JP7127013B2 - 表面から細菌バイオフィルムを低減または除去するためのサーモリシンの使用 - Google Patents

表面から細菌バイオフィルムを低減または除去するためのサーモリシンの使用 Download PDF

Info

Publication number
JP7127013B2
JP7127013B2 JP2019503673A JP2019503673A JP7127013B2 JP 7127013 B2 JP7127013 B2 JP 7127013B2 JP 2019503673 A JP2019503673 A JP 2019503673A JP 2019503673 A JP2019503673 A JP 2019503673A JP 7127013 B2 JP7127013 B2 JP 7127013B2
Authority
JP
Japan
Prior art keywords
tissue
composition
ulcer
bacterial
thermolysin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019503673A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019522017A (ja
JP2019522017A5 (enExample
Inventor
レイ・シ
キャサリン・ファンデルカール
アレクサ・ジョヴァノビック
エリック・ロシュ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith and Nephew Inc
Original Assignee
Smith and Nephew Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith and Nephew Inc filed Critical Smith and Nephew Inc
Publication of JP2019522017A publication Critical patent/JP2019522017A/ja
Publication of JP2019522017A5 publication Critical patent/JP2019522017A5/ja
Priority to JP2022089557A priority Critical patent/JP2022111186A/ja
Application granted granted Critical
Publication of JP7127013B2 publication Critical patent/JP7127013B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds containing nitrogen-to-oxygen bonds
    • A01N33/18—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24027—Thermolysin (3.4.24.27)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
JP2019503673A 2016-07-27 2017-07-26 表面から細菌バイオフィルムを低減または除去するためのサーモリシンの使用 Active JP7127013B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022089557A JP2022111186A (ja) 2016-07-27 2022-06-01 表面から細菌バイオフィルムを低減または除去するためのサーモリシンの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662367338P 2016-07-27 2016-07-27
US62/367,338 2016-07-27
PCT/IB2017/054535 WO2018020435A1 (en) 2016-07-27 2017-07-26 Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022089557A Division JP2022111186A (ja) 2016-07-27 2022-06-01 表面から細菌バイオフィルムを低減または除去するためのサーモリシンの使用

Publications (3)

Publication Number Publication Date
JP2019522017A JP2019522017A (ja) 2019-08-08
JP2019522017A5 JP2019522017A5 (enExample) 2020-08-06
JP7127013B2 true JP7127013B2 (ja) 2022-08-29

Family

ID=59738382

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019503673A Active JP7127013B2 (ja) 2016-07-27 2017-07-26 表面から細菌バイオフィルムを低減または除去するためのサーモリシンの使用
JP2022089557A Pending JP2022111186A (ja) 2016-07-27 2022-06-01 表面から細菌バイオフィルムを低減または除去するためのサーモリシンの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022089557A Pending JP2022111186A (ja) 2016-07-27 2022-06-01 表面から細菌バイオフィルムを低減または除去するためのサーモリシンの使用

Country Status (7)

Country Link
US (2) US11628207B2 (enExample)
EP (1) EP3490588A1 (enExample)
JP (2) JP7127013B2 (enExample)
CN (1) CN109475609A (enExample)
AU (1) AU2017304271B2 (enExample)
CA (1) CA3031866A1 (enExample)
WO (1) WO2018020435A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11628207B2 (en) * 2016-07-27 2023-04-18 Smith & Nephew, Inc. Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces
US11413300B2 (en) 2017-01-30 2022-08-16 Smith & Nephew, Inc. Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces
US20220306968A1 (en) * 2019-06-06 2022-09-29 Danisco Us Inc Methods and compositions for cleaning
CN116057158A (zh) * 2020-07-27 2023-05-02 联合利华知识产权控股有限公司 酶和表面活性剂用于抑制微生物的用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006504835A (ja) 2002-10-31 2006-02-09 カリーヌ マリオン、 バイオフィルムの除去方法
JP2013060592A (ja) 2011-09-09 2013-04-04 Toyota Motor Engineering & Manufacturing North America Inc 有機汚染を安定に自己洗浄するためのポリマー改質酵素を含むコーティング
JP2013531103A (ja) 2010-06-21 2013-08-01 トヨタ モーター エンジニアリング アンド マニュファクチャリング ノース アメリカ，インコーポレイティド 虫の体汚染の簡易洗浄のためのサモアーゼｃ１６０（登録商標）含有クリアコート
JP2015537004A (ja) 2012-11-14 2015-12-24 スミス アンド ネフュー インコーポレイテッド 安定なサーモリシンヒドロゲル
JP2016512829A (ja) 2013-03-15 2016-05-09 スミス アンド ネフュー インコーポレイテッド 活性剤送達のための溶解性ゲル形成フィルム

