JP7223809B2 - Anti-aging eye cream and its preparation method - Google Patents

Description

TECHNICAL FIELD The present invention belongs to the technical field of skin care products, and specifically relates to an anti-aging eye cream and its preparation method.

Skin aging is the most common aging phenomenon in the human body, mainly divided into natural aging and environmental aging. Mainly caused by light, it manifests as sagging skin, wrinkles that deepen and thicken, and pores that become enlarged. With age, facial skin gradually ages and eye skin problems become more pronounced. In order to delay the aging of the skin around the eyes, in addition to ensuring sufficient sleep and developing good lifestyle habits and eye habits in daily life, the general method is to prevent wrinkles and moisturizing effect. is to use eye cosmetics with With continuous research on wrinkle formation, anti-wrinkle cosmetics are further developed, but the processing of current anti-wrinkle cosmetics is mainly the preparation of raw materials by heating, stirring and uniform fusion in the appropriate proportions, In many cases, the interfacial effect between the raw materials cannot be broken, the quality of the finished product is uneven, the sediment is easy to form, and the anti-wrinkle effect is not great. For example, application number CN201410224642. X discloses an eye cream containing fucoidan and pomegranate extract and a method for its preparation. The eye cream containing fucoidan and pomegranate extract of that application is composed of the following ingredients in weight percent: 0.2%-2.0% fucoidan, 0.1%-1.0% pomegranate extract, glycerin. 4.0%-7.0%, transparent sodium phosphate 0.05%-0.1%, softener 1.5%-3.0%, cetostearyl alcohol 0.5%, IPM 2.0%- 3.0%, EUMULGIN S2 0.1%-1.0%, EUMULGIN S21 0.2%, thickener 0.5%, polydimethylsiloxane 1.0%, skin feel modifier 1.0%-2 .0%, ethylhexylglycerol 0.05%-0.5%, phenoxyethanol 0.5%-0.6%, flavors 0.05%-0.08%, and the balance deionized water. That application also discloses a method for preparing the eye cream. The eye cream of that application has anti-fine lines and anti-wrinkle function. The processing procedure of that application is simple heat stirring, uniform fusion, and the free radical scavenging effect of the final product is not remarkable, and needs further enhancement and improvement.

SUMMARY OF THE INVENTION It is an object of the present invention to provide an anti-aging eye cream and its preparation method in view of existing problems.

The present invention is realized by the following technical solutions.

Anti-aging eye cream consists of the following ingredients:
Skin care active agent (C20-22 alcohol phosphate), viscous solvent (butanediol, C20-22 alcohol), polysiloxane elastomer (polydimethylsiloxane), pH adjuster (triethanolamine), emollient (ethylene glycol palmitate, isononanoic acid) isononyl, hydrogenated polydecene, ethylhexylglycerol), adsorbent (silica), emulsion stabilizer (acrylic/C10-30 acrylic acid alkanol crosslinked polymer, polyacrylate-13, xanthan gum), structural reagent (xylitol glucoside, anhydroxylitol, xylitol , GLYCINE SOJA OIL, NYMPHAEA ALBA EXTRACT), NON-ESSENTIAL INGREDIENTS (HYDROXYPROPYL TETRAHYDROPYRANTRIOL, GLUCOSE, CHONDRUS CRISPUS EXTRACT, DUNALIELLA SALINA EXTRACT, African baobab (ADANSONIA DIGITATA) pulp extract, methylsilanol hydroxyproline aspartic acid, retinol, glycolipids, glycosphingolipids, acetyl hexapeptide, sodium palmitoylproline carboxylate, flavor), balance is water.

Further, the method for preparing the above anti-aging eye cream includes the following steps:
(1) Electron beam irradiation treatment:
By weight percent, 0.4-0.8% butanediol, 0.5-0.6% C20-22 alcohol phosphate, 0.2-0.4% C20-22 alcohol, 0.3-0 polydimethylsiloxane .5%, ethylene glycol palmitate 2-3%, isononyl isononanoate 1.3-1.6%, hydrogenated polydecene 0.7-0.9%, silica 2-3%, acrylic/C10-30 acrylic acid Alkanol crosslinked polymer 0.5-0.9%, polyacrylate-13 2.3-2.7%, xylitol glucoside 1.4-2%, anhydroxyritol 2.1-2.6%, xylitol 2.3% ~2.5%, Hydroxypropyl Tetrahydropyrantriol 1.3-1.7%, Xanthan Gum 4-5%, Glucose 2.1-2.5%, Chondrus Crispus Extract 5-6%, 3-5% Dunaliella Salina Extract, 2-4% Glycine Soja Oil, 5-7% African Baobab (ADANSONIA DIGITATA) Flesh Extract, 3.5% White Water Lily (NYMPHAEA ALBA) Extract ~4.5%, methylsilanol hydroxyproline aspartic acid 2.1-2.5%, retinol 3-4%, glycolipids 1.4-1.8%, glycosphingolipids 2-3%, acetyl hexapeptide- 8 0.8-1.4%, sodium palmitoylproline carboxylate 2.4-3%, triethanolamine 0.9-1.5%, ethylhexylglycerol 8-12%, flavor 0.07-0.09% , 30-40% of glycerin is weighed, the rest is water, mixed uniformly, put into GJ-1.5 type high-frequency high-voltage high-power electron accelerator and subjected to electron beam irradiation treatment, and after completion, mixture A prepared as

(2) Continuous flash explosion treatment:
The mixture A obtained in step (1) is placed in a continuous screw flash explosion device for continuous flash explosion treatment, and prepared as mixture B after completion.

(3) Microwave treatment:
The mixture B obtained in step (2) is placed in a microwave environment and subjected to microwave treatment, and after completion is provided as mixture C.

(4) Distributed processing:
The mixture C obtained in step (3) is placed in a dispersion cylinder and uniformly dispersed at a rotation speed of 700 to 1000 rpm to prepare a dispersion.

(5) UV-ultrasonic coupling treatment:
The dispersion obtained in step (4) is placed in an ultrasonic environment and subjected to UV-ultrasonic coupling treatment for 30-40 minutes.

Further, the dose during the electron beam irradiation treatment in step (1) is controlled to 2 to 3× ^{10 6} rad/s, and the treatment time is 5 to 10 minutes.

