JP7198813B2 - 気泡迂回領域を備えるマイクロ流体デバイス - Google Patents

気泡迂回領域を備えるマイクロ流体デバイス Download PDF

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JP7198813B2
JP7198813B2 JP2020518628A JP2020518628A JP7198813B2 JP 7198813 B2 JP7198813 B2 JP 7198813B2 JP 2020518628 A JP2020518628 A JP 2020518628A JP 2020518628 A JP2020518628 A JP 2020518628A JP 7198813 B2 JP7198813 B2 JP 7198813B2
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microchannel
bubble
substrate
observed
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JP2020536724A (ja
JP2020536724A5 (https=
Inventor
マダディ ホジャット
マイケル ウィルシェア トーマス
オハロラン ジョナサン
トーマス スカリー フィリップ
マーシャル ポール
ボアダ エドゥアルド
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QuantumDx Group Ltd
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QuantumDx Group Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/047—Additional chamber, reservoir
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0854—Double walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/088—Channel loops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
JP2020518628A 2017-10-16 2018-10-15 気泡迂回領域を備えるマイクロ流体デバイス Active JP7198813B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1716961.6A GB201716961D0 (en) 2017-10-16 2017-10-16 Microfluidic devices with bubble diversion
GB1716961.6 2017-10-16
PCT/GB2018/052958 WO2019077323A1 (en) 2017-10-16 2018-10-15 MICROFLUIDIC DEVICES WITH BUBBLE DEVIATION

Publications (3)

Publication Number Publication Date
JP2020536724A JP2020536724A (ja) 2020-12-17
JP2020536724A5 JP2020536724A5 (https=) 2021-09-16
JP7198813B2 true JP7198813B2 (ja) 2023-01-04

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JP2020518628A Active JP7198813B2 (ja) 2017-10-16 2018-10-15 気泡迂回領域を備えるマイクロ流体デバイス

Country Status (6)

Country Link
US (1) US11596944B2 (https=)
EP (1) EP3697532A1 (https=)
JP (1) JP7198813B2 (https=)
CN (1) CN111212688B (https=)
GB (1) GB201716961D0 (https=)
WO (1) WO2019077323A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11213824B2 (en) 2017-03-29 2022-01-04 The Research Foundation For The State University Of New York Microfluidic device and methods
US11701651B2 (en) 2017-11-28 2023-07-18 Inje University Industry-Academic Cooperation Foundation Microfluidic device capable of removing microbubbles in channel by using porous thin film, sample injection device for preventing inflow of bubbles, and method for bonding panel of microfluidic element by using mold-releasing film
CN110354523B (zh) * 2019-07-14 2024-02-06 河北龙亿环境工程有限公司 一种具有多微孔气泡罩的新型塔板
GB2636565A (en) 2023-11-16 2025-06-25 Quantumdx Group Ltd Flow regulators for the control of liquid fronts in microfluidic structures
EP4670844A1 (en) * 2024-06-26 2025-12-31 Dynamic Biosensors GmbH BUBBLE DETECTION IN A MICROFLUID CHANNEL

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520409A (ja) 2004-11-16 2008-06-19 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マイクロ流体素子
WO2011050110A1 (en) 2009-10-20 2011-04-28 Boston Microfluidics Methods and systems to collect and prepare samples, to implement, initiate and perform assays, and to control and manage fluid flow
US20150101422A1 (en) 2012-05-14 2015-04-16 Nanoentek, Inc. Sample analyzing chip
JP2017508956A (ja) 2014-02-10 2017-03-30 ナノバイオシス インコーポレーテッドＮａｎｏｂｉｏｓｙｓ Ｉｎｃ． 微少流体チップ及びこれを用いたリアルタイム分析装置
JP2017122618A (ja) 2016-01-06 2017-07-13 信越ポリマー株式会社 分析用基板およびその製造方法
JP2017519996A (ja) 2014-07-10 2017-07-20 ナノバイオシス インコーポレーテッドＮａｎｏｂｉｏｓｙｓ Ｉｎｃ． マイクロ流体チップ、その製造方法及びそれを用いた分析装置

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Publication number Priority date Publication date Assignee Title
US6635226B1 (en) * 1994-10-19 2003-10-21 Agilent Technologies, Inc. Microanalytical device and use thereof for conducting chemical processes
EP1855114A1 (en) 2005-03-01 2007-11-14 Rohm Co., Ltd. Microchannel and microfluid chip
JP4685611B2 (ja) 2005-12-02 2011-05-18 株式会社エンプラス 微小流体装置
US9962698B2 (en) 2012-09-05 2018-05-08 President And Fellows Of Harvard College Removing bubbles in microfluidic systems
JP2015166707A (ja) * 2014-03-04 2015-09-24 キヤノン株式会社 マイクロ流路デバイス
US20150352547A1 (en) 2014-06-06 2015-12-10 Berkeley Lights, Inc. Isolating Microfluidic Structures and Trapping Bubbles
KR101696259B1 (ko) * 2014-07-23 2017-01-13 나노바이오시스 주식회사 멀티플렉스 ｐｃｒ 칩 및 이를 포함하는 멀티플렉스 ｐｃｒ 장치
EP2985063A1 (en) 2014-08-15 2016-02-17 Carpegen GmbH Device for separating bubbles from a fluid
CN104225964B (zh) * 2014-09-17 2016-09-28 清华大学 微流体气泡排除装置及其制备方法以及微流体器件
JP6665548B2 (ja) * 2015-03-06 2020-03-13 ソニー株式会社 マイクロチップ、並びに分析装置及び分析方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520409A (ja) 2004-11-16 2008-06-19 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マイクロ流体素子
WO2011050110A1 (en) 2009-10-20 2011-04-28 Boston Microfluidics Methods and systems to collect and prepare samples, to implement, initiate and perform assays, and to control and manage fluid flow
US20150101422A1 (en) 2012-05-14 2015-04-16 Nanoentek, Inc. Sample analyzing chip
JP2017508956A (ja) 2014-02-10 2017-03-30 ナノバイオシス インコーポレーテッドＮａｎｏｂｉｏｓｙｓ Ｉｎｃ． 微少流体チップ及びこれを用いたリアルタイム分析装置
JP2017519996A (ja) 2014-07-10 2017-07-20 ナノバイオシス インコーポレーテッドＮａｎｏｂｉｏｓｙｓ Ｉｎｃ． マイクロ流体チップ、その製造方法及びそれを用いた分析装置
JP2017122618A (ja) 2016-01-06 2017-07-13 信越ポリマー株式会社 分析用基板およびその製造方法

Also Published As

Publication number Publication date
JP2020536724A (ja) 2020-12-17
US11596944B2 (en) 2023-03-07
US20200298232A1 (en) 2020-09-24
EP3697532A1 (en) 2020-08-26
WO2019077323A1 (en) 2019-04-25
CN111212688B (zh) 2022-06-17
CN111212688A (zh) 2020-05-29
GB201716961D0 (en) 2017-11-29

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