JP7347743B2 - トラジピタントによるアトピー性皮膚炎の改善された治療 - Google Patents

トラジピタントによるアトピー性皮膚炎の改善された治療 Download PDF

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JP7347743B2
JP7347743B2 JP2020515146A JP2020515146A JP7347743B2 JP 7347743 B2 JP7347743 B2 JP 7347743B2 JP 2020515146 A JP2020515146 A JP 2020515146A JP 2020515146 A JP2020515146 A JP 2020515146A JP 7347743 B2 JP7347743 B2 JP 7347743B2
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tradipitant
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JP2020533381A (ja
JP2020533381A5 (enExample
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ポリメロポウロス、ミハエル、エイチ．
シャオ、チャンフ
ビルズニク、ギュンター
へイトマン、アンドリュー
スミシェク、サンドラ
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Vanda Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Physical Education & Sports Medicine (AREA)
JP2020515146A 2017-09-13 2018-08-30 トラジピタントによるアトピー性皮膚炎の改善された治療 Active JP7347743B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762558303P 2017-09-13 2017-09-13
US62/558,303 2017-09-13
US201762572456P 2017-10-14 2017-10-14
US62/572,456 2017-10-14
PCT/US2018/048825 WO2019055225A1 (en) 2017-09-13 2018-08-30 ENHANCED TREATMENT OF ATOPIC DERMATITIS USING TRADIPITANT

Publications (3)

Publication Number Publication Date
JP2020533381A JP2020533381A (ja) 2020-11-19
JP2020533381A5 JP2020533381A5 (enExample) 2021-09-30
JP7347743B2 true JP7347743B2 (ja) 2023-09-20

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JP2020515146A Active JP7347743B2 (ja) 2017-09-13 2018-08-30 トラジピタントによるアトピー性皮膚炎の改善された治療

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Country Link
US (1) US11549147B2 (enExample)
EP (2) EP3681505B1 (enExample)
JP (1) JP7347743B2 (enExample)
KR (2) KR20250036264A (enExample)
CN (1) CN111093671A (enExample)
AU (1) AU2018331267B2 (enExample)
CA (1) CA3073998A1 (enExample)
CL (1) CL2020000655A1 (enExample)
IL (1) IL272949B2 (enExample)
MX (2) MX2020002852A (enExample)
WO (1) WO2019055225A1 (enExample)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
KR102860817B1 (ko) * 2015-03-04 2025-09-16 반다 파마슈티칼즈, 인코퍼레이티드. 트라디피턴트에 의한 치료 방법
CA3101210A1 (en) 2018-06-08 2019-12-12 Vanda Pharmaceuticals Inc. Method of treatment with tradipitant
CN115052599A (zh) * 2020-02-25 2022-09-13 万达制药公司 以川地匹坦对特应性皮炎的改进治疗
US20230145932A1 (en) 2020-03-26 2023-05-11 Vanda Pharmaceuticals Inc. Treatment of lower respiratory tract infection with tradipitant
WO2021225303A1 (ko) 2020-05-07 2021-11-11 주식회사 엘지에너지솔루션 고-니켈 전극 시트 및 이의 제조방법
US20240350469A1 (en) 2021-08-31 2024-10-24 Vanda Pharmaceuticals Inc. Treatment of lower respiratory tract infection with tradipitant
KR20250123807A (ko) 2022-12-21 2025-08-18 반다 파마슈티칼즈, 인코퍼레이티드. 트라디피탄트를 이용한 치료 방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004250329A (ja) 2002-12-26 2004-09-09 Dainippon Pharmaceut Co Ltd イサチン誘導体
JP2008530522A (ja) 2005-02-07 2008-08-07 ウニヴァズィテーツクリニークム ハンブルク−エッペンドルフ ヒト血清中のｃｄ２８に対する抗体の同定による、アレルギー性疾患、アトピー性疾患および／または自己免疫疾患の診断
JP2014193155A (ja) 2013-02-28 2014-10-09 Rohto Pharmaceut Co Ltd アトピー性疾患の発症又は重症化リスクの評価法
JP2016523260A (ja) 2013-06-24 2016-08-08 タイガーキャット ファーマ インコーポレイテッド そう痒におけるｎｋ−１受容体アンタゴニストのセルロピタントの使用
WO2016141341A1 (en) 2015-03-04 2016-09-09 Vanda Pharmaceuticals Inc. Method of treatment with tradipitant