According to the above technical solution, the raw materials such as butanediol, C20-22 alcohol phosphate, C20-22 alcohol are uniformly mixed in a suitable weight ratio and subjected to electron beam irradiation treatment, and the high energy from the electron accelerator The electron beam penetrates the mixture, forming a certain amount of active free radicals on the surface of each raw material in the mixture, uniformly decomposing the high molecular weight polymer, weakening the interfacial effect between each raw material component, and refining the mixture. In particular, the basic components of the functional ingredients are fused together and the mixture is processed homogeneously.

Further, the rotation speed of the screw during continuous flash explosion treatment in step (2) is controlled to 700-900 rpm, and the number of times of continuous flash explosion treatment is 11-13.

According to the above technical solutions, the mixture obtained after electron beam treatment is put into a continuous flash explosion device for continuous flash explosion treatment. In this process, after the raw material is steamed with high temperature and high pressure medium, the pressure is suddenly released, each raw material jointly releases energy, the gas medium and water in the raw material expand instantaneously, work outward, The degree of polymerization of raw materials is further reduced, and after repeated operation, the interfacial effect between raw materials is almost completely weakened, promoting uniform fusion between raw materials, and at the same time preventing the precipitation phenomenon of finished products.

Furthermore, the output of microwaves during the microwave treatment in step (3) is controlled to 600-800 W, and the microwave treatment time is 2-4 minutes.

According to the above technical solution, the flash explosion product is placed in a microwave environment, heated inside and outside evenly, and then subjected to uniform dispersion treatment to increase the degree of emulsification. Promotes fusion between retinol, African baobab (ADANSONIA DIGITATA) pulp extract, white lotus (NYMPHAEA ALBA) extract, methylsilanol hydroxyproline aspartate, glycolipids, glycosphingolipids, and butanediol, a C20-22 alcohol , to get more fine and uniform effect.

Further, the wavelength of ultraviolet rays during the ultraviolet-ultrasonic coupling treatment in step (5) is controlled to 200-400 nm, and the frequency of ultrasonic waves is 70-90 kHz.

According to the above technical solutions, through the combined action of ultraviolet light irradiation and ultrasonic waves, the finished product can be debubbled and thoroughly sterilized, while simultaneously decomposing, cross-linking and oxidizing the polymer, It improves the wettability and viscosity of the polymer, as well as increases the degree of emulsification and improves the quality of the finished product. Acetyl hexapeptide-8 provided in the present invention, hydroxypropyltetrahydropyrantriol, retinol, African baobab (ADANSONIA DIGITATA) pulp extract, white lotus (NYMPHAEA ALBA) extract, methylsilanol hydroxyproline aspartic acid, glycolipid, A synergistic combinatorial active composition of glycosphingolipids constructs an elemental anti-aging active system that effectively resists saccharification while resisting oxidation. As for anti-glycation, it can not only prevent glycation and cross-linking, but also achieve reversal of glycation. , protects the extracellular matrix and can also protect DNA. Said active composition may inhibit matrix metalloproteinases and collagenases, combat chronic roughness and dullness, restore skin elasticity, clarity and softness, while improving skin defense capabilities. can.

Compared with the prior art, the present invention has the following advantages.

The present application provides an anti-aging eye cream and its preparation method, the finally prepared eye cream has a relatively high scavenging rate of DPPH free radicals, and the scavenging rate of 0.1 mg/mL eye cream test solution is reaches 63.52%. That is, the eye cream prepared by the method of the present application has remarkable antioxidant and anti-aging effects.

FIG. 3 is a test data comparison chart of the free radical scavenging rate of each example and control group eye cream in specific embodiments of the present application.

Anti-aging eye cream consists of the following ingredients:
Skin care active agent (C20-22 alcohol phosphate), viscous solvent (butanediol, C20-22 alcohol), polysiloxane elastomer (polydimethylsiloxane), pH adjuster (triethanolamine), emollient (ethylene glycol palmitate, isononanoic acid) isononyl, hydrogenated polydecene, ethylhexylglycerol), adsorbent (silica), emulsion stabilizer (acrylic/C10-30 acrylic acid alkanol crosslinked polymer, polyacrylate-13, xanthan gum), structural reagent (xylitol glucoside, anhydroxylitol, xylitol , GLYCINE SOJA OIL, NYMPHAEA ALBA EXTRACT), NON-ESSENTIAL INGREDIENTS (HYDROXYPROPYL TETRAHYDROPYRANTRIOL, GLUCOSE, CHONDRUS CRISPUS EXTRACT, DUNALIELLA SALINA EXTRACT, African baobab (ADANSONIA DIGITATA) pulp extract, methylsilanol hydroxyproline aspartic acid, retinol, glycolipids, glycosphingolipids, acetyl hexapeptide, sodium palmitoylproline carboxylate, flavor), balance is water.

The method for preparing the above anti-aging eye cream includes the following steps:
(1) Electron beam irradiation treatment:
0.4-0.8% by weight butanediol, 0.5-0.6% C20-22 alcohol phosphate, 0.2-0.4% C20-22 alcohol, 0.3-0.4% polydimethylsiloxane. 5%, ethylene glycol palmitate 2-3%, isononyl isononanoate 1.3-1.6%, hydrogenated polydecene 0.7-0.9%, silica 2-3%, acrylic/C10-30 alkanol acrylate. Crosslinked polymer 0.5-0.9%, polyacrylate-13 2.3-2.7%, xylitol glucoside 1.4-2%, anhydroxyritol 2.1-2.6%, xylitol 2.3- 2.5%, Hydroxypropyl Tetrahydropyrantriol 1.3-1.7%, Xanthan Gum 4-5%, Glucose 2.1-2.5%, Chondrus Crispus Extract 5-6%, Donaliella Salina (DUNALIELLA SALINA) extract 3-5%, wild bean (GLYCINE SOJA) oil 2-4%, African baobab (ADANSONIA DIGITATA) pulp extract 5-7%, white water lily (NYMPHAEA ALBA) extract 3.5~ 4.5%, methylsilanol hydroxyproline aspartic acid 2.1-2.5%, retinol 3-4%, glycolipid 1.4-1.8%, glycosphingolipid 2-3%, acetyl hexapeptide-8 0.8-1.4%, sodium palmitoylproline carboxylate 2.4-3%, triethanolamine 0.9-1.5%, ethylhexylglycerol 8-12%, flavor 0.07-0.09%, 30-40% of glycerin is weighed, the remainder is water, mixed uniformly, put into GJ-1.5 type high-frequency high-voltage, high-power electron accelerator and subjected to electron beam irradiation treatment, and the dose is 2-3x. Controlled at 10 ⁶ rad/s, treatment time 5-10 min, ready as mixture A after completion;

