JP7132934B2 - ポリプロイド性アデノ随伴ウイルスベクターならびにその作製および使用の方法 - Google Patents

ポリプロイド性アデノ随伴ウイルスベクターならびにその作製および使用の方法 Download PDF

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JP7132934B2
JP7132934B2 JP2019545960A JP2019545960A JP7132934B2 JP 7132934 B2 JP7132934 B2 JP 7132934B2 JP 2019545960 A JP2019545960 A JP 2019545960A JP 2019545960 A JP2019545960 A JP 2019545960A JP 7132934 B2 JP7132934 B2 JP 7132934B2
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aav
capsid
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aav8
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JP2020511127A (ja
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リチャード ジュード サムルスキ
チェンウェン リ
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University of North Carolina at Chapel Hill
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14142—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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JP2019545960A 2017-03-15 2018-03-15 ポリプロイド性アデノ随伴ウイルスベクターならびにその作製および使用の方法 Active JP7132934B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762471762P 2017-03-15 2017-03-15
US62/471,762 2017-03-15
US201762520901P 2017-06-16 2017-06-16
US62/520,901 2017-06-16
US201862630558P 2018-02-14 2018-02-14
US62/630,558 2018-02-14
PCT/US2018/022725 WO2018170310A1 (en) 2017-03-15 2018-03-15 Polyploid adeno-associated virus vectors and methods of making and using the same

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JP2020511127A JP2020511127A (ja) 2020-04-16
JP2020511127A5 JP2020511127A5 (enExample) 2021-04-30
JP7132934B2 true JP7132934B2 (ja) 2022-09-07

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EP (2) EP3610023B1 (enExample)
JP (1) JP7132934B2 (enExample)
CN (2) CN110770346B (enExample)
AU (2) AU2018234695B2 (enExample)
CA (1) CA3054711A1 (enExample)
ES (1) ES2966692T3 (enExample)
IL (3) IL268891B2 (enExample)
WO (1) WO2018170310A1 (enExample)

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PT3356390T (pt) 2015-09-28 2021-04-21 Univ Florida Métodos e composições para vetores virais que se evadem a anticorpos
US12173305B2 (en) 2016-05-26 2024-12-24 University Of Iowa Research Foundation cis and trans requirements for terminal resolution of human bocavirus 1
US10550405B2 (en) 2017-03-15 2020-02-04 The University Of North Carolina At Chapel Hill Rational polyploid adeno-associated virus vectors and methods of making and using the same
JP2020530307A (ja) 2017-06-30 2020-10-22 インティマ・バイオサイエンス，インコーポレーテッド 遺伝子治療のためのアデノ随伴ウイルスベクター
JP2021519581A (ja) 2018-04-03 2021-08-12 ストライドバイオ，インコーポレイテッド 抗体を回避するウイルスベクター
SG11202009452WA (en) 2018-04-03 2020-10-29 Stridebio Inc Antibody-evading virus vectors
JP7425738B2 (ja) 2018-04-03 2024-01-31 ギンコ バイオワークス インコーポレイテッド 眼組織を標的とするウイルスベクター
NZ759802A (en) * 2018-05-07 2025-08-29 Univ North Carolina Chapel Hill Rational polyploid adeno-associated virus vectors and methods of making and using the same
JP2021523198A (ja) * 2018-05-14 2021-09-02 ビオマリン プハルマセウトイカル インコーポレイテッド 幼若対象におけるａａｖベクターの安定的発現
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CA3119771A1 (en) * 2018-11-20 2020-05-28 The Trustees Of The University Of Pennsylvania Compositions and methods useful for targeting the blood-brain barrier
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CA3137078A1 (en) * 2019-04-15 2020-10-22 University Of Iowa Research Foundation Methods and compositions for transgene expression
WO2020223236A1 (en) * 2019-04-29 2020-11-05 The Trustees Of The University Of Pennsylvania Novel aav capsids and compositions containing same
KR20220083714A (ko) 2019-10-17 2022-06-20 스트라이드바이오 인코포레이티드 니만-피크 질환 c형의 치료를 위한 아데노-연관 바이러스 벡터
CN111349148A (zh) * 2020-03-13 2020-06-30 辉大(上海)生物科技有限公司 一种腺相关病毒载体及其用途
EP4125977A4 (en) * 2020-05-05 2024-09-25 Duke University CROSS-SPECIES COMPATIBLE ADENO-ASSOCIATED VIRUS COMPOSITIONS AND METHODS OF USE THEREOF
CN115927398B (zh) * 2020-07-29 2024-11-19 北京三诺佳邑生物技术有限责任公司 一组肝靶向新型腺相关病毒的获得及其应用
AR123288A1 (es) 2020-08-19 2022-11-16 Stridebio Inc Vectores de virus adenoasociados para el tratamiento del síndrome de rett
CA3216491A1 (en) * 2021-04-16 2022-10-20 Asklepios Biopharmaceutical, Inc. Rational polyploid aav virions that cross the blood brain barrier and elicit reduced humoral response
CA3242989A1 (en) * 2021-12-21 2023-06-29 Research Institute At Nationwide Children's Hospital MATERIALS AND METHODS FOR THE TREATMENT OF MUSCULAR BELLY DYSTROPHY

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EP4303225B1 (en) 2025-11-26
CN110770346B (zh) 2024-01-12
IL268891B1 (en) 2024-05-01
EP4303225A3 (en) 2024-04-10
IL312266A (en) 2024-06-01
AU2024227303A1 (en) 2024-10-31
EP3610023B1 (en) 2023-10-04
JP2020511127A (ja) 2020-04-16
ES2966692T3 (es) 2024-04-23
CN117801075A (zh) 2024-04-02
CA3054711A1 (en) 2018-09-20
AU2018234695A1 (en) 2019-09-12
CN110770346A (zh) 2020-02-07
EP3610023A4 (en) 2021-01-20
IL312266B1 (en) 2024-11-01
AU2018234695B2 (en) 2024-10-03
IL312266B2 (en) 2025-03-01
IL268891A (en) 2019-10-31
EP3610023A1 (en) 2020-02-19
IL268891B2 (en) 2024-09-01
IL316259A (en) 2024-12-01
EP4303225A2 (en) 2024-01-10
WO2018170310A1 (en) 2018-09-20

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