JP7205940B2 - 固相反応チップ及びこれを用いた測定方法 - Google Patents

固相反応チップ及びこれを用いた測定方法 Download PDF

Info

Publication number
JP7205940B2
JP7205940B2 JP2021502126A JP2021502126A JP7205940B2 JP 7205940 B2 JP7205940 B2 JP 7205940B2 JP 2021502126 A JP2021502126 A JP 2021502126A JP 2021502126 A JP2021502126 A JP 2021502126A JP 7205940 B2 JP7205940 B2 JP 7205940B2
Authority
JP
Japan
Prior art keywords
substance
phase reaction
reaction chip
measured
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021502126A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2020171158A1 (ja
Inventor
昭雄 中原
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PARTNER FIRM CO., LTD.
Original Assignee
PARTNER FIRM CO., LTD.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PARTNER FIRM CO., LTD. filed Critical PARTNER FIRM CO., LTD.
Publication of JPWO2020171158A1 publication Critical patent/JPWO2020171158A1/ja
Application granted granted Critical
Publication of JP7205940B2 publication Critical patent/JP7205940B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N37/00—Details not covered by any other group of this subclass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Sustainable Development (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2021502126A 2019-02-20 2020-02-20 固相反応チップ及びこれを用いた測定方法 Active JP7205940B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2019028153 2019-02-20
JP2019028153 2019-02-20
JP2019113074 2019-06-18
JP2019113074 2019-06-18
PCT/JP2020/006695 WO2020171158A1 (ja) 2019-02-20 2020-02-20 固相反応チップ及びこれを用いた測定方法

Publications (2)

Publication Number Publication Date
JPWO2020171158A1 JPWO2020171158A1 (ja) 2021-12-23
JP7205940B2 true JP7205940B2 (ja) 2023-01-17

Family

ID=72144476

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021502126A Active JP7205940B2 (ja) 2019-02-20 2020-02-20 固相反応チップ及びこれを用いた測定方法

Country Status (4)

Country Link
JP (1) JP7205940B2 (zh)
KR (1) KR20210127945A (zh)
CN (1) CN113454462A (zh)
WO (1) WO2020171158A1 (zh)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007520712A (ja) 2004-02-03 2007-07-26 ベー・エル・アー・ハー・エム・エス・アクティエンゲゼルシャフト 患者サンプルにおけるＣｕ／Ｚｎスーパーオキシドジスムターゼ（Ｃｕ／ＺｎＳＯＤ）の濃度の選択的測定による敗血症の診断
JP2010032360A (ja) 2008-07-29 2010-02-12 Chisso Corp 磁性粒子を用いた測定対象物質の濃度測定法
WO2012001972A1 (ja) 2010-06-30 2012-01-05 株式会社メタボスクリーン マイクロ化学チップ、その製造方法、及びその使用方法
WO2012086346A1 (ja) 2010-12-22 2012-06-28 国立大学法人 岡山大学 抑制性補助刺激分子に対する抗体をマーカーとする慢性炎症性疾患の検査方法
JP2015500459A (ja) 2011-11-21 2015-01-05 アバクシス， インコーポレイテッド ラテラルフローおよび関連する免疫アッセイにおけるシグナル増幅
WO2015174430A1 (ja) 2014-05-15 2015-11-19 タカノ株式会社 試料分析装置
JP2016520192A (ja) 2013-05-14 2016-07-11 メタボロン，インコーポレイテッド 腎機能に関連付けられるバイオマーカーおよびそれを使用する方法
JP2016200431A (ja) 2015-04-08 2016-12-01 株式会社パートナーファーム 固相反応チップ及びこれを用いた測定方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8522388D0 (en) * 1985-09-10 1985-10-16 Lepetit Spa Receptor-antibody sandwich assay
JP2004222689A (ja) * 2003-01-20 2004-08-12 Ryokusei Mes Kk 遠心力利用液層反応装置
JP2011013000A (ja) 2009-06-30 2011-01-20 Consonal Biotechnologies Co Ltd バイオチップの分析方法及びその自動分析システム
JP6107244B2 (ja) 2013-03-08 2017-04-05 コニカミノルタ株式会社 蛍光色素標識用樹脂粒子及びその製造方法並びに該粒子を含む組織免疫染色用キット
JP6978081B2 (ja) 2016-09-26 2021-12-08 国立大学法人埼玉大学 Ａｉｅ活性化合物を包含する蛍光性微粒子

