AU2018280871B2 - CD38 modulating antibody - Google Patents

CD38 modulating antibody Download PDF

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Publication number
AU2018280871B2
AU2018280871B2 AU2018280871A AU2018280871A AU2018280871B2 AU 2018280871 B2 AU2018280871 B2 AU 2018280871B2 AU 2018280871 A AU2018280871 A AU 2018280871A AU 2018280871 A AU2018280871 A AU 2018280871A AU 2018280871 B2 AU2018280871 B2 AU 2018280871B2
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AU
Australia
Prior art keywords
antibody
acd38
seq
antigen
sequence
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Active
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AU2018280871A
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AU2018280871A8 (en
AU2018280871A1 (en
Inventor
Hemanta Baruah
Nina EISSLER
Simone FILOSTO
Anne Goubier
Beatriz GOYENECHEA CORZO
Pascal Merchiers
Kevin Moulder
Bianka Prinz
Josephine SALIMU
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Black Belt Therapeutics Ltd
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Black Belt Therapeutics Ltd
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
AU2018280871A 2017-06-08 2018-06-08 CD38 modulating antibody Active AU2018280871B2 (en)

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
US201762517150P 2017-06-08 2017-06-08
US201762517149P 2017-06-08 2017-06-08
US62/517,150 2017-06-08
US62/517,149 2017-06-08
US201762517734P 2017-06-09 2017-06-09
US201762517753P 2017-06-09 2017-06-09
US201762517164P 2017-06-09 2017-06-09
US201762517740P 2017-06-09 2017-06-09
US201762517745P 2017-06-09 2017-06-09
US201762517165P 2017-06-09 2017-06-09
US62/517,740 2017-06-09
US62/517,745 2017-06-09
US62/517,734 2017-06-09
US62/517,164 2017-06-09
US62/517,753 2017-06-09
US62/517,165 2017-06-09
US201762582676P 2017-11-07 2017-11-07
US201762582681P 2017-11-07 2017-11-07
US201762582653P 2017-11-07 2017-11-07
US201762582666P 2017-11-07 2017-11-07
US62/582,666 2017-11-07
US62/582,681 2017-11-07
US62/582,676 2017-11-07
US62/582,653 2017-11-07
PCT/EP2018/065243 WO2018224685A1 (en) 2017-06-08 2018-06-08 Cd38 modulating antibody

Publications (3)

Publication Number Publication Date
AU2018280871A1 AU2018280871A1 (en) 2020-01-16
AU2018280871A8 AU2018280871A8 (en) 2020-01-30
AU2018280871B2 true AU2018280871B2 (en) 2024-09-26

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
AU2018280871A Active AU2018280871B2 (en) 2017-06-08 2018-06-08 CD38 modulating antibody
AU2018280869A Active AU2018280869B2 (en) 2017-06-08 2018-06-08 CD38 modulating antibody
AU2025201908A Pending AU2025201908A1 (en) 2017-06-08 2025-03-17 CD38 modulating antibody

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2018280869A Active AU2018280869B2 (en) 2017-06-08 2018-06-08 CD38 modulating antibody
AU2025201908A Pending AU2025201908A1 (en) 2017-06-08 2025-03-17 CD38 modulating antibody

Country Status (8)

Country Link
US (3) US12161717B2 (enExample)
EP (2) EP3635003A1 (enExample)
JP (3) JP7237950B2 (enExample)
KR (3) KR102719065B1 (enExample)
CN (2) CN110997722B (enExample)
AU (3) AU2018280871B2 (enExample)
CA (2) CA3066555A1 (enExample)
WO (2) WO2018224683A1 (enExample)

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WO2020205499A1 (en) * 2019-03-29 2020-10-08 Sorrento Therapeutics, Inc. Engineered variant antibodies that bind cd38
KR20210144821A (ko) 2019-03-29 2021-11-30 아르커스 바이오사이언시즈 인코포레이티드 규명된 아데노신 지문을 이용한 암의 치료방법
CA3190385A1 (en) * 2020-09-10 2022-03-17 Alexander Anthony Zukiwski Methods of blood screening
CN114457028A (zh) * 2020-10-30 2022-05-10 未来智人再生医学研究院(广州)有限公司 一种表达cd38抗体的多能干细胞及其衍生物与应用
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Also Published As

Publication number Publication date
US12343394B2 (en) 2025-07-01
KR20200021068A (ko) 2020-02-27
CA3066555A1 (en) 2018-12-13
US20230103584A1 (en) 2023-04-06
WO2018224683A1 (en) 2018-12-13
EP3635003A1 (en) 2020-04-15
KR20200021069A (ko) 2020-02-27
JP7237951B2 (ja) 2023-03-13
KR102770106B1 (ko) 2025-02-21
AU2018280869B2 (en) 2025-01-02
CN110997722B (zh) 2023-09-26
JP2020522281A (ja) 2020-07-30
CN110997723B (zh) 2023-09-26
KR102719065B1 (ko) 2024-10-17
AU2018280869A1 (en) 2020-01-16
US12161717B2 (en) 2024-12-10
JP2020522280A (ja) 2020-07-30
AU2018280871A8 (en) 2020-01-30
US20210277138A1 (en) 2021-09-09
AU2025201908A1 (en) 2025-04-03
EP3635002A1 (en) 2020-04-15
NZ760342A (en) 2025-03-28
JP2023030071A (ja) 2023-03-07
JP7467584B2 (ja) 2024-04-15
JP7237950B2 (ja) 2023-03-13
NZ760448A (en) 2025-03-28
WO2018224685A1 (en) 2018-12-13
US20250367286A1 (en) 2025-12-04
CN110997722A (zh) 2020-04-10
AU2018280871A1 (en) 2020-01-16
KR20250025514A (ko) 2025-02-21
CN110997723A (zh) 2020-04-10
CA3066553A1 (en) 2018-12-13

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