JP7145080B2 - 重水素化ｊａｋ阻害剤による脱毛障害の処置 - Google Patents

重水素化ｊａｋ阻害剤による脱毛障害の処置 Download PDF

Info

Publication number
JP7145080B2
JP7145080B2 JP2018557837A JP2018557837A JP7145080B2 JP 7145080 B2 JP7145080 B2 JP 7145080B2 JP 2018557837 A JP2018557837 A JP 2018557837A JP 2018557837 A JP2018557837 A JP 2018557837A JP 7145080 B2 JP7145080 B2 JP 7145080B2
Authority
JP
Japan
Prior art keywords
compound
day
pharmaceutically acceptable
acceptable salt
phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018557837A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019516684A (ja
JP2019516684A5 (enExample
Inventor
ワグナー，アマンダ，ティー．
カッセラ，ジェームス，ブイ．
グラハム，フィリップ，ビー．
ブラマン，バージニア
ウッタムシン，ビニタ
ヘーン，ヤナ フォン
ハミルトン，コリーン，イー．
Original Assignee
コンサート ファーマシューティカルズ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60203616&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP7145080(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by コンサート ファーマシューティカルズ インコーポレイテッド filed Critical コンサート ファーマシューティカルズ インコーポレイテッド
Publication of JP2019516684A publication Critical patent/JP2019516684A/ja
Publication of JP2019516684A5 publication Critical patent/JP2019516684A5/ja
Priority to JP2022147751A priority Critical patent/JP7586868B2/ja
Application granted granted Critical
Publication of JP7145080B2 publication Critical patent/JP7145080B2/ja
Priority to JP2024195175A priority patent/JP2025026895A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018557837A 2016-05-04 2017-05-04 重水素化ｊａｋ阻害剤による脱毛障害の処置 Active JP7145080B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022147751A JP7586868B2 (ja) 2016-05-04 2022-09-16 重水素化ｊａｋ阻害剤による脱毛障害の処置
JP2024195175A JP2025026895A (ja) 2016-05-04 2024-11-07 重水素化ｊａｋ阻害剤による脱毛障害の処置

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201662331827P 2016-05-04 2016-05-04
US62/331,827 2016-05-04
US201662338869P 2016-05-19 2016-05-19
US62/338,869 2016-05-19
US201662418774P 2016-11-07 2016-11-07
US62/418,774 2016-11-07
US201662419237P 2016-11-08 2016-11-08
US62/419,237 2016-11-08
US201662434404P 2016-12-14 2016-12-14
US62/434,404 2016-12-14
US201762466358P 2017-03-02 2017-03-02
US62/466,358 2017-03-02
US201762492758P 2017-05-01 2017-05-01
US62/492,758 2017-05-01
PCT/US2017/031142 WO2017192905A1 (en) 2016-05-04 2017-05-04 Treatment of hair loss disorders with deuterated jak inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022147751A Division JP7586868B2 (ja) 2016-05-04 2022-09-16 重水素化ｊａｋ阻害剤による脱毛障害の処置

Publications (3)

Publication Number Publication Date
JP2019516684A JP2019516684A (ja) 2019-06-20
JP2019516684A5 JP2019516684A5 (enExample) 2020-06-18
JP7145080B2 true JP7145080B2 (ja) 2022-09-30

Family

ID=60203616

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018557837A Active JP7145080B2 (ja) 2016-05-04 2017-05-04 重水素化ｊａｋ阻害剤による脱毛障害の処置
JP2022147751A Active JP7586868B2 (ja) 2016-05-04 2022-09-16 重水素化ｊａｋ阻害剤による脱毛障害の処置
JP2024195175A Pending JP2025026895A (ja) 2016-05-04 2024-11-07 重水素化ｊａｋ阻害剤による脱毛障害の処置

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022147751A Active JP7586868B2 (ja) 2016-05-04 2022-09-16 重水素化ｊａｋ阻害剤による脱毛障害の処置
JP2024195175A Pending JP2025026895A (ja) 2016-05-04 2024-11-07 重水素化ｊａｋ阻害剤による脱毛障害の処置

Country Status (21)

Country Link
US (3) US10561659B2 (enExample)
EP (2) EP4424367A3 (enExample)
JP (3) JP7145080B2 (enExample)
KR (3) KR20190003711A (enExample)
CN (3) CN122440641A (enExample)
AU (3) AU2017261286B2 (enExample)
BR (1) BR112018072339A2 (enExample)
CA (1) CA3022519A1 (enExample)
DK (1) DK3452039T3 (enExample)
ES (1) ES2988629T3 (enExample)
FI (1) FI3452039T3 (enExample)
HR (1) HRP20241345T1 (enExample)
HU (1) HUE068643T2 (enExample)
LT (1) LT3452039T (enExample)
MX (6) MX388054B (enExample)
PL (1) PL3452039T3 (enExample)
PT (1) PT3452039T (enExample)
RS (1) RS66006B1 (enExample)
SI (1) SI3452039T1 (enExample)
SM (1) SMT202400389T1 (enExample)
WO (1) WO2017192905A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022171838A (ja) * 2016-05-04 2022-11-11 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化ｊａｋ阻害剤による脱毛障害の処置