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007520712A (ja) 2004-02-03 2007-07-26 ベー・エル・アー・ハー・エム・エス・アクティエンゲゼルシャフト 患者サンプルにおけるＣｕ／Ｚｎスーパーオキシドジスムターゼ（Ｃｕ／ＺｎＳＯＤ）の濃度の選択的測定による敗血症の診断
JP2010032360A (ja) 2008-07-29 2010-02-12 Chisso Corp 磁性粒子を用いた測定対象物質の濃度測定法
WO2012001972A1 (ja) 2010-06-30 2012-01-05 株式会社メタボスクリーン マイクロ化学チップ、その製造方法、及びその使用方法
WO2012086346A1 (ja) 2010-12-22 2012-06-28 国立大学法人 岡山大学 抑制性補助刺激分子に対する抗体をマーカーとする慢性炎症性疾患の検査方法
JP2015500459A (ja) 2011-11-21 2015-01-05 アバクシス， インコーポレイテッド ラテラルフローおよび関連する免疫アッセイにおけるシグナル増幅
JP2016520192A (ja) 2013-05-14 2016-07-11 メタボロン，インコーポレイテッド 腎機能に関連付けられるバイオマーカーおよびそれを使用する方法
WO2015174430A1 (ja) 2014-05-15 2015-11-19 タカノ株式会社 試料分析装置
JP2016200431A (ja) 2015-04-08 2016-12-01 株式会社パートナーファーム 固相反応チップ及びこれを用いた測定方法

Also Published As

Publication number Publication date
JPWO2020171158A1 (ja) 2021-12-23
WO2020171158A1 (ja) 2020-08-27
KR20210127945A (ko) 2021-10-25
CN113454462A (zh) 2021-09-28

Similar Documents

Publication Publication Date Title
US5501949A (en) Particle bound binding component immunoassay
US5236826A (en) Immunoassay for the detection or quantitation of an analyte
CN1946999B (zh) 用于光学检测系统的电致发光照明源
US8932878B2 (en) Diagnostic test kits employing an internal calibration system
CN1675544A (zh) 用于磁结合测定的自校正系统
CN1675545A (zh) 采用时间分辨荧光的基于膜的检测
CN103308489A (zh) 利用时间分辨上转换发光技术的侧向流动免疫测定法
EP0248892A1 (en) Particle-bound binding component immunoassay
JP2015511706A (ja) エバネッセントバイオセンサーを用いたリアルタイム診断アッセイ
JP6600861B2 (ja) 固相反応チップ及びこれを用いた測定方法
JP2003066045A (ja) アレルゲン試験チップ
EP2732288B1 (en) Biological microchip for the estimation of immunoglobulin e and g levels in human blood, method of assay thereof, and reagent kit comprising same
US20110293473A1 (en) Automatic analyzer
JP7205940B2 (ja) 固相反応チップ及びこれを用いた測定方法
JP4920173B2 (ja) 較正マイクロアレイ
CN111504959B (zh) C肽稀土荧光微球试剂盒及其检测卡和制备方法
CN210199121U (zh) 一种光激化学发光检测仪
WO2021025066A1 (ja) 固相反応容器及びこれを用いた測定方法
WO2021095858A1 (ja) 生理活性物質の測定方法
JP2006337077A (ja) 被検物質測定方法及び被検物質測定用キット
WO2021095790A1 (ja) 固相反応チップを用いた測定方法
CN216696335U (zh) 一种脂联素荧光定量免疫层析试剂条
JP2001272405A (ja) 検査キット
JPWO2006028174A1 (ja) 測定装置および測定方法
WO2020195991A1 (ja) 固相反応チップ及びこれを用いた測定方法

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210608

AA64 Notification of invalidation of claim of internal priority (with term)

Free format text: JAPANESE INTERMEDIATE CODE: A241764

Effective date: 20210914

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211022

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220405

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220606

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220803

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20221122

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20221222

R150 Certificate of patent or registration of utility model

Ref document number: 7205940

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150