JP7237950B2 - Ｃｄ３８調節抗体 - Google Patents

Ｃｄ３８調節抗体 Download PDF

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JP7237950B2
JP7237950B2 JP2020518572A JP2020518572A JP7237950B2 JP 7237950 B2 JP7237950 B2 JP 7237950B2 JP 2020518572 A JP2020518572 A JP 2020518572A JP 2020518572 A JP2020518572 A JP 2020518572A JP 7237950 B2 JP7237950 B2 JP 7237950B2
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antibody
seq
sequence
antigen
acd38
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JP2020522280A (ja
JP2020522280A5 (enExample
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パスカル メルヒールス
アンヌ グビエ
ケヴィン モウルダー
ニナ アイスラー
ジョセフィン サリム
シモーヌ フィロスト
コルソ ベアトリス ゴイエンチェア
ヘマンタ バルーア
ビアンカ プリンツ
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ブラック ベルト セラピューティクス リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020518572A 2017-06-08 2018-06-08 Ｃｄ３８調節抗体 Active JP7237950B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022202855A JP7467584B2 (ja) 2017-06-08 2022-12-20 Ｃｄ３８調節抗体

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
US201762517150P 2017-06-08 2017-06-08
US201762517149P 2017-06-08 2017-06-08
US62/517,150 2017-06-08
US62/517,149 2017-06-08
US201762517165P 2017-06-09 2017-06-09
US201762517740P 2017-06-09 2017-06-09
US201762517753P 2017-06-09 2017-06-09
US201762517164P 2017-06-09 2017-06-09
US201762517745P 2017-06-09 2017-06-09
US201762517734P 2017-06-09 2017-06-09
US62/517,165 2017-06-09
US62/517,753 2017-06-09
US62/517,745 2017-06-09
US62/517,164 2017-06-09
US62/517,740 2017-06-09
US62/517,734 2017-06-09
US201762582676P 2017-11-07 2017-11-07
US201762582681P 2017-11-07 2017-11-07
US201762582653P 2017-11-07 2017-11-07
US201762582666P 2017-11-07 2017-11-07
US62/582,653 2017-11-07
US62/582,676 2017-11-07
US62/582,681 2017-11-07
US62/582,666 2017-11-07
PCT/EP2018/065239 WO2018224683A1 (en) 2017-06-08 2018-06-08 Cd38 modulating antibody

Related Child Applications (1)

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JP2020522280A JP2020522280A (ja) 2020-07-30
JP2020522280A5 JP2020522280A5 (enExample) 2021-07-26
JP7237950B2 true JP7237950B2 (ja) 2023-03-13

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Country Status (8)

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US (3) US12161717B2 (enExample)
EP (2) EP3635003A1 (enExample)
JP (3) JP7237950B2 (enExample)
KR (3) KR102719065B1 (enExample)
CN (2) CN110997722B (enExample)
AU (3) AU2018280869B2 (enExample)
CA (2) CA3066553A1 (enExample)
WO (2) WO2018224683A1 (enExample)

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WO2019034752A1 (en) 2017-08-16 2019-02-21 Tusk Therapeutics Ltd CD38 MODULATOR ANTIBODY
CN110144008B (zh) * 2018-02-12 2021-03-19 杭州尚健生物技术有限公司 Cd38蛋白抗体及其应用
WO2020146795A1 (en) 2019-01-11 2020-07-16 Omeros Corporation Methods and compositions for treating cancer
CA3127520A1 (en) * 2019-01-23 2020-07-30 Encefa Cd31 competitors and uses thereof
JP2022524559A (ja) 2019-03-12 2022-05-06 アーカス バイオサイエンシーズ，インコーポレーテッド がん遺伝子によって促進されるがんの処置
EP3947465A4 (en) * 2019-03-29 2023-01-04 Sorrento Therapeutics, Inc. MODIFIED VARIANT ANTIBODIES BINDING TO CD38
CN113874397A (zh) 2019-03-29 2021-12-31 艾库斯生物科学有限公司 利用鉴定的腺苷指纹治疗癌症
JP2023541254A (ja) 2020-09-10 2023-09-29 キャシ ファーマシューティカルズ インコーポレイテッド 血液スクリーニング方法
CN114457028A (zh) * 2020-10-30 2022-05-10 未来智人再生医学研究院(广州)有限公司 一种表达cd38抗体的多能干细胞及其衍生物与应用
CN114437215B (zh) * 2020-11-05 2023-02-07 上海麦济生物技术有限公司 抗人cd38抗体及其制备方法和用途

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US20250367286A1 (en) 2025-12-04
AU2018280869B2 (en) 2025-01-02
US12343394B2 (en) 2025-07-01
KR20200021069A (ko) 2020-02-27
KR20200021068A (ko) 2020-02-27
JP2020522280A (ja) 2020-07-30
NZ760342A (en) 2025-03-28
AU2025201908A1 (en) 2025-04-03
CA3066553A1 (en) 2018-12-13
JP2023030071A (ja) 2023-03-07
WO2018224685A1 (en) 2018-12-13
KR102770106B1 (ko) 2025-02-21
WO2018224683A1 (en) 2018-12-13
JP7237951B2 (ja) 2023-03-13
JP7467584B2 (ja) 2024-04-15
KR102719065B1 (ko) 2024-10-17
CA3066555A1 (en) 2018-12-13
CN110997722A (zh) 2020-04-10
US12161717B2 (en) 2024-12-10
AU2018280871A1 (en) 2020-01-16
NZ760448A (en) 2025-03-28
EP3635002A1 (en) 2020-04-15
JP2020522281A (ja) 2020-07-30
AU2018280871B2 (en) 2024-09-26
KR20250025514A (ko) 2025-02-21
AU2018280869A1 (en) 2020-01-16
CN110997723B (zh) 2023-09-26
CN110997722B (zh) 2023-09-26
US20230103584A1 (en) 2023-04-06
AU2018280871A8 (en) 2020-01-30
CN110997723A (zh) 2020-04-10
EP3635003A1 (en) 2020-04-15
US20210277138A1 (en) 2021-09-09

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