(2) Continuous flash explosion treatment:
The mixture A obtained in step (1) is placed in a continuous screw flash explosion device for continuous flash explosion treatment, the rotation speed of the screw is controlled at 700-900 rpm, and the number of continuous flash explosion treatment is 11-13 times. Yes, provided as mixture B after completion;

(3) Microwave treatment:
The mixture B obtained in step (2) is placed in a microwave environment for microwave treatment, the microwave power is controlled at 600-800 W, the microwave treatment time is 2-4 minutes, and the mixture C is completed. prepared as

(4) Distributed processing:
The mixture C obtained in step (3) is placed in a dispersion cylinder and uniformly dispersed at a rotation speed of 700 to 1000 rpm to prepare a dispersion.

(5) UV-ultrasonic coupling treatment:
The dispersion obtained in step (4) is placed in an ultrasonic environment, subjected to ultraviolet-ultrasonic coupling treatment, the wavelength of ultraviolet rays is controlled to 200-400 nm, the frequency of ultrasonic waves is 70-90 kHz, and the frequency of ultrasonic waves is 30. It is sufficient to process for ~40 minutes.

In order to further interpret the present invention, it is described in detail below in conjunction with specific examples.

Example 1
Anti-aging eye cream consists of the following ingredients:
Skin care active agent (C20-22 alcohol phosphate), viscous solvent (butanediol, C20-22 alcohol), polysiloxane elastomer (polydimethylsiloxane), pH adjuster (triethanolamine), emollient (ethylene glycol palmitate, isononanoic acid) isononyl, hydrogenated polydecene, ethylhexylglycerol), adsorbent (silica), emulsion stabilizer (acrylic/C10-30 acrylic acid alkanol crosslinked polymer, polyacrylate-13, xanthan gum), structural reagent (xylitol glucoside, anhydroxylitol, xylitol , GLYCINE SOJA OIL, NYMPHAEA ALBA EXTRACT), NON-ESSENTIAL INGREDIENTS (HYDROXYPROPYL TETRAHYDROPYRANTRIOL, GLUCOSE, CHONDRUS CRISPUS EXTRACT, DUNALIELLA SALINA EXTRACT, African baobab (ADANSONIA DIGITATA) pulp extract, methylsilanol hydroxyproline aspartic acid, retinol, glycolipids, glycosphingolipids, acetyl hexapeptide, sodium palmitoylproline carboxylate, flavor), balance is water.

The method for preparing the above anti-aging eye cream includes the following steps:
(1) Electron beam irradiation treatment:
0.4% by weight butanediol, 0.5% C20-22 alcohol phosphate, 0.2% C20-22 alcohol, 0.3% polydimethylsiloxane, 2% ethylene glycol palmitate, 1.3 isononyl isononanoate %, hydrogenated polydecene 0.7%, silica 2%, acrylic/C10-30 acrylated alkanol crosslinked polymer 0.5%, polyacrylate-13 2.3%, xylitol glucoside 1.4%, anhydroxylitol 2. 1%, xylitol 2.3%, hydroxypropyltetrahydropyrantriol 1.3%, xanthan gum 4%, glucose 2.1%, CHONDRUS CRISPUS extract 5%, DUNALIELLA SALINA extract 3 %, GLYCINE SOJA oil 2%, African baobab (ADANSONIA DIGITATA) pulp extract 5%, White lotus (NYMPHAEA ALBA) extract 3.5%, Methylsilanol Hydroxyproline Aspartate 2.1%, Retinol 3% %, glycolipid 1.4%, glycosphingolipid 2%, acetyl hexapeptide-8 0.8%, sodium palmitoylproline carboxylate 2.4%, triethanolamine 0.9%, ethylhexylglycerol 8%, flavor 0 07% glycerin and 30% glycerin were weighed, and the remainder was water. The mixture was uniformly mixed and put into a GJ-1.5 type high-frequency, high-voltage, high-output electron accelerator for electron beam irradiation treatment. Controlled at 5×10 ⁶ rad/s, treatment time is 5 min, ready as mixture A after completion;

(2) Continuous flash explosion treatment:
The mixture A obtained in step (1) was placed in a continuous screw flash explosion device for continuous flash explosion treatment, the screw rotation speed was controlled at 700 rpm, and the number of continuous flash explosion treatments was 11 times, which was completed. provided as a post-mixture B,

(3) Microwave treatment:
The mixture B obtained in step (2) is placed in a microwave environment for microwave treatment, the microwave output is controlled at 600 W, the microwave treatment time is 2 minutes, and after completion, prepare as mixture C.

(4) Distributed processing:
The mixture C obtained in step (3) is placed in a dispersion cylinder and uniformly dispersed at a rotation speed of 700 rpm to prepare a dispersion.

(5) UV-ultrasonic coupling treatment:
The dispersion obtained in step (4) is placed in an ultrasonic environment, subjected to ultraviolet-ultrasonic coupling treatment, the wavelength of ultraviolet rays is controlled to 200 nm, the frequency of ultrasonic waves is 70 kHz, and the treatment may be performed for 30 minutes. .

Example 2
Anti-aging eye cream consists of the following ingredients:
Skin care active agent (C20-22 alcohol phosphate), viscous solvent (butanediol, C20-22 alcohol), polysiloxane elastomer (polydimethylsiloxane), pH adjuster (triethanolamine), emollient (ethylene glycol palmitate, isononanoic acid) isononyl, hydrogenated polydecene, ethylhexylglycerol), adsorbent (silica), emulsion stabilizer (acrylic/C10-30 acrylic acid alkanol crosslinked polymer, polyacrylate-13, xanthan gum), structural reagent (xylitol glucoside, anhydroxylitol, xylitol , GLYCINE SOJA OIL, NYMPHAEA ALBA EXTRACT), NON-ESSENTIAL INGREDIENTS (HYDROXYPROPYL TETRAHYDROPYRANTRIOL, GLUCOSE, CHONDRUS CRISPUS EXTRACT, DUNALIELLA SALINA EXTRACT, African baobab (ADANSONIA DIGITATA) pulp extract, methylsilanol hydroxyproline aspartic acid, retinol, glycolipids, glycosphingolipids, acetyl hexapeptide, sodium palmitoylproline carboxylate, flavor), balance is water.

