JP7160533B2 - 多発性骨髄腫（ｍｍ）の処置 - Google Patents

多発性骨髄腫（ｍｍ）の処置 Download PDF

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JP7160533B2
JP7160533B2 JP2017558542A JP2017558542A JP7160533B2 JP 7160533 B2 JP7160533 B2 JP 7160533B2 JP 2017558542 A JP2017558542 A JP 2017558542A JP 2017558542 A JP2017558542 A JP 2017558542A JP 7160533 B2 JP7160533 B2 JP 7160533B2
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pharmaceutical composition
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JP2018515513A (ja
JP2018515513A5 (enExample
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レクレア，ステファン
エンデル，ヤン
ヘルトレ，ステファン
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MorphoSys GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
JP2017558542A 2015-05-13 2016-05-13 多発性骨髄腫（ｍｍ）の処置 Active JP7160533B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021078658A JP2021130668A (ja) 2015-05-13 2021-05-06 多発性骨髄腫（ｍｍ）の処置

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15167597.2 2015-05-13
EP15167597 2015-05-13
PCT/EP2016/060810 WO2016180958A1 (en) 2015-05-13 2016-05-13 Treatment for multiple myeloma (mm)

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JP2021078658A Division JP2021130668A (ja) 2015-05-13 2021-05-06 多発性骨髄腫（ｍｍ）の処置

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JP2018515513A JP2018515513A (ja) 2018-06-14
JP2018515513A5 JP2018515513A5 (enExample) 2019-06-13
JP7160533B2 true JP7160533B2 (ja) 2022-10-25

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JP2021078658A Pending JP2021130668A (ja) 2015-05-13 2021-05-06 多発性骨髄腫（ｍｍ）の処置

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US (2) US10533057B2 (enExample)
EP (1) EP3294769B1 (enExample)
JP (2) JP7160533B2 (enExample)
KR (1) KR20180008571A (enExample)
CN (1) CN107614530A (enExample)
AU (1) AU2016260895B2 (enExample)
CA (1) CA2984464C (enExample)
CY (1) CY1123982T1 (enExample)
DK (1) DK3294769T3 (enExample)
ES (1) ES2862708T3 (enExample)
HR (1) HRP20210552T1 (enExample)
HU (1) HUE054271T2 (enExample)
IL (1) IL255552B (enExample)
LT (1) LT3294769T (enExample)
MX (1) MX380557B (enExample)
PL (1) PL3294769T3 (enExample)
PT (1) PT3294769T (enExample)
RS (1) RS61668B1 (enExample)
RU (1) RU2723047C2 (enExample)
SG (1) SG11201708691VA (enExample)
SI (1) SI3294769T1 (enExample)
SM (1) SMT202100202T1 (enExample)
WO (1) WO2016180958A1 (enExample)
ZA (1) ZA201708386B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20210044A1 (ar) 2010-12-30 2017-06-16 Takeda Pharmaceuticals Co الأجسام المضادة لـ cd38
HUE054271T2 (hu) * 2015-05-13 2021-08-30 Morphosys Ag Mielóma Multiplex (MM) kezelése
JP7316930B2 (ja) 2016-07-15 2023-07-28 武田薬品工業株式会社 形質芽細胞及び形質細胞枯渇療法に対する応答を評価するための方法及び材料
CN112739715A (zh) 2018-01-12 2021-04-30 武田药品工业株式会社 抗cd38抗体的皮下给药
CN110144008B (zh) * 2018-02-12 2021-03-19 杭州尚健生物技术有限公司 Cd38蛋白抗体及其应用
MX2020010144A (es) * 2018-03-28 2020-12-07 Takeda Pharmaceuticals Co Dosificación subcutánea de anticuerpos anti grupo de diferenciación 38 (cd38).
CN109265551B (zh) * 2018-09-25 2020-09-15 华东师范大学 Cd38抗体、嵌合抗原受体和药物
MX2021007047A (es) * 2018-12-14 2021-10-26 Morphosys Ag Formulaciones de anticuerpos.
SG11202108029XA (en) * 2019-01-28 2021-08-30 Sanofi Sa Methods of treating multiple myeloma
US20200308296A1 (en) * 2019-03-28 2020-10-01 Janssen Biotech, Inc. Clinically Proven Subcutaneous Pharmaceutical Compositions Comprising Anti-CD38 Antibodies and Their Uses in Combination with Pomalidomide and Dexamethasone

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013542191A (ja) 2010-09-27 2013-11-21 モルフォシス・アー・ゲー 多発性骨髄腫およびｎｈｌ治療用の抗ｃｄ３８抗体およびレナリドミドまたはボルテゾミブ