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3921318A1 (en) * 2019-02-06 2021-12-15 Concert Pharmaceuticals Inc. Process for preparing enantiomerically enriched jak inhibitors
WO2021236139A1 (en) * 2020-05-21 2021-11-25 Concert Pharmaceuticals, Inc. Novel deuterated jak inhibitor and uses thereof
US12643902B2 (en) 2020-08-12 2026-06-02 Sun Pharmaceutical Industries, Inc. Process for preparing enantiomerically enriched substituted pyrrolo[2,3-d]pyrimidines
US20220213105A1 (en) 2020-08-12 2022-07-07 Concert Pharmaceuticals, Inc. Process for preparing enantiomerically enriched jak inhibitors
CN116916927A (zh) * 2020-10-28 2023-10-20 太阳医药工业公司 用于用氘化jak抑制剂治疗脱发症的方案
US20230390292A1 (en) * 2020-10-28 2023-12-07 Sun Pharmaceutical Industries, Inc. Regimens for the treatment of hair loss disorders with deuterated jak inhibitors
CN112402615A (zh) * 2020-11-11 2021-02-26 长沙晶易医药科技有限公司 一种用于治疗斑秃的复方外用制剂及其制备方法
WO2023018904A1 (en) 2021-08-11 2023-02-16 Concert Pharmaceuticals, Inc. Treatment of hair loss disorders with deuterated jak inhibitors
AU2022328282A1 (en) 2021-08-12 2024-02-22 Sun Pharmaceutical Industries, Inc. Treatment of jak-inhibition-responsive disorders with prodrugs of jak inhibitors
WO2023215520A1 (en) 2022-05-04 2023-11-09 Sun Pharmaceutical Industries, Inc. Dosage regimens for treatment with deuterated jak inhibitors
US12364699B2 (en) * 2023-10-10 2025-07-22 Sun Pharmaceuticals Industries, Inc. Method of treating hair loss disorders
US12247034B1 (en) 2024-04-19 2025-03-11 Sun Pharmaceutical Industries, Inc. Crystalline form of deuruxolitinib phosphate
WO2026020112A1 (en) * 2024-07-19 2026-01-22 Sun Pharmaceutical Industries, Inc. Oral formulations of deuruxolitinib
US20260027120A1 (en) * 2024-07-25 2026-01-29 Sun Pharmaceutical Industries, Inc. Methods of treatment of jak inhibition responsive conditions with deuterated jak inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014500249A (ja) 2010-11-02 2014-01-09 ザ トラスティース オブ コロンビア ユニバーシティ インザ シティ オブ ニューヨーク 脱毛症の治療方法
JP2015117185A (ja) 2013-12-17 2015-06-25 コンサート ファーマシューティカルズ インコーポレイテッド ルキソリチニブの重水素化誘導体
US20150239896A1 (en) 2012-06-15 2015-08-27 Concert Pharmaceuticals, Inc. Deuterated Derivatives of Ruxolitinib
JP2015537030A (ja) 2012-11-15 2015-12-24 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ ルキソリチニブの徐放性投薬形態

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9925962D0 (en) 1999-11-02 1999-12-29 Novartis Ag Organic compounds
CZ20033211A3 (cs) 2001-05-03 2004-09-15 F. Hoffmann-La Roche Ag Farmaceutická léková forma amorfního nelfinavir mesylátu
WO2006039237A1 (en) 2004-09-29 2006-04-13 Cordis Corporation Pharmaceutical dosage forms of stable amorphous rapamycin like compounds
HUE028588T2 (hu) 2005-12-13 2016-12-28 Incyte Holdings Corp Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok
LT1993360T (lt) 2005-12-28 2017-06-12 Vertex Pharmaceuticals Incorporated N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
WO2010083283A2 (en) 2009-01-15 2010-07-22 Incyte Corporation Processes for preparing jak inhibitors and related intermediate compounds
US9198911B2 (en) 2010-11-02 2015-12-01 The Trustees Of Columbia University In The City Of New York Methods for treating hair loss disorders
DK2830662T3 (da) 2012-03-29 2019-01-02 Univ Columbia Fremgangsmåder til behandlng af hårtabsforstyrrelser
CA2879400A1 (en) * 2012-07-30 2014-02-06 Concert Pharmaceuticals, Inc. Deuterated ibrutinib
CN104725380B (zh) * 2013-12-18 2019-06-28 康塞特医药品有限公司 卢索替尼的氘代衍生物
MX2016010213A (es) * 2014-02-07 2017-04-13 Auspex Pharmaceuticals Inc Formulaciones farmaceuticas novedosas.
US10561659B2 (en) 2016-05-04 2020-02-18 Concert Pharmaceuticals, Inc. Treatment of hair loss disorders with deuterated JAK inhibitors
WO2023018904A1 (en) * 2021-08-11 2023-02-16 Concert Pharmaceuticals, Inc. Treatment of hair loss disorders with deuterated jak inhibitors
US12364699B2 (en) * 2023-10-10 2025-07-22 Sun Pharmaceuticals Industries, Inc. Method of treating hair loss disorders