The method for preparing the above anti-aging eye cream includes the following steps:
(1) Electron beam irradiation treatment:
0.6% by weight butanediol, 0.55% C20-22 alcohol phosphate, 0.3% C20-22 alcohol, 0.4% polydimethylsiloxane, 2.5% ethylene glycol palmitate, 1 isononyl isononanoate .45%, hydrogenated polydecene 0.8%, silica 2.5%, acrylic/C10-30 acrylic alkanol crosslinked polymer 0.7%, polyacrylate-13 2.5%, xylitol glucoside 1.7%, Hydroxylitol 2.35%, Xylitol 2.4%, Hydroxypropyl Tetrahydropyrantriol 1.5%, Xanthan Gum 4.5%, Glucose 2.3%, Chondrus Crispus Extract 5.5%, Donaliella Salina (DUNALIELLA SALINA) extract 4%, wild bean (GLYCINE SOJA) oil 3%, African baobab (ADANSONIA DIGITATA) pulp extract 6%, white lotus (NYMPHAEA ALBA) extract 4%, methylsilanol hydroxyproline aspartate 2 3%, retinol 3.5%, glycolipid 1.6%, glycosphingolipid 2.5%, acetyl hexapeptide-8 1.1%, sodium palmitoylproline carboxylate 2.7%, triethanolamine 1. 2%, ethylhexylglycerol 10%, flavor 0.08%, glycerin 35%, and the rest is water. Radiation treatment is carried out, the dose is controlled at 2.5×10 rad/s, the treatment time is 7.5 min, and is prepared as mixture A after completion;

(2) Continuous flash explosion treatment:
The mixture A obtained in step (1) was put into a continuous screw flash explosion device for continuous flash explosion treatment, the rotation speed of the screw was controlled at 800 rpm, and the number of continuous flash explosion treatments was 12 times, which was completed. provided as a post-mixture B,

(3) Microwave treatment:
The mixture B obtained in step (2) is placed in a microwave environment for microwave treatment, the microwave power is controlled at 700 W, the microwave treatment time is 3 minutes, and after completion, prepare as mixture C.

(4) Distributed processing:
The mixture C obtained in step (3) is placed in a dispersion cylinder and uniformly dispersed at a rotation speed of 8500 rpm to prepare a dispersion.

(5) UV-ultrasonic coupling treatment:
The dispersion obtained in step (4) is placed in an ultrasonic environment, subjected to ultraviolet-ultrasonic coupling treatment, the wavelength of ultraviolet rays is controlled to 300 nm, the frequency of ultrasonic waves is 80 kHz, and the treatment may be performed for 35 minutes. .

Example 3
Anti-aging eye cream consists of the following ingredients:
Skin care active agent (C20-22 alcohol phosphate), viscous solvent (butanediol, C20-22 alcohol), polysiloxane elastomer (polydimethylsiloxane), pH adjuster (triethanolamine), emollient (ethylene glycol palmitate, isononanoic acid) isononyl, hydrogenated polydecene, ethylhexylglycerol), adsorbent (silica), emulsion stabilizer (acrylic/C10-30 acrylic acid alkanol crosslinked polymer, polyacrylate-13, xanthan gum), structural reagent (xylitol glucoside, anhydroxylitol, xylitol , GLYCINE SOJA OIL, NYMPHAEA ALBA EXTRACT), NON-ESSENTIAL INGREDIENTS (HYDROXYPROPYL TETRAHYDROPYRANTRIOL, GLUCOSE, CHONDRUS CRISPUS EXTRACT, DUNALIELLA SALINA EXTRACT, African baobab (ADANSONIA DIGITATA) pulp extract, methylsilanol hydroxyproline aspartic acid, retinol, glycolipids, glycosphingolipids, acetyl hexapeptide, sodium palmitoylproline carboxylate, flavor), balance is water.

The method for preparing the above anti-aging eye cream includes the following steps:
(1) Electron beam irradiation treatment:
0.8% by weight butanediol, 0.6% C20-22 alcohol phosphate, 0.4% C20-22 alcohol, 0.5% polydimethylsiloxane, 3% ethylene glycol palmitate, 1.6 isononyl isononanoate %, hydrogenated polydecene 0.9%, silica 3%, acrylic/C10-30 acrylic alkanol crosslinked polymer 0.9%, polyacrylate-13 2.7%, xylitol glucoside 2%, anhydroxyritol 2.6%. , xylitol 2.5%, hydroxypropyltetrahydropyrantriol 1.7%, xanthan gum 5%, glucose 2.5%, CHONDRUS CRISPUS extract 5-6%, DUNALIELLA SALINA extract 5 %, Glycine Soja Oil 4%, African Baobab (Adansonia Digitata) Pulp Extract 7%, White Water Lily (NYMPHAEA ALBA) Extract 4.5%, Methylsilanol Hydroxyproline Aspartic Acid 2.5%, Retinol 4% %, glycolipid 1.8%, glycosphingolipid 3%, acetyl hexapeptide-8 1.4%, sodium palmitoylproline carboxylate 3%, triethanolamine 1.5%, ethylhexylglycerol 12%, flavor 0.09 % and 40% glycerin, and the rest is water. The mixture is uniformly mixed and placed in a GJ-1.5 high-frequency, high-voltage, high-power electron accelerator for electron beam irradiation treatment, with a dose of 3×10 ^{6 .} Controlled at rad/s, processing time is 10 min, ready as mixture A after completion;

(2) Continuous flash explosion treatment:
The mixture A obtained in step (1) was put into a continuous screw flash explosion device for continuous flash explosion treatment, the rotation speed of the screw was controlled at 900 rpm, and the number of continuous flash explosion treatments was 13 times, which was completed. provided as a post-mixture B,

(3) Microwave treatment:
The mixture B obtained in step (2) is placed in a microwave environment for microwave treatment, the microwave power is controlled to 800 W, the microwave treatment time is 4 min, and after completion, prepare as mixture C.

(4) Distributed processing:
The mixture C obtained in step (3) is placed in a dispersion cylinder and uniformly dispersed at a rotation speed of 1000 rpm to prepare a dispersion.

