JP7199359B2 - 特定のｖｍａｔ２インヒビターを投与するための方法 - Google Patents

特定のｖｍａｔ２インヒビターを投与するための方法 Download PDF

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JP7199359B2
JP7199359B2 JP2019540557A JP2019540557A JP7199359B2 JP 7199359 B2 JP7199359 B2 JP 7199359B2 JP 2019540557 A JP2019540557 A JP 2019540557A JP 2019540557 A JP2019540557 A JP 2019540557A JP 7199359 B2 JP7199359 B2 JP 7199359B2
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nbi
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isoquinolin
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JP2020514317A5 (OSRAM
JP2020514317A (ja
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クリストファー エフ． オブライエン，
ヘイグ ピー． ボゼジアン，
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ニューロクライン バイオサイエンシーズ，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Emergency Medicine (AREA)
JP2019540557A 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法 Active JP7199359B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022160177A JP2022174343A (ja) 2017-01-27 2022-10-04 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024092148A JP2024107167A (ja) 2017-01-27 2024-06-06 特定のｖｍａｔ２インヒビターを投与するための方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762451605P 2017-01-27 2017-01-27
US62/451,605 2017-01-27
PCT/US2017/055877 WO2018140092A1 (en) 2017-01-27 2017-10-10 Methods for the administration of certain vmat2 inhibitors

Related Child Applications (1)

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JP2022160177A Division JP2022174343A (ja) 2017-01-27 2022-10-04 特定のｖｍａｔ２インヒビターを投与するための方法

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JP2020514317A JP2020514317A (ja) 2020-05-21
JP2020514317A5 JP2020514317A5 (OSRAM) 2020-11-19
JP7199359B2 true JP7199359B2 (ja) 2023-01-05

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Application Number Title Priority Date Filing Date
JP2019540557A Active JP7199359B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2020520311A Active JP7090151B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2019540570A Active JP7199361B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2019540650A Active JP7107950B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2019540568A Active JP7199360B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022008580A Withdrawn JP2022040408A (ja) 2017-01-27 2022-01-24 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022113075A Withdrawn JP2022137219A (ja) 2017-01-27 2022-07-14 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022160177A Withdrawn JP2022174343A (ja) 2017-01-27 2022-10-04 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022160833A Withdrawn JP2022174345A (ja) 2017-01-27 2022-10-05 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022160831A Withdrawn JP2022174344A (ja) 2017-01-27 2022-10-05 特定のｖｍａｔ２インヒビターを投与するための方法
JP2023149999A Pending JP2023161033A (ja) 2017-01-27 2023-09-15 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024092155A Pending JP2024107169A (ja) 2017-01-27 2024-06-06 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024092152A Pending JP2024107168A (ja) 2017-01-27 2024-06-06 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024092148A Pending JP2024107167A (ja) 2017-01-27 2024-06-06 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024093040A Pending JP2024113134A (ja) 2017-01-27 2024-06-07 特定のｖｍａｔ２インヒビターを投与するための方法
JP2025126262A Pending JP2025146959A (ja) 2017-01-27 2025-07-29 特定のｖｍａｔ２インヒビターを投与するための方法

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JP2020520311A Active JP7090151B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2019540570A Active JP7199361B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2019540650A Active JP7107950B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2019540568A Active JP7199360B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022008580A Withdrawn JP2022040408A (ja) 2017-01-27 2022-01-24 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022113075A Withdrawn JP2022137219A (ja) 2017-01-27 2022-07-14 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022160177A Withdrawn JP2022174343A (ja) 2017-01-27 2022-10-04 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022160833A Withdrawn JP2022174345A (ja) 2017-01-27 2022-10-05 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022160831A Withdrawn JP2022174344A (ja) 2017-01-27 2022-10-05 特定のｖｍａｔ２インヒビターを投与するための方法
JP2023149999A Pending JP2023161033A (ja) 2017-01-27 2023-09-15 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024092155A Pending JP2024107169A (ja) 2017-01-27 2024-06-06 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024092152A Pending JP2024107168A (ja) 2017-01-27 2024-06-06 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024092148A Pending JP2024107167A (ja) 2017-01-27 2024-06-06 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024093040A Pending JP2024113134A (ja) 2017-01-27 2024-06-07 特定のｖｍａｔ２インヒビターを投与するための方法
JP2025126262A Pending JP2025146959A (ja) 2017-01-27 2025-07-29 特定のｖｍａｔ２インヒビターを投与するための方法

Country Status (12)

Country Link
US (9) US20190381016A1 (OSRAM)
JP (16) JP7199359B2 (OSRAM)
KR (14) KR20190108146A (OSRAM)
CN (6) CN110709071A (OSRAM)
AU (7) AU2017395702B2 (OSRAM)
CA (5) CA3051830A1 (OSRAM)
EA (5) EA201991784A1 (OSRAM)
MX (6) MX394415B (OSRAM)
MY (5) MY203491A (OSRAM)
PH (6) PH12022553251A1 (OSRAM)
SG (3) SG11201906885TA (OSRAM)
WO (5) WO2018140094A1 (OSRAM)

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Citations (1)

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