JP7349046B2 - Ｓａｒｍ１の阻害剤 - Google Patents

Ｓａｒｍ１の阻害剤 Download PDF

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Publication number
JP7349046B2
JP7349046B2 JP2023513172A JP2023513172A JP7349046B2 JP 7349046 B2 JP7349046 B2 JP 7349046B2 JP 2023513172 A JP2023513172 A JP 2023513172A JP 2023513172 A JP2023513172 A JP 2023513172A JP 7349046 B2 JP7349046 B2 JP 7349046B2
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Prior art keywords
compound
pharmaceutically acceptable
chiral
ring
mmol
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JP2023513172A
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English (en)
Japanese (ja)
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JP2023535236A (ja
Inventor
ボサナック，トッド
サイモン ブリアリー，アンドリュー
デブラジ，ラジェシュ
オーウェン ヒューズ，ロバート
アンドリュー ジャージェス－パイク，リチャード
アン パロット，シェリー
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Disarm Therapeutics Inc
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Disarm Therapeutics Inc
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Priority to JP2023145779A priority Critical patent/JP7756130B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023513172A 2020-08-24 2021-08-23 Ｓａｒｍ１の阻害剤 Active JP7349046B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023145779A JP7756130B2 (ja) 2020-08-24 2023-09-08 Ｓａｒｍ１の阻害剤

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063069408P 2020-08-24 2020-08-24
US63/069,408 2020-08-24
US202163142398P 2021-01-27 2021-01-27
US63/142,398 2021-01-27
PCT/US2021/047093 WO2022046606A1 (en) 2020-08-24 2021-08-23 Inhibitors of sarm1

Related Child Applications (1)

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JP2023145779A Division JP7756130B2 (ja) 2020-08-24 2023-09-08 Ｓａｒｍ１の阻害剤

Publications (2)

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JP2023535236A JP2023535236A (ja) 2023-08-16
JP7349046B2 true JP7349046B2 (ja) 2023-09-21

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JP2023145779A Active JP7756130B2 (ja) 2020-08-24 2023-09-08 Ｓａｒｍ１の阻害剤

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Country Status (18)

Country Link
US (2) US12043613B2 (OSRAM)
EP (1) EP4200293A1 (OSRAM)
JP (2) JP7349046B2 (OSRAM)
KR (1) KR20230057396A (OSRAM)
AU (2) AU2021333558C1 (OSRAM)
BR (1) BR112023002575A2 (OSRAM)
CA (1) CA3189181A1 (OSRAM)
CL (1) CL2023000525A1 (OSRAM)
CO (1) CO2023001975A2 (OSRAM)
CR (1) CR20230113A (OSRAM)
DO (1) DOP2023000038A (OSRAM)
EC (1) ECSP23012981A (OSRAM)
IL (1) IL300586A (OSRAM)
MX (1) MX2023002256A (OSRAM)
PE (1) PE20230737A1 (OSRAM)
TW (2) TW202334117A (OSRAM)
WO (1) WO2022046606A1 (OSRAM)
ZA (1) ZA202301801B (OSRAM)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3897670A4 (en) 2018-12-19 2022-09-07 Disarm Therapeutics, Inc. MRSA1 INHIBITORS IN COMBINATION WITH NEUROPROTECTIVE AGENTS
US12404265B2 (en) * 2020-08-04 2025-09-02 Nura Bio, Inc. Substituted pyridine derivatives as SARM1 inhibitors
CN116438171A (zh) 2020-09-16 2023-07-14 努拉生物公司 作为sarm1抑制剂的取代的吡啶衍生物
JP2024528036A (ja) 2021-07-28 2024-07-26 ヌラ バイオ，インク． Ｓａｒｍ１阻害剤としての置換ピリジン誘導体
JP2025523905A (ja) * 2022-07-21 2025-07-25 アミリックス ファーマシューティカルズ，インコーポレイティッド オリゴヌクレオチド組成物及びその方法
EP4634156A1 (en) * 2022-12-15 2025-10-22 Sironax Ltd Sarm1 modulators, preparations, and uses thereof
EP4655069A1 (en) 2023-01-24 2025-12-03 Disarm Therapeutics, Inc. Pyridazines as sarm1 inhibitors
TW202509019A (zh) * 2023-04-27 2025-03-01 香港商維泰瑞隆（香港）生物科技有限公司 Sarm1調節子、其製劑及用途
CN119219603A (zh) * 2023-06-28 2024-12-31 科辉智药(深圳)新药研究中心有限公司 Sarm1酶活性抑制剂及其用途
WO2025045746A1 (en) * 2023-08-25 2025-03-06 F. Hoffmann-La Roche Ag Pyrazole derivatives as sarm1 inhibitors useful for the treatment of neurodegenerative disorders
WO2025049184A1 (en) 2023-08-25 2025-03-06 Eli Lilly And Company (s)-3-((6-fluoropyridin-3-yl)methyl)-1-(5-(pyridin-4-yl)-4h-1,2,4-triazol-3-yl)piperidin-2-one benzenesulfonate
WO2025076017A1 (en) * 2023-10-05 2025-04-10 Genentech, Inc. Carbamates for use as sarm1 inhibitors
WO2025076088A1 (en) * 2023-10-05 2025-04-10 Genentech, Inc. Lactams for use as sarm1 inhibitors
WO2025157895A1 (en) 2024-01-25 2025-07-31 UCB Biopharma SRL Pyrrolidinone derivatives