(5) UV-ultrasonic coupling treatment:
The dispersion obtained in step (4) is placed in an ultrasonic environment, subjected to ultraviolet-ultrasonic coupling treatment, the wavelength of ultraviolet rays is controlled to 400 nm, the frequency of ultrasonic waves is 90 kHz, and the treatment may be performed for 40 minutes. .

Example 4
Anti-aging eye cream consists of the following ingredients:
Skin care active agent (C20-22 alcohol phosphate), viscous solvent (butanediol, C20-22 alcohol), polysiloxane elastomer (polydimethylsiloxane), pH adjuster (triethanolamine), emollient (ethylene glycol palmitate, isononanoic acid) isononyl, hydrogenated polydecene, ethylhexylglycerol), adsorbent (silica), emulsion stabilizer (acrylic/C10-30 acrylic acid alkanol crosslinked polymer, polyacrylate-13, xanthan gum), structural reagent (xylitol glucoside, anhydroxylitol, xylitol , GLYCINE SOJA OIL, NYMPHAEA ALBA EXTRACT), NON-ESSENTIAL INGREDIENTS (HYDROXYPROPYL TETRAHYDROPYRANTRIOL, GLUCOSE, CHONDRUS CRISPUS EXTRACT, DUNALIELLA SALINA EXTRACT, African baobab (ADANSONIA DIGITATA) pulp extract, methylsilanol hydroxyproline aspartic acid, retinol, glycolipids, glycosphingolipids, acetyl hexapeptide, sodium palmitoylproline carboxylate, flavor), balance is water.

The method for preparing the above anti-aging eye cream includes the following steps:
(1) Electron beam irradiation treatment:
0.6% by weight butanediol, 0.55% C20-22 alcohol phosphate, 0.3% C20-22 alcohol, 0.4% polydimethylsiloxane, 2.5% ethylene glycol palmitate, 1 isononyl isononanoate .45%, hydrogenated polydecene 0.8%, silica 2.5%, acrylic/C10-30 acrylic alkanol crosslinked polymer 0.7%, polyacrylate-13 2.5%, xylitol glucoside 1.7%, Hydroxylitol 2.35%, Xylitol 2.4%, Hydroxypropyl Tetrahydropyrantriol 1.5%, Xanthan Gum 4.5%, Glucose 2.3%, Chondrus Crispus Extract 5.5%, Donaliella Salina (DUNALIELLA SALINA) extract 4%, wild bean (GLYCINE SOJA) oil 3%, African baobab (ADANSONIA DIGITATA) pulp extract 6%, white lotus (NYMPHAEA ALBA) extract 4%, methylsilanol hydroxyproline aspartate 2 3%, retinol 3.5%, glycolipid 1.6%, glycosphingolipid 2.5%, acetyl hexapeptide-8 1.1%, sodium palmitoylproline carboxylate 2.7%, triethanolamine 1. 2%, ethylhexylglycerol 10%, flavor 0.08%, glycerin 35%, the rest is water, mixed uniformly and put into a continuous screw flash explosion device for continuous flash explosion treatment, The rotation speed is controlled at 800 rpm, the number of continuous flash explosion treatment is 12 times, and it is prepared as mixture B after completion;

(2) Microwave treatment:
The mixture B obtained in step (1) is placed in a microwave environment for microwave treatment, the microwave output is controlled at 700 W, the microwave treatment time is 3 minutes, and after completion, prepare as mixture C.

(3) Distributed processing:
The mixture C obtained in step (2) is placed in a dispersion cylinder and uniformly dispersed at a rotation speed of 8500 rpm to prepare a dispersion.

(4) UV-ultrasonic coupling treatment:
The dispersion obtained in step (3) is placed in an ultrasonic environment, subjected to ultraviolet-ultrasonic coupling treatment, the wavelength of ultraviolet light is controlled to 300 nm, the frequency of ultrasonic waves is 80 kHz, and the treatment may be performed for 35 minutes. .

Example 5
Anti-aging eye cream consists of the following ingredients:
Skin care active agent (C20-22 alcohol phosphate), viscous solvent (butanediol, C20-22 alcohol), polysiloxane elastomer (polydimethylsiloxane), pH adjuster (triethanolamine), emollient (ethylene glycol palmitate, isononanoic acid) isononyl, hydrogenated polydecene, ethylhexylglycerol), adsorbent (silica), emulsion stabilizer (acrylic/C10-30 acrylic acid alkanol crosslinked polymer, polyacrylate-13, xanthan gum), structural reagent (xylitol glucoside, anhydroxylitol, xylitol , GLYCINE SOJA OIL, NYMPHAEA ALBA EXTRACT), NON-ESSENTIAL INGREDIENTS (HYDROXYPROPYL TETRAHYDROPYRANTRIOL, GLUCOSE, CHONDRUS CRISPUS EXTRACT, DUNALIELLA SALINA EXTRACT, African baobab (ADANSONIA DIGITATA) pulp extract, methylsilanol hydroxyproline aspartic acid, retinol, glycolipids, glycosphingolipids, acetyl hexapeptide, sodium palmitoylproline carboxylate, flavors), balance is water.

The method for preparing the above anti-aging eye cream includes the following steps:
(1) Electron beam irradiation treatment:
0.6% by weight butanediol, 0.55% C20-22 alcohol phosphate, 0.3% C20-22 alcohol, 0.4% polydimethylsiloxane, 2.5% ethylene glycol palmitate, 1 isononyl isononanoate .45%, hydrogenated polydecene 0.8%, silica 2.5%, acrylic/C10-30 acrylic alkanol crosslinked polymer 0.7%, polyacrylate-13 2.5%, xylitol glucoside 1.7%, Hydroxylitol 2.35%, Xylitol 2.4%, Hydroxypropyl Tetrahydropyrantriol 1.5%, Xanthan Gum 4.5%, Glucose 2.3%, Chondrus Crispus Extract 5.5%, Donaliella Salina (DUNALIELLA SALINA) extract 4%, wild bean (GLYCINE SOJA) oil 3%, African baobab (ADANSONIA DIGITATA) pulp extract 6%, white lotus (NYMPHAEA ALBA) extract 4%, methylsilanol hydroxyproline aspartate 2 3%, retinol 3.5%, glycolipid 1.6%, glycosphingolipid 2.5%, acetyl hexapeptide-8 1.1%, sodium palmitoylproline carboxylate 2.7%, triethanolamine 1. 2%, ethylhexylglycerol 10%, flavor 0.08%, glycerin 35%, and the rest is water. Radiation treatment is carried out, the dose is controlled at 2.5×10 rad/s, the treatment time is 7.5 min, and is prepared as mixture A after completion;

(2) Microwave treatment:
The mixture A obtained in step (1) is placed in a microwave environment for microwave treatment, the microwave power is controlled at 700 W, the microwave treatment time is 3 minutes, and the mixture C is prepared after completion.

