JP7212683B2 - 抗がん剤としての環状ジヌクレオチド - Google Patents

抗がん剤としての環状ジヌクレオチド Download PDF

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Publication number
JP7212683B2
JP7212683B2 JP2020520205A JP2020520205A JP7212683B2 JP 7212683 B2 JP7212683 B2 JP 7212683B2 JP 2020520205 A JP2020520205 A JP 2020520205A JP 2020520205 A JP2020520205 A JP 2020520205A JP 7212683 B2 JP7212683 B2 JP 7212683B2
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purin
hexaoxa
mmol
octadecane
amino
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Japanese (ja)
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JP2020536897A5 (https=
JP2020536897A (ja
Inventor
ブライアン・イー・フィンク
ダームパル・エス・ドッド
ユーフェン・ジャオ
ラン－イン・チン
ジェミン・ルアン
ラルグディ・エス・ハリクリシュナン
ムソニ・ジー・カマウ
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Bristol Myers Squibb Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2020520205A 2017-10-10 2018-10-09 抗がん剤としての環状ジヌクレオチド Active JP7212683B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762570386P 2017-10-10 2017-10-10
US62/570,386 2017-10-10
PCT/US2018/054944 WO2019074887A1 (en) 2017-10-10 2018-10-09 CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS

Publications (3)

Publication Number Publication Date
JP2020536897A JP2020536897A (ja) 2020-12-17
JP2020536897A5 JP2020536897A5 (https=) 2021-11-18
JP7212683B2 true JP7212683B2 (ja) 2023-01-25

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JP2020520205A Active JP7212683B2 (ja) 2017-10-10 2018-10-09 抗がん剤としての環状ジヌクレオチド

Country Status (7)

Country Link
US (1) US11660311B2 (https=)
EP (1) EP3694867B1 (https=)
JP (1) JP7212683B2 (https=)
KR (1) KR102885797B1 (https=)
CN (1) CN111344297B (https=)
ES (1) ES3058522T3 (https=)
WO (1) WO2019074887A1 (https=)

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TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
US11110106B2 (en) 2018-10-29 2021-09-07 Venenum Biodesign, LLC Sting agonists for treating bladder cancer and solid tumors
AU2019371206A1 (en) 2018-10-29 2021-05-27 Venenum Biodesign, LLC Novel sting agonists
WO2021013234A1 (en) 2019-07-25 2021-01-28 Beigene, Ltd. Cyclic dinucleotides as sting agonists
WO2021206158A1 (ja) 2020-04-10 2021-10-14 小野薬品工業株式会社 がん治療方法
CN111592570B (zh) * 2020-05-15 2022-04-29 清华大学 新型sting激动剂及其制备方法和应用

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WO2017161349A1 (en) 2016-03-18 2017-09-21 Immune Sensor, Llc Cyclic di-nucleotide compounds and methods of use

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Also Published As

Publication number Publication date
KR20200061399A (ko) 2020-06-02
EP3694867A1 (en) 2020-08-19
WO2019074887A1 (en) 2019-04-18
ES3058522T3 (en) 2026-03-11
US11660311B2 (en) 2023-05-30
CN111344297A (zh) 2020-06-26
CN111344297B (zh) 2023-10-20
EP3694867B1 (en) 2025-12-24
JP2020536897A (ja) 2020-12-17
EP3694867C0 (en) 2025-12-24
US20220117995A1 (en) 2022-04-21
KR102885797B1 (ko) 2025-11-12

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