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WO2020158762A1 (ja) 2019-01-30 2020-08-06 武田薬品工業株式会社 複素環化合物
JP2021506979A (ja) 2017-12-22 2021-02-22 ラヴェンナ ファーマシューティカルズ，インコーポレイテッド ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアリール−ビピリジンアミン誘導体
JP2021528488A (ja) 2018-06-07 2021-10-21 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１阻害剤
WO2022031736A1 (en) 2020-08-04 2022-02-10 Nura Bio, Inc. Substituted pyridine derivatives as sarm1 inhibitors

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JP2021506979A (ja) 2017-12-22 2021-02-22 ラヴェンナ ファーマシューティカルズ，インコーポレイテッド ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアリール−ビピリジンアミン誘導体
JP2021528488A (ja) 2018-06-07 2021-10-21 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１阻害剤
WO2020158762A1 (ja) 2019-01-30 2020-08-06 武田薬品工業株式会社 複素環化合物
WO2022031736A1 (en) 2020-08-04 2022-02-10 Nura Bio, Inc. Substituted pyridine derivatives as sarm1 inhibitors

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CO2023001975A2 (es) 2023-03-07
CA3189181A1 (en) 2022-03-03
AU2021333558A1 (en) 2023-03-02
KR20230057396A (ko) 2023-04-28
TW202214597A (zh) 2022-04-16
MX2023002256A (es) 2023-03-17
AU2021333558B2 (en) 2024-02-22
ECSP23012981A (es) 2023-03-31
EP4200293A1 (en) 2023-06-28
DOP2023000038A (es) 2023-03-15
US20240376083A1 (en) 2024-11-14
TWI786777B (zh) 2022-12-11
AU2021333558C1 (en) 2024-06-20
JP2023535236A (ja) 2023-08-16
AU2024203373A1 (en) 2024-06-13
CR20230113A (es) 2023-04-14
BR112023002575A2 (pt) 2023-03-07
CL2023000525A1 (es) 2023-09-15
TW202334117A (zh) 2023-09-01
TW202530197A (zh) 2025-08-01
JP7756130B2 (ja) 2025-10-17
PE20230737A1 (es) 2023-05-03
WO2022046606A1 (en) 2022-03-03
US20220056013A1 (en) 2022-02-24
IL300586A (en) 2023-04-01
JP2024016014A (ja) 2024-02-06
US12043613B2 (en) 2024-07-23
ZA202301801B (en) 2024-09-25

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