Step-4 Preparation of 2-(2-(6-(3-(aminomethyl)phenyl)imidazo[l,2-b]pyridazine-8- carboxamido)phenyl)acetic acid (27f)
• Step-l Preparation of ethyl 2-(2-(7-chlorofuro[2,3-c]pyridine-5-carboxamido)phenyl)acetate
• Step-2 Preparation of ethyl 2-(2-(7-(3-(aminomethyl)phenyl)furo[2,3-c]pyridine-5- carboxamido)phenyl)acetate (28c)
• Step-3 Preparation of 2-(2-(7-(3-(aminomethyl)phenyl)furo[2,3-c]pyridine-5- carboxamido)phenyl)acetic acid (28d)
• Step-l Preparation of (S)-2-(3-(l-((ter/-butoxycarbonyl)amino)ethyl)phenyl)pyrrolo[2,l- f [l,2,4]triazine-4-carboxylic acid (29a)
• Step-2 Preparation of (S)-ethyl 2-(2-(2-(3-( l -((tert- butoxycarbonyl)amino)ethyl)phenyl)pyrrolo[2, 1 -f] [ 1 ,2,4]triazine-4- carboxamido)phenyl)acetate (29b)
• Step-3 Preparation of (S)-ethyl 2-(2-(2-(3-(l-aminoethyl)phenyl)pyrrolo[2, l- f][l,2,4]triazine-4-carboxamido)phenyl)acetate (29c)
• Step-4 Preparation of (S)-2-(2-(2-(3-(l-aminoethyl)phenyl)pyrrolo[2,l-f][l,2,4]triazine-4- carboxamido)phenyl)acetic acid (29d)
• Step-l Preparation of ethyl 2-(2-(7-bromo-l,2-dimethyl-lH-benzo[d]imidazole-5- carboxamido)phenyl)acetate (30b)
• Compound 30b was prepared according to the procedure reported in step-l of Scheme-7 from 7-bromo-l, 2-dimethyl- lH-benzo[d]imidazole-5-carboxylic acid (30a) (500 mg, 2.53 mmol; CAS# 1420800-25-4) in MeOH (10 mL) using ethyl 2-(2-aminophenyl)acetate (5e) (549 mg, 3.07 mmol) and EDCI (641 mg, 3.34 mmol).
• Step-2 Preparation of ethyl 2-(2-(7-(3-(aminomethyl)phenyl)-l,2-dimethyl-lH- benzo[d]imidazole-5-carboxamido)phenyl)acetate (30c)
• Step-3 Preparation of 2-(2-(7-(3-(aminomethyl)phenyl)-l,2-dimethyl-lH-benzo[d]imidazole- 5-carboxamido)phenyl)acetic acid (30d)
• Step-l Preparation of ethyl 4-(3-(((fer/-butoxycarbonyl)amino)methyl)phenyl)thieno[3,2- d]pyrimidine-2-carboxylate (31b)
• Step-2 Preparation of 4-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)thieno[3,2- d]pyrimidine-2-carboxylic acid (31c)
• Step-3 Preparation of ethyl 2-(2-(4-(3-(((/er/- butoxycarbonyl)amino)methyl)phenyl)thieno[3,2-d]pyrimidine-2- carboxamido)phenyl)acetate (31d)
• Step-4 Preparation of ethyl 2-(2-(4-(3-(aminomethyl)phenyl)thieno[3,2-d]pyrimidine-2- carboxamido)phenyl)acetate (31e)
• Step-5 Preparation of 2-(2-(4-(3-(aminomethyl)phenyl)thieno[3,2-d]pyrimidine-2- carboxamido)phenyl)acetic acid (31f)
• Step-l Preparation of /ert-butyl 3-(2-chlorothieno[2,3-d]pyrimidin-4-yl)benzylcarbamate
• Step-2 Preparation of /ert-butyl 3-(2-(l-ethoxyvinyl)thieno[2,3-d]pyrimidin-4- yl)benzylcarbamate (32c)
• Compound 32c was prepared according to the procedure reported in step-l of Scheme- 1 from /er/-butyl 3-(2-chlorothieno[2,3-d]pyrimidin-4-yl)benzylcarbamate (32b) (4.5 g, 11.97 mmol) in DMF (60 mL) using 1 -ethoxy vinyltri-n-butyltin (4.89 mL, 14.37 mmol) and Pd(PPh 3 )4 (0.692 g, 0.599 mmol) in argon atmosphere and heating at 110 °C for 10 h.
• Step-3 Preparation of ethyl 4-(3-(((fer/-butoxycarbonyl)amino)methyl)phenyl)thieno[2,3- d]pyrimidine-2-carboxylate (32d)
• Step-4 Preparation of 4-(3-(((/er/-butoxycarbonyl)amino)methyl)phenyl)thieno[2,3- d]pyrimidine-2-carboxylic acid (32e)
• Step-5 Preparation of ethyl 2-(2-(4-(3-(((l rl- butoxycarbonyl)amino)methyl)phenyl)thieno[2,3-d]pyrimidine-2- carboxamido)phenyl)acetate (32f)
• Step-6 Preparation of ethyl 2-(2-(4-(3-(aminomethyl)phenyl)thieno[2,3-d]pyrimidine-2- carboxamido)phenyl)acetate (32g)
• Step-7 Preparation of 2-(2-(4-(3-(aminomethyl)phenyl)thieno[2,3-d]pyrimidine-2- carboxamido)phenyl)acetic acid (32h)
• Step-l Preparation of (R)-ethyl 2-(3-(l-((tert-butoxycarbonyl)amino)ethyl)-2- fluorophenyl)pyrrolo[2, 1 -f] [ 1 ,2,4]triazine-4-carboxylate (33b)
• Step-2 Preparation of (R)-2-(3-(l-((/er/-butoxycarbonyl)amino)ethyl)-2- fluorophenyl)pyrrolo[2,l-f][l,2,4]triazine-4-carboxylic acid (33c)
• Step-3 Preparation of (R)-ethyl 2-(2-(2-(3-(l-((/er/-butoxycarbonyl)amino)ethyl)-2- fluorophenyl)pyrrolo[2, 1 -f] [ 1 ,2,4]triazine-4-carboxamido)phenyl)acetate (33d)
• Step-4 Preparation of (R)-ethyl 2-(2-(2-(3-(l-aminoethyl)-2-fluorophenyl)pyrrolo[2, l- f][l,2,4]triazine-4-carboxamido)phenyl)acetate (33e)
• Step-5 Preparation of (R)-2-(2-(2-(3-(l-aminoethyl)-2-fluorophenyl)pyrrolo[2,l- f [l,2,4]triazine-4-carboxamido)phenyl)acetic acid (33f)
• Step-l Preparation of ethyl 2-(3-(((fer/-butoxycarbonyl)amino)methyl)-2- fluorophenyl)pyrrolo[2, 1 -f] [ 1 ,2,4]triazine-4-carboxylate (34b)
• Step-2 Preparation of 2-(3-(((/er/-butoxycarbonyl)amino)methyl)-2- fluorophenyl)pyrrolo[2,l-f][l,2,4]triazine-4-carboxylic acid (34c)

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