(3) Distributed processing:
The mixture C obtained in step (2) is placed in a dispersion cylinder and uniformly dispersed at a rotation speed of 8500 rpm to prepare a dispersion.

(4) UV-ultrasonic coupling treatment:
The dispersion obtained in step (3) is placed in an ultrasonic environment, subjected to ultraviolet-ultrasonic coupling treatment, the wavelength of ultraviolet light is controlled to 300 nm, the frequency of ultrasonic waves is 80 kHz, and the treatment may be performed for 35 minutes. .

Example 6
Anti-aging eye cream consists of the following ingredients:
Skin care active agent (C20-22 alcohol phosphate), viscous solvent (butanediol, C20-22 alcohol), polysiloxane elastomer (polydimethylsiloxane), pH adjuster (triethanolamine), emollient (ethylene glycol palmitate, isononanoic acid) isononyl, hydrogenated polydecene, ethylhexylglycerol), adsorbent (silica), emulsion stabilizer (acrylic/C10-30 acrylic acid alkanol crosslinked polymer, polyacrylate-13, xanthan gum), structural reagent (xylitol glucoside, anhydroxylitol, xylitol , GLYCINE SOJA OIL, NYMPHAEA ALBA EXTRACT), NON-ESSENTIAL INGREDIENTS (HYDROXYPROPYL TETRAHYDROPYRANTRIOL, GLUCOSE, CHONDRUS CRISPUS EXTRACT, DUNALIELLA SALINA EXTRACT, African baobab (ADANSONIA DIGITATA) pulp extract, methylsilanol hydroxyproline aspartic acid, retinol, glycolipids, glycosphingolipids, acetyl hexapeptide, sodium palmitoylproline carboxylate, flavor), balance is water.

The method for preparing the above anti-aging eye cream includes the following steps:
(1) Electron beam irradiation treatment:
0.6% by weight butanediol, 0.55% C20-22 alcohol phosphate, 0.3% C20-22 alcohol, 0.4% polydimethylsiloxane, 2.5% ethylene glycol palmitate, 1 isononyl isononanoate .45%, hydrogenated polydecene 0.8%, silica 2.5%, acrylic/C10-30 acrylic alkanol crosslinked polymer 0.7%, polyacrylate-13 2.5%, xylitol glucoside 1.7%, Hydroxylitol 2.35%, Xylitol 2.4%, Hydroxypropyl Tetrahydropyrantriol 1.5%, Xanthan Gum 4.5%, Glucose 2.3%, Chondrus Crispus Extract 5.5%, Donaliella Salina (DUNALIELLA SALINA) extract 4%, wild bean (GLYCINE SOJA) oil 3%, African baobab (ADANSONIA DIGITATA) pulp extract 6%, white lotus (NYMPHAEA ALBA) extract 4%, methylsilanol hydroxyproline aspartate 2 3%, retinol 3.5%, glycolipid 1.6%, glycosphingolipid 2.5%, acetyl hexapeptide-8 1.1%, sodium palmitoylproline carboxylate 2.7%, triethanolamine 1. 2%, ethylhexylglycerol 10%, flavor 0.08%, glycerin 35%, and the rest is water. Radiation treatment is carried out, the dose is controlled at 2.5×10 rad/s, the treatment time is 7.5 min, and is prepared as mixture A after completion;

(2) Continuous flash explosion treatment:
The mixture A obtained in step (1) was put into a continuous screw flash explosion device for continuous flash explosion treatment, the rotation speed of the screw was controlled at 800 rpm, and the number of continuous flash explosion treatments was 12 times, which was completed. provided as a post-mixture B,

(3) Distributed processing:
The mixture B obtained in step (2) is placed in a dispersion cylinder and uniformly dispersed at a rotation speed of 8500 rpm to prepare a dispersion.

(4) UV-ultrasonic coupling treatment:
The dispersion obtained in step (3) is placed in an ultrasonic environment, subjected to ultraviolet-ultrasonic coupling treatment, the wavelength of ultraviolet rays is controlled to 300 nm, the frequency of ultrasonic waves is 80 kHz, and the treatment time is 35 minutes. good.

Example 7
Anti-aging eye cream consists of the following ingredients:
Skin care active agent (C20-22 alcohol phosphate), viscous solvent (butanediol, C20-22 alcohol), polysiloxane elastomer (polydimethylsiloxane), pH adjuster (triethanolamine), emollient (ethylene glycol palmitate, isononanoic acid) isononyl, hydrogenated polydecene, ethylhexylglycerol), adsorbent (silica), emulsion stabilizer (acrylic/C10-30 acrylic acid alkanol crosslinked polymer, polyacrylate-13, xanthan gum), structural reagent (xylitol glucoside, anhydroxylitol, xylitol , GLYCINE SOJA OIL, NYMPHAEA ALBA EXTRACT), NON-ESSENTIAL INGREDIENTS (HYDROXYPROPYL TETRAHYDROPYRANTRIOL, GLUCOSE, CHONDRUS CRISPUS EXTRACT, DUNALIELLA SALINA EXTRACT, African baobab (ADANSONIA DIGITATA) pulp extract, methylsilanol hydroxyproline aspartic acid, retinol, glycolipids, glycosphingolipids, acetyl hexapeptide, sodium palmitoylproline carboxylate, flavors), balance is water.