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197291A (en) 1974-01-08 1980-04-08 Gerold K. V. Klein Hydrolytic enzyme material
JPS5692217A (en) 1979-12-26 1981-07-25 Kowa Co Easily absorbable enzyme preparation
IT1264322B (it) 1992-07-30 1996-09-23 Lanfranco Callegaro Esteri di gellano autoreticolato, procedimento di preparazione e loro applicazioni farmaceutiche e biomedico-sanitarie
CA2106609A1 (en) 1992-09-28 1994-03-29 Irene Yeatman Aldridge Proteases to inhibit and remove biofilm
US5902600A (en) 1992-12-21 1999-05-11 Healthpoint, Ltd. Hydrogel polymer wound dressing
DE19857237A1 (de) 1997-12-23 1999-06-24 Henkel Kgaa Strahlenhärtbare Kaschierklebestoffe
US6395529B1 (en) 1998-11-10 2002-05-28 Novozymes Biotech, Inc. Polypeptides having lactonohydrolase activity and nucleic acids encoding same
US6548556B2 (en) 2000-12-27 2003-04-15 Healthpoint, Ltd. Stable enzymatic wound debrider
US6399092B1 (en) 2000-12-27 2002-06-04 Healthpoint, Ltd. Anhydrous, hydrophilic absorbent wound dressing (tube) with antimicrobials or other pharmaceutically active agents
US20030026794A1 (en) 2001-07-31 2003-02-06 Howard Fein Selective enzyme treatment of skin conditions
US6479060B1 (en) 2001-09-04 2002-11-12 Healthpoint, Ltd. Elegant hydrogenated castor oil ointments
US20030198631A1 (en) 2002-04-18 2003-10-23 Healthpoint, Ltd. Thermolysin enzymatic wound debrider
KR20050052666A (ko) 2002-10-10 2005-06-03 다이버사 코포레이션 프로테아제, 이를 암호화하는 핵산, 및 이를 제조하고사용하는 방법
US20050079594A1 (en) * 2002-10-31 2005-04-14 Karine Marion Method of removing a biofilm
AU2003284385B2 (en) 2002-12-20 2009-08-27 Rutgers, The State University Of New Jersey Compositions and methods for enzymatic detachment of bacterial and fungal biofilms
US8821862B2 (en) 2002-12-20 2014-09-02 Kane Biotech Inc. Soluble β-N-acetylglucosaminidase based antibiofilm compositions and uses thereof
US20100221237A1 (en) 2003-03-26 2010-09-02 Biosynexus Incorporated Enzyme disruption of bacterial biofilms
US7785584B2 (en) 2003-08-13 2010-08-31 Healthpoint, Ltd. Ointment wound spray
ES2421538T3 (es) 2003-10-29 2013-09-03 Cystic Fibrosis Foundation Therapeutics Inc Proteasas no pancreáticas para controlar la concentración de colecistocinina (CCK) en plasma y para tratar el dolor
GB0326194D0 (en) 2003-11-10 2003-12-17 Univ Kent Canterbury Proteins involved in signal transduction
US20080177217A1 (en) 2004-05-14 2008-07-24 Hans-Dietrich Polaschegg Taurolidine Formulations and Delivery: Therapeutic Treatments and Antimicrobial Protection Against Bacterial Biofilm Formation
EP1666075A1 (en) 2004-10-04 2006-06-07 Switch Biotech Aktiengesellschaft Wound dressing compositions, especially for delivery of protease inhibitors
IL165334A0 (en) 2004-11-22 2006-01-15 Mediwound Ltd Debriding composition from bromelain and methods of producing same
JP5242402B2 (ja) 2005-10-11 2013-07-24 アマノ エンザイム ユーエスエー カンパニー，リミテッド Ｐａｉ−１の酵素阻害物質
US8287858B2 (en) 2006-08-10 2012-10-16 Jon Barron Proteolytic enzyme formulations
AT504159A1 (de) 2006-08-16 2008-03-15 Marlyn Nutraceuticals Inc Verwendung von proteasen
DK2132316T3 (da) 2007-03-23 2015-06-22 Danisco Us Inc Forøget amylaseproduktion ved n-terminal addition til modent amylaseprotein
JP2008290966A (ja) 2007-05-24 2008-12-04 Michiharu Sasaki 養毛剤
HUE034051T2 (en) * 2007-11-27 2018-01-29 Algipharma As Use of alginate-containing oligomers to combat biofilms
AT506095A1 (de) 2007-12-03 2009-06-15 Volopharm Gmbh Verwendung von proteasen
US8309081B2 (en) 2008-11-18 2012-11-13 Scarguard Labs, Llc. Composition and method for treatment of bruising
JP2010126710A (ja) * 2008-12-01 2010-06-10 Kao Corp バイオフィルム除去剤組成物
WO2010079209A2 (en) 2009-01-08 2010-07-15 Golub Alexandr A Compositions for treating wounds and skin conditions
GB0905451D0 (en) 2009-03-31 2009-05-13 Novabiotics Ltd Biofilms
EP2504025A4 (en) 2009-11-23 2013-05-01 Stephen F Olmstead COMPOSITIONS AND METHODS USING SERRATIA PEPTIDASE FOR INHIBITING AND TREATING BIOFILMS ASSOCIATED WITH PARTICULAR SUFFERING
NZ600403A (en) 2009-12-08 2014-01-31 Smith & Nephew Orthopaedics Ag Enzymatic wound debriding compositions with enhanced enzymatic activity
US20140154235A1 (en) 2011-05-12 2014-06-05 Smith & Nephew Orthopaedics Ag Wound debridement compositions containing seaprose and methods of wound treatment using same
WO2013096337A1 (en) 2011-12-20 2013-06-27 Kci Licensing, Inc. Composition for enzymatic debridement
AU2013259360B2 (en) 2012-05-11 2017-07-13 Smith & Nephew, Inc. Use of Seaprose to remove bacterial biofilm
EP2968374A4 (en) 2013-03-15 2016-08-10 Alphabet 3 Llc M METHODS AND COMPOSITIONS FOR IMPROVING OXYGEN RATE IN FABRICS
US20170152462A1 (en) 2014-04-11 2017-06-01 Novozymes A/S Detergent Composition
CN107920510A (zh) 2015-08-24 2018-04-17 史密夫和内修有限公司 中等极性油与抗菌剂的组合在细菌生物膜上的协同抗菌活性
US11628207B2 (en) * 2016-07-27 2023-04-18 Smith & Nephew, Inc. Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces
US11413300B2 (en) * 2017-01-30 2022-08-16 Smith & Nephew, Inc. Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006504835A (ja) 2002-10-31 2006-02-09 カリーヌ マリオン、 バイオフィルムの除去方法
JP2013531103A (ja) 2010-06-21 2013-08-01 トヨタ モーター エンジニアリング アンド マニュファクチャリング ノース アメリカ，インコーポレイティド 虫の体汚染の簡易洗浄のためのサモアーゼｃ１６０（登録商標）含有クリアコート
JP2013060592A (ja) 2011-09-09 2013-04-04 Toyota Motor Engineering & Manufacturing North America Inc 有機汚染を安定に自己洗浄するためのポリマー改質酵素を含むコーティング
JP2015537004A (ja) 2012-11-14 2015-12-24 スミス アンド ネフュー インコーポレイテッド 安定なサーモリシンヒドロゲル
JP2016512829A (ja) 2013-03-15 2016-05-09 スミス アンド ネフュー インコーポレイテッド 活性剤送達のための溶解性ゲル形成フィルム

