JP7154229B2 - Ｉｒａｋ－４阻害剤として有用なチエノピリジンおよびベンゾチオフェン - Google Patents

Ｉｒａｋ－４阻害剤として有用なチエノピリジンおよびベンゾチオフェン Download PDF

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Publication number
JP7154229B2
JP7154229B2 JP2019561740A JP2019561740A JP7154229B2 JP 7154229 B2 JP7154229 B2 JP 7154229B2 JP 2019561740 A JP2019561740 A JP 2019561740A JP 2019561740 A JP2019561740 A JP 2019561740A JP 7154229 B2 JP7154229 B2 JP 7154229B2
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methoxy
pyridine
carboxamide
oxopyrrolidin
alkyl
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Japanese (ja)
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JP2020519596A5 (https=
JP2020519596A (ja
Inventor
サリーム・アーマッド
リン・リー
リデット・エイ・ネガシュ
ジョン・ハインズ
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2019561740A 2017-05-11 2018-05-10 Ｉｒａｋ－４阻害剤として有用なチエノピリジンおよびベンゾチオフェン Active JP7154229B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762504956P 2017-05-11 2017-05-11
US62/504,956 2017-05-11
PCT/US2018/031945 WO2018209012A1 (en) 2017-05-11 2018-05-10 Thienopyridines and benzothiophenes useful as irak4 inhibitors

Publications (3)

Publication Number Publication Date
JP2020519596A JP2020519596A (ja) 2020-07-02
JP2020519596A5 JP2020519596A5 (https=) 2021-06-10
JP7154229B2 true JP7154229B2 (ja) 2022-10-17

Family

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JP2019561740A Active JP7154229B2 (ja) 2017-05-11 2018-05-10 Ｉｒａｋ－４阻害剤として有用なチエノピリジンおよびベンゾチオフェン

Country Status (29)

Country Link
US (1) US10829496B2 (https=)
EP (1) EP3621960B1 (https=)
JP (1) JP7154229B2 (https=)
KR (1) KR102604900B1 (https=)
CN (1) CN110612298B (https=)
AR (1) AR111689A1 (https=)
AU (1) AU2018265130B2 (https=)
BR (1) BR112019023290A2 (https=)
CA (1) CA3062602A1 (https=)
CL (1) CL2019003198A1 (https=)
CO (1) CO2019012494A2 (https=)
CY (1) CY1124552T1 (https=)
DK (1) DK3621960T3 (https=)
EA (1) EA039189B1 (https=)
ES (1) ES2889926T3 (https=)
HR (1) HRP20211583T1 (https=)
HU (1) HUE056493T2 (https=)
IL (1) IL270494B (https=)
LT (1) LT3621960T (https=)
MX (1) MX2019012929A (https=)
MY (1) MY200228A (https=)
PE (1) PE20191817A1 (https=)
PL (1) PL3621960T3 (https=)
PT (1) PT3621960T (https=)
RS (1) RS62430B1 (https=)
SI (1) SI3621960T1 (https=)
SM (1) SMT202100568T1 (https=)
TW (1) TW201900640A (https=)
WO (1) WO2018209012A1 (https=)

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US11292792B2 (en) 2018-07-06 2022-04-05 Kymera Therapeutics, Inc. Tricyclic CRBN ligands and uses thereof
JP7623943B2 (ja) 2018-11-30 2025-01-29 カイメラ セラピューティクス， インコーポレイテッド Ｉｒａｋ分解剤およびそれらの使用
BR112021026517A2 (pt) 2019-06-28 2022-05-10 Kymera Therapeutics Inc Degradadores de irak e usos dos mesmos
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CN114127075B (zh) 2019-07-18 2024-05-14 百时美施贵宝公司 可用作IRAK4抑制剂的吡唑并[3,4-d]吡咯并[1,2-b]哒嗪基化合物
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JP7573596B2 (ja) * 2019-07-23 2024-10-25 ブリストル－マイヤーズ スクイブ カンパニー Ｉｒａｋ４阻害剤として有用なチエノピリジニルおよびチアゾロピリジニル化合物
WO2021026181A1 (en) 2019-08-06 2021-02-11 Bristol-Myers Squibb Company Bicyclic heterocyclic compounds useful as irak4 inhibitors
ES3059914T3 (en) 2019-08-13 2026-03-24 Bristol Myers Squibb Co Bicyclic heteroaryl compounds useful as irak4 inhibitors
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WO2021127190A1 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2021127283A2 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2021158495A1 (en) 2020-02-03 2021-08-12 Bristol-Myers Squibb Company Benzo[5,6][1,4]dioxino[2,3-b]pyridine compounds useful as irak4 inhibitors
CN111285844B (zh) * 2020-02-24 2022-08-12 河南师范大学 具有生物活性的苯并噻吩取代酰胺类化合物及其合成方法和应用
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
PH12023500015A1 (en) 2020-12-30 2024-03-11 Kymera Therapeutics Inc Irak degraders and uses thereof
WO2022174268A1 (en) 2021-02-15 2022-08-18 Kymera Therapeutics, Inc. Irak4 degraders and uses thereof
AU2022271290A1 (en) 2021-05-07 2023-11-23 Kymera Therapeutics, Inc. Cdk2 degraders and uses thereof
US12187744B2 (en) 2021-10-29 2025-01-07 Kymera Therapeutics, Inc. IRAK4 degraders and synthesis thereof
EP4472967A4 (en) 2022-01-31 2026-04-15 Kymera Therapeutics Inc Iraqi Degradation Agents and Their Uses

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Also Published As

Publication number Publication date
HRP20211583T1 (hr) 2022-01-07
BR112019023290A2 (pt) 2020-06-16
WO2018209012A1 (en) 2018-11-15
KR102604900B1 (ko) 2023-11-21
PT3621960T (pt) 2021-09-16
US10829496B2 (en) 2020-11-10
EA201992674A1 (ru) 2020-04-06
MY200228A (en) 2023-12-15
SMT202100568T1 (it) 2021-11-12
AU2018265130A1 (en) 2020-01-02
HUE056493T2 (hu) 2022-02-28
EA039189B1 (ru) 2021-12-15
CA3062602A1 (en) 2018-11-15
EP3621960B1 (en) 2021-08-04
ES2889926T3 (es) 2022-01-14
KR20200004871A (ko) 2020-01-14
CL2019003198A1 (es) 2020-03-20
CN110612298B (zh) 2023-05-05
CO2019012494A2 (es) 2020-01-17
EP3621960A1 (en) 2020-03-18
CN110612298A (zh) 2019-12-24
MX2019012929A (es) 2020-01-14
IL270494B (en) 2022-04-01
AR111689A1 (es) 2019-08-07
PL3621960T3 (pl) 2021-11-08
AU2018265130B2 (en) 2022-03-24
CY1124552T1 (el) 2022-07-22
JP2020519596A (ja) 2020-07-02
RS62430B1 (sr) 2021-11-30
TW201900640A (zh) 2019-01-01
US20200062777A1 (en) 2020-02-27
DK3621960T3 (da) 2021-09-27
SI3621960T1 (sl) 2021-11-30
PE20191817A1 (es) 2019-12-27
LT3621960T (lt) 2021-10-11

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