JP7209464B2 - ヒトインターロイキン－２に対する免疫刺激性モノクローナル抗体 - Google Patents
ヒトインターロイキン－２に対する免疫刺激性モノクローナル抗体 Download PDFInfo
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- JP7209464B2 JP7209464B2 JP2017501280A JP2017501280A JP7209464B2 JP 7209464 B2 JP7209464 B2 JP 7209464B2 JP 2017501280 A JP2017501280 A JP 2017501280A JP 2017501280 A JP2017501280 A JP 2017501280A JP 7209464 B2 JP7209464 B2 JP 7209464B2
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/246—IL-2
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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| PCT/IB2015/055226 WO2016005950A1 (en) | 2014-07-10 | 2015-07-10 | Immune-stimulating monoclonal antibodies against human interleukin-2 |
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| WO2017122130A1 (en) * | 2016-01-11 | 2017-07-20 | Novartis Ag | Immune-stimulating humanized monoclonal antibodies against human interleukin-2, and fusion proteins thereof |
| MX2019003543A (es) | 2016-09-28 | 2019-06-17 | Xoma Us Llc | Anticuerpos que se fijan al interleucina-2 y sus usos. |
| GB201621806D0 (en) * | 2016-12-21 | 2017-02-01 | Philogen Spa | Immunocytokines with progressive activation mechanism |
| EP3585404A4 (en) * | 2017-02-23 | 2021-04-14 | City of Hope | METHODS OF IN VIVO EXPANSION OF CD8 + T-LYMPHOCYTES AND PREVENTION OR TREATMENT OF GRAFT HOST REACTION (GVHD) |
| MX2019011252A (es) * | 2017-03-23 | 2020-01-23 | Univ Pennsylvania | Anticuerpos anti-c5a y usos de los mismos. |
| JP7057980B2 (ja) * | 2017-05-25 | 2022-04-21 | インスティテュート フォー ベーシック サイエンス | 抗－ヒトインターロイキン－２抗体及びその用途 |
| WO2020036635A2 (en) | 2018-03-19 | 2020-02-20 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and cd122/cd132 agonists for the treatment of cancer |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| CN115768483A (zh) | 2020-01-13 | 2023-03-07 | 西纳福克斯股份有限公司 | 抗体与免疫细胞衔接器的缀合物 |
| KR102627471B1 (ko) | 2020-02-16 | 2024-01-18 | 아울로스 바이오사이언스 인코포레이티드 | 조작된 항-il-2 항체 |
| AU2021327147A1 (en) * | 2020-08-18 | 2023-04-06 | Universität Zürich | A CD25-biased anti-IL-2 antibody |
| CN117157107A (zh) | 2021-02-08 | 2023-12-01 | 西纳福克斯股份有限公司 | 多功能抗体 |
| JP2024539749A (ja) | 2021-10-14 | 2024-10-29 | ラッティコン （スージョウ） バイオファーマシューティカルズ カンパニー リミテッド | 新規な抗体－サイトカイン融合タンパク質及びその製造方法と使用 |
| US11773160B1 (en) | 2022-08-05 | 2023-10-03 | Anaveon AG | Immune-stimulating IL-2 fusion proteins |
| CN119775409B (zh) * | 2025-03-05 | 2025-07-11 | 深圳真实生物医药科技有限公司 | 靶向sost的抗体及其用途 |
Citations (3)
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| JP2012183077A (ja) | 2005-07-08 | 2012-09-27 | Biogen Idec Ma Inc | 抗αＶβ６抗体およびその使用 |
| JP2013536191A (ja) | 2010-08-12 | 2013-09-19 | イーライ リリー アンド カンパニー | 抗Ｎ３ｐＧｌｕアミロイドβペプチド抗体及びその使用 |
| WO2013157105A1 (ja) | 2012-04-18 | 2013-10-24 | 公立大学法人大阪市立大学 | ムチンサブタイプ５ａｃ特異的ヒト化抗体およびその利用 |
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| CA1340853C (en) * | 1983-12-23 | 1999-12-21 | Hsiang-Fu Kung | Purification of recombinant interleukin-2 |
| JPS62269698A (ja) * | 1986-03-17 | 1987-11-24 | エフ．ホフマン ― ラ ロシュ アーゲー | Ｉｌ−２蛋白質に対するモノクロ−ナル抗体 |
| US6111090A (en) | 1996-08-16 | 2000-08-29 | Schering Corporation | Mammalian cell surface antigens; related reagents |
| JP4440344B2 (ja) | 1996-08-16 | 2010-03-24 | シェーリング コーポレイション | 哺乳動物細胞表面抗原；関連試薬 |
| EP0985039B1 (en) | 1997-06-12 | 2008-02-20 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| EP2572714A1 (en) | 2002-12-30 | 2013-03-27 | 3M Innovative Properties Company | Immunostimulatory Combinations |
| WO2006083289A2 (en) | 2004-06-04 | 2006-08-10 | Duke University | Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity |
| WO2006128690A1 (en) * | 2005-06-01 | 2006-12-07 | Micromet Ag | Anti-il2 antibodies |
| EP1987065A4 (en) * | 2006-02-16 | 2010-01-20 | Nascent Biolog Inc | METHOD FOR IMPROVING THE IMMUNE FUNCTION AND METHOD FOR PREVENTING OR TREATING DISEASES IN MAMMALS |
| CN101045923B (zh) * | 2006-03-31 | 2011-11-23 | 沈阳三生制药有限责任公司 | 生产一种白细胞介素类似物的方法 |
| CN104548091A (zh) | 2008-02-11 | 2015-04-29 | 治疗科技公司 | 用于肿瘤治疗的单克隆抗体 |
| ES2694564T3 (es) | 2011-02-10 | 2018-12-21 | Roche Glycart Ag | Polipéptidos de interleucina-2 mutantes |
| CN112587658A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| WO2015109212A1 (en) * | 2014-01-17 | 2015-07-23 | Pfizer Inc. | Anti-il-2 antibodies and compositions and uses thereof |
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2015
- 2015-07-10 CN CN201580048027.0A patent/CN106604932B/zh active Active
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| JP2012183077A (ja) | 2005-07-08 | 2012-09-27 | Biogen Idec Ma Inc | 抗αＶβ６抗体およびその使用 |
| JP2013536191A (ja) | 2010-08-12 | 2013-09-19 | イーライ リリー アンド カンパニー | 抗Ｎ３ｐＧｌｕアミロイドβペプチド抗体及びその使用 |
| WO2013157105A1 (ja) | 2012-04-18 | 2013-10-24 | 公立大学法人大阪市立大学 | ムチンサブタイプ５ａｃ特異的ヒト化抗体およびその利用 |
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| Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．，２０１０，Ｖｏｌ．１０７，Ｎｏ．５，ｐ．２１７１－２１７６ |
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| CA2954476A1 (en) | 2016-01-14 |
| AU2015287227B2 (en) | 2021-02-18 |
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| ES2779977T3 (es) | 2020-08-21 |
| DK3166973T3 (da) | 2020-04-06 |
| US20210230269A1 (en) | 2021-07-29 |
| EP3693389C0 (en) | 2024-09-04 |
| CN106604932B (zh) | 2024-12-10 |
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