The method for preparing the above anti-aging eye cream includes the following steps:
(1) Electron beam irradiation treatment:
0.6% by weight butanediol, 0.55% C20-22 alcohol phosphate, 0.3% C20-22 alcohol, 0.4% polydimethylsiloxane, 2.5% ethylene glycol palmitate, 1 isononyl isononanoate .45%, hydrogenated polydecene 0.8%, silica 2.5%, acrylic/C10-30 acrylic alkanol crosslinked polymer 0.7%, polyacrylate-13 2.5%, xylitol glucoside 1.7%, Hydroxylitol 2.35%, Xylitol 2.4%, Hydroxypropyl Tetrahydropyrantriol 1.5%, Xanthan Gum 4.5%, Glucose 2.3%, Chondrus Crispus Extract 5.5%, Donaliella Salina (DUNALIELLA SALINA) extract 4%, wild bean (GLYCINE SOJA) oil 3%, African baobab (ADANSONIA DIGITATA) pulp extract 6%, white lotus (NYMPHAEA ALBA) extract 4%, methylsilanol hydroxyproline aspartate 2 3%, retinol 3.5%, glycolipid 1.6%, glycosphingolipid 2.5%, acetyl hexapeptide-8 1.1%, sodium palmitoylproline carboxylate 2.7%, triethanolamine 1. 2%, ethylhexylglycerol 10%, flavor 0.08%, glycerin 35%, and the rest is water. Radiation treatment is carried out, the dose is controlled at 2.5×10 rad/s, the treatment time is 7.5 min, and is prepared as mixture A after completion;

(2) Continuous flash explosion treatment:
The mixture A obtained in step (1) was put into a continuous screw flash explosion device for continuous flash explosion treatment, the rotation speed of the screw was controlled at 800 rpm, and the number of continuous flash explosion treatments was 12 times, which was completed. provided as a post-mixture B,

(3) Microwave treatment:
The mixture B obtained in step (2) is placed in a microwave environment for microwave treatment, the microwave power is controlled at 700 W, the microwave treatment time is 3 minutes, and after completion, prepare as mixture C.

(4) UV-ultrasonic coupling treatment:
The mixture C obtained in step (3) is placed in an ultrasonic environment, subjected to ultraviolet-ultrasonic coupling treatment, the wavelength of ultraviolet rays is controlled to 300 nm, the frequency of ultrasonic waves is 80 kHz, and the treatment time is 35 minutes. .

Example 8
Anti-aging eye cream consists of the following ingredients:
Skin care active agent (C20-22 alcohol phosphate), viscous solvent (butanediol, C20-22 alcohol), polysiloxane elastomer (polydimethylsiloxane), pH adjuster (triethanolamine), emollient (ethylene glycol palmitate, isononanoic acid) isononyl, hydrogenated polydecene, ethylhexylglycerol), adsorbent (silica), emulsion stabilizer (acrylic/C10-30 acrylic acid alkanol crosslinked polymer, polyacrylate-13, xanthan gum), structural reagent (xylitol glucoside, anhydroxylitol, xylitol , GLYCINE SOJA OIL, NYMPHAEA ALBA EXTRACT), NON-ESSENTIAL INGREDIENTS (HYDROXYPROPYL TETRAHYDROPYRANTRIOL, GLUCOSE, CHONDRUS CRISPUS EXTRACT, DUNALIELLA SALINA EXTRACT, African baobab (ADANSONIA DIGITATA) pulp extract, methylsilanol hydroxyproline aspartic acid, retinol, glycolipids, glycosphingolipids, acetyl hexapeptide, sodium palmitoylproline carboxylate, flavor), balance is water.
The method for preparing the above anti-aging eye cream includes the following steps:

(1) Electron beam irradiation treatment:
0.6% by weight butanediol, 0.55% C20-22 alcohol phosphate, 0.3% C20-22 alcohol, 0.4% polydimethylsiloxane, 2.5% ethylene glycol palmitate, 1 isononyl isononanoate .45%, hydrogenated polydecene 0.8%, silica 2.5%, acrylic/C10-30 acrylic alkanol crosslinked polymer 0.7%, polyacrylate-13 2.5%, xylitol glucoside 1.7%, Hydroxylitol 2.35%, Xylitol 2.4%, Hydroxypropyl Tetrahydropyrantriol 1.5%, Xanthan Gum 4.5%, Glucose 2.3%, Chondrus Crispus Extract 5.5%, Donaliella Salina (DUNALIELLA SALINA) extract 4%, wild bean (GLYCINE SOJA) oil 3%, African baobab (ADANSONIA DIGITATA) pulp extract 6%, white lotus (NYMPHAEA ALBA) extract 4%, methylsilanol hydroxyproline aspartate 2 3%, retinol 3.5%, glycolipid 1.6%, glycosphingolipid 2.5%, acetyl hexapeptide-8 1.1%, sodium palmitoylproline carboxylate 2.7%, triethanolamine 1. 2%, ethylhexylglycerol 10%, flavor 0.08%, glycerin 35%, and the rest is water. Radiation treatment is carried out, the dose is controlled at 2.5×10 rad/s, the treatment time is 7.5 min, and is prepared as mixture A after completion;

(2) Continuous flash explosion treatment:
The mixture A obtained in step (1) was put into a continuous screw flash explosion device for continuous flash explosion treatment, the rotation speed of the screw was controlled at 800 rpm, and the number of continuous flash explosion treatments was 12 times, which was completed. provided as a post-mixture B,

(3) Microwave treatment:
The mixture B obtained in step (2) is placed in a microwave environment for microwave treatment, the microwave power is controlled at 700 W, the microwave treatment time is 3 minutes, and after completion, prepare as mixture C.

(4) Distributed processing:
The mixture C obtained in step (3) can be put into a dispersion cylinder and evenly dispersed at a rotational speed of 8500 rpm.

Control Group Application No. CN201410224642. X discloses an eye cream containing fucoidan and pomegranate extract and a method for its preparation.

In order to compare the technical effects of the present application, the eye creams were prepared by the methods of Example 2, Examples 4-8 and the control group respectively, and the antioxidant of the eye creams prepared by each set of methods in the DPPH method. , to measure the free radical scavenging capacity. Specifically, it is as follows.

