CA3066555A1 - Cd38 modulating antibody - Google Patents

Cd38 modulating antibody Download PDF

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Publication number
CA3066555A1
CA3066555A1 CA3066555A CA3066555A CA3066555A1 CA 3066555 A1 CA3066555 A1 CA 3066555A1 CA 3066555 A CA3066555 A CA 3066555A CA 3066555 A CA3066555 A CA 3066555A CA 3066555 A1 CA3066555 A1 CA 3066555A1
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CA
Canada
Prior art keywords
antibody
antigen
binding fragment
sequence
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3066555A
Other languages
English (en)
French (fr)
Inventor
Pascal Merchiers
Anne Goubier
Kevin Moulder
Nina EISSLER
Josephine SALIMU
Simone FILOSTO
Beatriz GOYENECHEA CORZO
Hemanta Baruah
Bianka Prinz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Black Belt Therapeutics Ltd
Original Assignee
Black Belt Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Black Belt Therapeutics Ltd filed Critical Black Belt Therapeutics Ltd
Publication of CA3066555A1 publication Critical patent/CA3066555A1/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74Inducing cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CA3066555A 2017-06-08 2018-06-08 Cd38 modulating antibody Pending CA3066555A1 (en)

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
US201762517150P 2017-06-08 2017-06-08
US201762517149P 2017-06-08 2017-06-08
US62/517,150 2017-06-08
US62/517,149 2017-06-08
US201762517734P 2017-06-09 2017-06-09
US201762517753P 2017-06-09 2017-06-09
US201762517164P 2017-06-09 2017-06-09
US201762517740P 2017-06-09 2017-06-09
US201762517745P 2017-06-09 2017-06-09
US201762517165P 2017-06-09 2017-06-09
US62/517,740 2017-06-09
US62/517,745 2017-06-09
US62/517,734 2017-06-09
US62/517,164 2017-06-09
US62/517,753 2017-06-09
US62/517,165 2017-06-09
US201762582676P 2017-11-07 2017-11-07
US201762582681P 2017-11-07 2017-11-07
US201762582653P 2017-11-07 2017-11-07
US201762582666P 2017-11-07 2017-11-07
US62/582,666 2017-11-07
US62/582,681 2017-11-07
US62/582,676 2017-11-07
US62/582,653 2017-11-07
PCT/EP2018/065243 WO2018224685A1 (en) 2017-06-08 2018-06-08 Cd38 modulating antibody

Publications (1)

Publication Number Publication Date
CA3066555A1 true CA3066555A1 (en) 2018-12-13

Family

ID=62620847

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3066555A Pending CA3066555A1 (en) 2017-06-08 2018-06-08 Cd38 modulating antibody
CA3066553A Pending CA3066553A1 (en) 2017-06-08 2018-06-08 Cd38 modulating antibody

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3066553A Pending CA3066553A1 (en) 2017-06-08 2018-06-08 Cd38 modulating antibody

Country Status (8)

Country Link
US (3) US12161717B2 (enExample)
EP (2) EP3635003A1 (enExample)
JP (3) JP7237950B2 (enExample)
KR (3) KR102719065B1 (enExample)
CN (2) CN110997722B (enExample)
AU (3) AU2018280871B2 (enExample)
CA (2) CA3066555A1 (enExample)
WO (2) WO2018224683A1 (enExample)

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CA3190385A1 (en) * 2020-09-10 2022-03-17 Alexander Anthony Zukiwski Methods of blood screening
CN114457028A (zh) * 2020-10-30 2022-05-10 未来智人再生医学研究院(广州)有限公司 一种表达cd38抗体的多能干细胞及其衍生物与应用
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Also Published As

Publication number Publication date
US12343394B2 (en) 2025-07-01
KR20200021068A (ko) 2020-02-27
US20230103584A1 (en) 2023-04-06
WO2018224683A1 (en) 2018-12-13
EP3635003A1 (en) 2020-04-15
KR20200021069A (ko) 2020-02-27
JP7237951B2 (ja) 2023-03-13
KR102770106B1 (ko) 2025-02-21
AU2018280869B2 (en) 2025-01-02
CN110997722B (zh) 2023-09-26
AU2018280871B2 (en) 2024-09-26
JP2020522281A (ja) 2020-07-30
CN110997723B (zh) 2023-09-26
KR102719065B1 (ko) 2024-10-17
AU2018280869A1 (en) 2020-01-16
US12161717B2 (en) 2024-12-10
JP2020522280A (ja) 2020-07-30
AU2018280871A8 (en) 2020-01-30
US20210277138A1 (en) 2021-09-09
AU2025201908A1 (en) 2025-04-03
EP3635002A1 (en) 2020-04-15
NZ760342A (en) 2025-03-28
JP2023030071A (ja) 2023-03-07
JP7467584B2 (ja) 2024-04-15
JP7237950B2 (ja) 2023-03-13
NZ760448A (en) 2025-03-28
WO2018224685A1 (en) 2018-12-13
US20250367286A1 (en) 2025-12-04
CN110997722A (zh) 2020-04-10
AU2018280871A1 (en) 2020-01-16
KR20250025514A (ko) 2025-02-21
CN110997723A (zh) 2020-04-10
CA3066553A1 (en) 2018-12-13

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