JP7149272B2 - β－セクレターゼ阻害剤としてのチアジン誘導体および使用方法 - Google Patents

β－セクレターゼ阻害剤としてのチアジン誘導体および使用方法 Download PDF

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JP7149272B2
JP7149272B2 JP2019531722A JP2019531722A JP7149272B2 JP 7149272 B2 JP7149272 B2 JP 7149272B2 JP 2019531722 A JP2019531722 A JP 2019531722A JP 2019531722 A JP2019531722 A JP 2019531722A JP 7149272 B2 JP7149272 B2 JP 7149272B2
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compound
tautomer
amino
dihydro
methyl
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JP2020503292A (ja
JP2020503292A5 (cg-RX-API-DMAC7.html
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ブルボー，マシュー・ピー
ハリントン，ポール・イー
リウ，チンイエン
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アムジエン・インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
JP2019531722A 2016-12-15 2017-12-13 β－セクレターゼ阻害剤としてのチアジン誘導体および使用方法 Active JP7149272B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662434714P 2016-12-15 2016-12-15
US62/434,714 2016-12-15
PCT/US2017/066179 WO2018112083A1 (en) 2016-12-15 2017-12-13 Thiazine derivatives as beta-secretase inhibitors and methods of use

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JP2020503292A JP2020503292A (ja) 2020-01-30
JP2020503292A5 JP2020503292A5 (cg-RX-API-DMAC7.html) 2021-01-28
JP7149272B2 true JP7149272B2 (ja) 2022-10-06

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US (1) US10889579B2 (cg-RX-API-DMAC7.html)
EP (1) EP3555084B1 (cg-RX-API-DMAC7.html)
JP (1) JP7149272B2 (cg-RX-API-DMAC7.html)
AU (1) AU2017376444B2 (cg-RX-API-DMAC7.html)
CA (1) CA3047288A1 (cg-RX-API-DMAC7.html)
ES (1) ES2910791T3 (cg-RX-API-DMAC7.html)
MA (1) MA54100A (cg-RX-API-DMAC7.html)
MX (1) MX388697B (cg-RX-API-DMAC7.html)
WO (1) WO2018112083A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020503293A (ja) * 2016-12-15 2020-01-30 アムジエン・インコーポレーテツド β−セクレターゼ阻害剤としてのオキサジン誘導体および使用方法

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EP3555084B1 (en) 2016-12-15 2022-03-16 Amgen Inc. Thiazine derivatives as beta-secretase inhibitors and methods of use
AU2017376446B2 (en) 2016-12-15 2021-10-14 Amgen Inc. 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
AU2017378316B2 (en) 2016-12-15 2021-04-01 Amgen Inc. Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020503293A (ja) * 2016-12-15 2020-01-30 アムジエン・インコーポレーテツド β−セクレターゼ阻害剤としてのオキサジン誘導体および使用方法
JP7177773B2 (ja) 2016-12-15 2022-11-24 アムジエン・インコーポレーテツド β－セクレターゼ阻害剤としてのオキサジン誘導体および使用方法

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CA3047288A1 (en) 2018-06-21
EP3555084A1 (en) 2019-10-23
US10889579B2 (en) 2021-01-12
MX388697B (es) 2025-03-20
AU2017376444B2 (en) 2021-09-30
AU2017376444A1 (en) 2019-07-04
MA54100A (fr) 2021-10-20
JP2020503292A (ja) 2020-01-30
EP3555084B1 (en) 2022-03-16
ES2910791T3 (es) 2022-05-13
MX2019007102A (es) 2019-12-16
WO2018112083A1 (en) 2018-06-21
US20200062743A1 (en) 2020-02-27

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