(1) Preparation of test product solution:
Weigh 0.5 g of the eye cream test products prepared by the methods of Example 2, Examples 4-8 and the control group, respectively, and dissolve each in ethanol solution to a constant volume of 100 mL to obtain a mass concentration of 5 mg/mL. . Next, take 10 mL, 5 mL, 2 mL, 1 mL, 0.5 mL, and 0.1 mL, respectively, and adjust the volume to 100 mL with ethanol to obtain 0.5 mg/mL, 0.25 mg/mL, and 0.1 mg/mL. , 0.05 mg/mL, 0.025 mg/mL, 0.005 mg/mL to obtain test product solutions with different mass concentrations;

(2) Preparation of DPPH solution:
Take 2 mg of DPPH, put it in a 50 mL brown volumetric flask, add absolute ethanol up to the marked line, and shake evenly to obtain a DPPH solution with a mass concentration of 0.04 mg/mL. Store in a refrigerator at 4°C

(3) Measurement of DPPH free radical scavenging ability:
Pipette each 2 mL of ethanol and DPPH solution accurately, put them in a 10 mL test tube with a stopper, shake well after mixing, measure the absorbance (Ac) at 517 nm after 30 min, test product solution, ethanol Pipette each 2 mL accurately, put it in a 10 mL test tube with a stopper, shake well after mixing, measure the absorbance (Aj) at 517 nm after 30 min, and test product, DPPH solution exactly 2 mL each Pipette, place in a 10 mL test tube with a stopper, shake well after mixing, leave at room temperature for 30 min, and measure absorbance (Ai) at 517 nm. Measure twice in parallel. Calculate the DPPH free radical scavenging rate of the test sample by the following formula.

具体的な試験比較データは図１に示される。

Specific test comparison data is shown in FIG.

As can be seen from FIG. 1, the present application provides an anti-aging eye cream and its preparation method, the finally prepared eye cream has a relatively high scavenging rate of DPPH free radicals, and 0.1 mg/mL eye cream. The removal rate of the test solution reaches 63.52%. That is, the eye cream prepared by the method of the present application has remarkable antioxidant and anti-aging effects.

The above is only a preferred embodiment of the present invention, and the present invention is not limited by the above-described embodiments, and the equivalent embodiments of equivalent variations that have been changed or modified in accordance with the concept of the present invention are within the spirit of the specification. without departing from the scope of the present invention.

Claims (6)

a skin care active comprising a C20-22 alcohol phosphate, a viscous solvent comprising butanediol, a C20-22 alcohol, a polysiloxane elastomer comprising polydimethylsiloxane, a pH adjuster comprising triethanolamine, ethylene glycol palmitate, Emollients including isononyl isononanoate, polydecene hydrogenation, ethylhexylglycerol; adsorbents including silica; emulsion stabilizers including acrylic/C10-30 acrylic alkanol crosslinked polymers, polyacrylate-13, xanthan gum; Structural reagents including hydroxylitol, xylitol, GLYCINE SOJA oil, NYMPHAEA ALBA extract and hydroxypropyl tetrahydropyrantriol, glucose, CHONDRUS CRISPUS extract, DUNALIELLA SALINA ) extract, African baobab (ADANSONIA DIGITATA) pulp extract, methylsilanol hydroxyproline aspartic acid, retinol, glycolipids, glycosphingolipids, acetyl hexapeptide, sodium palmitoylproline carboxylate, flavor, and the remaining An anti-aging eye cream comprising: water; A method for preparing an anti-aging eye cream according to claim 1, characterized in that it comprises the steps of:
(1) Electron beam irradiation treatment:
0.4-0.8% by weight butanediol, 0.5-0.6% C20-22 alcohol phosphate, 0.2-0.4% C20-22 alcohol, 0.3-0.4% polydimethylsiloxane. 5%, ethylene glycol palmitate 2-3%, isononyl isononanoate 1.3-1.6%, hydrogenated polydecene 0.7-0.9%, silica 2-3%, acrylic/C10-30 alkanol acrylate. Crosslinked polymer 0.5-0.9%, polyacrylate-13 2.3-2.7%, xylitol glucoside 1.4-2%, anhydroxyritol 2.1-2.6%, xylitol 2.3- 2.5%, Hydroxypropyl Tetrahydropyrantriol 1.3-1.7%, Xanthan Gum 4-5%, Glucose 2.1-2.5%, Chondrus Crispus Extract 5-6%, Donaliella Salina (DUNALIELLA SALINA) extract 3-5%, wild bean (GLYCINE SOJA) oil 2-4%, African baobab (ADANSONIA DIGITATA) pulp extract 5-7%, white water lily (NYMPHAEA ALBA) extract 3.5~ 4.5%, methylsilanol hydroxyproline aspartic acid 2.1-2.5%, retinol 3-4%, glycolipid 1.4-1.8%, glycosphingolipid 2-3%, acetyl hexapeptide-8 0.8-1.4%, sodium palmitoylproline carboxylate 2.4-3%, triethanolamine 0.9-1.5%, ethylhexylglycerol 8-12%, flavor 0.07-0.09%, 30 to 40% of glycerin is weighed, the rest is water, mixed uniformly, put into a GJ-1.5 high-frequency high-voltage, high-power electron accelerator, subjected to electron beam irradiation treatment, and after completion, mixture A prepare,
(2) Continuous flash explosion treatment:
The mixture A obtained in step (1) is placed in a continuous screw flash explosion device for continuous flash explosion treatment, and prepared as mixture B after completion.
(3) Microwave treatment:
The mixture B obtained in step (2) is placed in a microwave environment and subjected to microwave treatment, and after completion is provided as mixture C.
(4) Distributed processing:
The mixture C obtained in step (3) is placed in a dispersion cylinder and uniformly dispersed at a rotation speed of 700 to 1000 rpm to prepare a dispersion.
(5) UV-ultrasonic coupling treatment:
The dispersion obtained in step (4) is placed in an ultrasonic environment and subjected to UV-ultrasonic coupling treatment for 30-40 minutes. 3. The anti-aging eye according to claim 2, wherein the dose during the electron beam irradiation treatment in step (1) is controlled to 2 to 3× ^{10 6} rad/s, and the treatment time is 5 to 10 minutes. Method of preparation of cream. 3. The anti-rust according to claim 2, wherein the rotation speed of the screw during continuous flash explosion treatment in step (2) is controlled to 700 to 900 rpm, and the number of times of continuous flash explosion treatment is 11 to 13 times. Method for preparing aging eye cream. 3. The anti-aging eye cream according to claim 2, wherein the output of microwaves during the microwave treatment in step (3) is controlled to 600 to 800 W, and the microwave treatment time is 2 to 4 minutes. Method of preparation. Anti-aging according to claim 2, characterized in that the wavelength of the ultraviolet rays during the ultraviolet-ultrasonic coupling treatment in step (5) is controlled to 200 to 400 nm, and the frequency of the ultrasonic waves is 70 to 90 kHz. Method of preparing eye cream.

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