JP7142022B2 - Ｍａｌｔ１の阻害剤およびそれらの使用 - Google Patents

Ｍａｌｔ１の阻害剤およびそれらの使用 Download PDF

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Publication number
JP7142022B2
JP7142022B2 JP2019549411A JP2019549411A JP7142022B2 JP 7142022 B2 JP7142022 B2 JP 7142022B2 JP 2019549411 A JP2019549411 A JP 2019549411A JP 2019549411 A JP2019549411 A JP 2019549411A JP 7142022 B2 JP7142022 B2 JP 7142022B2
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alkyl
unsubstituted
substituted
alkenyl
alkynyl
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JP2020511454A5 (https=
JP2020511454A (ja
Inventor
グレイ，ナタナエル，エス．
スコット，デイビッド，エー．
ハッチャー，ジョン
メルニック，アリ，エム．
ギャバス，ロレーナ，フォンタン
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Cornell University
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Cornell University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2019549411A 2017-03-08 2018-03-08 Ｍａｌｔ１の阻害剤およびそれらの使用 Active JP7142022B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762468758P 2017-03-08 2017-03-08
US62/468,758 2017-03-08
US201762553336P 2017-09-01 2017-09-01
US62/553,336 2017-09-01
PCT/US2018/021481 WO2018165385A1 (en) 2017-03-08 2018-03-08 Inhibitors of malt1 and uses thereof

Publications (3)

Publication Number Publication Date
JP2020511454A JP2020511454A (ja) 2020-04-16
JP2020511454A5 JP2020511454A5 (https=) 2021-04-15
JP7142022B2 true JP7142022B2 (ja) 2022-09-26

Family

ID=63448912

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JP2019549411A Active JP7142022B2 (ja) 2017-03-08 2018-03-08 Ｍａｌｔ１の阻害剤およびそれらの使用

Country Status (4)

Country Link
US (1) US11248007B2 (https=)
EP (1) EP3592731A4 (https=)
JP (1) JP7142022B2 (https=)
WO (1) WO2018165385A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3490995A1 (en) * 2016-07-29 2019-06-05 Lupin Limited Substituted thiazolo-pyridine compounds as malt1 inhibitors
WO2018020474A1 (en) * 2016-07-29 2018-02-01 Lupin Limited Substituted thiazolo-pyridine compounds as malt1 inhibitors
TWI795381B (zh) 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
WO2020111087A1 (ja) * 2018-11-28 2020-06-04 武田薬品工業株式会社 複素環化合物
KR20220002883A (ko) * 2019-03-12 2022-01-07 퀴델 코포레이션 자가항체 검출용 조성물, 키트, 및 방법
ES2949871T3 (es) * 2019-04-11 2023-10-03 Janssen Pharmaceutica Nv Anillos de piridina que contienen derivados como inhibidores de MALT1
WO2021000855A1 (en) * 2019-07-01 2021-01-07 Qilu Regor Therapeutics Inc. Malt1 inhibitors and uses thereof
JP7672402B2 (ja) * 2020-05-27 2025-05-07 武田薬品工業株式会社 複素環化合物の製造方法
US20230414629A1 (en) * 2020-11-12 2023-12-28 Monopteros Therapeutics, Inc. Materials and methods of treating cancer
WO2023125877A1 (zh) 2021-12-30 2023-07-06 上海翰森生物医药科技有限公司 三并环类衍生物抑制剂、其制备方法和应用
WO2024196769A2 (en) * 2023-03-17 2024-09-26 The Trustees Of The University Of Pennsylvania Combinations of retinaldehyde dehydrogenase 1 (raldh1) inhibitors and immunostimulators and methods using same

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5596001A (en) 1993-10-25 1997-01-21 Pfizer Inc. 4-aryl-3-(heteroarylureido)quinoline derivatves
WO2014086478A1 (en) 2012-12-03 2014-06-12 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of malt1 protease
WO2015181747A1 (en) 2014-05-28 2015-12-03 Novartis Ag Novel pyrazolo pyrimidine derivatives and their use as malt1 inhibitors
JP2015536990A (ja) 2012-11-09 2015-12-24 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ Ｍａｌｔ１の低分子阻害剤
JP2019522035A (ja) 2016-07-29 2019-08-08 ルピン・リミテッド Ｍａｌｔ１阻害剤としての置換チアゾロ−ピリジン化合物
JP2019537599A (ja) 2016-11-01 2019-12-26 コーネル ユニバーシティー Ｍａｌｔ１分解のための化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9090592B2 (en) * 2010-12-30 2015-07-28 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
GB2504550A (en) 2012-08-03 2014-02-05 Nanyang Polytechnic Diarylurea compound PQ401 for inhibiting the growth and/or proliferation of cancer stem cells

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5596001A (en) 1993-10-25 1997-01-21 Pfizer Inc. 4-aryl-3-(heteroarylureido)quinoline derivatves
JP2015536990A (ja) 2012-11-09 2015-12-24 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ Ｍａｌｔ１の低分子阻害剤
WO2014086478A1 (en) 2012-12-03 2014-06-12 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of malt1 protease
WO2015181747A1 (en) 2014-05-28 2015-12-03 Novartis Ag Novel pyrazolo pyrimidine derivatives and their use as malt1 inhibitors
JP2019522035A (ja) 2016-07-29 2019-08-08 ルピン・リミテッド Ｍａｌｔ１阻害剤としての置換チアゾロ−ピリジン化合物
JP2019537599A (ja) 2016-11-01 2019-12-26 コーネル ユニバーシティー Ｍａｌｔ１分解のための化合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Chemical Information and Modeling，2011年，Vol. 51, No. 6，pp. 1474-1491

Also Published As

Publication number Publication date
EP3592731A1 (en) 2020-01-15
EP3592731A4 (en) 2020-10-07
WO2018165385A1 (en) 2018-09-13
US20200385405A1 (en) 2020-12-10
JP2020511454A (ja) 2020-04-16
US11248007B2 (en) 2022-02-15

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