JP7161466B2 - グリコピロニウム化合物を作製するための方法及び使用する方法 - Google Patents

グリコピロニウム化合物を作製するための方法及び使用する方法 Download PDF

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JP7161466B2
JP7161466B2 JP2019503315A JP2019503315A JP7161466B2 JP 7161466 B2 JP7161466 B2 JP 7161466B2 JP 2019503315 A JP2019503315 A JP 2019503315A JP 2019503315 A JP2019503315 A JP 2019503315A JP 7161466 B2 JP7161466 B2 JP 7161466B2
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JP2019524752A5 (enExample
JP2019524752A (ja
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アンソニー エイドリアン ショー
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Journey Medical Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2019503315A 2016-08-02 2017-08-01 グリコピロニウム化合物を作製するための方法及び使用する方法 Active JP7161466B2 (ja)

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JP2022165169A JP2022191407A (ja) 2016-08-02 2022-10-14 グリコピロニウム化合物を作製するための方法及び使用する方法

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US201662370172P 2016-08-02 2016-08-02
US62/370,172 2016-08-02
PCT/US2017/044988 WO2018026869A1 (en) 2016-08-02 2017-08-01 Processes for making, and methods of using, glycopyrronium compounds

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JP2019524752A5 JP2019524752A5 (enExample) 2020-09-10
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US (2) US10906871B2 (enExample)
EP (1) EP3494106B1 (enExample)
JP (2) JP7161466B2 (enExample)
CA (1) CA3030772A1 (enExample)
WO (1) WO2018026869A1 (enExample)

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Publication number Priority date Publication date Assignee Title
JP2021532112A (ja) * 2018-07-24 2021-11-25 ドクトア・アウグスト・ボルフ・ゲーエムベーハー・ウント・コンパニー・カー・ゲー−アルツナイミツテル 抗コリン性化合物の局所用エマルション
CN114008023B (zh) * 2019-05-23 2024-02-09 科研制药株式会社 索吡溴铵的晶型及其制备方法
WO2021113260A1 (en) 2019-12-02 2021-06-10 Dermira, Inc. Diester containing compounds for treating hyperhidrosis
CN113321605A (zh) * 2021-07-02 2021-08-31 浙江倍合德制药有限公司 一种1-甲基-3-吡咯烷醇的制备方法
US11807604B1 (en) * 2022-02-16 2023-11-07 Miralogx Llc Pharmaceutical compounds, pharmaceutical compositions, and methods of treating asthma and other disorders
CN115925603B (zh) * 2022-11-29 2025-07-22 山东齐都药业有限公司 索吡溴铵的制备方法

Citations (6)

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JP2001504459A (ja) 1996-11-11 2001-04-03 ノエ・クリスティアン・エル 対掌体純粋な、塩基性アリール―シクロアルキル―ヒドロキシカルボン酸エステル、その製造方法及びこれを薬剤に使用する方法
JP2009515889A (ja) 2005-11-10 2009-04-16 ボーダー、ニコラス・エス ソフト型抗コリン作動性エステル
CN101759619A (zh) 2010-01-19 2010-06-30 苏州天马精细化学品股份有限公司 (s)-3-羟基吡咯烷及其n-衍生物的制备方法
JP2012523390A (ja) 2009-04-09 2012-10-04 ノバルティス アーゲー ピロリジニウム塩の調製方法
CN103012231A (zh) 2012-12-14 2013-04-03 沈阳药科大学 格隆溴铵手性对映体的制备方法和应用
CN104586841A (zh) 2013-10-30 2015-05-06 中国药科大学 (3r,2’r)-格隆溴铵作为m3毒蕈碱性受体拮抗剂在制药中的用途

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FI49713C (fi) 1974-05-15 1975-09-10 Medica Pharma Co Ltd Terapeuttisesti tehokkaan erytro-1-metyyli-3-pyrrolidinyyli-alfa-syklo -pentyylimandelaattimetobromidin valmistusmenetelmä.
GB8628138D0 (en) 1986-11-25 1986-12-31 Greenbank Eng Co Ltd Suction drying apparatus
WO1998000016A1 (en) 1996-07-01 1998-01-08 Sepracor, Inc. Methods and compositions for treating urinary incontinence using enantiomerically enriched (r,r)-glycopyrrolate
EP0909172A4 (en) 1996-07-01 1999-06-09 Sepracor Inc METHODS AND COMPOSITIONS FOR TREATING URINARY INCONTINENCE WITH ENANTIOMERIC ENRICHED (R, s) -GLYCOPYRROLATE
US6063808A (en) 1996-07-01 2000-05-16 Sepracor Inc. Methods and compositions for treating urinary incontinence using enantiomerically enriched (S,S)-glycopyrrolate
US6433003B1 (en) 1999-04-23 2002-08-13 Arthur M. Bobrove Method for treating hyperhidrosis in mammals
ES2206021B1 (es) 2002-04-16 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de pirrolidinio.
US8252316B2 (en) 2002-05-03 2012-08-28 Purepharm Inc. Method of topically applying glycopyrrolate solution using absorbent pad to reduce sweating
CA2384922C (en) 2002-05-03 2008-09-02 Purepharm Inc. Topical glycopyrrolate product for the reduction of sweating
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JP2009515889A (ja) 2005-11-10 2009-04-16 ボーダー、ニコラス・エス ソフト型抗コリン作動性エステル
JP2012523390A (ja) 2009-04-09 2012-10-04 ノバルティス アーゲー ピロリジニウム塩の調製方法
CN101759619A (zh) 2010-01-19 2010-06-30 苏州天马精细化学品股份有限公司 (s)-3-羟基吡咯烷及其n-衍生物的制备方法
CN103012231A (zh) 2012-12-14 2013-04-03 沈阳药科大学 格隆溴铵手性对映体的制备方法和应用
CN104586841A (zh) 2013-10-30 2015-05-06 中国药科大学 (3r,2’r)-格隆溴铵作为m3毒蕈碱性受体拮抗剂在制药中的用途

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Wu, W.-M.; Wu, J.; Mori, N.; Buchwald, P.; Bodor, N.，Stereoisomers of N-substituted soft anticholinergics and their zwitterionic metabolite based on glycopyrrolate - syntheses and pharmacological evaluations，Pharmazie，2008年，63(3),，200-209

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US10906871B2 (en) 2021-02-02
EP3494106A1 (en) 2019-06-12
JP2022191407A (ja) 2022-12-27
US20210130289A1 (en) 2021-05-06
CA3030772A1 (en) 2018-02-08
US20190161443A1 (en) 2019-05-30
JP2019524752A (ja) 2019-09-05
US11352323B2 (en) 2022-06-07
EP3494106B1 (en) 2022-07-20
WO2018026869A1 (en) 2018-02-08

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