JP7166292B2 - Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法 - Google Patents

Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法 Download PDF

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JP7166292B2
JP7166292B2 JP2019562380A JP2019562380A JP7166292B2 JP 7166292 B2 JP7166292 B2 JP 7166292B2 JP 2019562380 A JP2019562380 A JP 2019562380A JP 2019562380 A JP2019562380 A JP 2019562380A JP 7166292 B2 JP7166292 B2 JP 7166292B2
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compound
cancer
crystalline solid
pyruvate
xrpd pattern
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JP2020521732A (ja
JP2020521732A5 (OSRAM
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ハリド シャー，
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エグゼリクシス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
JP2019562380A 2017-05-26 2018-05-26 Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法 Active JP7166292B2 (ja)

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JP2022127094A JP7437460B2 (ja) 2017-05-26 2022-08-09 Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法
JP2024018527A JP7659097B2 (ja) 2017-05-26 2024-02-09 Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法

Applications Claiming Priority (3)

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US201762511714P 2017-05-26 2017-05-26
US62/511,714 2017-05-26
PCT/US2018/034784 WO2018218233A1 (en) 2017-05-26 2018-05-26 Crystalline solid forms of salts of n-{4-[(6,7-dimethoxyquinolin-4-yl) oxy]phenyl}-n'-(4-fluorphenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use

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JP2022127094A Division JP7437460B2 (ja) 2017-05-26 2022-08-09 Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法

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JP2020521732A JP2020521732A (ja) 2020-07-27
JP2020521732A5 JP2020521732A5 (OSRAM) 2021-07-26
JP7166292B2 true JP7166292B2 (ja) 2022-11-07

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JP2019562380A Active JP7166292B2 (ja) 2017-05-26 2018-05-26 Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法
JP2022127094A Active JP7437460B2 (ja) 2017-05-26 2022-08-09 Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法
JP2024018527A Active JP7659097B2 (ja) 2017-05-26 2024-02-09 Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法

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JP2022127094A Active JP7437460B2 (ja) 2017-05-26 2022-08-09 Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法
JP2024018527A Active JP7659097B2 (ja) 2017-05-26 2024-02-09 Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法

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US (3) US11279675B2 (OSRAM)
EP (1) EP3630726B1 (OSRAM)
JP (3) JP7166292B2 (OSRAM)
KR (1) KR102611445B1 (OSRAM)
CN (1) CN110621662B (OSRAM)
AU (1) AU2018272088C1 (OSRAM)
CA (1) CA3060370A1 (OSRAM)
DK (1) DK3630726T3 (OSRAM)
EA (1) EA039654B1 (OSRAM)
ES (1) ES2909390T3 (OSRAM)
HU (1) HUE058196T2 (OSRAM)
IL (1) IL270780B2 (OSRAM)
MA (1) MA48776A (OSRAM)
MX (1) MX2019012505A (OSRAM)
PL (1) PL3630726T3 (OSRAM)
PT (1) PT3630726T (OSRAM)
SG (1) SG11201909161PA (OSRAM)
UA (1) UA127760C2 (OSRAM)
WO (1) WO2018218233A1 (OSRAM)
ZA (1) ZA201906127B (OSRAM)

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CN117624045A (zh) 2018-01-26 2024-03-01 埃克塞里艾克西斯公司 用于治疗激酶依赖性病症的化合物
CN113292537B (zh) 2018-06-15 2024-04-05 汉达癌症医药责任有限公司 激酶抑制剂的盐类及其组合物
RS67216B1 (sr) * 2018-12-13 2025-10-31 Exelixis Inc Kristalni oblici i oblici soli inhibitora kinaze
AU2019449809A1 (en) * 2019-06-03 2021-12-16 Exelixis, Inc. Crystalline salt forms of a kinase inhibitor
WO2023165948A1 (en) 2022-03-01 2023-09-07 Synthon B.V. Cabozantinib salt with l-(+)-tartaric acid and solid forms thereof
AU2024215796A1 (en) 2023-01-31 2025-05-15 Handa Oncology, Llc Improved cabozantinib compositions and methods of use
US11814356B1 (en) 2023-03-29 2023-11-14 Apotex Inc. Salt of cabozantinib

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022145852A (ja) * 2017-05-26 2022-10-04 エグゼリクシス， インコーポレイテッド Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法
JP7437460B2 (ja) 2017-05-26 2024-02-22 エグゼリクシス， インコーポレイテッド Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法
JP2024036690A (ja) * 2017-05-26 2024-03-15 エグゼリクシス， インコーポレイテッド Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法
JP7659097B2 (ja) 2017-05-26 2025-04-08 エグゼリクシス， インコーポレイテッド Ｎ－｛４－［（６，７－ジメトキシキノリン－４－イル）オキシ］フェニル｝－ｎ’－（４－フルオロフェニル）シクロプロパン－１，１－ジカルボキサミドの塩の結晶性固体形態、製造プロセス、及び使用方法

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CN110621662B (zh) 2023-06-23
EP3630726B1 (en) 2021-12-22
IL270780A (en) 2020-01-30
IL270780B1 (en) 2024-12-01
AU2018272088A8 (en) 2019-10-24
AU2018272088A1 (en) 2019-10-17
WO2018218233A1 (en) 2018-11-29
MA48776A (fr) 2020-04-08
MX2019012505A (es) 2019-12-19
UA127760C2 (uk) 2023-12-27
US20210261509A1 (en) 2021-08-26
EP3630726A1 (en) 2020-04-08
IL270780B2 (en) 2025-04-01
US20240010621A1 (en) 2024-01-11
US11279675B2 (en) 2022-03-22
EA039654B1 (ru) 2022-02-22
NZ757564A (en) 2025-05-02
JP2022145852A (ja) 2022-10-04
JP2020521732A (ja) 2020-07-27
PL3630726T3 (pl) 2022-05-09
JP2024036690A (ja) 2024-03-15
DK3630726T3 (da) 2022-03-07
CA3060370A1 (en) 2018-11-29
CN110621662A (zh) 2019-12-27
AU2018272088C1 (en) 2022-09-22
PT3630726T (pt) 2022-03-02
US12227481B2 (en) 2025-02-18
SG11201909161PA (en) 2019-10-30
US11731941B2 (en) 2023-08-22
JP7659097B2 (ja) 2025-04-08
US20220162166A1 (en) 2022-05-26
KR102611445B1 (ko) 2023-12-06
ES2909390T3 (es) 2022-05-06
HUE058196T2 (hu) 2022-07-28
JP7437460B2 (ja) 2024-02-22
AU2018272088B2 (en) 2022-06-16
EA201992803A1 (ru) 2020-04-16
ZA201906127B (en) 2022-11-30
KR20200010205A (ko) 2020-01-30

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