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US20020164788A1 (en) 1994-12-02 2002-11-07 The Wellcome Foundation Limited Humanized antibodies to CD38
AU770718B2 (en) 1998-06-05 2004-02-26 Mayo Foundation For Medical Education And Research Use of genetically engineered antibodies to CD38 to treat multiple myeloma
EP1174440A1 (en) 2000-07-19 2002-01-23 U-BISys B.V. A selectively-expressed epitope on the human CD38 molecule detected by a phage display library-derived human scFv antibody fragment
SG142330A1 (en) 2004-02-06 2008-05-28 Morphosys Ag De Anti-cd38 human antibodies and uses therefor
AU2005235811B2 (en) 2004-02-06 2011-11-03 Morphosys Ag Anti-CD38 human antibodies and uses therefor
MX2007011064A (es) 2005-03-23 2008-02-19 Genmab As Anticuerpos contra cd38 para tratamiento de mieloma multiple.
US20090123950A1 (en) 2005-05-24 2009-05-14 Morphosys Ag Generation And Profiling Of Fully Human Hucal Gold®-Derived Therapeutic Antibodies Specific For Human CD38
NZ566915A (en) 2005-10-12 2011-09-30 Morphosys Ag Generation and profiling of human derived therapeutic antibodies specific for human CD38
PL2068874T3 (pl) * 2006-08-07 2015-06-30 Abbvie Biotherapeutics Inc Sposoby leczenia szpiczaka mnogiego z użyciem terapii skojarzonych opartych na przeciwciałach anty-cs1
TR201910145T4 (tr) * 2006-09-26 2019-08-21 Genmab As Tümörlerin tedavi edilmesine yönelik anti-CD38 artı kortikosteroidler artı bir kortikosteroid-olmayan kemoterapötik.
EP1914242A1 (en) 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
EP2580243B1 (en) * 2010-06-09 2019-10-16 Genmab A/S Antibodies against human cd38
US9738933B2 (en) * 2012-12-05 2017-08-22 H. Lee Moffitt Cancer Center And Research Institute, Inc. RNF41 as a biomarker predicting response to lenalidomide in non-del(5q) MDS
CN103421115B (zh) * 2013-09-02 2015-06-03 东南大学 一种cd38纳米抗体及应用
TN2016000142A1 (en) * 2013-10-31 2017-10-06 Sanofi Sa Specific anti-cd38 antibodies for treating human cancers.
WO2015195476A1 (en) 2014-06-16 2015-12-23 Mayo Foundation For Medical Education And Research Treating myelomas
US10617757B2 (en) * 2014-08-08 2020-04-14 The Regents Of The University Of California Methods for treating multiple myeloma
MA40608A (fr) 2014-09-09 2016-03-17 Janssen Biotech Inc Polythérapies avec des anticorps anti-cd38
HUE054271T2 (hu) * 2015-05-13 2021-08-30 Morphosys Ag Mielóma Multiplex (MM) kezelése

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JP2013542191A (ja) 2010-09-27 2013-11-21 モルフォシス・アー・ゲー 多発性骨髄腫およびｎｈｌ治療用の抗ｃｄ３８抗体およびレナリドミドまたはボルテゾミブ

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Ｈｉｓｔｏｒｙ ｏｆ Ｃｈａｎｇｅｓ ｆｏｒ Ｓｔｕｄｙ： ＮＣＴ０１４２１１８６，ＣｌｉｎｉｃａｌＴｒｉａｌｓ．ｇｏｖ ａｒｃｈｉｖｅ，２０１５年 ３月１８日，ＵＲＬ，ｈｔｔｐｓ：／／ｃｌｉｎｉｃａｌｔｒｉａｌｓ．ｇｏｖ／ｃｔ２／ｈｉｓｔｏｒｙ／ＮＣＴ０１４２１１８６？Ｖ＿９＝Ｖｉｅｗ
ソルコート静注液１００ｍｇ，添付文書，富士製薬工業株式会社，第１０版，ｐ．１－４

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RU2017137496A (ru) 2019-06-13
KR20180008571A (ko) 2018-01-24
US11591406B2 (en) 2023-02-28
CN107614530A (zh) 2018-01-19
HRP20210552T1 (hr) 2021-05-14
IL255552A (en) 2018-01-31
RU2723047C2 (ru) 2020-06-08
RU2017137496A3 (enExample) 2019-06-13
EP3294769A1 (en) 2018-03-21
PT3294769T (pt) 2021-04-13
LT3294769T (lt) 2021-04-26
EP3294769B1 (en) 2021-01-13
SI3294769T1 (sl) 2021-07-30
SG11201708691VA (en) 2017-11-29
AU2016260895A1 (en) 2017-11-09
CA2984464C (en) 2023-10-10
SMT202100202T1 (it) 2021-05-07
AU2016260895B2 (en) 2021-08-05
US20190048091A1 (en) 2019-02-14
ZA201708386B (en) 2019-06-26
PL3294769T3 (pl) 2021-07-05
ES2862708T3 (es) 2021-10-07
JP2018515513A (ja) 2018-06-14
US10533057B2 (en) 2020-01-14
CY1123982T1 (el) 2022-05-27
IL255552B (en) 2022-01-01
JP2021130668A (ja) 2021-09-09
RS61668B1 (sr) 2021-04-29
MX380557B (es) 2025-03-12
MX2017014396A (es) 2018-03-23
HUE054271T2 (hu) 2021-08-30
DK3294769T3 (da) 2021-03-08
US20200079871A1 (en) 2020-03-12
WO2016180958A1 (en) 2016-11-17
CA2984464A1 (en) 2016-11-17

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