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014500249A (ja) 2010-11-02 2014-01-09 ザ トラスティース オブ コロンビア ユニバーシティ インザ シティ オブ ニューヨーク 脱毛症の治療方法
US20150239896A1 (en) 2012-06-15 2015-08-27 Concert Pharmaceuticals, Inc. Deuterated Derivatives of Ruxolitinib
JP2015537030A (ja) 2012-11-15 2015-12-24 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ ルキソリチニブの徐放性投薬形態
JP2015117185A (ja) 2013-12-17 2015-06-25 コンサート ファーマシューティカルズ インコーポレイテッド ルキソリチニブの重水素化誘導体

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. Am. Acad. Dermatol.，2016年，Vol.74, No.2，p.1-5(p.370-371)
JAMA Dermatology，2016年，Vol.152, No.4，p.490-491
Nat. Med.，2014年，Vol.20, No.9，p.1-17(p.1043-1049)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022171838A (ja) * 2016-05-04 2022-11-11 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化ｊａｋ阻害剤による脱毛障害の処置
JP7586868B2 (ja) 2016-05-04 2024-11-19 サン ファーマシューティカル インダストリーズ，インコーポレイテッド 重水素化ｊａｋ阻害剤による脱毛障害の処置

Also Published As

Publication number Publication date
EP4424367A3 (en) 2024-11-13
JP2019516684A (ja) 2019-06-20
MX388054B (es) 2025-03-19
JP7586868B2 (ja) 2024-11-19
EP3452039A4 (en) 2019-12-25
AU2017261286B2 (en) 2023-03-23
SI3452039T1 (sl) 2024-12-31
JP2025026895A (ja) 2025-02-26
MX2023002325A (es) 2023-03-22
EP4424367A2 (en) 2024-09-04
AU2017261286A1 (en) 2018-11-22
AU2023201112B2 (en) 2025-05-08
US20200222408A1 (en) 2020-07-16
CN122440641A (zh) 2026-07-24
KR20190003711A (ko) 2019-01-09
US10561659B2 (en) 2020-02-18
US20240423986A1 (en) 2024-12-26
ES2988629T3 (es) 2024-11-21
HUE068643T2 (hu) 2025-01-28
KR102810262B1 (ko) 2025-05-19
PL3452039T3 (pl) 2024-11-18
EP3452039B1 (en) 2024-07-03
CA3022519A1 (en) 2017-11-09
LT3452039T (lt) 2024-10-25
BR112018072339A2 (pt) 2019-02-19
MX2023002323A (es) 2023-03-22
FI3452039T3 (fi) 2024-10-02
JP2022171838A (ja) 2022-11-11
DK3452039T3 (da) 2024-10-07
MX2021014175A (es) 2022-01-04
AU2025213576A1 (en) 2025-08-21
MX2018013347A (es) 2019-09-02
MX2023002321A (es) 2023-03-22
HRP20241345T1 (hr) 2024-12-20
AU2023201112A1 (en) 2023-03-30
PT3452039T (pt) 2024-10-07
KR20250070139A (ko) 2025-05-20
KR20230086814A (ko) 2023-06-15
MX2023002324A (es) 2023-03-22
CN109069493A (zh) 2018-12-21
WO2017192905A1 (en) 2017-11-09
CN121868312A (zh) 2026-04-17
SMT202400389T1 (it) 2024-11-15
US20190160068A1 (en) 2019-05-30
US12076323B2 (en) 2024-09-03
EP3452039A1 (en) 2019-03-13
RS66006B1 (sr) 2024-10-31

Similar Documents

Publication Publication Date Title
JP7586868B2 (ja) 重水素化ｊａｋ阻害剤による脱毛障害の処置
US12285432B2 (en) Treatment of hair loss disorders with deuterated JAK inhibitors
US20230390292A1 (en) Regimens for the treatment of hair loss disorders with deuterated jak inhibitors
US20250275977A1 (en) Dosage regimens for treatment with deuterated jak inhibitors
HK40112813A (en) Treatment of hair loss disorders with deuterated jak inhibitors
EA052710B1 (ru) Лечение нарушений, характеризующихся выпадением волос, с помощью дейтерированных ингибиторов jak
HK40002100A (en) Treatment of hair loss disorders with deuterated jak inhibitors
OA21444A (en) Regimens For The Treatment Of Hair Loss Disorders With Deuterated Jak Inhibitors.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200501

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200501

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20210324

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210330

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210616

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210930

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20211118

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220207

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220518

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220819

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220916

R150 Certificate of patent or registration of utility model

Ref document number: 7145080

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313111

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250