CN111212688B - 具有气泡转移的微流控装置 - Google Patents

具有气泡转移的微流控装置 Download PDF

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Publication number
CN111212688B
CN111212688B CN201880067130.3A CN201880067130A CN111212688B CN 111212688 B CN111212688 B CN 111212688B CN 201880067130 A CN201880067130 A CN 201880067130A CN 111212688 B CN111212688 B CN 111212688B
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microchannel
region
bubble transfer
transfer zone
imaged
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CN111212688A (zh
Inventor
霍贾特·马达迪
托马斯·迈克尔·威尔沙尔
乔纳森·奥汉隆
菲利普·托马斯·斯库利
保罗·马歇尔
爱德华多·博阿达
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QuantumDx Group Ltd
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QuantumDx Group Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/047—Additional chamber, reservoir
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0854—Double walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/088—Channel loops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201880067130.3A 2017-10-16 2018-10-15 具有气泡转移的微流控装置 Active CN111212688B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1716961.6A GB201716961D0 (en) 2017-10-16 2017-10-16 Microfluidic devices with bubble diversion
GB1716961.6 2017-10-16
PCT/GB2018/052958 WO2019077323A1 (en) 2017-10-16 2018-10-15 MICROFLUIDIC DEVICES WITH BUBBLE DEVIATION

Publications (2)

Publication Number Publication Date
CN111212688A CN111212688A (zh) 2020-05-29
CN111212688B true CN111212688B (zh) 2022-06-17

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CN201880067130.3A Active CN111212688B (zh) 2017-10-16 2018-10-15 具有气泡转移的微流控装置

Country Status (6)

Country Link
US (1) US11596944B2 (https=)
EP (1) EP3697532A1 (https=)
JP (1) JP7198813B2 (https=)
CN (1) CN111212688B (https=)
GB (1) GB201716961D0 (https=)
WO (1) WO2019077323A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11213824B2 (en) 2017-03-29 2022-01-04 The Research Foundation For The State University Of New York Microfluidic device and methods
US11701651B2 (en) 2017-11-28 2023-07-18 Inje University Industry-Academic Cooperation Foundation Microfluidic device capable of removing microbubbles in channel by using porous thin film, sample injection device for preventing inflow of bubbles, and method for bonding panel of microfluidic element by using mold-releasing film
CN110354523B (zh) * 2019-07-14 2024-02-06 河北龙亿环境工程有限公司 一种具有多微孔气泡罩的新型塔板
GB2636565A (en) 2023-11-16 2025-06-25 Quantumdx Group Ltd Flow regulators for the control of liquid fronts in microfluidic structures
EP4670844A1 (en) * 2024-06-26 2025-12-31 Dynamic Biosensors GmbH BUBBLE DETECTION IN A MICROFLUID CHANNEL

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635226B1 (en) * 1994-10-19 2003-10-21 Agilent Technologies, Inc. Microanalytical device and use thereof for conducting chemical processes
JP2008520409A (ja) 2004-11-16 2008-06-19 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マイクロ流体素子
EP1855114A1 (en) 2005-03-01 2007-11-14 Rohm Co., Ltd. Microchannel and microfluid chip
JP4685611B2 (ja) 2005-12-02 2011-05-18 株式会社エンプラス 微小流体装置
EP2490800A4 (en) * 2009-10-20 2013-05-01 Boston Microfluidics METHODS AND SYSTEMS FOR COLLECTING AND PREPARING SAMPLES, IMPLEMENTING, STARTING AND TESTING AND CONTROLLING AND MANAGING A FLUID FLOW
KR101175594B1 (ko) * 2012-05-14 2012-08-21 주식회사 나노엔텍 샘플분석용 칩
US9962698B2 (en) 2012-09-05 2018-05-08 President And Fellows Of Harvard College Removing bubbles in microfluidic systems
KR101562318B1 (ko) * 2014-02-10 2015-10-22 나노바이오시스 주식회사 미세유체 칩 및 이를 이용한 실시간 분석 장치
JP2015166707A (ja) * 2014-03-04 2015-09-24 キヤノン株式会社 マイクロ流路デバイス
US20150352547A1 (en) 2014-06-06 2015-12-10 Berkeley Lights, Inc. Isolating Microfluidic Structures and Trapping Bubbles
KR102195769B1 (ko) 2014-07-10 2020-12-30 주식회사 미코바이오메드 미세유체 칩, 이의 제조 방법 및 이를 이용한 분석 장치
KR101696259B1 (ko) * 2014-07-23 2017-01-13 나노바이오시스 주식회사 멀티플렉스 ｐｃｒ 칩 및 이를 포함하는 멀티플렉스 ｐｃｒ 장치
EP2985063A1 (en) 2014-08-15 2016-02-17 Carpegen GmbH Device for separating bubbles from a fluid
CN104225964B (zh) * 2014-09-17 2016-09-28 清华大学 微流体气泡排除装置及其制备方法以及微流体器件
JP6665548B2 (ja) * 2015-03-06 2020-03-13 ソニー株式会社 マイクロチップ、並びに分析装置及び分析方法
JP6687937B2 (ja) 2016-01-06 2020-04-28 国立研究開発法人産業技術総合研究所 分析用基板の製造方法

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Publication number Publication date
JP2020536724A (ja) 2020-12-17
US11596944B2 (en) 2023-03-07
US20200298232A1 (en) 2020-09-24
JP7198813B2 (ja) 2023-01-04
EP3697532A1 (en) 2020-08-26
WO2019077323A1 (en) 2019-04-25
CN111212688A (zh) 2020-05-29
GB201716961D0 (en) 2017-11-29

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