JP7084057B2 - 新規抗ｐａｄ２抗体 - Google Patents
新規抗ｐａｄ２抗体 Download PDFInfo
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- JP7084057B2 JP7084057B2 JP2020525771A JP2020525771A JP7084057B2 JP 7084057 B2 JP7084057 B2 JP 7084057B2 JP 2020525771 A JP2020525771 A JP 2020525771A JP 2020525771 A JP2020525771 A JP 2020525771A JP 7084057 B2 JP7084057 B2 JP 7084057B2
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Images
Classifications
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- C—CHEMISTRY; METALLURGY
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- C12Y305/03006—Arginine deiminase (3.5.3.6)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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| CN118001407B (zh) * | 2024-04-02 | 2024-06-21 | 北京大学人民医院 | Pad2在制备治疗缺血缺氧性恶性心律失常药物中的应用 |
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| WO2014086365A1 (en) | 2012-12-03 | 2014-06-12 | Rigshospitalet | Anti-pad2 antibodies and treatment of autoimmune diseases |
| WO2016155745A1 (en) | 2015-03-27 | 2016-10-06 | Rigshospitalet | Cross-reactive anti-pad antibodies |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US20040110938A1 (en) * | 2000-02-24 | 2004-06-10 | Parekh Rajesh Bhikhu | Proteins, genes and their use for diagnosis and treatment of schizophrenia |
| CA2561742A1 (en) * | 2004-04-01 | 2005-10-27 | Sequenom, Inc. | Methods for identifying risk of osteoarthritis and treatments thereof |
| WO2007095250A2 (en) * | 2006-02-13 | 2007-08-23 | The Cleveland Clinic Foundation | Compositions and methods for inhibiting optic nerve damage |
| EP2527369A3 (en) * | 2007-09-13 | 2012-12-19 | University Of Zurich Prorektorat Forschung | Monoclonal amyloid beta (abeta)-specific antibody and uses thereof |
| US9718877B2 (en) * | 2008-06-04 | 2017-08-01 | Modiquest B.V. | Anti-inflammatory agents |
| US8975033B2 (en) * | 2012-11-05 | 2015-03-10 | The Johns Hopkins University | Human autoantibodies specific for PAD3 which are cross-reactive with PAD4 and their use in the diagnosis and treatment of rheumatoid arthritis and related diseases |
| CN104360070B (zh) * | 2014-11-28 | 2017-02-22 | 山东新创生物科技有限公司 | 肽基精氨酸脱亚胺酶2在制备肿瘤临床血液诊断试剂中的应用 |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2014086365A1 (en) | 2012-12-03 | 2014-06-12 | Rigshospitalet | Anti-pad2 antibodies and treatment of autoimmune diseases |
| WO2016155745A1 (en) | 2015-03-27 | 2016-10-06 | Rigshospitalet | Cross-reactive anti-pad antibodies |
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| CA3102360A1 (en) | 2019-12-26 |
| US20210246225A1 (en) | 2021-08-12 |
| EP3816289A4 (en) | 2022-03-02 |
| CN112262213A (zh) | 2021-01-22 |
| EP3816289A1 (en) | 2021-05-05 |
| WO2019244934A1 (ja) | 2019-12-26 |
| JP2022119899A (ja) | 2022-08-17 |
| JPWO2019244934A1 (ja) | 2021-06-24 |
| JP7411264B2 (ja) | 2024-01-11 |
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