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Bacteriology，2013年，Vol.195, No.8, pp.1645-1655

Also Published As

Publication number Publication date
CN109475609A (zh) 2019-03-15
EP3490588A1 (en) 2019-06-05
AU2017304271B2 (en) 2024-07-18
US11628207B2 (en) 2023-04-18
JP2022111186A (ja) 2022-07-29
JP2019522017A (ja) 2019-08-08
AU2017304271A1 (en) 2019-02-28
US20190262437A1 (en) 2019-08-29
WO2018020435A1 (en) 2018-02-01
US20230346898A1 (en) 2023-11-02
CA3031866A1 (en) 2018-02-01

Similar Documents

Publication Publication Date Title
US20230346898A1 (en) Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces
EP2515869B1 (en) Wound care products
JP7118022B2 (ja) 細菌性バイオフィルムを除去するためのセアプローゼの使用
US11641856B2 (en) Synergistic antibacterial activity of medium polarity oils in combination with antibacterial agents on bacterial biofilms
US11957698B2 (en) Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces
KR20220027799A (ko) 항미생물제 내성의 유도 없이 생물막을 치료하기 위한 조성물
CN114206113A (zh) 抗微生物组合物和包含该组合物的制品

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190129

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20190206

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20190213

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200625

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200625

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210614

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210913

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20220207

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220601

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20220601

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20220610

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20220613

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220719

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220817

R150 Certificate of patent or registration of utility model

Ref document number: 7127013

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250