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DK1501808T3 (da) 2002-04-26 2008-10-13 Lilly Co Eli Tachykininreceptor-antagonister
MXPA04010622A (es) 2002-04-26 2005-01-25 Lilly Co Eli Derivados de triazol como antagonistas de receptor de taquicinina.
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
BRPI0415010B8 (pt) 2003-10-24 2021-05-25 Lilly Co Eli formas cristalinas iv e v de {2-[1-(3,5-bis-trifluorometilbenzil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]-piridin-3-il)-(2-clorofenil)-metanona, (2-clorofenil)-[2-(2-hidróxi-2-piridin-4-il-vinil)piridin-3-il]metanona, seus processos de preparação, e composição farmacêutica sólida
JP4673068B2 (ja) 2005-01-19 2011-04-20 独立行政法人科学技術振興機構 Ｔｈ１型アレルギー疾患治療用組成物
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JP5443168B2 (ja) 2006-12-20 2014-03-19 イーライ リリー アンド カンパニー ｛２−［１−（３，５−ビス−トリフルオロメチル−ベンジル）−５−ピリジン−４−イル−１ｈ−［１，２，３］トリアゾール−４−イル］−ピリジン−３−イル｝−（２−クロロフェニル）−メタノンの調製において有用な新規の中間体及び方法
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JP2004250329A (ja) 2002-12-26 2004-09-09 Dainippon Pharmaceut Co Ltd イサチン誘導体
JP2008530522A (ja) 2005-02-07 2008-08-07 ウニヴァズィテーツクリニークム ハンブルク−エッペンドルフ ヒト血清中のｃｄ２８に対する抗体の同定による、アレルギー性疾患、アトピー性疾患および／または自己免疫疾患の診断
JP2014193155A (ja) 2013-02-28 2014-10-09 Rohto Pharmaceut Co Ltd アトピー性疾患の発症又は重症化リスクの評価法
JP2016523260A (ja) 2013-06-24 2016-08-08 タイガーキャット ファーマ インコーポレイテッド そう痒におけるｎｋ−１受容体アンタゴニストのセルロピタントの使用
WO2016141341A1 (en) 2015-03-04 2016-09-09 Vanda Pharmaceuticals Inc. Method of treatment with tradipitant

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PLoS One，2016年，Vol.11, No.5, e0156077，pp.1-15

Also Published As

Publication number Publication date
EP4487912A3 (en) 2025-03-26
US20210062262A1 (en) 2021-03-04
KR20200054232A (ko) 2020-05-19
CN111093671A (zh) 2020-05-01
RU2020112222A (ru) 2021-10-13
KR20250036264A (ko) 2025-03-13
JP2020533381A (ja) 2020-11-19
EP3681505B1 (en) 2024-12-18
CA3073998A1 (en) 2019-03-21
MX2024004377A (es) 2024-04-26
EP3681505A1 (en) 2020-07-22
EP3681505C0 (en) 2024-12-18
BR112020004964A2 (pt) 2020-09-15
IL272949B2 (en) 2025-07-01
AU2018331267B2 (en) 2024-03-07
EP4487912A2 (en) 2025-01-08
IL272949B1 (en) 2025-03-01
WO2019055225A1 (en) 2019-03-21
US11549147B2 (en) 2023-01-10
IL272949A (en) 2020-04-30
AU2018331267A1 (en) 2020-04-16
MX2020002852A (es) 2020-07-22
CL2020000655A1 (es) 2020-10-09

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